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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
PIT
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "PIT" in MCE Product Catalog:
7
Research Areas:
Cardiovascular Disease Metabolic Disease Endocrinology Cancer
Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC50=24 nM) and androgen receptor (IC50=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca 2+ channels to exert antihypertensive effects .
1
1 Cited Publications
Cat. No.: HY-N0805A
CAS No.: 18649-93-9
Category:
Triterpenes Alisma plantago-aquatica Linn. Terpenoids Metabolic Disease Plants Alismataceae Disease Research Fields
Target:
1
1 Cited Publications
Cat. No.: HY-P82917
Synonyms: anti-Interferon regulatory factor 6; anti-IRF 6; anti-LPS; anti-OFC 6; anti-PIT; anti-PPS; anti-PPS1; anti-VWS; anti-VWS1; Interferon regulatory factor 6 antibody; IRF 6 antibody; LPS antibody; OFC 6 antibody; PIT antibody; PPS antibody; PPS1 antibody; VWS antibody; VWS1 antibody;
Synonyms: 2,2'-Pyridylisatogen tosylate
Target:
Research Areas:
PIT (2,2'-Pyridylisatogen tosylate) is a selective and non-competitive antagonist of P2Y1 receptor with an IC50 value of 0.14 μM for human P2Y1 receptor. PIT antagonizes P2Y1 receptor signaling without affecting nucleotide binding. PIT is an irreversible antagonist of responses to ATP at metabotropic purinoceptors (of the P2Y family) in some smooth muscles. PIT can be used for the research of chronic bronchitis and asthma .
PIT-1 is a selective PIP3 (phosphatidylinositol 3,4,5-trisphosphate) antagonist. PIT-1 inhibits cancer cell survival and induces apoptosis by inhibition of PIP3 dependent PI3K / Akt signaling. PIT-1 exhibits antitumor activity in vivo .
Cat. No.: HY-D2443
Cat. No.: HY-N7646
CAS No.: 143601-09-6
Category:
Curculigo orchioides Gaertn. Other Diseases Phenols Polyphenols Plants Disease Research Fields Amaryllidaceae
Target:
Cat. No.: HY-124348
CAS No.: 701947-53-7
Synonyms: 3,5-Dimethyl PIT-1
DM-PIT-1 is a PIP3/PH (phosphatidylinositol-3,4,5-triphosphate/Pleckstrin) interaction inhibitor. DM-PIT-1 decreases he expression of P-Akt, P-GSK-3-β, P-p70S6K, P-S6, P-4E-BP1. DM-PIT-1 induces apoptosis and shows anticancer activity. DM-PIT-1 has the potential for the research of ovarian cancer .
Cat. No.: HY-B0561S4
Cat. No.: HY-RS06910
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Research Areas:
IRF6 Human Pre-designed siRNA Set A contains three designed siRNAs for IRF6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-103224R
CAS No.: 53501-41-0
Target:
Research Areas:
PIT-1 (Standard) is the analytical standard of PIT-1. This product is intended for research and analytical applications. PIT-1 is a selective PIP3 (phosphatidylinositol 3,4,5-trisphosphate) antagonist. PIT-1 inhibits cancer cell survival and induces apoptosis by inhibition of PIP3 dependent PI3K / Akt signaling. PIT-1 exhibits antitumor activity in vivo .
Cat. No.: HY-108662R
CAS No.: 56583-49-4
Synonyms: 2,2'-Pyridylisatogen tosylate (Standard)
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Research Areas:
PIT (Standard) is the analytical standard of PIT (HY-108662). This product is intended for research and analytical applications. PIT (2,2'-Pyridylisatogen tosylate) is a selective and non-competitive antagonist of P2Y1 receptor with an IC50 value of 0.14 μM for human P2Y1 receptor. PIT antagonizes P2Y1 receptor signaling without affecting nucleotide binding. PIT is an irreversible antagonist of responses to ATP at metabotropic purinoceptors (of the P2Y family) in some smooth muscles. PIT can be used for the research of chronic bronchitis and asthma .
Cat. No.: HY-N0805AR
CAS No.: 18649-93-9
Cat. No.: HY-D3432
Cat. No.: HY-159978
CAS No.: 1628848-73-6
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Research Areas:
EOS789 is an orally active sodium-dependent phosphate transporter inhibitor, with IC50 values of 6.8, 1.5, and 1.7 μM against human NaPi-IIb, PiT-1, PiT-2, respectively; and IC50 values of 3.9, 1.9, and 1.7 μM against rat NaPi-IIb, PiT-1, PiT-2, respectively. EOS789 inhibits intestinal phosphate absorption, increases fecal phosphate excretion, reduces urinary phosphate excretion, and decreases the levels of serum phosphate, FGF23, and adult parathyroid hormone. EOS789 ameliorates ectopic thoracic aortic calcification, renal injury and hyperphosphatemia, and inhibits the expression of fibrosis markers. EOS789 can be used for the research of hyperphosphatemia and chronic kidney disease-mineral and bone disorder (CKD-MBD) .
Cat. No.: HY-P11797
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Research Areas:
Cat. No.: HY-P702038
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SLC20A2; Sodium-dependent phosphate transporter 2; Gibbon ape leukemia virus receptor 2; GLVR-2; Phosphate transporter 2; PIT-2; PIT2; hPIT2; Solute carrier family 20 member 2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
