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Results for "

Salvia miltiorrhiza

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (4) Apoptosis (6) Autophagy (6) Bacterial (2) Bcl-2 Family (2) Cadherin (1) Carboxylesterase (CES) (3) Caspase (2) Collagen (1) DNA/RNA Synthesis (1) GABA Receptor (2) Interleukin Related (1) Keap1-Nrf2 (3) Mitochondrial Metabolism (1) MyD88 (1) NF-κB (2) NO Synthase (3) PARP (1) Reference Standards (8) SARS-CoV (6) STAT (2) TGF-β Receptor (1) TNF Receptor (1) Toll-like Receptor (TLR) (1) VEGFR (2) Virus Protease (2) Xanthine Oxidase (2)
By Research Areas:	Cancer (13) Cardiovascular Disease (12) Infection (2) Inflammation/Immunology (7) Metabolic Disease (1) Neurological Disease (4)

By Targets:

AMPK (4)

Apoptosis (6)

Autophagy (6)

Bacterial (2)

Bcl-2 Family (2)

Cadherin (1)

Carboxylesterase (CES) (3)

Caspase (2)

Collagen (1)

DNA/RNA Synthesis (1)

GABA Receptor (2)

Interleukin Related (1)

Keap1-Nrf2 (3)

Mitochondrial Metabolism (1)

MyD88 (1)

NF-κB (2)

NO Synthase (3)

PARP (1)

Reference Standards (8)

SARS-CoV (6)

STAT (2)

TGF-β Receptor (1)

TNF Receptor (1)

Toll-like Receptor (TLR) (1)

VEGFR (2)

Virus Protease (2)

Xanthine Oxidase (2)

By Research Areas:

Cancer (13)

Cardiovascular Disease (12)

Infection (2)

Inflammation/Immunology (7)

Metabolic Disease (1)

Neurological Disease (4)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0135

Tanshinone IIA 35+ Cited Publications Dan Shen ketone	VEGFR	Cardiovascular Disease Cancer
Tanshinone IIA (Tan IIA) is one of the main compositions in the root of Salvia miltiorrhiza Bunge. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2.

HY-N1362

Salvianolic acid B 15+ Cited Publications Lithospermic acid B	Autophagy	Cardiovascular Disease
Salvianolic acid B is an active ingredient of Salvia miltiorrhiza, which has been widely applied in China for the management of various microcirculation-related disorders, such as cardiovascular disease, cerebrovascular disease, and diabetic vascular complication.

HY-N0174

Cryptotanshinone Maximum Cited Publications 46 Publications Verification Cryptotanshinon; Tanshinone c	STAT Autophagy	Cancer
Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC₅₀ of 4.6 μM.

HY-N0823

Lithospermic acid 5+ Cited Publications (+)-Lithospermic acid	NO Synthase AMPK Keap1-Nrf2 Xanthine Oxidase Apoptosis	Cardiovascular Disease Inflammation/Immunology
Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl₄)-induced acute liver damage in vitro and in vivo .

HY-N0360

Dihydrotanshinone I 10+ Cited Publications	SARS-CoV	Cardiovascular Disease
Dihydrotanshinone I is a natural compound extracted from Salvia miltiorrhiza Bunge which has been widely used for treating cardiovascular diseases. Dihydrotanshinone I exhibits entry-blocking effect for MERS-CoV.

HY-N1951

Miltirone 2 Publications Verification Rosmariquinone	GABA Receptor Apoptosis Carboxylesterase (CES) SARS-CoV	Neurological Disease Cancer
Miltirone is an orally active natural compound found in the root of Salvia miltiorrhiza. Miltirone is a central benzodiazepine receptor partial agonist, with an IC₅₀ of 0.3 μM. Miltirone induces ROS - and-p53 dependent apoptosis. Miltirone inhibits carboxylesterase 2 (CES2; K_i = 0.04 μM) and SARS-CoV main protease (Mpro) .

HY-B0923

Danthron 4 Publications Verification Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone	AMPK Autophagy Bacterial Virus Protease	Cancer
Danthron is a natural product extracted from the traditional Chinese medicine Salvia miltiorrhiza Bunge. Danthron functions in regulating glucose and lipid metabolism by activating AMPK.

HY-119720

Neocryptotanshinone	NF-κB NO Synthase	Inflammation/Immunology
Neocryptotanshinone, a fatty diterpenoids from Salvia Miltiorrhiza, inhibits lipopolysaccharide-induced inflammation by suppression of NF-κB and iNOS signaling pathways .

HY-N3201

Neoprzewaquinone A	Others	Others
Neoprzewaquinone A is isolated from the roots of Salvia miltiorrhiza .

HY-N1179

Tanshinone IIB	Apoptosis	Cardiovascular Disease Neurological Disease
Tanshinone IIB is a major active constituent of the roots of Salvia miltiorrhiza (Danshen) widely used for the research of stroke and coronary heart disease in Asian countries. Tanshinone IIB has a neuroprotective effect via inhibition of apoptosis .

HY-N10686

Tanshinone IIA anhydride	Carboxylesterase (CES)	Cancer
Tanshinone IIA anhydride, present in root extracts of Salvia miltiorrhiza, acts as an inhibitor of human carboxylesterase (CE). Tanshinone IIA anhydride has a K_i value of 1.9 nM against hCE1 and a K_i value of 1.4 nM against hiCE. Tanshinone IIA anhydride forms a stable covalent complex with serine Ser221 at the active site of hCE1, blocking the catalytic cycle of carboxylesterase, and the activity of the inactivated enzyme cannot recover spontaneously. Tanshinone IIA anhydride is applicable in metabolism-related studies .

HY-N1180

Tanshinlactone	SARS-CoV Keap1-Nrf2	Infection
Tanshinlactone is a compound found in Salvia miltiorrhiza with anti-coronavirus (CoV) and anti-tumor activities. Tanshinlactone induces methuocytic cell death (methuosis) by activating the NRF2 pathway, and selectively kills ER ⁺, HER2 ⁺/EGFR ⁺ breast cancer cells. Tanshinlactone is applicable to research related to breast cancer and coronavirus infections .

HY-N7522

Salvianolic acid E	Others	Others
Salvianolic acid E is a natural compound isolated from Salvia miltiorrhiza .

HY-N0320

Salvianolic acid D	Bcl-2 Family Caspase Toll-like Receptor (TLR) MyD88 NF-κB	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Salvianolic acid D is a depside. Salvianolic acid D can be isolated from Salvia miltiorrhiza (Danshen). Salvianolic acid D promotes the expression of Bcl-2, and inhibits the expressions of Bax, Cleaved caspase-3 and -9. Salvianolic acid D reduces the expression levels of TLR4, MyD88 and TRAF6 proteins both in vitro and in vivo, and significantly inhibits the nuclear translocation of NF-κB. Salvianolic acid D inhibits the cytoplasmic translocation of HMGB1. Salvianolic acid D suppresses inflammatory responses and alleviates cerebral ischemia-reperfusion injury. Salvianolic acid D serves as a potential antiplatelet active component .

HY-123080

Tanshinol B	Others	Others
Tanshinol B is a bioactive component of Salvia miltiorrhiza, which can be isolated from the 50% ethanol extract of the roots and rhizomes of Seaweed prowazekii .

HY-N1362R

Salvianolic acid B (Standard) Lithospermic acid B (Standard)	Reference Standards Autophagy	Cardiovascular Disease
Salvianolic acid B (Standard) is the analytical standard of Salvianolic acid B. This product is intended for research and analytical applications. Salvianolic acid B is an active ingredient of Salvia miltiorrhiza, which has been widely applied in China for the management of various microcirculation-related disorders, such as cardiovascular disease, cerebrovascular disease, and diabetic vascular complication.

HY-N1951R

Miltirone (Standard) Rosmariquinone (Standard)	Reference Standards GABA Receptor Apoptosis Carboxylesterase (CES) SARS-CoV	Neurological Disease Cancer
Miltirone is an orally active natural compound found in the root of Salvia miltiorrhiza. Miltirone is a central benzodiazepine receptor partial agonist, with an IC50 of 0.3 μM. Miltirone induces ROS - and-p53 dependent apoptosis. Miltirone inhibits carboxylesterase 2 (CES2; Ki = 0.04 μM) and SARS-CoV main protease (Mpro) .

HY-N10800

1,2,6,7,8,9-Hexahydro-1,6,6-trimethyl-3,11-dioxanaphth[2,1-e]azulene-10,12-dione	Others	Cancer
1,2,6,7,8,9-Hexahydro-1,6,6-trimethyl-3,11-dioxanaphth[2,1-e]azulene-10,12-dione is a kind of chemical constituents of Salvia miltiorrhiza f. alba. The dihydroisotanshinone with a para-quinone moiety shows cytotoxicity and anti-tumor activity .

HY-N0135R

Tanshinone IIA (Standard) Dan Shen ketone (Standard)	Reference Standards VEGFR	Cardiovascular Disease Cancer
Tanshinone IIA (Standard) is the analytical standard of Tanshinone IIA. This product is intended for research and analytical applications. Tanshinone IIA (Tan IIA) is one of the main compositions in the root of Salvia miltiorrhiza Bunge. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2.

HY-120451

Salvinone	Others	Inflammation/Immunology
Salvinone (Compound 49) is a compound that can be isolated from Salvia miltiorrhiza .

HY-N8674

Dihydroisotanshinone II	Others	Others
Dihydroisotanshinone II is a Diterpenoids product that can be isolated from the roots of Salvia miltiorrhiza .

HY-126416

Methyl tanshinonate	SARS-CoV	Infection Metabolic Disease
Methyl tanshinonate is a tanshinone, that can be isolated from Salvia miltiorrhiza (S. miltiorrhiza) Bunge (Lamiaceae). Methyl tanshinonate is a potent inhibitor of M ^pro enzyme in SARS-CoV (IC₅₀ = 21.1 µM). Methyl tanshinonate can be used for diabetes and SARS-CoV research .

HY-N0320R

Salvianolic acid D (Standard)	Reference Standards Others	Cardiovascular Disease
Salvianolic acid D (Standard) is the analytical standard of Salvianolic acid D. This product is intended for research and analytical applications. Salvianolic acid D, isolated from Salvia miltiorrhiza, is a potential antiplatelet activity compound .

HY-B0923R

Danthron (Standard) Dantron (Standard); Chrysazin (Standard); 1,8-Dihydroxyanthraquinone (Standard)	Reference Standards AMPK Autophagy Bacterial Virus Protease	Cancer
Danthron (Standard) is the analytical standard of Danthron. This product is intended for research and analytical applications. Danthron is a natural product extracted from the traditional Chinese medicine Salvia miltiorrhiza Bunge. Danthron functions in regulating glucose and lipid metabolism by activating AMPK.

HY-N0174R

Cryptotanshinone (Standard) Cryptotanshinon (Standard); Tanshinone c (Standard)	Reference Standards STAT Autophagy	Cancer
Cryptotanshinone (Standard) is the analytical standard of Cryptotanshinone. This product is intended for research and analytical applications. Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC₅₀ of 4.6 μM.

HY-N0360R

Dihydrotanshinone I (Standard)	Reference Standards SARS-CoV	Cardiovascular Disease
Dihydrotanshinone I (Standard) is the analytical standard of Dihydrotanshinone I. This product is intended for research and analytical applications. Dihydrotanshinone I is a natural compound extracted from Salvia miltiorrhiza Bunge which has been widely used for treating cardiovascular diseases. Dihydrotanshinone I exhibits entry-blocking effect for MERS-CoV.

HY-N0823R

Lithospermic acid (Standard) (+)-Lithospermic acid (Standard)	Reference Standards NO Synthase AMPK Keap1-Nrf2 Xanthine Oxidase Apoptosis	Cardiovascular Disease Inflammation/Immunology
Lithospermic acid (Standard) is the analytical standard of Lithospermic acid. This product is intended for research and analytical applications. Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl4)-induced acute liver damage in vitro and in vivo .

HY-N8617

Trijuganone C	DNA/RNA Synthesis Caspase PARP Bcl-2 Family Mitochondrial Metabolism Apoptosis	Cancer
Trijuganone C is a tanshinone-type diterpenoid compound. Trijuganone C can be isolated from the roots of Salvia miltiorrhiza Bunge. Trijuganone C induces chromatin condensation, DNA fragmentation, activation of Caspase-3, -8 and -9, as well as cleavage of PARP. Trijuganone C activates Bid and Bax, leading to loss of mitochondrial membrane potential and inducing the release of cytochrome c from mitochondria into the cytosol. Trijuganone C exerts antiproliferative effects through Apoptosis induction mediated by Mitochondrial dysfunction and Caspase activation. Trijuganone C exhibits significant antiproliferative activity against leukemia cells and colon cancer cells .

HY-W420454

Danshenspiroketallactone	Others	Inflammation/Immunology Cancer
Danshenspiroketallactone is a lactone found in the roots of Salvia miltiorrhiza. Danshenspiroketallactone shows no anti-inflammatory and anticancer activity .

HY-N10922

(3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone	Others	Cancer
(3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone (compound 3), a Palmitate, can be isolated from the root tissue of Salvia miltiorrhiza. (3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone (compound 3) shows anti-cancer activity against human cancer cell lines with DC₅₀s of 25.5 μg/mL (HeLa), 37.5 μg/mL (HepG2), 30.2 μg/mL (OVCAR-3), respectively .

HY-125127

Danshenxinkun C	Others	Others
Danshenxinkun C is a Diterpenoids product that can be isolated from the roots of Salvia miltiorrhiza Bge. .

HY-N16737

Trijugin A	Others	Others
Trijugin A is a gemmane-type sesquiterpenoid compound that can be isolated from the whole plant of Salvia miltiorrhiza with three pairs of leaves .

HY-N16743

Trijugin B	Others	Others
Trijugin B is a gemmane-type sesquiterpenoid that can be isolated from the whole plant of Salvia miltiorrhiza with three pairs of leaves .

HY-N16744

Trijugin C	Others	Others
Trijugin C is a gemmane-type sesquiterpenoid that can be isolated from the whole plant of Salvia miltiorrhiza with three pairs of leaves .

HY-N17650

Salviamarinic acid A	TGF-β Receptor Collagen Cadherin	Inflammation/Immunology
Salviamarinic acid A is a water-soluble phenolic acid that can be extracted from Salvia miltiorrhiza with potent anti-pulmonary fibrosis activity. Salviamarinic acid A significantly increases cell viability, cell index, cell motility and E-cadherin expression, and reduces TGF-β1, α-SMA and Collagen I levels. Salviamarinic acid A can be used for pulmonary fibrosis research .

HY-134028

Arucadiol	TNF Receptor Interleukin Related	Cardiovascular Disease
Arucadiol is a rosane-type diterpenoid anti-inflammatory agent. 5 μM Arucadiol significantly inhibits LPS-induced TNF-α, IL-1β, and IL-8 production (inhibition rates of 39.8%, 44.4%, and 34.5%, respectively). Arucadiol exerts its anti-inflammatory activity by inhibiting the mRNA and protein expression of inflammatory cytokines and can be used in research on inflammation-related cardiovascular diseases such as atherosclerosis. Arucadiol can be naturally extracted from the roots of Salvia miltiorrhiza var. alba .

Cat. No.	Product Name

HY-L243

Quinones Library	92 compounds
Quinone compounds are a significant class of natural products featuring a conjugated quinone structure, widely distributed in plants, fungi, and microorganisms. Based on their core structures, they can be primarily categorized into benzoquinones, naphthoquinones, phenanthrenequinones, and anthraquinones, among others. This structural diversity endows quinone compounds with a broad spectrum of pharmacological activities, making them key components in traditional Chinese medicine (such as rhubarb, Lithospermum erythrorhizon, and Salvia miltiorrhiza). Modern research has confirmed that their activities encompass anti-tumor, anti-inflammatory, antibacterial, antiviral, antiplatelet aggregation, and neuroprotective effects, among others, establishing them as an important source for drug development. MCE designs a unique collection of 92 quinones that all come from natural products. MCE Quinones Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

Quinones Library

92 compounds

Quinone compounds are a significant class of natural products featuring a conjugated quinone structure, widely distributed in plants, fungi, and microorganisms. Based on their core structures, they can be primarily categorized into benzoquinones, naphthoquinones, phenanthrenequinones, and anthraquinones, among others. This structural diversity endows quinone compounds with a broad spectrum of pharmacological activities, making them key components in traditional Chinese medicine (such as rhubarb, Lithospermum erythrorhizon, and Salvia miltiorrhiza). Modern research has confirmed that their activities encompass anti-tumor, anti-inflammatory, antibacterial, antiviral, antiplatelet aggregation, and neuroprotective effects, among others, establishing them as an important source for drug development.

MCE designs a unique collection of 92 quinones that all come from natural products. MCE Quinones Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

Tanshinone IIA 35+ Cited Publications Dan Shen ketone	Quinones Classification of Application Fields Terpenoids Labiatae Samanea saman (Jacq.) Merr. Diterpenoids Plants Naphthalene Quinones Disease Research Fields Source Classification Cancer	VEGFR
Tanshinone IIA (Tan IIA) is one of the main compositions in the root of Salvia miltiorrhiza Bunge. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2.

Salvianolic acid B 15+ Cited Publications Lithospermic acid B	Cardiovascular Disease Classification of Application Fields Labiatae Samanea saman (Jacq.) Merr. Phenols Polyphenols Plants Disease Research Fields Source Classification	Autophagy
Salvianolic acid B is an active ingredient of Salvia miltiorrhiza, which has been widely applied in China for the management of various microcirculation-related disorders, such as cardiovascular disease, cerebrovascular disease, and diabetic vascular complication.

Cryptotanshinone Maximum Cited Publications 46 Publications Verification Cryptotanshinon; Tanshinone c	Quinones Classification of Application Fields Labiatae Samanea saman (Jacq.) Merr. Plants Naphthalene Quinones Disease Research Fields Source Classification Cancer	STAT Autophagy
Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC₅₀ of 4.6 μM.

Lithospermic acid 5+ Cited Publications (+)-Lithospermic acid	Classification of Application Fields Labiatae Samanea saman (Jacq.) Merr. Other Phenylpropanoids Phenols Polyphenols Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields Source Classification	NO Synthase AMPK Keap1-Nrf2 Xanthine Oxidase Apoptosis
Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl₄)-induced acute liver damage in vitro and in vivo .

Dihydrotanshinone I 10+ Cited Publications	Cardiovascular Disease Quinones Classification of Application Fields Labiatae Samanea saman (Jacq.) Merr. Plants Phenanthrenequinones Disease Research Fields Source Classification	SARS-CoV
Dihydrotanshinone I is a natural compound extracted from Salvia miltiorrhiza Bunge which has been widely used for treating cardiovascular diseases. Dihydrotanshinone I exhibits entry-blocking effect for MERS-CoV.

Miltirone 2 Publications Verification Rosmariquinone	Terpenoids Labiatae Samanea saman (Jacq.) Merr. Diterpenoids Plants Source Classification	GABA Receptor Apoptosis Carboxylesterase (CES) SARS-CoV
Miltirone is an orally active natural compound found in the root of Salvia miltiorrhiza. Miltirone is a central benzodiazepine receptor partial agonist, with an IC₅₀ of 0.3 μM. Miltirone induces ROS - and-p53 dependent apoptosis. Miltirone inhibits carboxylesterase 2 (CES2; K_i = 0.04 μM) and SARS-CoV main protease (Mpro) .

Danthron 4 Publications Verification Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone	Quinones Classification of Application Fields Anthraquinones Labiatae Samanea saman (Jacq.) Merr. Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	AMPK Autophagy Bacterial Virus Protease
Danthron is a natural product extracted from the traditional Chinese medicine Salvia miltiorrhiza Bunge. Danthron functions in regulating glucose and lipid metabolism by activating AMPK.

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