31 Results for "

component C1

" in MedChemExpress (MCE) Product Catalog:
Products (31)

31 Results for "component C1" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-N5112A
CAS No.: 34539-65-6
Synonyms: Arnebin 1
β,β-Dimethylacrylalkannin (Arnebin 1) is an orally active FGFR1 inhibitor (IC50=2.5 μM) and the main active component of Lithospermum erythrorhizon. β,β-Dimethylacrylalkannin blocks downstream signaling by binding to the ATP pocket of FGFR1, and regulates the CDK1/Cdc25C pathway and ROS-JNK axis, thereby inducing G2/M phase arrest, necrosis and apoptosis in cancer cells, and inhibiting tumor proliferation. β,β-Dimethylacrylalkannin also acts as a colistin adjuvant to disrupt the cell membrane of Gram-negative bacteria. β,β-Dimethylacrylalkannin exhibits significant tumor-inhibitory effects with no obvious toxicity in PDX models, but chronic exposure to high doses may alter the relative lung/liver weights of rats, while acute exposure to high doses causes responses such as reduced motor activity. β,β-Dimethylacrylalkannin finds wide application in studies related to hepatocellular carcinoma, colorectal cancer, colistin-resistant bacterial infections, hepatitis and psoriasis .
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1
1 Cited Publications
Cat. No.: HY-N2392
CAS No.: 75288-96-9
Kukoamine A, a spermine alkaloid, is an orally active and brain-penetrant component found in the root barks of Lycium chinense (L. chinense) Miller. Kukoamine A inhibits purified Crithidia fasciculata trypanothione reductase and soybean lipoxygenase, activates μ-opioid receptor. Kukoamine A can inhibt cancer cell proliferation, migration and invasion, cause G0/G1 phase cell cycle arrest and induce apoptosis. Kukoamine A exerts neuroprotective effect and can induce autophagy . Kukoamine A inhibits LPS (HY-D1056)-induced NO, ROS, PGE2, TNF-α, IL-1β, IL-6 production and COX-2 activity. Kukoamine A reverses palmitic acid-induced insulin resistance, lipid accumulation, and oxidative stress via downregulation of Srebp-1c. Kukoamine A can be used for the research of cancer, infection, inflammation, metabolic and neurological disease, such as glioblastoma and Parkinson's disease .
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1
1 Cited Publications
Cat. No.: HY-P76185
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Complement component 1 Q subcomponent-binding protein, mitochondrial; HABP1
Species:  
Source:  
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1
1 Cited Publications
Cat. No.: HY-P7691
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rHuCD93, His; Complement component C1q Receptor; Matrix-Remodeling-Associated Protein 4CD93; CD93
Species:  
Source:  
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Cat. No.: HY-148286
CAS No.: 26098-04-4
Purity:  ≥98.0%
Target:  

Antibiotic Bacterial

Research Areas:  

Infection

Gentamicin C1a is the precursor of the semi-synthetic antibiotic Etimicin, and has antibacterial activity. Gentamicin C1a is the major component of the Gentamicin complex .
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Cat. No.: HY-P991127
CAS No.: 2922766-89-8
Synonyms: DNTH103

Target:  

Complement System

Research Areas:  

Inflammation/Immunology

Claseprubart (DNTH103) is an inhibitor targeting C1s of the complement system and an inhibitor of the C1 component of the complement cascade. Claseprubart is in phase 2 clinical evaluation. Claseprubart has application potential in research related to multifocal motor neuropathy and generalized myasthenia gravis .
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Cat. No.: HY-P99050
CAS No.: 2049079-64-1
Synonyms: BIVV009; IPN-009; TNT009

Target:  

Complement System

Research Areas:  

Endocrinology

Sutimlimab is a humanized monoclonal IgG4 antibody. Sutimlimab inhibits complement protein component 1, s subcomponent (C1s). Sutimlimab blocks C3 and C4 activation. Sutimlimab can be used for the research of cold agglutinin disease and complement-mediated hemolytic uremic syndrome .
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Cat. No.: HY-112307A
CAS No.: 124011-52-5
Purity:  99.97%
(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol (sodium) is an anionic phospholipid, can be studied for drug delivery and the synthesis of liposomes. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol-containing liposomes can induce Tregs that are specific for the liposomes’ cargo. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol is taken up by antigen-presenting cells mediated via complement component 1q (C1q) .
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Cat. No.: HY-N1464A
CAS No.: 25274-27-5
Aristolone is a sesquiterpene that can be isolated from Aristolochia debilis, Rosmarinus officinalis and Ficus Auriculata. Aristolone in Ara Fruit can be used as a prediction of apoptosis in HeLa cells. Aristolone inhibits the C1 complement component. Aristolone produces cytotoxicity effects on cells. Aristolone has anticancer properties and can be studied in research for cervical cancer .
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Cat. No.: HY-N0729S3
CAS No.: 98353-71-0
Linoleic acid- 13C1 is the 13C labeled Linoleic acid. Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism .
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Cat. No.: HY-117057S
CAS No.: 2692624-21-6
Hexaenoic acid-d6 is deuterium labeled Hexaenoic acid. Very long chain polyunsaturated fatty acids (VLCPUFAs) are important components of ceramides and sphingomyelin and are present in retina, sperm, and brain. Tetratriaconta-16(Z),19(Z),22(Z),25(Z),28(Z),31(Z)-hexaenoic acid is a C34:6 VLCPUFA whose specific biological actions are largely unknown. This VLCPUFA, along with others, has been investigated for its role in activating protein kinase C .
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Cat. No.: HY-B0158S2
CAS No.: 478511-19-2
Synonyms: Cytosine β-D-riboside-13C-1; Cytosine-1-β-D-ribofuranoside-13C-1
Cytidine- 13C-1 is the 13C labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholami
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Cat. No.: HY-135534
CAS No.: 6184-11-8
Target:  

Dipeptidyl Peptidase

Research Areas:  

Others

Lysine 4-nitroanilide is an amino acid derivative of 4-nitroanilide (component C1 substrate) used in enzymology research and as a substrate for arylamidase/DPP-3 activity assays.
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Cat. No.: HY-P5528
Target:  

Peptides

Research Areas:  

Others

2Abz-SLGRKIQIK(Dnp)-NH2 is a biological active peptide. (This peptide is a second complement component (C2), the physiological substrate for the proenzyme Cls, first complement component. The complement system is a central component of host defense but can also contribute to the inflammation seen in pathological conditions. The C1s protease of the C1 complex initiates the host defense pathway. This peptide employs 2Abz/Dnp FRET pair for quantitation of complement enzyme activity.)
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Cat. No.: HY-W371164
CAS No.: 1016866-61-7
Target:  

Complement System

Research Areas:  

Inflammation/Immunology

C1s-IN-1 (compound A1) is a selective and competitive inhibitor of C1s. C1s-IN-1 binds directly to C1s with a Kd of 9.8 μM .
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Cat. No.: HY-148286R
CAS No.: 26098-04-4
Gentamicin C1a (Standard) is the analytical standard of Gentamicin C1a. This product is intended for research and analytical applications. Gentamicin C1a is the precursor of the semi-synthetic antibiotic Etimicin, and has antibacterial activity. Gentamicin C1a is the major component of the Gentamicin complex .
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Cat. No.: HY-P700696
Purity:  ≥ 90%, as determined by Bis-Tris PAGE.
Synonyms: Complement C1s subcomponent; C1 esterase;
Species:  
Source:  
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Cat. No.: HY-P81468
Synonyms: C1qa; Complement C1q subcomponent subunit A; Complement component 1 q subcomponent A chain; Complement component 1 q subcomponent alpha polypeptide;

Host:  

Rabbit

Application:  

IHC-P

Reactivity:  

Human

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Cat. No.: HY-P81468A
Synonyms: C1qa; Complement C1q subcomponent subunit A; Complement component 1 q subcomponent A chain; Complement component 1 q subcomponent alpha polypeptide;

Host:  

Rabbit

Application:  

IHC-P

Reactivity:  

Human

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Cat. No.: HY-P81889
Synonyms: C1qb; Complement component 1 q subcomponent B chain

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF

Reactivity:  

Human

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