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Isoforms Recommended:	USP8

Results for "

USP8

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) Autophagy (1) Deubiquitinase (15) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (15) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (1) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13814

PR-619 Maximum Cited Publications 38 Publications Verification	Deubiquitinase Autophagy Apoptosis	Cancer
PR-619 is a broad-range and reversible DUB inhibitor with EC₅₀s of 3.93, 4.9, 6.86, 7.2, and 8.61 μM for *USP4, USP8, USP7, USP2, and USP5*, respectively. PR-619 induces ER Stress and ER-Stress related apoptosis .

HY-50737A

DUB-IN-2 15+ Cited Publications	Deubiquitinase	Cancer
DUB-IN-2 is a potent deubiquitinase inhibitor with an IC₅₀ of 0.28 μM for USP8 .

HY-151563

*OTUB1/USP8-IN-1* 2 Publications Verification	Deubiquitinase	Cancer
OTUB1/USP8-IN-1 is a potent dual *OTUB1/USP8* inhibitor with IC₅₀ values of 0.17 and 0.28 nM for OTUB1 and USP8, respectively. OTUB1/USP8-IN-1 can be used in research of cancer .

HY-150505

DC-U4106 1 Publications Verification	Deubiquitinase Apoptosis	Cancer
DC-U4106 is a *USP8* targeting inhibitor with the K_dvalue of 4.7 μM and the IC₅₀ value of 1.2 μM. DC-U4106 can target the ubiquitin pathway and facilitate the degradation of Erα. DC-U4106 inhibits tumor growth with minimal toxicity and has the potential for the research of breast cancer .

HY-50737

DUB-IN-3 5+ Cited Publications	Deubiquitinase	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
DUB-IN-3 (compound 22c) is a potent and selective inhibitor of the deubiquitinating enzyme *USP8* with an IC₅₀ value of 0.56 μM. DUB-IN-3 is promising for research of cancer, neurodegenerative diseases, inflammation, viral infection and cardiovascular disease .

HY-162312

LLK203	Deubiquitinase Apoptosis	Cancer
LLK203 is a potent *USP2/USP8* dual-target inhibitor with IC₅₀s of 0.89 μM and 0.52 μM, respectively. LLK203 leads a degradation of ERα and induces apoptosis of breast cancer MCF-7 cells. LLK203 demonstrates antitumor activities against the 4T1 tumor mice model .

HY-50736

DUB-IN-1 4 Publications Verification	Deubiquitinase	Cancer
DUB-IN-1 is an active inhibitor of ubiquitin-specific proteases (USPs), with an IC₅₀ of 0.85 μM for USP8 .

HY-147032

USP8-IN-1	Deubiquitinase	Cancer
USP8-IN-1 is a *USP8* inhibitor with an IC₅₀ of 1.9 μM. USP8-IN-1 inhibits H1975 cell growth with a GI₅₀ of 82.04 μM (CN111138358A; U10) .

HY-149230

USP28-IN-4	Deubiquitinase	Cancer
USP28-IN-4 is a *USP28* inhibitor (IC₅₀=0.04 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-4 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-4 also decreases the ankyrase-1/2 level in vitro. USP28-IN-4 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331) .

HY-RS15569

USP8 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
USP8 Human Pre-designed siRNA Set A contains three designed siRNAs for USP8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

USP8 Human Pre-designed siRNA Set A USP8 Human Pre-designed siRNA Set A

HY-151563A

*OTUB1/USP8-IN-1 TFA* 2 Publications Verification	Deubiquitinase	Cancer
OTUB1/USP8-IN-1 TFA is the TFA salt form of OTUB1/USP8-IN-1 (HY-151563). OTUB1/USP8-IN-1 TFA is a dual inhibitor for *OTUB1/USP8, IC₅₀* for OTUB1 and USP8 is 0.17 and 0.28 nM, respectively. OTUB1/USP8-IN-1 TFA inhibits proliferation of NSCLC cells. OTUB1/USP8-IN-1 TFA exhibits good pharmacokinetic characters in ICR mouse, and exhibits antitumor activity in H1975 xenograft mouse model .

HY-149902

USP8-IN-3	Deubiquitinase	Cancer
USP8-IN-3 (Compd U51) is a deubiquitinase *USP8* inhibitor with an IC₅₀ value of 4.0 μM. USP8-IN-3 also inhibits the proliferation of GH3 and H1957 cells with GI₅₀s of 37.03 μM and 6.01 μM, respectively .

HY-178124

Huib32	Deubiquitinase	Neurological Disease Cancer
Huib32 is a potent small-molecule inhibitor of *USP32* (IC₅₀ = 21.2 nM), exhibiting high selectivity over other closely related deubiquitinating enzymes (DUBs), such as USP8/10/16, UCHL1 and OTUB2. Huib32 reversibly inhibits USP32 by covalently binding to the active site Cys743, which enhances substrate ubiquitination, alters endosomal morphology, and mimics USP32 depletion. Huib32 can be used for breast, ovarian, and lung cancer and Alzheimer's and Parkinson’s diseases research .

HY-149901

USP8-IN-2	Deubiquitinase	Cancer
USP8-IN-2 (Compd U52) is a deubiquitinase *USP8* inhibitor with an IC₅₀ value of 6.0 μM. USP8-IN-2 also inhibits the proliferation of H1957 cells with an GI₅₀ value of 24.93 μM, respectively .

HY-RS16638

Usp8 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Usp8 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Usp8 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Usp8 Mouse Pre-designed siRNA Set A Usp8 Mouse Pre-designed siRNA Set A

HY-RS23073

Usp8 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Usp8 Rat Pre-designed siRNA Set A contains three designed siRNAs for Usp8 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Usp8 Rat Pre-designed siRNA Set A Usp8 Rat Pre-designed siRNA Set A

HY-149229

USP28-IN-3	Deubiquitinase	Cancer
USP28-IN-3 is a *USP28* inhibitor (IC₅₀=0.1 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-3 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-3 also decreases the ankyrase-1/2 level in vitro. USP28-IN-3 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331) .

HY-149228

USP28-IN-2	Deubiquitinase	Cancer
USP28-IN-2 is a *USP28* inhibitor (IC₅₀=0.3 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-2 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-2 also decreases the ankyrase-1/2 level in vitro. USP28-IN-2 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331) .

Species:	Human (2)
Tag:	His (1) GST (1)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P703651

	USP8 Protein, Human (sf9) Ubiquitin carboxyl-terminal hydrolase 8; Deubiquitinating enzyme 8; Ubiquitin isopeptidase Y (hUBPy); Ubiquitin thioesterase 8; Ubiquitin-specific-processing protease 8; KIAA0055; UBPY	Human	Sf9 insect cells
	USP8 is a key hydrolase in cellular regulation and plays a crucial role in protein turnover by efficiently deubiquitinating proteins and preventing degradation. Its activity spans "Lys-48" and "Lys-63" linked ubiquitin chains, highlighting its versatility. USP8 Protein, Human (sf9) is the recombinant human-derived USP8 protein, expressed by Sf9 insect cells, with tag free.

HY-P703652

	USP8 Protein, Human (sf9, His, GST) Ubiquitin carboxyl-terminal hydrolase 8; Deubiquitinating enzyme 8; Ubiquitin isopeptidase Y (hUBPy); Ubiquitin thioesterase 8; Ubiquitin-specific-processing protease 8; KIAA0055; UBPY	Human	Sf9 insect cells
	USP8 is a key hydrolase in cellular regulation and plays a crucial role in protein turnover by efficiently deubiquitinating proteins and preventing degradation. Its activity spans "Lys-48" and "Lys-63" linked ubiquitin chains, highlighting its versatility. USP8 Protein, Human (sf9, His, GST) is the recombinant human-derived USP8 protein, expressed by Sf9 insect cells, with N-His and N-GST labeled tag.

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USP8 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
USP8 Human Pre-designed siRNA Set A contains three designed siRNAs for USP8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Usp8 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Usp8 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Usp8 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Usp8 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Usp8 Rat Pre-designed siRNA Set A contains three designed siRNAs for Usp8 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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