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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
30 Results for "
bromodomain-containing
" in MedChemExpress (MCE) Product Catalog:
Products (30)
30 Results for "bromodomain-containing" in MCE Product Catalog:
10
10 Publications Verification
Cat. No.: HY-18975
CAS No.: 1714146-59-4
Target:
Domaines de recherche:
I-BRD9 is a selective cellular chemical probe of bromodomain-containing protein 9 (BRD9) with pIC50 value of 7.3 μM. I-BRD9 has high selectivity for bromodomain and extra terminal domain (BET) family and highly homologous bromodomain-containing protein 7 (BRD7). I-BRD9 can be used to identify genes regulated by BRD9 in Kasumi-1 cells involved in oncology and immune response pathways .
4
4 Cited Publications
Cat. No.: HY-16586
CAS No.: 1403764-72-6
Domaines de recherche:
PFI-1, a chemical probe, is a selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM in a cell-free assay.
4
4 Cited Publications
Cat. No.: HY-P7846
Pureté: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: BRD4; Mitotic Chromosome-Associated Protein; bromodomain containing 4; bromodomain-containing Protein 4; HUNKI; Chromosome-Associated Protein; HUNK1; bromodomain-containing Protein 4 Variant; MCAP; bromodomain-containing 4; CAP; Protein HUNK1; FSHRG4; BRD4 Protein; Female Sterile Homeotic Related Gene 4; CDLS6
Species:
Human
Source:
E. coli
2
2 Cited Publications
Target:
Domaines de recherche:
ZL0454 is a potent and selective Bromodomain-containing protein 4 (BRD4) inhibitor with an IC50 of 49 and 32 nM for BD1 and BD2.
1
1 Cited Publications
Target:
Domaines de recherche:
BAZ1A-IN-1 is a potent inhibitor of BAZ1A (bromodomain-containing protein). BAZ1A-IN-1 shows a KD value of 0.52 μM against BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-viability activity against cancer cell lines expressing a high level of BAZ1A, but weak or no activity against cancer cells with a low expression level of BAZ1A .
Synonyms: AP1867-PEG2-JQ1; AP-PEG2-JQ1
Target:
Domaines de recherche:
NICE-01 (AP1867-PEG2-JQ1; AP-PEG2-JQ1) is a bifunctional compound that bind to proteins in separate cellular compartments that can induce nuclear import of cytosolic cargoes, using nuclear-localized bromodomain-containing protein 4 (BRD4) as a “carrier” for co-import and nuclear trapping of cytosolic proteins .
Domaines de recherche:
CF53 is a highly potent, selective and orally active inhibitor of BET protein, with a Ki of <1 nM, Kd of 2.2 nM and an IC50 of 2 nM for BRD4 BD1. CF53 binds to both the BD1 and BD2 domains of BRD2, BRD3, BRD4, and BRDT BET proteins with high affinities, very selective over non-BET bromodomain-containing proteins. CF53 shows potent anti-tumor activity both in vitro and in vivo .
Cat. No.: HY-19760
CAS No.: 1422554-34-4
Target:
Domaines de recherche:
I-BET282 is a pan-inhibitor of all eight BET bromodomains, and selectivity over other representative bromodomain-containing proteins. I-BET282 shows pIC50s ranging 6.4-7.7 for BRD2 (BD1/BD2), BRD2 (BD1/BD), BRD3 (BD1/BD), and BRD4 (BD1/BD) .
Cat. No.: HY-W017851
CAS No.: 1198-97-6
Target:
Domaines de recherche:
4-Phenyl-2-pyrrolidinone is a precursor and synthetic intermediate. 4-Phenyl-2-pyrrolidinone can be used as a precursor in the synthesis of compounds with anticonvulsant and nootropic activities and is an intermediate in the synthesis of bromodomain-containing protein 4 (BRD4) bromodomain 1 inhibitors .
Target:
Domaines de recherche:
ZL0420 is a potent and selective bromodomain-containing protein 4 (BRD4) inhibitor with IC50 values of 27 nM against BRD4 BD1 and 32 nM against BRD4 BD2.
Target:
Domaines de recherche:
UMB-32, a potent, selective BRD4 inhibitor, binds BRD4 with the Kd of 550 nM, and IC50 of 637 nM. UMB-32 also shows potency against TAF1, a bromodomain-containing transcription factor .
Target:
Domaines de recherche:
BRD7-IN-2 (compound 2-77) is a potent inhibitor of bromodomain-containing protein 7 (BRD7), targeting to prostate cancer cells. BRD7-IN-2 is selective for BRD7 rather than BRD9, with IC50s of 5.4 μM, and >300 μM, respectively.
Domaines de recherche:
BRD4/CK2-IN-1 is the first highly effective and oral active dual-target inhibitor of BRD4/CK2 (bromodomain-containing protein 4/casein kinase 2), with IC50s of 180 nM and 230 nM for BRD4 and CK2, respectively. BRD4/CK2-IN-1 has strong anticancer activity without obvious toxicities. BRD4/CK2-IN-1 induces apoptosis and autophagy-associated cell death in triple-negative breast cancer (TNBC)
Cat. No.: HY-112149A
CAS No.: 2229039-45-4
Target:
Domaines de recherche:
(E/Z)-ZL0420 is a racemic compound of (Z)-ZL0420 and (E)-ZL0420 isomers. (E)-ZL0420 is a potent and selective bromodomain-containing protein 4 (BRD4) inhibitor with IC50 values of 27 nM against BRD4 BD1 and 32 nM against BRD4 BD2 .
Cat. No.: HY-149421
CAS No.: 3032601-04-7
Target:
Domaines de recherche:
BRD7-IN-3 (compound 1-78) is a dual inhibitor of bromodomain-containing proteins BRD7/BRD9 with IC50s of 1.6 μM and 2.7 μM respectively .
Cat. No.: HY-P703596
Pureté: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: BRD3; bromodomain-containing Protein 3; bromodomain containing 3; RING3-Like Protein; RING3L; bromodomain-containing Protein 3 Short Isoform; KIAA0043; bromodomain-containing 3; FSHRG2; Alternative Protein BRD3; ORFX; RING3-Like; Female Sterile Homeotic R
Species:
Human
Source:
E. coli
Cat. No.: HY-P702876
Pureté: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: BRD3; bromodomain-containing Protein 3; bromodomain containing 3; RING3-Like Protein; RING3L; bromodomain-containing Protein 3 Short Isoform; KIAA0043; bromodomain-containing 3; FSHRG2; Alternative Protein BRD3; ORFX; RING3-Like; Female Sterile Homeotic R
Species:
Human
Source:
E. coli
Cat. No.: HY-P702877
Pureté: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: BRD3; bromodomain-containing Protein 3; bromodomain containing 3; RING3-Like Protein; RING3L; bromodomain-containing Protein 3 Short Isoform; KIAA0043; bromodomain-containing 3; FSHRG2; Alternative Protein BRD3; ORFX; RING3-Like; Female Sterile Homeotic R
Species:
Human
Source:
E. coli
Cat. No.: HY-122573
CAS No.: 1914047-59-8
Domaines de recherche:
Bromodomain inhibitor-13 (Compound 1) is an analog of PFI-3 (HY-12409). Bromodomain inhibitor-13 is a bromodomain-containing protein (BCP) inhibitor. Bromodomain inhibitor-13 targets SMARCA2, SMARCA4, PB1(5), and second bromodomain of PB1 (PB1(2)) with KD values of 37, 53, 30, and 190 nM, respectively .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
