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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
437 Results for "
Substrate peptides
" in MedChemExpress (MCE) Product Catalog:
Products (437)
437 Results for "Substrate peptides" in MCE Product Catalog:
16
16 Publications Verification
Target:
Forschungsgebiete:
EED226 is a polycomb repressive complex 2 (PRC2) inhibitor, which binds to the K27me3-pocket on embryonic ectoderm development (EED) and shows strong antitumor activity in xenograft mice model . EED226 is a potent, selective, and orally bioavailable EED inhibitor . EED226 inhibits PRC2 with an IC50 of 23.4 nM when the H3K27me0 peptide is used as a substrate in the in vitro enzymatic assays .
9
9 Cited Publications
Synonyms: KX2-391; KX-01
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Forschungsgebiete:
Tirbanibulin (KX2-391) is an inhibitor of Src that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines.
9
9 Cited Publications
Synonyms: KX2-391 dihydrochloride; KX-01 dihydrochloride
Target:
Forschungsgebiete:
Tirbanibulin (dihydrochloride) (KX2-391 (dihydrochloride)) is an inhibitor of Src that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines.
9
9 Cited Publications
Synonyms: KX2-391 Mesylate; KX01 Mesylate
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Forschungsgebiete:
Tirbanibulin Mesylate (KX2-391 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines.
7
7 Cited Publications
Art. -Nr.: HY-18962
CAS. Nr.: 20324-87-2
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Forschungsgebiete:
AMI-1 is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 exerts PRMTs inhibitory effects by blocking peptide-substrate binding .
7
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AMI-1 free acid is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 free acid exerts PRMTs inhibitory effects by blocking peptide-substrate binding .
5
5 Cited Publications
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Forschungsgebiete:
ERAP1-IN-1 is an endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitor. ERAP1-IN-1 competitively inhibits ERAP1 activity towards a nonamer peptide representative of physiological substrates .
5
5 Cited Publications
Synonyms: AKR-501 maleate; E5501 maleate; YM477 maleate
Forschungsgebiete:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Avatrombopag (AKR-501) maleate is an orally active, non-peptide thrombopoietin receptor (TPO receptor) agonist (EC50: 3.3 nM). Avatrombopag maleate mimics the biological activity of TPO. Avatrombopag maleate increases platelet production by activating intracellular signaling systems and promotes the production of platelets and megakaryocytes from hematopoietic precursor cells. Avatrombopag maleate is a substrate for cytochrome P450 (CYP) 2C9 and CYP3A .
4
4 Cited Publications
Art. -Nr.: HY-P2377
CAS. Nr.: 219137-85-6
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3
3 Cited Publications
Art. -Nr.: HY-P2295
3
3 Cited Publications
Art. -Nr.: HY-P0136
CAS. Nr.: 125911-68-4
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3
3 Cited Publications
Synonyms: Z-LLE-AMC
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3
3 Cited Publications
Art. -Nr.: HY-19593
CAS. Nr.: 59456-70-1
Nikkomycin Z is a nucleoside peptide and an orally active antifungal agent. Nikkomycin Z inhibits chitin synthesis by acting as a competitive analogue of the chitin synthase substrate UDP-N-acetylglucosamine. Nikkomycin Z has antifungal activity .
3
3 Cited Publications
Art. -Nr.: HY-163316
CAS. Nr.: 3030697-87-8
Forschungsgebiete:
SIRT4-IN-1 is a selective and potent Sirtuin 4 (Sirt4) inhibitor with an IC50 of 16 μM for hSirt4. SIRT4-IN-1 also inhibits hSirt1, hSirt2, hSirt3, hSirt4 and hSirt6. SIRT4-IN-1 competes with acyl peptide substrate for Sirt4's acyl binding site, and is noncompetitive with NAD +. SIRT4-IN-1 increases glutamate dehydrogenase (GDH) activity and rescues pyruvate dehydrogenase (PDH) activity. SIRT4-IN-1 inhibits adipocyte differentiation and suppresses Sirt4 overexpression-induced increased differentiation. SIRT4-IN-1 can be used for the researches of cancer and metabolic disease .
2
2 Cited Publications
Art. -Nr.: HY-P4931
CAS. Nr.: 720710-69-0
2
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2
2 Cited Publications
Art. -Nr.: HY-P3815
CAS. Nr.: 132176-35-3
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2
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2
2
2 Cited Publications
Art. -Nr.: HY-P2536
CAS. Nr.: 305336-82-7
Forschungsgebiete:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
