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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
cutaneous diseases
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "cutaneous diseases" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P1181A
Research Areas:
Cardiovascular Disease Infection Inflammation/Immunology Cancer
1
1 Cited Publications
Synonyms: FPL 59002
Target:
Research Areas:
Nedocromil (FPL 59002) is a mast cell stabilizer and an inhibitor of IL-8 production. Nedocromil inhibits mast cell degranulation and collagen synthesis induced by activated mast cells, indirectly interfering with IL-1β signaling. Nedocromil reduces conjunctival eosinophil infiltration and improves the cutaneous manifestations of chronic graft-versus-host disease (including reducing fibrosis, loss of fat and hair follicles, and inflammatory infiltration). Nedocromil can be used in research on chronic graft-versus-host disease, asthma, and allergic conjunctivitis .
Target:
Research Areas:
PAD-IN-2 is a potent pad4 inhibitor (IC50: <1 μM). PAD-IN-2 can be used in the research of auto-immune diseases and cancers, such as rheumatoid arthritis, vasculitis, systemic lupus erythematosis, cutaneous lupus erythematosis, ulcerative colitis, cystic fibrosis, asthma, multiple sclerosis and psoriasis .
Cat. No.: HY-P1181
CAS No.: 868247-72-7
Research Areas:
Cardiovascular Disease Infection Inflammation/Immunology Cancer
Synonyms: TO 188; Tazalest; Tazanol
Target:
Research Areas:
Tazanolast (TO 188) is an orally active selective mast cell stabilizer. Tazanolast prevents the elevation of intracellular calcium concentration, inhibits calcium uptake and Protein kinase C translocation, without directly inhibiting phospholipase C. Tazanolast inhibits ozone-induced airway hyperresponsiveness to Methacholine in guinea pigs, as well as passive cutaneous anaphylaxis, Schultz-Dale reaction, experimental asthma, passive cutaneous anaphylaxis in rats, and increased cutaneous vascular permeability in rats. Tazanolast does not alter airway responsiveness in sham-exposed guinea pigs, cell distribution in bronchoalveolar lavage fluid after ozone exposure, type II-IV allergic reactions, or histamine release from atopic leukocytes. Tazanolast can be used in research related to allergic diseases .
Target:
Research Areas:
AN0128 is a boron-containing antibacterial and anti-inflammatory agent. AN0128 against S. aureus, S. epidermidis, P. acnes, B. subtilis with minimum inhibitory concentration (MIC) values of 1, 0.5, 0.3, 1 μg/mL. AN0128 can be used for the research of periodontal disease and cutaneous diseases .
Cat. No.: HY-N4267
CAS No.: 13060-14-5
Cat. No.: HY-178227
CAS No.: 2319609-67-9
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
KY19334 is a CXXC5-DVL inhibitor. KY19334 can activate the Wnt/β-catenin pathway by inhibiting CXXC5-Dvl interaction. KY19334 can inhibit cancer cells proliferation, migration, invasion and transformation by inhibiting CDK1. KY19334 can accelerate wound healing and exert regenerative effects. KY19334 can be used for the researches of cancer, inflammation, metabolic and neurological disease, such as cutaneous squamous cell carcinoma and diabetes .
Cat. No.: HY-115676
CAS No.: 2048226-46-4
Target:
Research Areas:
GSK199 analog hydrochloride belongs to a class of compounds that inhibit PAD4 (guanidinoarginine deiminase 4). GSK199 analog hydrochloride has potential uses in diseases including rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosus, and psoriasis .
Cat. No.: HY-13448R
CAS No.: 69049-73-6
Synonyms: FPL 59002 (Standard)
Research Areas:
Nedocromil (FPL 59002) (Standard) is the analytical standard of Nedocromil (HY-13448). This product is intended for research and analytical applications. Nedocromil (FPL 59002) calcium is a mast cell stabilizer and an inhibitor of IL-8 production. Nedocromil calcium inhibits mast cell degranulation and collagen synthesis induced by activated mast cells, indirectly interfering with IL-1β signaling. Nedocromil calcium reduces conjunctival eosinophil infiltration and improves the cutaneous manifestations of chronic graft-versus-host disease (including reducing fibrosis, loss of fat and hair follicles, and inflammatory infiltration). Nedocromil calcium can be used in research on chronic graft-versus-host disease, asthma, and allergic conjunctivitis .
Cat. No.: HY-W341759
CAS No.: 484-23-1
1,4-Dihydrazinylphthalazine (Compound 2) is an antiparasitic agent targeting
Leishmania spp. 1,4-Dihydrazinylphthalazine is promising for research of tropical diseases, particularly cutaneous leishmaniasis .
Cat. No.: HY-N18182
CAS No.: 172705-25-8
Target:
Cat. No.: HY-106390A
CAS No.: 110714-10-8
Target:
Research Areas:
GYKI 12743 is a vasoselective, postsynaptic α-adrenoceptor blocker. GYKI 12743 inhibits but does not completely eliminate the cutaneous microcirculatory blood flow reduction evoked by electrical stimulation of the peripheral stump of the cut saphenous nerve in rats. GYKI 12743 can be used for the study of neurological diseases .
Cat. No.: HY-101810R
CAS No.: 82989-25-1
Synonyms: TO 188 (Standard); Tazalest (Standard); Tazanol (Standard)
Target:
Research Areas:
Tazanolast (Standard) (TO 188 (Standard)) is the analytical standard of Tazanolast (HY-101810). This product is intended for research and analytical applications. Tazanolast (TO 188) is an orally active selective mast cell stabilizer. Tazanolast prevents the elevation of intracellular calcium concentration, inhibits calcium uptake and Protein kinase C translocation, without directly inhibiting phospholipase C. Tazanolast inhibits ozone-induced airway hyperresponsiveness to Methacholine in guinea pigs, as well as passive cutaneous anaphylaxis, Schultz-Dale reaction, experimental asthma, passive cutaneous anaphylaxis in rats, and increased cutaneous vascular permeability in rats. Tazanolast does not alter airway responsiveness in sham-exposed guinea pigs, cell distribution in bronchoalveolar lavage fluid after ozone exposure, type II-IV allergic reactions, or histamine release from atopic leukocytes. Tazanolast can be used in research related to allergic diseases .
Cat. No.: HY-10979R
CAS No.: 872044-70-7
Target:
Research Areas:
AN0128 (Standard) is the analytical standard of AN0128 (HY-10979). This product is intended for research and analytical applications. AN0128 is a boron-containing antibacterial and anti-inflammatory agent. AN0128 against S. aureus, S. epidermidis, P. acnes, B. subtilis with minimum inhibitory concentration (MIC) values of 1, 0.5, 0.3, 1 μg/mL. AN0128 can be used for the research of periodontal disease and cutaneous diseases .
Cat. No.: HY-165553
CAS No.: 873541-45-8
Target:
Research Areas:
ASB16165 is a selective and potent PDE7A inhibitor with an IC50 of 15 nM against human PDE7A. ASB16165 inhibits IL-12-induced IFN-γ production via a cAMP/PKA-dependent mechanism, reduces cutaneous TNF-α production, and suppresses keratinocyte proliferation. ASB16165 can be used in research on skin diseases such as psoriasis .
Category:
Target:
Cat. No.: HY-13448A
CAS No.: 101626-68-0
Synonyms: FPL 59002 calcium
Target:
Research Areas:
Nedocromil (FPL 59002) calcium is a mast cell stabilizer and an inhibitor of IL-8 production. Nedocromil calcium inhibits mast cell degranulation and collagen synthesis induced by activated mast cells, indirectly interfering with IL-1β signaling. Nedocromil calcium reduces conjunctival eosinophil infiltration and improves the cutaneous manifestations of chronic graft-versus-host disease (including reducing fibrosis, loss of fat and hair follicles, and inflammatory infiltration). Nedocromil calcium can be used in research on chronic graft-versus-host disease, asthma, and allergic conjunctivitis .
Cat. No.: HY-L114
1,665 compounds
Inflammation promotes physiological and pathological processes by the activation of the immune system, local vascular system, and various cells within the damaged tissue. Accumulating epidemiological and clinical evidence shows that chronic inflammation is causally linked to various human diseases, including cerebrovascular, cardiovascular, joint, cutaneous, pulmonary, blood, liver, and intestinal diseases as well as diabetes.
Various natural products from Traditional Chinese Medicine (TCM) have been shown to safely suppress proinflammatory pathways and control inflammation-associated disease. MCE designs a unique collection of 1,665 Traditional Chinese Medicine active compounds with anti-inflammatory activity, which are derived from Coptis chinensis, Radix isatidis, Flos Lonicerae, Forsythia suspensa, etc. MCE Anti-inflammatory Traditional Chinese Medicine Active Compound Library is a useful tool for discovery anti-inflammatory drugs from TCM.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
