32 Results for "

amidated

" in MedChemExpress (MCE) Product Catalog:
Products (32)

32 Results for "amidated" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-P1723
CAS No.: 1370290-58-6
Synonyms: Neuropeptide Q
Spexin (Neuropeptide Q) is a selective agonist of galanin receptors GAL2 and GAL3, and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin can function through both central and peripheral actions. Spexin upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents). Spexin improves cardiac function in the Doxorubicin hydrochloride (HY-15142)-induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin can be used to study obesity and its related metabolic disorders, cardiovascular diseases (e.g., cardioprotection), and side effects of tumor chemotherapy .
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Cat. No.: HY-P1465
CAS No.: 108153-74-8
Synonyms: Secretin (28-54), (human)
Target:  

Secretin Receptor

Research Areas:  

Metabolic Disease Cancer

Human secretin is a 27-amino acid residue C-terminally amidated peptide, which acts on human secretin receptors .
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Cat. No.: HY-P0199
CAS No.: 75976-10-2
Synonyms: Human pancreatic polypeptide
Research Areas:  

Metabolic Disease Endocrinology

Pancreatic Polypeptide, human is a C-terminally amidated 36 amino acid peptide, which acts as a neuropeptide Y (NPY) Y4/Y5 receptor agonist.
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Cat. No.: HY-P5726
CAS No.: 302343-01-7
Target:  

Bacterial Antibiotic

Research Areas:  

Infection Cancer

Aurein 1.2 is a C-terminally amidated antimicrobial peptide found in Litoria raniformis. Aurein 1.2 exhibits moderate, broad-spectrum antimicrobial activity against a variety of bacteria, with a MIC of 12-100 μg/mL. Aurein 1.2 forms an amphipathic α-helix with distinct hydrophilic and hydrophobic faces, and may exert antimicrobial and cytotoxic effects on tumor cells by disrupting cell membranes. Aurein 1.2 can be used in studies related to antimicrobial peptides, membrane-active peptides, and tumor cytotoxicity .
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Cat. No.: HY-W338852
CAS No.: 25351-24-0
Target:  

Drug Metabolite

Research Areas:  

Cancer

Gentisuric acid, a metabolite of Aspirin (HY-14654), is a substrate of α-amidating monooxygenase (PAM). Gentisuric acid prevents DNA-damage by Mitomycin C (HY-13316) .
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Cat. No.: HY-W015464
CAS No.: 16284-60-9
N-Isovaleroylglycine is a peptidylglycine α-amidating monooxygenase (PAM) inhibitor with a Ki value of 2.0 mM against human hsPAM. N-Isovaleroylglycine undergoes oxidative cleavage by purified rat PAM to produce fatty acid amide and glyoxylic acid. N-Isovaleroylglycine exerts competitive inhibition by binding to hsPAM, blocking the amidation of dansyl-Tyr-Val-Gly. N-Isovaleroylglycine exhibits lowered urinary abundance in MRSA-infected mice, which qualifies it as a non-invasive biomarker. N-Isovaleroylglycine can be used in studies related to Staphylococcus aureus pneumonia and diabetic foot .
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Cat. No.: HY-P1884
Target:  

Bacterial

Research Areas:  

Infection

LL-37, acetylated, amidated is a cathelicidin peptide LL-37 acetylated on the N-terminus and amidated on the C-terminus. The single human cathelicidin peptide LL-37 has antimicrobial and anti-biofilm activity against multiple Gram-positive and Gram-negative human pathogens, and has wound-healing effects on the host .
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Cat. No.: HY-145951
CAS No.: 2202782-90-7
Research Areas:  

Cancer

Amidate-VC-PAB-MMAF consists a cleavable ADC linker (Amidate-VC-PAB) and a potent tubulin polymerization inhibitor (MMAF). Amidate-VC-PAB-MMAF can be used in the synthesis of antibody-drug conjugates (ADCs). Amidate-VC-PAB-MMAF reduces off-target cytotoxicity of ADCs .
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Cat. No.: HY-P1465A
Synonyms: Secretin (28-54), (human) TFA
Target:  

Secretin Receptor

Research Areas:  

Metabolic Disease Cancer

Human secretin TFA is a 27-amino acid residue C-terminally amidated peptide, which acts on human secretin receptors .
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Cat. No.: HY-168761
CAS No.: 18416-54-1
Target:  

Endogenous Metabolite

Research Areas:  

Metabolic Disease

N-Cholyl-L-alanine is a bile acid amidate, which is found in human fecal samples .
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Cat. No.: HY-P1421
CAS No.: 1081110-72-6
Target:  

PERK GHSR Apoptosis

Research Areas:  

Metabolic Disease

Obestatin(human) is a 23-amino acid amidated peptide that regulates appetite and gastrointestinal motility via its interaction with GPR39. Obestatin(human) can be used for weight loss. Obestatin(human) cannot penetrate the cell membrane .
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Cat. No.: HY-P3588
CAS No.: 2920938-90-3
N-Acetyl semax amidate is a synthetic heptapeptide with nootropic and neuroprotective activities, derived from Met-Glu-His-Phe-Pro-Gly-Pro via N-terminal acetylation and C-terminal amidation modifications. N-Acetyl semax amidate exerts neuroprotective effects by upregulating the expression of BDNF and NGF, inhibiting neuronal apoptosis, alleviating oxidative stress, and reducing glutamate excitotoxicity. N-Acetyl semax amidate can be used in relevant research on central nervous system diseases such as ischemic stroke, cognitive impairment, and neurodegenerative diseases .
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Cat. No.: HY-P0303
CAS No.: 309247-84-5
Crustacean cardioactive peptide, free acid is a highly conserved, amidated cyclic nonapeptide, first isolated from the pericardial organs of the shore crab Carcinus maenas, where it has a role in regulating heartbeat; Crustacean cardioactive peptide, free acid also modulates the neuronal activity in other arthropods.
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Cat. No.: HY-P5182A
Target:  

Potassium Channel

Research Areas:  

Inflammation/Immunology

HsTX1 (TFA) toxin, from the scorpion Heterometrus spinnifer, is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges. HsTX1 (TFA) is an the inhibitor of potassium channel, with IC50 for Kv1.3 of 12 pM and inhibits TEM cell activation and attenuates inflammation in autoimmunity .
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Cat. No.: HY-P5490
CAS No.: 1370290-59-7
Synonyms: NPQ 53-70
Target:  

Peptides

Research Areas:  

Others

Spexin-2 (53-70), human,mouse,rat (NPQ 53-70) is a biological active peptide. (This is Spexin-2 (53-70), non-amidated version of the novel peptide hormone that is derived from prohormone proNPQ and is conserved amongst mammalian species. It is a central modulator of cardiovascular and renal function. Spexin-2, when administered to rats, decreases heart rate and increases urine flow rate)
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Cat. No.: HY-P3843
CAS No.: 99588-52-0
Neuropeptide AF (cattle), an amidated octadecapeptide, is RFamide neuropeptide. Neuropeptide AF (cattle) acts as a ligand of Mas-related gene receptor A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR)) (EC50 of ~60 nM) and MrgprC11 (EC50 of ~300 nM). Neuropeptide AF (cattle) also activate to the G protein-coupled receptors NPFF1 (Neuropeptide Y Receptor) (EC50 of ~25-325 nM) and NPFF2 (EC50 of ~1-5 nM). Neuropeptide AF (cattle) shows anti-opiate and related pain modulation effects .
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Cat. No.: HY-W338852R
CAS No.: 25351-24-0
Research Areas:  

Cancer

Gentisuric acid (Standard) is the analytical standard of Gentisuric acid. This product is intended for research and analytical applications. Gentisuric acid, a metabolite of Aspirin (HY-14654), is a substrate of α-amidating monooxygenase (PAM). Gentisuric acid prevents DNA-damage by Mitomycin C (HY-13316)[1][2].
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Cat. No.: HY-P10290
CAS No.: 99575-89-0
Research Areas:  

Neurological Disease

Neuropeptide Y (human) free acid is the deamidated form of Neuropeptide Y (human, rat, mouse) (HY-P0198). The amidation of Neuropeptide Y C-terminal tyrosine is critical for its function. Non-amidated Neuropeptide Y fails to elicit G protein signaling .
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Cat. No.: HY-P5182
CAS No.: 201948-00-7
Target:  

Potassium Channel

Research Areas:  

Inflammation/Immunology

HsTX1, from the scorpion Heterometrus spinnifer, is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges. HsTX1, an the inhibitor of potassium channel, with IC50 for Kv1.3 of 12 pM inhibits TEM cell activation and attenuates inflammation in autoimmunity .
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Cat. No.: HY-P5771
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

Jingzhaotoxin-IX, a C-terminally amidated peptide composed of 35 amino acid residues, is a neurotoxin. Jingzhaotoxin-IX inhibits voltage-gated sodium channels (both tetrodotoxin-resistant and tetrodotoxin-sensitive isoforms) and Kv2.1 channel. Jingzhaotoxin-IX has no effect on delayed rectifier potassium channel Kv1.1, 1.2 and 1.3 .
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