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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
PIT
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "PIT" in MCE Product Catalog:
Synonyms: 2,2'-Pyridylisatogen tosylate
Target:
Research Areas:
PIT (2,2'-Pyridylisatogen tosylate) is a selective and non-competitive antagonist of P2Y1 receptor with an IC50 value of 0.14 μM for human P2Y1 receptor. PIT antagonizes P2Y1 receptor signaling without affecting nucleotide binding. PIT is an irreversible antagonist of responses to ATP at metabotropic purinoceptors (of the P2Y family) in some smooth muscles. PIT can be used for the research of chronic bronchitis and asthma .
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Research Areas:
Cardiovascular Disease Metabolic Disease Endocrinology Cancer
Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC50=24 nM) and androgen receptor (IC50=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca 2+ channels to exert antihypertensive effects .
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1 Cited Publications
Cat. No.: HY-N0805A
CAS No.: 18649-93-9
Category:
Triterpenes Alisma plantago-aquatica Linn. Terpenoids Metabolic Disease Plants Disease Research Fields Alismataceae Extract
Target:
1
1 Cited Publications
Cat. No.: HY-P82917
Synonyms: anti-Interferon regulatory factor 6; anti-IRF 6; anti-LPS; anti-OFC 6; anti-PIT; anti-PPS; anti-PPS1; anti-VWS; anti-VWS1; Interferon regulatory factor 6 antibody; IRF 6 antibody; LPS antibody; OFC 6 antibody; PIT antibody; PPS antibody; PPS1 antibody; VWS antibody; VWS1 antibody;
PIT-1 is a selective PIP3 (phosphatidylinositol 3,4,5-trisphosphate) antagonist. PIT-1 inhibits cancer cell survival and induces apoptosis by inhibition of PIP3 dependent PI3K / Akt signaling. PIT-1 exhibits antitumor activity in vivo .
Cat. No.: HY-N7646
CAS No.: 143601-09-6
Category:
Curculigo orchioides Gaertn. Other Diseases Amaryllidaceae Extract Phenols Polyphenols Plants Disease Research Fields
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Cat. No.: HY-124348
CAS No.: 701947-53-7
Synonyms: 3,5-Dimethyl PIT-1
DM-PIT-1 is a PIP3/PH (phosphatidylinositol-3,4,5-triphosphate/Pleckstrin) interaction inhibitor. DM-PIT-1 decreases he expression of P-Akt, P-GSK-3-β, P-p70S6K, P-S6, P-4E-BP1. DM-PIT-1 induces apoptosis and shows anticancer activity. DM-PIT-1 has the potential for the research of ovarian cancer .
Cat. No.: HY-B0561S4
Cat. No.: HY-RS06910
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Research Areas:
IRF6 Human Pre-designed siRNA Set A contains three designed siRNAs for IRF6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-103224R
CAS No.: 53501-41-0
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PIT-1 (Standard) is the analytical standard of PIT-1. This product is intended for research and analytical applications. PIT-1 is a selective PIP3 (phosphatidylinositol 3,4,5-trisphosphate) antagonist. PIT-1 inhibits cancer cell survival and induces apoptosis by inhibition of PIP3 dependent PI3K / Akt signaling. PIT-1 exhibits antitumor activity in vivo .
Cat. No.: HY-108662R
CAS No.: 56583-49-4
Synonyms: 2,2'-Pyridylisatogen tosylate (Standard)
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Research Areas:
PIT (Standard) is the analytical standard of PIT (HY-108662). This product is intended for research and analytical applications. PIT (2,2'-Pyridylisatogen tosylate) is a selective and non-competitive antagonist of P2Y1 receptor with an IC50 value of 0.14 μM for human P2Y1 receptor. PIT antagonizes P2Y1 receptor signaling without affecting nucleotide binding. PIT is an irreversible antagonist of responses to ATP at metabotropic purinoceptors (of the P2Y family) in some smooth muscles. PIT can be used for the research of chronic bronchitis and asthma .
Cat. No.: HY-N0805AR
CAS No.: 18649-93-9
Cat. No.: HY-159978
CAS No.: 1628848-73-6
Synonyms: EOS789
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Research Areas:
Atidafonat is an orally active sodium-dependent phosphate transporter inhibitor, with IC50 values of 6.8, 1.5, and 1.7 μM against human NaPi-IIb, PiT-1, PiT-2, respectively; and IC50 values of 3.9, 1.9, and 1.7 μM against rat NaPi-IIb, PiT-1, PiT-2, respectively. Atidafonat inhibits intestinal phosphate absorption, increases fecal phosphate excretion, reduces urinary phosphate excretion, and decreases the levels of serum phosphate, FGF23, and adult parathyroid hormone. Atidafonat ameliorates ectopic thoracic aortic calcification, renal injury and hyperphosphatemia, and inhibits the expression of fibrosis markers. Atidafonat can be used for the research of hyperphosphatemia and chronic kidney disease-mineral and bone disorder (CKD-MBD) .
Cat. No.: HY-DY2038
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Lignin Staining Solution (Pianeze Method) is a multichromatic staining solution for plant histology composed of malachite green, Martius yellow and acid fuchsin. Lignin Staining Solution (Pianeze Method) enables lignified secondary walls to appear bright green, non-lignified secondary walls to appear red, and tracheid pit membranes to appear pale red after long-time immersion. Lignin Staining Solution (Pianeze Method) can be used to distinguish lignified cell walls from non-lignified structures and observe the morphology of pit membranes in plant tissue sections such as fern rhizomes. Lignin Staining Solution (Pianeze Method) can be applied to relevant studies on flax wilt and root rot .
Cat. No.: HY-D3432
Cat. No.: HY-P702038
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SLC20A2; Phosphate Transporter 2; Prev. GLVR2; Epididymis Secretory Sperm Binding Protein; Prev. MLVAR; Phosphate Transporter; Sodium-Dependent Phosphate Transporter 2; GLVR-2; PIT-2; IBGC1; PIT2; IBGC2; Gibbon Ape Leukemia Virus Receptor 2; IBGC3; Glvr-2
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-W747074
CAS No.: 71781-66-3
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Tauroursodeoxycholic acid-3-sulfate disodium is a taurine-conjugated 3-sulfated bile acid that belongs to endogenous sulfated bile acid metabolites and is detectable in human and animal serum, urine, bile, and metabolomics panels. Tauroursodeoxycholic acid-3-sulfate disodium occurs at higher concentrations in the gallbladder of hibernating snakes of the five-paced pit viper species than in active snakes. Tauroursodeoxycholic acid-3-sulfate disodium can serve as a biochemical indicator in research related to hepatobiliary diseases .
Cat. No.: HY-P11797
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
