28 Results for "

PSGL1

" in MedChemExpress (MCE) Product Catalog:
Products (28)

28 Results for "PSGL1" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-103358
CAS No.: 257292-29-8
Purity:  99.63%
Target:  

P-selectin

Research Areas:  

Inflammation/Immunology

KF38789 is a selective inhibitor of P-selectin-PSGL-1 binding. KF38789 inhibits the binding of U937 cells to immobilized P-selectin immunoglobulin G chimeric protein (P-selectin-Ig) with an IC50 value of 1.97 μM [1].
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1
1 Cited Publications
Cat. No.: HY-P9987
CAS No.: 1690318-25-2
Synonyms: hSel001; SEG101

Target:  

P-selectin

Research Areas:  

Cardiovascular Disease

Crizanlizumab is an anti-P-selectin monoclonal antibody. Crizanlizumab binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand 1 (PSGL-1). Crizanlizumab prevents vaso-occlusive crises (VOCs) and can be used for research of sickle cell disease [1] .
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1
1 Cited Publications
Cat. No.: HY-P99263
CAS No.: 1256258-86-2
Synonyms: Anti-Human selectin P Recombinant Antibody

Target:  

P-selectin

Research Areas:  

Cardiovascular Disease

Inclacumab (Anti-Human selectin P Recombinant Antibody) is a human monoclonal IgG4 antibody selectively targets P-selectin with a Kd value of 9.9 nM. Inclacumab inhibits P-selectin glycoprotein ligand 1 (PSGL-1) mimetic peptide bind with P-selectin with an IC50 value of 1.9 μg/mL and strongly inhibits cell adhesion [1] .
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1
1 Cited Publications
Cat. No.: HY-P991447

Target:  

VISTA

Research Areas:  

Cancer

Anti-VSIR/VISTA Antibody (SG7) is an antibody targeting VISTA, with a Kd of 0.14 nM for human VISTA and 1 nM for mouse VISTA. Anti-VSIR/VISTA Antibody (SG7) blocks the function of VISTA, prevents VISTA from binding to T cells, restores suppressed T cell activation, and blocks the interactions between VISTA and PSGL-1 as well as VSIG3. Anti-VSIR/VISTA Antibody (SG7) slows tumor growth, reduces PMN-MDSCs, and increases the numbers of CD4 + and CD8 + T cells in the tumor microenvironment. Anti-VSIR/VISTA Antibody (SG7) can be used in studies related to melanoma, colon cancer, and breast cancer [1].
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Cat. No.: HY-P99378
CAS No.: 2158362-38-8
Synonyms: ALTB-168; Anti-PSGL1/CD162 Reference Antibody (neihulizumab); AbGn-168

Target:  

Apoptosis

Research Areas:  

Inflammation/Immunology

Neihulizumab (ALTB-168) is an immune checkpoint agonistic antibody that binds to human CD162 (PSGL-1), leading to downregulation of activated T-cells. Neihulizumab can be uesd for steroid-refractory acute graft-versus-host-disease (SR-aGVHD), psoriasis, psoriatic arthritis and ulcerative colitis research [1].
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Cat. No.: HY-P6442
CAS No.: 1020407-90-2
Chemerin15 is an anti-inflammatory peptide derived from Chemerin. Chemerin15 binds to ChemR23. Chemerin15 inhibits TNFα-induced activation of Syk, ERK and Src kinases. Chemerin15 increases the expression of p-p38 mRNA and protein. Chemerin15 mediates phagocytosis, resolution of inflammation, CD62L shedding and downregulation of PSGL-1 expression in macrophages and microglia. Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury via ChemR23. Chemerin15 enhances microglial phagocytosis, thereby alleviating cerebral ischemia-reperfusion injury [1] .
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Cat. No.: HY-125475
CAS No.: 927881-99-0
Synonyms: GMI-1070
Target:  

E-Selectin

Research Areas:  

Cardiovascular Disease

Rivipansel is a small-molecule glycomimetic pan-selectin antagonist with inhibitory activity against E-selectin and P-selectin. Rivipansel binds tightly to the lectin domain of E-selectin, and selectively blocks the recognition of CD62L by E-selectin without affecting the binding of PSGL-1 to E-selectin. Rivipansel functionally inhibits the adhesion of hematopoietic cells to endothelial cells, and is applicable to research related to sickle cell disease [1] .
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Cat. No.: HY-P990166
Anti-Mouse PSGL-1/CD162 Antibody (4RA10) is a rat-derived IgG1 κ type antibody inhibitor, targeting to mouse PSGL-1/CD162. Anti-Mouse PSGL-1/CD162 Antibody (4RA10) blocks PSGL signaling and inhibits leukocyte rolling. Anti-Mouse PSGL-1/CD162 Antibody (4RA10) can be used for the researches of inflammation, immunology and infection, such as pneumonia and lymphocytic choriomeningitis virus infection [1] .
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Cat. No.: HY-122655
CAS No.: 2002363-68-8
HMCEF is an orally active P-selectin inhibitor and inhibits P-selectin expression. HMCEF blocks the interaction between P-selectin and natural ligands, such as PSGL-1. HMCEF inhibits thrombosis and inflammation in mice [1].
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Cat. No.: HY-P991432

Target:  

TNF Receptor NF-κB c-Myc

Research Areas:  

Cancer

VTX-0811 is a human IgG4 monoclonal antibody (mAb) targeting PSGL1/CD162. VTX-0811 up-regulates TNF-α/NF-κB and chemokine-mediated signaling and down-regulates oxidative phosphorylation, fatty acid metabolism, and Myc signaling pathways. VTX-0811 increases the proportion of CD8+ T cells among infiltrating T cells. VTX-0811 has antitumor activity in a humanized mouse PDX model of melanoma [1].
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Cat. No.: HY-P9987A
CAS No.: 1690318-25-2

Target:  

P-selectin

Research Areas:  

Inflammation/Immunology

Crizanlizumab (anti-P-selectin) is an anti-P-selectin monoclonal antibody. Crizanlizumab binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand 1 (PSGL-1). Crizanlizumab prevents vaso-occlusive crises (VOCs) and can be used for research of sickle cell disease [1] .
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Cat. No.: HY-P84565
Synonyms: CLA; PSGL1; PSGL-1

Host:  

Mouse

Application:  

IHC-P, FC, ELISA

Reactivity:  

Human

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Cat. No.: HY-P84565A
Synonyms: CLA; PSGL1; PSGL-1

Host:  

Mouse

Application:  

IHC-P, FC, ELISA

Reactivity:  

Human

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Cat. No.: HY-P700815
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CLA; PSGL-1; PSGL1; CD162; SELPLG; Selectin P ligand; Selp1; Selpl
Species:  
Source:  
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Cat. No.: HY-P700816
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CLA; PSGL-1; PSGL1; CD162; SELPLG; Selectin P ligand; Selp1; Selpl
Species:  
Source:  
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Cat. No.: HY-P84970
Synonyms: CLA; CD162; PSGL1; PSGL-1; PSGL-1; p-selectin glycoprotein ligand-1; CD 162 antibody; CD162 antibody; CD162 antigen antibody; CLA antibody; Cutaneous lymphocyte associated associated antigen antibody; P selectin glycoprotein ligand 1 antibody; P selectin glycoprotein ligand 1 precursor antibody; P-selectin glycoprotein ligand 1 antibody; PSGL 1 antibody; PSGL-1 antibody; PSGL1 antibody; Selectin P ligand antibody; SELPL_HUMAN antibody; SELPLG antibody;

Host:  

Mouse

Application:  

ELISA

Reactivity:  

Human

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Cat. No.: HY-P78819
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: PSGL1; CD162; SELPLG; Selectin P ligand
Species:  
Source:  
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Cat. No.: HY-P7800
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: rMuCD162, C-Fc; PSGL-1; CD162; SELPLG; CLA;
Species:  
Source:  
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Cat. No.: HY-P81711
Synonyms: CD162; CLA; PSGL1; SELPLG

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, IP

Reactivity:  

Human

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Cat. No.: HY-P77165
Purity:  ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: P-selectin glycoprotein ligand 1; PSGL-1; Selectin P ligand; CD162; SELPLG
Species:  
Source:  
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