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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
23 Results for "
Plasmodium falciparum 3D7 strain
" in MedChemExpress (MCE) Product Catalog:
Products (23)
23 Results for "Plasmodium falciparum 3D7 strain" in MCE Product Catalog:
1
1 Cited Publications
CWHM-1008 is a potent and orally active antimalarial agent, with EC50 values of 46 and 21 nM against agent-sensitive Plasmodium falciparum 3D7 and drug-resistant Dd2 strains, respectively .
Hex is an enolase inhibitor and antimalarial agent with Ki values of 74.4 nM and 269.4 nM for ENO2 and ENO1, respectively. Hex is a NfENO and TbENO inhibitor with IC50s value of 0.14 μM and 2.1 μM, respectively. Hex has antimalarial activity against Plasmodium falciparum 3D7, Naegleria fowleri trophozoites and Plasmodium berghei ANKA strain. Hex has anti-tumor effects against intracranial tumors .
Cat. No.: HY-N2891
CAS No.: 53948-07-5
Synonyms: Aristololactam A II
Cat. No.: HY-N13288
CAS No.: 148683-93-6
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Cat. No.: HY-173027
CAS No.: 634190-75-3
SPB07935 inhibits the plasmepsin II in Plasmodium falciparum and can be used as an antimalarial agent. SPB07935 regulates the life cycle of P. falciparum, inhibits the growth of Plasmodium strains FcB1 and 3D7 with IC50 of 8 μM and 4.7 μM .
Cat. No.: HY-182348
LSPN959 is a slow-acting indole peptidomimetic antiplasmodial agent with submicromolar activity against the Plasmodium falciparum 3D7 strain. LSPN959 does not inhibit plastid-dependent isoprenoid biosynthesis. The combination of LSPN959 with Artesunate (HY-N0193) exhibits an additive effect against Plasmodium falciparum. LSPN959 can be used in malaria research .
Cat. No.: HY-149782
CAS No.: 521297-42-7
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Phosphodiesterase-IN-1 (Compound 7) is a phosphodiesterase (PDE) inhibitor with anti-Plasmodium activity. Phosphodiesterase-IN-1 has antiproliferative activity against P. falciparum (strain 3D7) with an IC50 value of 0.64 μM .
Cat. No.: HY-147850
CAS No.: 2091841-46-0
JMI-346 is a potent PfFP-2 (Plasmodium falciparum falcipain-2 protease) inhibitor. JMI-346 inhibits the growth of CQ S (3D7; IC50=13 µM) and CQ R (RKL-9; IC50=33 µM) strains of P. falciparum. JMI-346 has the potential to be used as an anti-malarial agent .
Cat. No.: HY-136783
CAS No.: 333311-00-5
G6PD-IN-2 is a Plasmodium falciparum glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC50 value of 0.2 μM. G6PD-IN-2 exerts weak inhibitory activity on Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase (PfGluPho) with an IC50 value of 22.0 μM. G6PD-IN-2 inhibits growth of Plasmodium falciparum 3D7 strain and exhibits low cytotoxicity in hepatocytes. G6PD-IN-2 can be used for the research of malaria .
Cat. No.: HY-170783
DXR-IN-4 (Compound 12a) is the inhibitor for 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR). DXR-IN-4 inhibits DXR in Plasmodium falciparum Pf DXR, Escherichia coli Ec DXR, and Mycobacterium tuberculosis Mt DXR with IC50s of 18, 4.9 and 89 nM, respectively. DXR-IN-4 exhibits antimalarial activity that inhibits P. falciparum strains 3D7 and Dd2 with IC50 of 11 μM and 12 μM .
Cat. No.: HY-158721
CAS No.: 1214268-60-6
Synonyms: Marinamide
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Cat. No.: HY-147849
CAS No.: 2227315-30-0
JMI-105 is a potent PfFP-2 (Plasmodium falciparum falcipain-2 protease) inhibitor. JMI-105 inhibits the growth of CQ S (3D7; IC50=8.8 µM) and CQ R (RKL-9; IC50=14.3 µM) strains of P. falciparum. JMI-105 significantly decreases parasitemia and prolonged host survival in a murine model with P. berghei ANKA infection. JMI-105 has the potential to be used as an anti-malarial agent .
Cat. No.: HY-120462
CAS No.: 1254834-91-7
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Genz-669178 is an inhibitor for dihydroorotate dehydrogenase (DHODH) with IC50 of 0.015-0.05 μM in Plasmodium spp.. Genz-669178 inhibits P. berghei, P. falciparum strains 3D7 and Dd2 with IC50 of 0.068, 0.008 and 0.01 μM, respectively. Genz-669178 exhibits anti-malarial efficacy in P. berghei-infected mice with ED50 of 13-21 mg/kg/day. Genz-669178 exhibits good pharmacokinetic characteristics in mice .
Cat. No.: HY-184182
CAS No.: 2770244-63-6
Antimalarial agent 64 is an orally active acridine-based antimalarial derivative and also a rapid-acting inhibitor of hemozoin formation. Antimalarial agent 64 exhibits nanomolar inhibitory activity against field isolates of Plasmodium falciparum and Plasmodium vivax. Antimalarial agent 64 localizes near the digestive vacuole of Plasmodium. Antimalarial agent 64 can be used for the research of malaria .
Cat. No.: HY-187525
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PfSUB1-IN-2 is an irreversible covalent peptidic diaryl phosphonate inhibitor of Plasmodium falciparum serine protease PfSUB1 with an IC50 of 167 nM and an EC50 of 22.2 μM against Plasmodium falciparum strain growth. PfSUB1-IN-2 can be used for the research of malaria .
Cat. No.: HY-184181
CAS No.: 1596337-67-5
Antimalarial agent 63 is an inhibitor of Plasmodium falciparum. Antimalarial agent 63 exhibits inhibitory activity against field isolates of Plasmodium falciparum and Plasmodium vivax. Antimalarial agent 63 shows an antagonistic interaction when used in combination with Proguanil (HY-B0806) against Plasmodium falciparum. Antimalarial agent 63 has low cytotoxicity to hepatocytes and a high selectivity index. Antimalarial agent 63 can be used in the research of malaria .
Cat. No.: HY-W742094
CAS No.: 6092-18-8
Cycotiamine is an S-acylated thiamine derivative with antiplasmodial activity. Cycotiamine inhibits the proliferation of Plasmodium falciparum and Plasmodium knowlesi. Cycotiamine can be used in malaria-related research .
Cat. No.: HY-183450
CAS No.: 71458-51-0
Supradamal is a peptidyl-prolyl cis-trans isomerase (PPIase) inhibitor with an IC50 of 83 nM against *Plasmodium falciparum* and an IC50 of 75 nM against *Plasmodium vivax*. Supradamal inhibits the development, maturation and in vitro growth of *Plasmodium falciparum* trophozoites. Supradamal is applicable to malaria-related research .
Cat. No.: HY-N19238
CAS No.: 84224-28-2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
