108 Results for "

delivery efficiency

" in MedChemExpress (MCE) Product Catalog:
Products (108)

108 Results for "delivery efficiency" in MCE Product Catalog:

26
26 Publications Verification
Cat. No.: HY-112764
CAS No.: 160743-62-4
Purity:  98.40%
mPEG2000-DMG is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. mPEG2000-DMG is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles .
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15
15 Cited Publications
Cat. No.: HY-D0040
CAS No.: 1461-15-0
Synonyms: Fluorexon
Calcein is a fluorescent dye and self-quenching probe, used as an indicator of lipid vesicle leakage, and also as a complexometric indicator for titration of calcium ions with EDTA, and for fluorometric determination of calcium. Calcein cannot directly cross the intact cell membrane of a living cell, unlike Calcein-AM (HY-D0041) which is cell-permeable. Calcein can also be used as a model drug for evaluating efficiency and bioavailability of drug delivery systems .
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1
1 Cited Publications
Cat. No.: HY-W127512
CAS No.: 546-18-9
Target:  

Drug Intermediate

Research Areas:  

Others

5β-Cholanic acid is a hydrophobic modifier used to modify polymer carriers. 5β-Cholanic acid can improve the acid stability, cell penetration efficiency and drug sustained release ability of nanocarriers, and optimize the oral effectiveness of delivered molecules. 5β-Cholanic acid can covalently bind to Glycol chitosan (GC) to form a GC-CA conjugate, which optimizes the hydrophobic anchoring ability of nanoparticles and enables them to be stably adsorbed on the surface of PLGA nanoparticles. Such nanoparticles can resist dissociation in the gastric acid environment and maintain positive charge to enhance endocytic uptake by intestinal epithelial cells (such as Caco-2 cells). 5β-Cholanic acid can be used in the development of drug delivery systems .
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1
1 Cited Publications
Cat. No.: HY-153229
Firefly luciferase mRNA-LNP is a lipid nanoparticle (LNP) containing firefly luciferase mRNA. Firefly luciferase mRNA-LNP exhibits a stable nanostructure, in which LNP plays a key role in effectively protecting and transporting mRNA to cells. Luciferase is a bioluminescent reporter gene for gene regulation and functional studies. Firefly Luciferase mRNA-LNP expresses firefly luciferase protein after entering the cells, which is often used for promoter activity detection or dual fluorescent molecular complementation experiments. Firefly luciferase mRNA-LNP is studied in research for RNA delivery, cell viability, and translation efficiency .
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1
1 Cited Publications
Cat. No.: HY-P5623
CAS No.: 115136-25-9
Synonyms: RVG29; RDP; Rabies Virus Glycoprotein-29
RVG (RVG29) is a blood-brain barrier-permeable peptide derived from rabies virus glycoprotein, which binds to the α-7 subunit of neuronal nicotinic acetylcholine receptor (AchR). RVG efficiently delivers drugs to nerve cells and antigen-presenting cells in a targeted manner, and enhances the efficiency of antigen presentation and drug delivery .
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1
1 Cited Publications
Cat. No.: HY-N5139
CAS No.: 93685-90-6
Synonyms: Lecithins, egg yolk; Belovo PL 85
Lecithins, egg (Lecithins, egg yolk; Belovo PL 85) is an orally active natural phospholipid mixture extracted from egg yolks . Lecithins, egg inhibits the activities of acetylcholinesterase (AChE) and angiotensin-converting enzyme (ACE). Lecithins, egg exhibits antibacterial, antioxidant and anti-inflammatory activities, and helps delay cellular senescence. Lecithins, egg enhances nerve conduction, improves memory and cognitive function, and exerts positive effects on delaying neurodegenerative diseases. Lecithins, egg promotes lipid absorption and alleviates diarrhea. Lecithins, egg acts as a high-efficiency drug carrier for the preparation of targeted drug delivery systems such as liposomes .
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1
1 Cited Publications
Cat. No.: HY-P0328
CAS No.: 103425-05-4
Target:  

VSV

Research Areas:  

Infection

VSV-G tag Peptide is a 11 amino acid peptide derived from the Vesicular Stomatitis viral glycoprotein. VSV-G tag Peptide can integrate into the cell membranes of animal cells, induce cell fusion, and significantly enhance the efficiency of DNA transfection into animal cells. VSV-G tag Peptide can be used for research on drug delivery .
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1
1 Cited Publications
Cat. No.: HY-W583868
CAS No.: 26662-94-2
Synonyms: 1,2-POPE; 16:0-18:1 PE
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines .
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Cat. No.: HY-148842
CAS No.: 2639634-80-1
Purity:  98.13%
Synonyms: C14-494
C14-4 is an ionizable lipid utilized for the synthesis of lipid nanoparticles (LNPs). C14-4 enhances mRNA delivery, enabling the effective transport of mRNA to primary human T cells, which in turn induces functional protein expression. C14-4 demonstrates high transfection efficiency while maintaining low cytotoxicity .
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Cat. No.: HY-P5423
CAS No.: 107658-43-5
Target:  

Exosomes Liposome

Research Areas:  

Cancer

GALA is a pH-responsive amphipathic peptide consisting of 30 amino acids, which acts as a lung endothelium-targeting ligand. GALA undergoes a conformational transition from random coil to α-helix in an acidic environment at pH 5.0, thereby inducing endosomal membrane destabilization and fusion. GALA-modified liposomes traverse lung endothelial cells via clathrin-dependent endocytosis and transcytosis, and specifically accumulate in the lungs after intravenous injection. GALA significantly promotes the cytosolic release of cargos carried by exosomes, plasmids and liposomes, effectively enhances gene transfection efficiency, and drives gene knockdown of functional macromolecules (such as siRNA) in alveolar epithelial cells (with no significant cytotoxicity at effective concentrations). GALA serves as a critical tool for studies on lung cancer metastasis (e.g., melanoma lung metastasis) and lung-targeted drug delivery systems .
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Cat. No.: HY-P10709
CAS No.: 847058-45-1
Target:  

Collagen

Research Areas:  

Cardiovascular Disease Cancer

CREKA peptide is a selective non-covalent binding agent targeting fibrin, type IV collagen, and fibronectin, often used as a targeting ligand to modify delivery carriers. CREKA peptide specifically recognizes fibrin, fibronectin, and type IV collagen that are excessively deposited in the tumor microenvironment or fibrotic tissue, mediating the targeted accumulation of the carrier at the lesion site and promoting drug internalization into target cells (such as cancer cells and activated hepatic stellate cells). CREKA peptide can enhance targeted delivery efficiency, increase drug concentration at the lesion site, and reduce systemic side effects .
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Cat. No.: HY-154644
CAS No.: 8030-76-0
Soya Lecithin is a phospholipid mixture that can be used as a drug delivery vehicle and is a pharmaceutical excipient. Soya Lecithin can form a lipid bilayer structure through self-assembly, and its binding properties are amphiphilic (hydrophilic head and hydrophobic tail), encapsulating hydrophobic drugs. Soya Lecithin forms stable nanoliposomes or microemulsions, improves the solubility and cellular uptake efficiency of poorly soluble drugs (such as Curcumin (HY-N0005)), and exerts activities such as enhancing drug delivery and regulating cell proliferation .
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Cat. No.: HY-P4121
CAS No.: 1898254-09-5
Target:  

Potassium Channel

Research Areas:  

Inflammation/Immunology Cancer

L17E is an attenuated cationic amphiphilic lytic (ACAL) peptide that can be used to deliver a variety of macromolecules, including proteins, antibodies, and DNA nanostructures. L17E inserts and cleaves the membrane structure through electrostatic interaction, enabling intracellular escape. The efficiency of L17E-mediated delivery is strongly correlated with the expression level of KCNN4 (the gene encoding the calcium-activated potassium channel KCa3.1). L17E also promotes the cellular uptake of macromolecules by inducing micropinocytosis. L17E can be further optimized and improved through dimerization strategies and in combination with other delivery systems, such as nuclear localization signal peptides and cell membrane-coated nanoparticles .
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Cat. No.: HY-148049
CAS No.: 1821214-50-9
Purity:  ≥98.0%
TT3 is an ionizable lipid-like material and a lipid nanoparticle (LLNs)-based mRNA delivery vector. TT3 exhibits liver and spleen specificity and excellent delivery efficiency .
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Cat. No.: HY-150150F
Cy3-siRNA Negative Control is Cy3-labeled SiRNA Negative Control (HY-150150). Cy3-siRNA Negative Control can be used for easy visualization and assessment of transfection efficiency.
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Cat. No.: HY-153080
Purity:  94.6%
Target:  

Fluorescent Dye mRNA

Research Areas:  

Others

Firefly Luciferase mRNA (N1-Me-Pseudo UTP) is a modified form of firefly luciferase mRNA, which is N1-methylated pseudo uridine (N1-Me-Pseudo UTP). Firefly Luciferase mRNA (N1-Me-Pseudo UTP) is a commonly used reporter molecule in biomedical and mRNA research and its core function is to rapidly and quantitatively monitor the expression and delivery efficiency of mRNA through the emission of light signals .
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Cat. No.: HY-172279A
DSPE-PEG2000-TAT is a cell-penetrating peptide-modified PEGylated phospholipid conjugate and cellular uptake enhancer. DSPE-PEG2000-TAT forms via conjugation of Cys-TAT to DSPE-PEG2000-Mal. DSPE-PEG2000-TAT enhances liposomal cellular uptake and siRNA transfection efficiency in glomerular mesangial and macrophage cells. DSPE-PEG2000-TAT can be used for drug delivery .
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Cat. No.: HY-112766
CAS No.: 201036-16-0
Purity:  ≥98.0%
Target:  

Liposome

Research Areas:  

Others

DPyPE is a neutral phosphatidylethanolamine lipid composed of a polyisoprene alkyl chain with two pyridine-containing phosphine ligands. DPyPE is mainly used in liposome formulations and to enhance the efficiency of gene delivery in vitro and in vivo. For example, DPyPE can be mixed with cationic lipids such as VC1052 (HY-156616) (in a 1:1 ratio) to form the vaccine adjuvant Vaxfectin (HY-142998). DPyPE assists VC1052 in binding to negatively charged pDNA to form a uniform liposome complex by regulating the fluidity and stability of the liposome membrane .
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Cat. No.: HY-153232
eGFP circRNA-LNP is a lipid nanoparticle (LNP) containing eGFP circRNA, suitable for assays of RNA delivery, translation efficiency, cell viability, etc. eGFP circRNA carries Enhanced Green Fluorescent Protein (Enhanced Green Fluorescent Protein) eGFP, which will express green fluorescent protein after entering the cell. eGFP is commonly used as a reporter gene detectable by fluorescence microscopy or flow cytometry .
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Cat. No.: HY-150220
CAS No.: 125401-63-0
Purity:  ≥97.0%
1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate is a lipid used in the synthesis of phospholipid vesicles. 1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate works with other lipids to convert polydisperse vesicles into vesicles of uniform size by freeze-thaw and extrusion techniques. 1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate can enhance protein encapsulation efficiency for drug delivery and biochemical applications .
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