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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
TMEM175
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "TMEM175" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-161949
CAS No.: 1369963-51-8
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AP-6 is a selective inhibitor of TMEM175 with activity in modulating lysosomal function. Acute inhibition of TMEM175 by AP-6 increases lysosomal macromolecular catabolism, thereby accelerating macrophage and other digestive processes. AP-6 may be used in Parkinson's disease research .
Cat. No.: HY-162666
CAS No.: 3038770-25-8
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TMEM175 modulator 1 (compound 47) is a TMEM175 modulator.TMEM175 modulator 1 modulates activity of the lysosomal potassium ion channel TMEM175.TMEM175 modulator 1 can be used for the research of parkinson’s disease, dementia, alzheimer’s disease, l-dopa induced dyskinesia .
Cat. No.: HY-33878
CAS No.: 21203-86-1
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2-PPA is a lysosomal potassium and proton channel TMEM175 pore blocker. 2-PPA binds at a TMEM175 pore site to occlude potassium and proton ion permeation pathways. 2-PPA increases lysosomal macromolecule catabolism, accelerates macropinocytosis. 2-PPA binds to hepatic protein in covalent. 2-PPA can be used for the research of Parkinson's disease .
Cat. No.: HY-RS29457
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TMEM175 Monkey Pre-designed siRNA Set A contains three designed siRNAs for TMEM175 (Monkey), as well as a negative control, a positive control, and a FAM-labeled negative control.
Components
TMEM175 siRNA-1: 5 nmol (HPLC)
TMEM175 siRNA-2: 5 nmol (HPLC)
TMEM175 siRNA-3: 5 nmol (HPLC)
siRNA Negative Control: 5 nmol (HPLC)
FAM-labeled siRNA Negative Control: 5 nmol (HPLC)
GAPDH siRNA Positive Control: 5 nmol (HPLC)
Components
TMEM175 siRNA-1: 5 nmol (HPLC)
TMEM175 siRNA-2: 5 nmol (HPLC)
TMEM175 siRNA-3: 5 nmol (HPLC)
siRNA Negative Control: 5 nmol (HPLC)
FAM-labeled siRNA Negative Control: 5 nmol (HPLC)
GAPDH siRNA Positive Control: 5 nmol (HPLC)
Cat. No.: HY-182768
CAS No.: 3119251-34-9
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TMEM175 modulator 4 (Compound 3) is a TMEM175 modulator. TMEM175 modulator 4 modulates the activity of the lysosomal potassium channel TMEM175. TMEM175 modulator 4 can be used for research related to Parkinson's disease .
Cat. No.: HY-RS14683
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TMEM175 Human Pre-designed siRNA Set A contains three designed siRNAs for TMEM175 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS19555
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Tmem175 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tmem175 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-181621
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Tmem175 modulator 2 (example 180) is a TMEM175 modulator.Tmem175 modulator 2 can be used for the research of neurodegenerative disorders .
Cat. No.: HY-186261
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TMEM175 agonist 7 is a TMEM175 agonist with an EC50 of 543 nM. TMEM175 agonist 7 is applicable to the research of neurodegenerative diseases and lysosomal storage disorders .
Cat. No.: HY-186258
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TMEM175 agonist 4 (Compound 276) is a TMEM175 agonist. TMEM175 agonist 4 can be used for the research of neurodegenerative diseases and lysosomal storage diseases .
Cat. No.: HY-186259
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TMEM175 agonist 5 (Compound 252) is a TMEM175 agonist with an EC50 of 421 nM in FLIPR cell assays. TMEM175 agonist 5 can be used for the research of neurodegenerative diseases and lysosomal storage disorders .
Cat. No.: HY-186257
CAS No.: 3129652-66-7
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TMEM175 agonist 3 (Compound 123) is a TMEM175 agonist, with an EC50 of 0.044 μM in human TMEM175 FLIPR assays and an EC50 of 0.073 μM in human TMEM175 EP assays. TMEM175 agonist 3 can be used in the research of Parkinson's disease, dementia with Lewy bodies, rapid eye movement sleep behavior disorder, amyotrophic lateral sclerosis, and lysosomal storage diseases .
Cat. No.: HY-186254
CAS No.: 3129652-92-9
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TMEM175 agonist 2 is a TMEM175 agonist with an EC50 of 0.0446 μM in human FLIPR assays and an EC50 of 0.0453 μM in human TMEM175 EP assays. TMEM175 agonist 2 can be used in research related to Parkinson's disease, dementia with Lewy bodies, rapid eye movement sleep behavior disorder, amyotrophic lateral sclerosis, and lysosomal storage diseases .
Cat. No.: HY-186253
CAS No.: 3129653-69-3
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TMEM175 agonist 1 is a TMEM175 agonist, with a human EC50 of 0.378 μM in FLIPR assays and a human EC50 of 0.886 μM in EP analyses. TMEM175 agonist 1 can be used in the research of Parkinson's disease, dementia with Lewy bodies, rapid eye movement sleep behavior disorder, amyotrophic lateral sclerosis, and lysosomal storage diseases .
Cat. No.: HY-181622
CAS No.: 3115239-67-0
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TMEM175 modulator 3 (Compound 14) is a TMEM175 modulator. TMEM175 modulator 3 can be used in research on neurodegenerative diseases .
Cat. No.: HY-186260
CAS No.: 3132328-83-4
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TMEM175 agonist 6 (Compound F-101) is a TMEM175 agonist. TMEM175 agonists can restore/enhance the function of lysosomes and reduce aSyn aggregation, thus being applicable for the research of diseases such as Parkinson's disease .
Cat. No.: HY-RS26051
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Tmem175 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tmem175 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P703367
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Endosomal/lysosomal proton channel TMEM175; Potassium channel TMEM175; Transmembrane protein 175; hTMEM175; TMEM175; Homo sapiens; Human; Ion channel; Potassium channel
Cat. No.: HY-P703368
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Endosomal/lysosomal proton channel TMEM175; Potassium channel TMEM175; Transmembrane protein 175; hTMEM175; TMEM175; Homo sapiens; Human; Ion channel; Potassium channel
Cat. No.: HY-182464
CAS No.: 893603-33-3
Target:
DABMA is a TMEM175 channel activator with a human EC50 of 17.9 μM. DABMA directly increases TMEM175 channel current via interaction with intracellular, transmembrane, or endosomal lumen-associated domains, and does not alter TMEM175 mRNA or protein levels. DABMA delays endolysosomal substrate degradation, modulates endolysosomal trafficking, increases acidic organelle accumulation, induces cholesterol accumulation and altered late endosome morphology. DABMA can be used for the research of coronavirus disease, Clostridium difficile infection, Pseudomonas aeruginosa infection, rabies, and influenza virus infection .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
