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Triterpene Saponin

" in MedChemExpress (MCE) Product Catalog:

60

Inhibitors & Agonists

60

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0250
    Saikosaponin D
    Maximum Cited Publications
    10 Publications Verification

    		 STAT NF-κB Estrogen Receptor/ERR Bacterial Infection Inflammation/Immunology Cancer
    Saikosaponin D is a triterpene saponin isolated from Bupleurum, with anti-inflammatory, anti-bacterial, anti-tumor, and anti-allergic activities; Saikosaponin D inhibits selectin, STAT3 and NF-kB and activates estrogen receptor-β.
    Saikosaponin D
  • HY-N1404
    Sodium aescinate
    2 Publications Verification

    		 NF-κB Inflammation/Immunology Cancer
    Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities . Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway .
    Sodium aescinate
  • HY-N0632
    Esculentoside A
    2 Publications Verification

    		 COX NF-κB Inflammation/Immunology
    Esculentoside A (EsA), a kind of triterpene saponin isolated from roots of Phytolacca esculenta . Esculentoside A (EsA) possesses anti-inflammatory activity in acute and chronic experimental models , has selective inhibitory activity towards cyclooxygenase-2 (COX-2) . Esculentoside A (EsA) suppresses inflammatory responses in LPS-induced acute lung injury (ALI) through inhibition of the nuclear factor kappa B (NF-ΚB) and mitogen activated protein kinase (MAPK) signaling pathways .
    Esculentoside A
  • HY-N0864
    Macranthoidin B

    Macranthoiside I

    		 Apoptosis COX Reactive Oxygen Species (ROS) Caspase SOD Cancer
    Macranthoidin B (Macranthoiside I) is an orally active triterpene saponin. Macranthoidin B inhibits epithelial-mesenchymal transition in endometriosis via the COX‑2/PGE2 pathway, and also induces tumor cell apoptosis and inhibits their proliferation by regulating metabolism and increasing ROS levels . Macranthoidin B can be used in studies related to endometriosis, colorectal cancer and hepatocellular carcinoma .
    Macranthoidin B
  • HY-N2541
    Gymnemic acid I

    		Taste Receptor mTOR Autophagy Apoptosis Metabolic Disease
    Gymnemic acid I is a bioactive triterpene saponin found in Gymnema sylvestre. Gymnemic acid I is an antisweetness inhibitor via human sweet receptor type 1 receptor 2 (T1R2) and T1R3. Gymnemic acid I is a ribosomal protein biosynthesis inhibitor. Gymnemic acid I has antidiabetic effects. Gymnema acid I induces autophagy-protected MIN-6 cells from apoptosis under high glucose stress by inhibiting the phosphorylation activity of mTOR .
    Gymnemic acid I
  • HY-N0046
    Notoginsenoside Fe

    Notoginseng Triterpenes; Ginsenoside Mb

    		 Apoptosis Src Neurological Disease Metabolic Disease Cancer
    Notoginsenoside Fe (Notoginseng triterpenes; Ginsenoside Mb) is a saponin with anti-obesity and anti-neuroblastoma activities. Notoginsenoside Fe can be isolated from leaves of Panax notoginseng. Notoginsenoside Fe specifically activates paraventricular nucleus neurons in the hypothalamus, effectively reducing body weight, improving fasting blood glucose and protecting liver function by decreasing food intake, increasing resting metabolic rate and enhancing energy expenditure. Notoginsenoside Fe also inhibits the c-Src signaling pathway, blocks the proliferation and viability of human neuroblastoma cells, while improving mitochondrial dysfunction and alleviating apoptosis. Notoginsenoside Fe can be used in studies related to diet-induced obesity and neuroblastoma .
    Notoginsenoside Fe
  • HY-N9517
    QS 7

    QS 7 Api

    		 Others Inflammation/Immunology Cancer
    QS 7 (QS 7 Api) is a triterpene saponin found in the bark of Quillaja saponaria and immune adjuvant with immune response potentiator activity. QS 7 can be used as vaccine adjuvant for the research of antitumor and antiviral vaccine development .
    QS 7
  • HY-N2138
    Buddlejasaponin IVb

    		Others Inflammation/Immunology
    Buddlejasaponin IVb (Compound 2), a triterpene saponin isolated from Clinopodium chinense (Benth.) O. Kuntze, Compound 2 has hemostasis efficacy, shortens thrombin time (TT) by 20.6 % .
    Buddlejasaponin IVb
  • HY-N7952
    Achyranthoside D

    		Others Others
    Achyranthoside D is a triterpene saponin from Achyranthes root .
    Achyranthoside D
  • HY-N6924
    Zingibroside R1
    1 Publications Verification

    		 HIV PIN1 Fungal GLUT Reactive Oxygen Species (ROS) Infection Neurological Disease Metabolic Disease Cancer
    Zingibroside R1 is an orally active triterpene saponin with multiple biological activities including antioxidant, anti-inflammatory, antiviral, and metabolic regulatory properties. Zingibroside R1 reduces the expression of PIN family members, inhibits the expression of PLT1/PLT2, WOX5, SHR, and SCR, disrupts auxin transport and distribution, triggers plant ROS responses, and inhibits root growth. Zingibroside R1 extends the lifespan of Caenorhabditis elegans, enhances its heat stress resistance, and improves its motor ability. Hydrogel derivatives of Zingibroside R1 inhibit the proliferation of Candida albicans by binding to its β-1,3-glucan and exhibit antifungal activity. Zingibroside R1 inhibits GLUT1-mediated uptake and alleviates liver injury. Zingibroside R1 can be used in research related to neurodegenerative diseases, vulvovaginal candidiasis, acute liver injury, Ehrlich ascites tumor and HIV-1 infection .
    Zingibroside R1
  • HY-N7616
    Oleanolic acid-3-O-glucosyl(1-2)xylyl(1-3)glucosiduronic acid

    		Others Others
    Oleanolic acid-3-O-glucosyl(1-2)xylyl(1-3)glucosiduronic acid is a nature occurring triterpene saponin .
    Oleanolic acid-3-O-glucosyl(1-2)xylyl(1-3)glucosiduronic acid
  • HY-N7497
    Protoescigenin

    		Others Others
    Protoescigenin is the main aglycone of horse chestnut saponin mixture known as escin. Protoescigenin is selected as substrate for exploratory chemistry towards selective protection, followed by propargyl ether formation and subsequent condensation with azido-monosaccharides, to obtain novel triazole linked conjugates of the triterpene .
    Protoescigenin
  • HY-N7687
    Caulophyllogenin

    		PPAR Metabolic Disease Inflammation/Immunology
    Caulophyllogenin is a triterpene saponin extracted from M. polimorpha. Caulophyllogenin is a partial PPARγ agonist, with an EC50 of 12.6 μM. Caulophyllogenin can be used for the research of type-2 diabetes, obesity, metabolic syndrome and inflammation .
    Caulophyllogenin
  • HY-N9402
    Prosaikogenin A

    		Others Cardiovascular Disease
    Prosaikogenin A is a triterpene saponin isolated from Clinopodium chinense. Prosaikogenin A has significant promoting effects on platelet aggregation with an EC50 value of 12.2 μM .
    Prosaikogenin A
  • HY-N6252
    Gypenoside XLVI
    1 Publications Verification

    		 Others Cancer
    Gypenoside XLVI is one of the major dammarane-type triterpenoid saponins from Gynostamma pentaphallum . Gypenoside XLVI has a tetracyclic triterpene structure and possess potent non-small cell lung carcinoma A549 cell inhibitory activity .
    Gypenoside XLVI
  • HY-N11923
    Lysimachigenoside C

    		Others Others
    Lysimachigenoside C is a triterpene saponin isolated from Lysimachia foenum-graecum Hance .
    Lysimachigenoside C
  • HY-N11924
    Foenumoside B

    		AMPK PPAR Metabolic Disease
    Foenumoside B is a triterpene saponin isolated from Lysimachia foenum-graecum. Foenumoside B activates AMPK signaling, inhibits PPARγ-induced adipogenesis, and shifts lipid metabolism toward lipolysis. Foenumoside B can be used in the study of obesity and obesity-related metabolic diseases .
    Foenumoside B
  • HY-N0250R
    Saikosaponin D (Standard)

    		Reference Standards STAT NF-κB Estrogen Receptor/ERR Bacterial Infection Inflammation/Immunology Cancer
    Saikosaponin D (Standard) is the analytical standard of Saikosaponin D. This product is intended for research and analytical applications. Saikosaponin D is a triterpene saponin isolated from Bupleurum, with anti-inflammatory, anti-bacterial, anti-tumor, and anti-allergic activities; Saikosaponin D inhibits selectin, STAT3 and NF-kB and activates estrogen receptor-β.
    Saikosaponin D (Standard)
  • HY-N4217
    Saikosaponin I

    		Others Others
    Saikosaponin I is a triterpene saponin extracted from Bupleurum falcatum L. Saikosaponin can be used to treat fever, inflammation, liver disease, and nephritis .
    Saikosaponin I
  • HY-N0554R
    Escin IA (Standard)

    		Reference Standards HIV Protease Infection Cancer
    Escin IA (Standard) is the analytical standard of Escin IA. This product is intended for research and analytical applications. Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression .
    Escin IA (Standard)
  • HY-125686
    Beesioside Q

    		Others Others
    Beesioside Q is a oleanolic acid triterpene saponin isolated from the rhizome of Beesia calthaefolia (Maxim.) Ulbr .
    Beesioside Q
  • HY-N0632R
    Esculentoside A (Standard)

    		Reference Standards COX NF-κB Inflammation/Immunology
    Esculentoside A (Standard) is the analytical standard of Esculentoside A. This product is intended for research and analytical applications. Esculentoside A (EsA), a kind of triterpene saponin isolated from roots of Phytolacca esculenta . Esculentoside A (EsA) possesses anti-inflammatory activity in acute and chronic experimental models , has selective inhibitory activity towards cyclooxygenase-2 (COX-2) . Esculentoside A (EsA) suppresses inflammatory responses in LPS-induced acute lung injury (ALI) through inhibition of the nuclear factor kappa B (NF-ΚB) and mitogen activated protein kinase (MAPK) signaling pathways .
    Esculentoside A (Standard)
  • HY-N11034
    24-Hydroxy-licorice-saponin A3

    		Others Others
    24-Hydroxy-licorice-saponin A3 is an oleanane-type triterpene saponin (OTS). 24-Hydroxy-licorice-saponin A3 can be isolated from G. uralensis. .
    24-Hydroxy-licorice-saponin A3
  • HY-N12190
    Centellasaponin A

    		Others Others
    Centellasaponin A (compound 10) is a pentacyclic triterpene saponin isolated from the methanolic extract of Centella asiatica .
    Centellasaponin A
  • HY-N8763
    Ciwujianoside E

    Guaianin A

    		 Others Neurological Disease
    Ciwujianoside E is a triterpene saponin that can be isolated from Acanthopanax senticosus. Ciwujianoside E can be used in study sedative-hypnotic drug .
    Ciwujianoside E
  • HY-N9324
    Ilexoside O

    		Xanthine Oxidase Inflammation/Immunology
    Ilexoside O is a triterpene saponin isolated from the roots of Ilex pubescens. Ilexoside O exhibits weak xanthine oxidase (XOD) inhibitory activity (IC50=53.05 μM) .
    Ilexoside O
  • HY-N12225
    Isoasiaticoside

    		Others Neurological Disease
    Isoasiaticoside is a pentacyclic triterpene saponin that can be isolated from Centella asiatica. Isoasiaticoside has potential neuroprotective effects in the 6-OHDA (HY-B1081)-induced PC12 cell model .
    Isoasiaticoside
  • HY-N15218
    Akebia saponin F

    		Others Others
    Akebia saponin F is a triterpene saponin found in Stauntonia hexaphylla .
    Akebia saponin F
  • HY-N7235
    Lanatoside E

    		Others Cancer
    Lanatoside E is a cyclic triterpene saponin with antitumor activity .
    Lanatoside E
  • HY-N11810
    Polyfuroside

    		Others Others
    Polyfuroside is a triterpenoid saponin, which can be isolated from the defatted rhizome of jade bamboo .
    Polyfuroside
  • HY-125121
    Esculentoside C

    		Biochemical Assay Reagents Others
    Esculentoside C is a triterpene saponin. Esculentoside C can be obtained from the root of Phytolacca esculenta .
    Esculentoside C
  • HY-N9328
    Tarasaponin IV

    		Others Cancer
    Tarasaponin IV, as an oleanane-type triterpene saponin, is isolated from the bark of Aralia elata. Tarasaponin IV can be used for the research of cancer .
    Tarasaponin IV
  • HY-N9524
    Ilexoside XLVIII

    		Acyltransferase Metabolic Disease
    Ilexoside XLVIII is an acyl CoA cholesteryl acyl transferase (ACAT) inhibitor. Ilexoside XLVIII is a triterpene saponin isolated from an aqueous extract of the leaves of Ilex kudincha .
    Ilexoside XLVIII
  • HY-N7497R
    Protoescigenin (Standard)

    		Reference Standards Others Others
    Protoescigenin (Standard) is the analytical standard of Protoescigenin. This product is intended for research and analytical applications. Protoescigenin is the main aglycone of horse chestnut saponin mixture known as escin. Protoescigenin is selected as substrate for exploratory chemistry towards selective protection, followed by propargyl ether formation and subsequent condensation with azido-monosaccharides, to obtain novel triazole linked conjugates of the triterpene .
    Protoescigenin (Standard)
  • HY-N17972
    Floranotoginsenoside D

    		Others Others
    Floranotoginsenoside D (Compound 4) is a dammarane-type triterpene saponin found in the flowers of Panax notoginseng .
    Floranotoginsenoside D
  • HY-N13138
    Angulasaponin B

    		NO Synthase Inflammation/Immunology
    Angulasaponin B, a natural product, can be obtained from Vigna angularis. Angulasaponin B inhibits nitric oxide production in LPS-activated RAW264.7 macrophages with IC50 values ​​ranging from 13 μM to 24 μM .
    Angulasaponin B
  • HY-N0864R
    Macranthoidin B (Standard)

    Macranthoiside I (Standard)

    		 Reference Standards Others Cancer
    Macranthoidin B (Macranthoiside I) Standard is the analytical standard of Macranthoidin B (HY-N0864). This product is intended for research and analytical applications. Macranthoidin B (Macranthoiside I) is an orally active triterpene saponin. Macranthoidin B inhibits epithelial-mesenchymal transition in endometriosis via the COX‑2/PGE2 pathway, and also induces tumor cell apoptosis and inhibits their proliferation by regulating metabolism and increasing ROS levels . Macranthoidin B can be used in studies related to endometriosis, colorectal cancer and hepatocellular carcinoma .
    Macranthoidin B (Standard)
  • HY-N18022
    Septemloside D

    		Others Others
    Septemloside D (Compound 5) is a hederagenin triterpene saponin found in Kalopanacis Cortex .
    Septemloside D
  • HY-N18039
    Esculentoside S

    		Drug Derivative Others
    Esculentoside S is a bidesmodic triterpene saponin, found in the leaves of Phytolacca acinosa .
    Esculentoside S
  • HY-N18013
    Septemloside II

    		Others Others
    Septemloside II (Compound 6) is a triterpene saponin found in the dried stem bark of Kalopanax pictus (Kalopanacis Cortex) .
    Septemloside II
  • HY-N19718
    Betavulgaroside I

    		Drug Derivative Infection
    Betavulgaroside I (Compound 1) is a triterpene saponin found in sugar beet (Beta vulgaris) and beetroot. Betavulgaroside I can be used for research on antifungal activity .
    Betavulgaroside I
  • HY-N18040
    Esculentoside F

    		Drug Derivative Others
    Esculentoside F is a triterpene saponin found in the root of Phytolacca acinosa Roxb .
    Esculentoside F
  • HY-N17994
    GypenosideZ-2

    		Drug Derivative Others
    GypenosideZ-2 is a dammarane-type triterpene saponin found in the aerial parts of Gynostemma pentaphyllum (Thunb.) Makino .
    GypenosideZ-2
  • HY-N19713
    Araliasaponin XIV

    		Drug Derivative Others
    Araliasaponin XIV is an oleanane-type triterpene saponin that can be found in the roots of Aralia chinensis .
    Araliasaponin XIV
  • HY-N17332
    Betavulgaroside III

    		Others Inflammation/Immunology
    Betavulgaroside III is a triterpene seco-glycoside plant saponin. Betavulgaroside III exhibits anti-inflammatory activity .
    Betavulgaroside III
  • HY-N19858
    Millettiasaponin B

    		Others Cancer
    Millettiasaponin B is an oleanane-type triterpene saponin found in the roots of Millettia speciosa. Millettiasaponin B can be used in leukemia research .
    Millettiasaponin B
  • HY-N17243
    Aesculinoside C

    		Others Others
    Aesculinoside C is an acylated polyhydroxy oleanane-type triterpene saponin that is found in the seeds of Aesculus chinensis .
    Aesculinoside C
  • HY-N18269
    3-O-α-L-Arabinopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl ester

    		Fungal Infection
    3-O-α-L-Arabinopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl ester is an anti-fungal triterpene saponin. 3-O-α-L-Arabinopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl ester can be isolated from the aerial parts of Clematis tangutica. 3-O-α-L-Arabinopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl ester exhibits antifungal activity against fungal strains (P. avellaneum, C. glabrata, S. cerevisiae, T. beigelii), with the strongest activity against S. cerevisiae .
    3-O-α-L-Arabinopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl ester
  • HY-N18388
    Bacopaside VI

    		Others Others
    Bacopaside VI is a Bacopaside. Bacopaside VI can be isolated from Bacopa monnieri .
    Bacopaside VI
  • HY-N19048
    Semen ziziphi spinosae extract

    		Others Others
    Semen Ziziphi Spinosae Extract is derived from the dried seeds of Ziziphus jujuba Mill.var.spinosa, a plant of the Rhamnaceae family. The active ingredients include flavonoid glycosides, triterpenes, saponins and organic acids, etc.
    Semen ziziphi spinosae extract

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