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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
Phosphatase-IN-2
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "Phosphatase-IN-2" in MCE Product Catalog:
Cat. No.: HY-180456
CAS No.: 2361524-76-5
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Phosphatase-IN-2 (Compound 26) is a CpxA phosphatase inhibitor. Phosphatase-IN-2 can be used in the research of Escherichia coli infection .
4
4 Cited Publications
Cat. No.: HY-18756
CAS No.: 56990-57-9
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NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively . NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26) [2].
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4 Cited Publications
Cat. No.: HY-N0743
CAS No.: 63038-10-8
Category:
Natural Products Umbelliferae Extract Dicerothamnus rhinocerotis Plants Disease Research Fields Cancer
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4
4 Cited Publications
Cat. No.: HY-18756A
CAS No.: 56932-43-5
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NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively . NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26) [2].
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Sitneprotafib (JAB-3312) is an orally effective anticancer phosphatase SHP2 inhibitor (IC50: 1.9 nM) with anti-cancer activity. Sitneprotafib has good tolerability and significantly induced tumor regression in a KYSE-520 mouse xenograft model .
Synonyms: RMC-4630; SHP2-IN-7
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Vociprotafib (RMC-4630) is an orally active, selective and potent phosphatase SHP2 inhibitor, which blocks activation of the RAS-RAF-MEK-ERK signaling pathway with antitumor activity. Vociprotafib accelerates the time to, and increases the magnitude of, tumor regressions in Osimertinib (HY-15772)-sensitive EGFR-mutant tumors of mice [2] .
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1,2-Diarachidonoyl-sn-glycero-3-phosphoethanolamine (DAPE) is a phospholipid phosphatidylethanolamine. Unlike other phospholipid phosphatidylethanolamines, 1,2-Diarachidonoyl-sn-glycero-3-phosphoethanolamine has no significant effect on protein phosphatase PP2A activity and does not inhibit insulin-stimulated GLUT4 translocation .
Cat. No.: HY-164220
CAS No.: 2919466-30-9
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PPM1A-IN-1 (Compound IV-4) is an inhibitor for PP2C Ser/Thr phosphatase protein phosphatase Mg2+/Mn2+-dependent 1A. PPM1A-IN-1 exhibits antibacterial activity against Mycobacterium tuberculosis .
Cat. No.: HY-173084
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BRD6257 is an orally active inhibitor for protein phosphatase, Mg2+/Mn2+ dependent 1D PPM1D with an IC50 of 5 nM. BRD6257 activates p53 signaling pathway with an EC50 of 51 nM, increases the p21 expression, inhibits the proliferation of cancer cell MOLM13 (IC50=2.8 μM). BRD6257 exhibits good metabolic stability in human and rat liver microsomes .
Cat. No.: HY-106702A
CAS No.: 87810-56-8
Synonyms: PD 110161; CL 1565A; CI-920
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Cat. No.: HY-120159
CAS No.: 1710337-31-7
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GS-493 is a selective protein tyrosine phosphatase SHP2 (PTPN11) inhibitor with an IC50 of 71 nM. GS-493 is 29- and 45-fold more active toward SHP2 than related SHP1 and PTP1B. GS-493 blocks cellular motility and growth of cancer cells. Antitumor activity .
Cat. No.: HY-P11334
CAS No.: 850131-23-6
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Cat. No.: HY-162355
CAS No.: 2376012-00-7
SHP2-IN-27 (compound 28) is an allosteric inhibitor of tyrosine phosphatase SH2 .
Cat. No.: HY-P3355
CAS No.: 2883747-74-6
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Cat. No.: HY-P3354
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Cat. No.: HY-W009458
CAS No.: 3318-43-2
Synonyms: 3-IP sodium
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
