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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
Tip60
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "Tip60" in MCE Product Catalog:
14
14 Publications Verification
Synonyms: Tip60 HAT inhibitor
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
MG149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50 = 47 uM); little potent for PCAF and p300 (IC50 >200 uM). MG 149 inhibits KAT8 and blocks PINK1 kinase activity. MG149 inhibits the phosphorylation of Parkin and ubiquitin, thereby suppressing the initiation of PINK1-dependent mitophagy. MG 149 can reverse chronic restraint stress (CRS) induced hypertension and related molecular changes. MG 149 commonly used in research on diseases such as hypertension and Parkinson's disease .
7
7 Cited Publications
Target:
Research Areas:
NU9056 is a potent and selective Tip60 (KAT5) histone acetyltransferase inhibitor with an of 2 µM. NU9056 shows >16-fold selectivity for Tip60 over PCAF, p300 and GCN5. NU9056 induces apoptosis of prostate cancer cells .
3
3 Cited Publications
Target:
Research Areas:
TH1834 is a specific Tip60 (KAT5) histone acetyltransferase (HAT) inhibitor. TH1834 induces apoptosis and increases DNA damage in breast cancer. TH1834 does not affect the activity of related histone acetyltransferase MOF. Anticancer activity .
3
3 Cited Publications
Target:
Research Areas:
TH1834 dihydrochloride is a specific Tip60 (KAT5) histone acetyltransferase inhibitor. TH1834 dihydrochloride induces apoptosis and increases DNA damage in breast cancer. TH1834 dihydrochloride does not affect the activity of related histone acetyltransferase MOF. Anticancer activity .
2
2 Cited Publications
Cat. No.: HY-P701625
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: KAT8; Histone acetyltransferase KAT8; Lysine acetyltransferase 8; MOZ; YBF2/SAS3; SAS2 and Tip60 protein 1; MYST-1; hMOF
1
1 Cited Publications
Cat. No.: HY-P71707
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: 60kDa Tat interactive protein; cPLA2 interacting protein; ESA1; Histone acetyltransferase HTATip; HTATip1; K(lysine) acetyltransferase 5; PLIP; Tat interacting protein, 60kDa; Tip; Tip60
1
1 Cited Publications
Cat. No.: HY-P86929
Synonyms: Histone acetyltransferase KAT6A EC:2.3.1.48 MOZ, YBF2/SAS3, SAS2 and Tip60 protein 3 (MYST-3) Monocytic leukemia zinc finger protein Runt-related transcription factor-binding protein 2 Zinc finger protein 220 KAT6A MOZ MYST3 RUNXBP2 Histone acetyltransferase KAT6A EC:2.3.1.48 MOZ, YBF2/SAS3, SAS2 and Tip60 protein 3 (MYST-3) Monocytic leukemia zinc finger protein Runt-related transcription factor-binding protein 2 Zinc finger protein 220 KAT6A MOZ MYST3 RUNXBP2 ZNF220
Cat. No.: HY-RS07080
Research Areas:
KAT5 Human Pre-designed siRNA Set A contains three designed siRNAs for KAT5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P704206
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KIAA0383; MORF; MOZ2; MYST4Histone acetyltransferase KAT6B; Histone acetyltransferase MOZ2; MOZ, YBF2/SAS3, SAS2 and Tip60 protein 4 (MYST-4); Monocytic leukemia zinc finger protein-related factor
Species:
Source:
Cat. No.: HY-P86929A
Synonyms: Histone acetyltransferase KAT6A EC:2.3.1.48 MOZ, YBF2/SAS3, SAS2 and Tip60 protein 3 (MYST-3) Monocytic leukemia zinc finger protein Runt-related transcription factor-binding protein 2 Zinc finger protein 220 KAT6A MOZ MYST3 RUNXBP2 Histone acetyltransferase KAT6A EC:2.3.1.48 MOZ, YBF2/SAS3, SAS2 and Tip60 protein 3 (MYST-3) Monocytic leukemia zinc finger protein Runt-related transcription factor-binding protein 2 Zinc finger protein 220 KAT6A MOZ MYST3 RUNXBP2 ZNF220
Cat. No.: HY-RS23862
Target:
Research Areas:
Kat5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Kat5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17408
Target:
Research Areas:
Kat5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kat5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-186091
CAS No.: 2097535-26-5
Target:
Research Areas:
AcdK is a non-natural amino acid and a precursor of allysine. AcdK allows site-specific incorporation into target proteins in E. coli via the amber suppression strategy. AcdK enables site-specific lysine dimethylation or monomethylation modification of target proteins. AcdK can synthesize site-specific lysine-methylated variants of histone H3 and p53, which is applicable for investigating the substrate specificity and catalytic function of epigenetic enzymes .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
