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Results for "

Piper

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (2) Antibiotic (3) Apoptosis (3) Bacterial (10) Calcium Channel (2) Carboxylesterase (CES) (2) Cathepsin (1) Cytochrome P450 (6) Dihydroorotate Dehydrogenase (2) DNA/RNA Synthesis (1) Drug Derivative (1) Drug Intermediate (2) Endogenous Metabolite (4) Environmental Pollutants (1) ERK (1) Ferroptosis (2) Fungal (7) GABA Receptor (4) Glutathione Peroxidase (2) Heme Oxygenase (HO) (2) Herbicide (1) IKK (2) Insecticide (3) Interleukin Related (1) Isotope-Labeled Compounds (1) JAK (2) Keap1-Nrf2 (2) Mitochondrial Metabolism (1) Monoamine Oxidase (2) NF-κB (3) NO Synthase (3) NOD-like Receptor (NLR) (2) PAI-1 (2) Parasite (4) Platelet-activating Factor Receptor (PAFR) (4) Proton Pump (2) Reactive Oxygen Species (ROS) (1) Reference Standards (11) SARS-CoV (1) Sodium Channel (2) STAT (2) Thrombin (2) TNF Receptor (1) Toll-like Receptor (TLR) (2) Trk Receptor (1) TRP Channel (2) Tyrosinase (2)
By Research Areas:	Cancer (15) Cardiovascular Disease (11) Infection (23) Inflammation/Immunology (19) Metabolic Disease (3) Neurological Disease (14)

By Targets:

Amyloid-β (2)

Antibiotic (3)

Apoptosis (3)

Bacterial (10)

Calcium Channel (2)

Carboxylesterase (CES) (2)

Cathepsin (1)

Cytochrome P450 (6)

Dihydroorotate Dehydrogenase (2)

DNA/RNA Synthesis (1)

Drug Derivative (1)

Drug Intermediate (2)

Endogenous Metabolite (4)

Environmental Pollutants (1)

ERK (1)

Ferroptosis (2)

Fungal (7)

GABA Receptor (4)

Glutathione Peroxidase (2)

Heme Oxygenase (HO) (2)

Herbicide (1)

IKK (2)

Insecticide (3)

Interleukin Related (1)

Isotope-Labeled Compounds (1)

JAK (2)

Keap1-Nrf2 (2)

Mitochondrial Metabolism (1)

Monoamine Oxidase (2)

NF-κB (3)

NO Synthase (3)

NOD-like Receptor (NLR) (2)

PAI-1 (2)

Parasite (4)

Platelet-activating Factor Receptor (PAFR) (4)

Proton Pump (2)

Reactive Oxygen Species (ROS) (1)

Reference Standards (11)

SARS-CoV (1)

Sodium Channel (2)

STAT (2)

Thrombin (2)

TNF Receptor (1)

Toll-like Receptor (TLR) (2)

Trk Receptor (1)

TRP Channel (2)

Tyrosinase (2)

By Research Areas:

Cancer (15)

Cardiovascular Disease (11)

Infection (23)

Inflammation/Immunology (19)

Metabolic Disease (3)

Neurological Disease (14)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0921

Dihydromethysticin (+)-Dihydromethysticin	Carboxylesterase (CES) NOD-like Receptor (NLR) Apoptosis	Cancer
Dihydromethysticin is an orally active natural active ingredient. Dihydromethysticin can be extracted from Piper methysticum. Dihydromethysticin inhibits carboxylesterase 1 (K_i = 68.2 μM) and CYP2A5. Dihydromethysticin upregulates NLRC3 and induces Apoptosis. Dihydromethysticin exhibits anticancer activity against colorectal cancer and lung adenoma .

HY-N2096

Kavain 2 Publications Verification	GABA Receptor	Neurological Disease
Kavain is a class of kavalactone isolated from Piper methysticum, which has anxiolytic properties in animals and humans. Kavain positively modulated γ-Aminobutyric acid type A (GABAA) receptor .

HY-N2905

Aurantiamide acetate 3 Publications Verification Asperglaucide	Cathepsin	Inflammation/Immunology
Aurantiamide acetate (TMC-58A) is a selective and orally active cathepsin inhibitor isolated from Portulaca oleracea L. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases .

HY-N3097

Pellitorine	TRP Channel Amyloid-β Toll-like Receptor (TLR) Keap1-Nrf2 Heme Oxygenase (HO) Dihydroorotate Dehydrogenase Ferroptosis PAI-1 NF-κB ERK Proton Pump Glutathione Peroxidase Thrombin Insecticide Bacterial	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Pellitorine is a bioactive natural amide compound. Pellitorine can competitively antagonize the activation of TRPV1 by Capsaicin (HY-10448), thereby reducing pain signal transmission. Pellitorine improves cognitive dysfunction by upregulating the BDNF-ERK1/2-CREB and Nrf2-HO-1 pathways. Pellitorine exerts anti-inflammatory and anti-sepsis effects by inhibiting the release of high mobility group protein B1 (HMGB1) and the expression of RAGE/TLR4. Pellitorine exerts its antithrombotic effect by prolonging the clotting time, inhibiting the activity of clotting factors and thrombin. Pellitorine inhibits lipid peroxidation and resists ferroptosis by upregulating GPX4 and DHODH. Pellitorine kills Aedes aegypti mosquito larvae by inhibiting V-type H⁺-ATPase and aquaporin 4 (AaAQP4). Pellitorine exhibits anti-cancer activity (e.g., leukemia and breast cancer) and has inhibitory effects on certain bacteria .

HY-N1887

4-Allylcatechol 1 Publications Verification Hydroxychavicol; 4-Allylpyrocatechol	Bacterial Antibiotic TNF Receptor Interleukin Related	Infection Cardiovascular Disease Neurological Disease Cancer
4-Allylcatechol (4-Allylpyrocatechol) is a xylan which has oral activity and can be isolated from the root of Piper taiwanense. 4-Allylcatechol has a strong inhibitory activity against collagen-induced platelet aggregation (IC₅₀ = 5.3 μM). In addition, 4-Allylcatechol has anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv (MIC = 27.6 μg/mL) .

HY-B1671

(+)-Kavain	GABA Receptor Sodium Channel Calcium Channel	Neurological Disease Metabolic Disease
(+)-Kavain, a main kavalactone that can be extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na ⁺ and Ca ²⁺ channels . (+)-Kavain is shown to bind at the α4β2δ GABA_A receptor and potentiate GABA efficacy . (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied .

HY-126562

Piperlonguminine 1 Publications Verification	Bacterial Fungal Antibiotic	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Piperlonguminine is an alkaloid amide isolated from the Piper species. Piperlonguminine shows various biological properties, including anti-inflammatory, antitumor, neuroprotective, anti-platelet, anti-melanogenic, antifungal and antibacterial activities .

HY-N0918

Desmethoxyyangonin Demethoxyyangonin; 5,6-Dehydrokavain	Monoamine Oxidase JAK IKK STAT NO Synthase Cytochrome P450	Neurological Disease Inflammation/Immunology
Desmethoxyyangonin is one of the six major kavalactones found in the Piper methysticum (kava) plant. Desmethoxyyangonin is a selective inhibitor of monoamine oxidase-B (MAO-B) (IC₅₀: 0.123 µM). Desmethoxyyangonin exerts anti-inflammatory effects by inhibiting Jak2/STAT3 and IKK signaling pathways. Desmethoxyyangonin induces CYP3A23 expression and leads to skeletal muscle relaxation .

HY-N10663

Kadsurenone	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
Kadsurenone is a lignan with specific antagonistic activity against platelet-activating factor. Kadsurenone can be derived from the stem of Piper kadsura .

HY-W088037

Tridecane	Environmental Pollutants	Others
Tridecane is a short chain aliphatic hydrocarbon containing 13 carbon atoms. Tridecane is an volatile oil component isolated from essential oil of Piper aduncum L. Tridecane is a stress compound released by the brown marmorated stink bugs stress compound .

HY-W357140

β-Phenylethyl β-D-glucoside Phenylethyl β-D-glucopyranoside	Fungal	Infection
β-Phenylethyl β-D-glucoside (Phenylethyl β-D-glucopyranoside) (Compound 7), a phenolic compounds, is an antifungal agent. β-Phenylethyl β-D-glucoside can be isolated from the leaves of Piper crocatum. β-Phenylethyl β-D-glucoside has antifungal activity against Candida albicans. β-Phenylethyl β-D-glucoside can be used for fungal infections research .

HY-N2465

Methylsticin	Others	Inflammation/Immunology
Methylsticin is a kavalactone isolated from the Piper methysticum . Methylsticin exhibit osteoclast formation inhibitory activity .

HY-W088037S

Tridecane-d28	Isotope-Labeled Compounds	Others
Tridecane-d₂₈ is the deuterium labeled Tridecane . Tridecane is a short chain aliphatic hydrocarbon containing 13 carbon atoms. Tridecane is an volatile oil component isolated from essential oil of Piper aduncum L. Tridecane is a stress compound released by the brown marmorated stink bugs stress compound .

HY-121909

Piperic acid	Bacterial	Infection
Piperic acid is a natural antioxidant and antibacterial agent. Piperic acid can be used in food preservation and human health .

HY-W022390

3-(3,4,5-Trimethoxyphenyl)propanoic acid	Endogenous Metabolite	Others
3-(3,4,5-Trimethoxyphenyl)propanoic acid is found in herbs and spices. 3-(3,4,5-Trimethoxyphenyl)propanoic acid is a constituent of Piper longum (long pepper) and Piper retrofractum (Javanese long pepper).

HY-N3915

Futoquinol	NO Synthase	Neurological Disease Inflammation/Immunology
Futoquinol is a neolignan isolated from the dried aerial parts of Piper kadsura (Piperaceae). Futoquinol potently inhibits NO production in microglia cells. Futoquinol has anti-neuroinflammatory activities .

HY-N10743

Pipercide	Parasite	Infection
Pipercide is an amide of piper nigrum fruits. Pipercide has larvicidal activity to mosquito. Pipercide acts on the nervous system and induces repetitive discharge on the central nerve cord. Pipercide can be used as an insecticide .

HY-N3987

Hancinone C	Others	Others
Hancinone C (compound 2) is a natural product that can be found in Piper hancei .

HY-N0144B

Isochavicine	Others	Others
Isochavicine is an alkaloids that can be isolated from Piper retrofractum. Isochavicine inhibits the seedling growth of cress with I₅₀ values of 11 μM .

HY-204591

Black pepper oleoresin	Drug Derivative	Others
Black pepper oleoresin is a substance extracted from the pepper plant (Piper nigrum), which has aroma, spiciness, and bioactive components. It is widely used in food, health products, cosmetics, and daily chemical products.

HY-N11031

Z-Antiepilepsirine	Parasite	Infection
Z-Antiepilepsirine is an amide alkaloid that can be found in Piper capense L.f. Z-Antiepilepsirine shows antiplasmodial activity with an IC₅₀ value of 27 µM for W2 strain of Plasmodium falciparum .

HY-N3489

Isodihydrofutoquinol B	Others	Neurological Disease
Isodihydrofutoquinol B (compound 9), an active compound, can be isolated from the stems of Piper kadsura (Choisy) Ohwi. Isodihydrofutoquinol B has A neuroprotective effect on Aβ25-35-induced PC12 cell damage with E₅₀ values of 3.06-29.3μM .

HY-121205

Guineesine	SARS-CoV	Others
Guineesine can be isolated from Piper longum L .

HY-N3051

Piperlotine A	Others	Cardiovascular Disease
Piperlotine A is an alkaloid isolated from Piper lolot, with potent antiplatelet aggregation activity .

HY-N3049

Piperlotine C	Others	Cardiovascular Disease
Piperlotine C is an alkaloid isolated from Piper lolot, with anti-platelet aggregation induced by arachidonic acid, and the IC₅₀ is 26.6 µg/mL .

HY-N3566

Cepharadione A	Others	Inflammation/Immunology
Cepharadione A can be isolated from the roots of Piper betle Linn. Cepharadione A inhibits FMLP/CB induced elastase release by human neutrophils .

HY-N12120

Retrofractamide A	Others	Metabolic Disease
Retrofractamide A is an amide constituent that can be isolated from the fruit of Piper chaba. Retrofractamide A promotes adipogenesis in 3T3-L1 cells .

$Retrofractamide A$

HY-N16565

Piperchabamide B	Others	Cancer
Piperchabamide B is an amide alkaloid. Piperchabamide B can be isolated from the fruits of Piper longum. Piperchabamide B exhibits anticancer activity against acute promyelocytic leukemia, non-small cell lung cancer, and breast cancer .

HY-N1620

1-Cinnamoylpyrrolidine	DNA/RNA Synthesis Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
1-Cinnamoylpyrrolidine (Compound 3), a crude extract prepared from Piper caninum, is a DNA strand scission agent, induces the relaxation of supercoiled pBR322 plasmid DNA . 1-Cinnamoylpyrrolidine (Compound 4) inhibits platelet aggregation induced by PAF with an IC₅₀ of 37.3 μM .

HY-N8212

Isofutoquinol A	Others	Others
Isofutoquinol A is a neolignan that can be found in Piper futokadzura .

HY-N1817

Demethoxypiplartine	Fungal	Infection
Demethoxypiplartine is an amide alkaloids which can be isolated from Piper flaviflorum and Piper sarmentosum. Demethoxypiplartine has antifungal activity against Cryptococcus neoformans with the IC₅₀ of 18.1 μg/mL .

HY-N9884

(-)-Galbelgin	Others	Others
(-)-Galbelgin is a lignan diastereoisomer. (-)-Galbelgin can be isolated from Piper kadsura .

HY-N9192

2,2-Dimethyl-8-prenylchromene 6-carboxylic acid	Others	Others
2,2-Dimethyl-8-prenylchromene 6-carboxylic acid (compound 2) is a natural product that can be found in Piper aduncum .

HY-N15528

Pipercroside A	Cytochrome P450 Fungal	Infection
Pipercroside A is found in Piper crocatum Ruiz & Pav. Pipercroside A is a CYP51 inhibitor. Pipercroside A has antifungal activity .

HY-N15529

Pipercroside B	Cytochrome P450 Fungal	Infection
Pipercroside B is found in Piper crocatum Ruiz & Pav. Pipercroside B is a CYP51 inhibitor. Pipercroside B has antifungal activity .

HY-N10421

Dihydrocubebin (-)-Dihydrocubebin	Cytochrome P450	Others
Dihydrocubebin is a compound isolated from Piper cubeba as potent and selective inhibitors against cytochrome P450 3A4 (CYP3A4) .

HY-N1237

Sitosteryl palmitate Sitosterol palmitate; β-Sitosterol hexadecanoate; β-Sitosteryl palmitate	Others	Others
Sitosteryl palmitate (Sitosterol palmitate) is a natural product that can be isolated from Piper betle, Vachellia pennatula and other organisms .

HY-134625

Kalecide	Insecticide	Others
Kalecide is an isobutylamide found in Piper guineense. Kalecide shows insecticidal activity and can be used for insecticide .

HY-N11761

4,5-Dihydropiperlonguminine	Parasite	Infection
4,5-Dihydropiperlonguminine is a natural product that can be isolated from the seeds of Piper tuberculatum Jacq. (Piperaceae). 4,5-Dihydropiperlonguminine is a insecticide against velvetbean caterpillars .

HY-N10664

Piperlactam S	Others	Infection Inflammation/Immunology Cancer
Piperlactam S is an active compound. Piperlactam S can be isolated from Piper kadsura. Piperlactam S can be used for the research of chronic inflammation .

HY-N11905

Kadsurenin A	Others	Inflammation/Immunology
Kadsurenin A is a bioactive Lignan from the genus Piper* L*.

HY-W022390R

3-(3,4,5-Trimethoxyphenyl)propanoic acid (Standard)	Reference Standards Endogenous Metabolite	Others
3-(3,4,5-Trimethoxyphenyl)propanoic acid is found in herbs and spices. 3-(3,4,5-Trimethoxyphenyl)propanoic acid is a constituent of Piper longum (long pepper) and Piper retrofractum (Javanese long pepper).

HY-N9873

Hancinone	Others	Others
Hancinone is a lignanoid, which can be isolated from Piper pleiocarpum Chang .

HY-N11921

Kadsurin A analogue-1	Others	Others
Kadsurin A analogue-1 (Compound 8) is a lignan can be extracted from Piper argyrophylum .

HY-N3192

Nervogenic acid	Bacterial	Infection
Nervogenic acid is an aromatic compound that can be isolated from Piper elongatum VAHL. Nervogenic acid has antibacterial activities and antioxidative effects .

HY-N1866

N-(3-Phenylpropanoyl)pyrrole	Others	Others
N-(3-Phenylpropanoyl)pyrrole is a natural product, that can be isolated from the fresh roots, fruits and leaves of Piper sarmentosum .

HY-N12118

Piperanine	Fungal	Infection
Piperanine is an antifungal agent. Piperanine shows growth inhibition against the fungus Cladosporium claspoirioides. Piperanine can be isolated from the fruits of Piper retrofractum .

HY-N1580

Pyrroside B	Others	Others
Pyrroside B (compound 1) can be isolated from the methanol (MeOH) extract of the aerial part of Piper elongatum VAHL. Pyrroside B has antioxidative activity .

HY-N3436

Kadsurin A	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
Kadsurin A is a new lignan can be isolated from Piper futokadsura. Kadsurin A is a platelet activating factor (PAF) receptor antagonist that weakly inhibits the binding of PAF to its receptor .

HY-N12121

Piperundecalidine	Others	Infection Inflammation/Immunology
Piperundecalidine is an amide alkaloids that can be purified from Piper longum L. Piperundecalidine shows various biological properties, such as anti-inammatory, analgesic, anti-amoebic, anti-depressant, hepatoprotective,etc. .

Cat. No.	Product Name	Category	Target	Chemical Structure