43 Results for "

Phorbol ester

" in MedChemExpress (MCE) Product Catalog:
Products (43)

43 Results for "Phorbol ester" in MCE Product Catalog:

825
825 Publications Verification
Cat. No.: HY-18739
CAS No.: 16561-29-8
Synonyms: PMA; TPA; Phorbol myristate acetate
Phorbol 12-myristate 13-acetate (PMA; TPA; Phorbol myristate acetate), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator . Phorbol 12-myristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells (Validated by MedChemExpress) .
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-N2609
CAS No.: 2196-14-7
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-18985
CAS No.: 37558-16-0
Synonyms: Phorbol dibutyrate; PDBu
Target:  

PKC

Research Areas:  

Cancer

Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator and a potent skin tumor promoter .
loading...
    loading...
Cat. No.: HY-116291
CAS No.: 27536-56-7
Purity:  ≥98.0%
Synonyms: 4αPDD
Target:  

TRP Channel CHIKV

Research Areas:  

Infection Inflammation/Immunology

4α-Phorbol 12,13-didecanoate (4αPDD) is a transient receptor potential vanilloid 4 (TRPV4) agonist. 4α-Phorbol 12,13-didecanoate can promote Ca 2+ influx, induce ATP release and function as an osmoreceptor. 4α-Phorbol 12,13-didecanoate can inhibit water intake and increase maximal micturition pressure in rats. 4α-Phorbol 12,13-didecanoate can be used for the researches of inflammation and infection, such as chikungunya virus (CHIKV) .
loading...
    loading...
Cat. No.: HY-18739R
CAS No.: 16561-29-8
Synonyms: PMA (Standard); TPA (Standard); Phorbol myristate acetate (Standard)
Phorbol 12-myristate 13-acetate (PMA; TPA; Phorbol myristate acetate) (Standard) is the analytical standard of Phorbol 12-myristate 13-acetate. This product is intended for research and analytical applications.
loading...
    loading...
Cat. No.: HY-N2147
CAS No.: 17673-25-5
Synonyms: 4β-Phorbol
Phorbol is the flagship member of the tigliane diterpene family. Phorbol can be isolated from natural sources and through semisynthesis. Phorbol can form esters that have a wide array of biological properties, which includes the induction of angiogenesis in vitro and promoting tumor in vivo .
loading...
    loading...
Cat. No.: HY-W743654
CAS No.: 470-38-2
Target:  

Apoptosis

Research Areas:  

Cancer

Capsorubin is a carotenoid found in peppers with multiple biological activities. Capsorubin (167 μM) inhibits lipid peroxidation induced by 2,2'-azobis(2,4-dimethylvaleronitrile) (AMVN) in vitro. Capsorubin (1 μM) reduces UVB-induced DNA strand breaks and apoptosis in human dermal fibroblasts. Capsorubin also inhibits Epstein-Barr virus early antigen (EBV-EA) activation induced by phorbol 12-myristate 13-acetate in Raji cells, a marker of tumorigenesis.
loading...
    loading...
Cat. No.: HY-160070
CAS No.: 24928-17-4
Target:  

HIV

Research Areas:  

Cancer

Phorbol-12,13-didecanoate is an anti-viral TPA compound and a tumor promoter. It can cause changes in actin-containing structures [1] .
loading...
    loading...
Cat. No.: HY-114095
CAS No.: 1158347-73-9
Purity:  99.64%
Synonyms: VU0285655-1
BML-280 (VU0285655-1) is a potent and selective phospholipase D2 (PLD2) inhibitor. BML-280 has the ability to prevent caspase-3 cleavage and reduction in cell viability induced by high glucose. BML-280 can be used for rheumatoid arthritis research .
loading...
    loading...
Cat. No.: HY-W743654R
CAS No.: 470-38-2
Research Areas:  

Cancer

Capsorubin (Standard) is the analytical standard of Capsorubin. This product is intended for research and analytical applications. Capsorubin is a carotenoid found in peppers with multiple biological activities. Capsorubin (167 μM) inhibits lipid peroxidation induced by 2,2'-azobis(2,4-dimethylvaleronitrile) (AMVN) in vitro. Capsorubin (1 μM) reduces UVB-induced DNA strand breaks and apoptosis in human dermal fibroblasts. Capsorubin also inhibits Epstein-Barr virus early antigen (EBV-EA) activation induced by phorbol 12-myristate 13-acetate in Raji cells, a marker of tumorigenesis.
loading...
    loading...
Cat. No.: HY-18985G
CAS No.: 37558-16-0
Synonyms: Phorbol dibutyrate (GMP); PDBu (GMP)
Phorbol 12,13-dibutyrate (Phorbol dibutyrate) (GMP) is Phorbol 12,13-dibutyrate (HY-18985) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Phorbol 12,13-dibutyrate is a PKC activator and a potent skin tumor promoter .
loading...
    loading...
Cat. No.: HY-118442
CAS No.: 24558-60-9
Synonyms: Tetradecasphing-4-enine
Target:  

PKC

Sphingosine (d14:1) (Tetradecasphing-4-enine), a sphingolipid, is a potent Protein kinase C (PKC) inhibitor. Sphingosine (d14:1) prevents its interaction with sn-1,2-diacylglycerol (DAG)/Phorbol esters .
loading...
    loading...
Cat. No.: HY-N10866
CAS No.: 92214-56-7
Phorbol 12-tiglate is a derivative of Phorbol (HY-N2147). Phorbol, a hydrolyzed product of Croton oil, promotes tumor development by activating protein kinase C. Phorbol and its derivatives can be used to construct carcinogenic models in biomedical research .
loading...
    loading...
Cat. No.: HY-129330
CAS No.: 80998-07-8
Sapintoxin D is a fluorescent phorbol ester that can be used to study the activation of protein kinase C (PKC). Sapintoxin D is a calcium-dependent PKC activator .
loading...
    loading...
Cat. No.: HY-123487
CAS No.: 79083-69-5
Sapintoxin A is a phorbol ester that can be isolated from the unripe fruits of Sapium indicum .
loading...
    loading...
Cat. No.: HY-118725
CAS No.: 111149-87-2
Luffariellolide is an inhibitor of human synovial fluid phospholipase A2 (HSF-PLA2) (IC50=5 μM). Luffariellolide effectively inhibits phorbol ester (PMA)-induced ear edema (ED50=50 μg/ear) .
loading...
    loading...
Cat. No.: HY-P5452
CAS No.: 379711-25-8
Target:  

PKC

Research Areas:  

Others

PKCd (8-17) is a biological active peptide. (This peptide is derived from the V1 domain of protein kinase C (PKC)d. It inhibits phorbol 12-myristate 13-acetate (PMA)-induced PKCd translocation and activation. Inhibition of PKCd reduces ischemia damage in cardiac and cerebral cells, induces proliferation of fibroblasts, and inhibits graft coronary artery disease in mice.)
loading...
    loading...
Cat. No.: HY-172546
Synonyms: LysoGM2 ammonium
Target:  

PKC

Research Areas:  

Metabolic Disease

Lyso-monosialoganglioside GM2 (LysoGM2) ammonium is a lysosphingolipid and protein kinase C inhibitor (IC50: 50 μM). Lyso-monosialoganglioside GM2 ammonium can inhibit the binding of protein kinase C to Phorbol 12,13-dibutyrate (HY-18985). Lyso-monosialoganglioside GM2 ammonium is a specific biomarker for GM2 gangliosidosis. Lyso-monosialoganglioside GM2 ammonium can be used in the research of sphingolipidoses .
loading...
    loading...
Cat. No.: HY-N10872
CAS No.: 2253772-04-0
Phorbol-12-(2-methylbutyrate) is a nature product that could be isolated form croton oil .
loading...
    loading...
Cat. No.: HY-N2408
CAS No.: 26241-63-4
Synonyms: IsoPhorbol; α-Phorbol
4α-Phorbol is a compound that can be isolated from croton oil .
loading...
    loading...