Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
eEF2K
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "eEF2K" in MCE Product Catalog:
9
3
3 Cited Publications
NH125 is a potent and selective inhibitor of eukaryotic elongation factor 2 kinase (eEF-2K/CaMKIII) with an IC50 of 60 nM for eEF-2K. NH125 kills methicillin-resistant S. aureus (MRSA) persisters by interacting with and disrupting membranes [2].
1
1 Cited Publications
Referencia número: HY-P701676
Pureza: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: eEF2K; Eukaryotic elongation factor 2 kinase; eEF-2 kinase; eEF-2K; Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase
PROTAC eEF2K degrader-1 (Compound 11l) is an eEF2K-Targeting PROTAC small molecule that induces apoptosis in MDA-MB-231 cells. PROTAC eEF2K degrader-1 mediates eEF2K degradation .
Referencia número: HY-177720
No. CAS: 1044797-96-7
Target:
Áreas de investigación:
eEF2K degrader-2 (Compound C1) is a molecular glucose degrading agent that targets the eEF2K protein. eEF2K degrader-2 can significantly inhibit the proliferation, migration, invasion and induce apoptosis of triple negative breast cancer (TNBC) cells. eEF2K degrader-2 has no obvious organ toxicity or pathological damage. eEF2K degrader-2 can be used in the research of cancer such as breast cancer .
Referencia número: HY-RS04181
Target:
Áreas de investigación:
EEF2K Human Pre-designed siRNA Set A contains three designed siRNAs for EEF2K gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-RS26516
Target:
Áreas de investigación:
Eef2k Rat Pre-designed siRNA Set A contains three designed siRNAs for Eef2k gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-RS20013
Target:
Áreas de investigación:
Eef2k Mouse Pre-designed siRNA Set A contains three designed siRNAs for Eef2k gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-184950
No. CAS: 2458170-55-1
Áreas de investigación:
eEF2K ligand-1 is a PROTAC target protein ligand that targets eEF2K, and it is applicable to research related to PROTAC synthesis. eEF2K ligand-1 serves as the target protein of PROTAC eEF2K degrader-1 (HY-146324) .
Referencia número: HY-123024
No. CAS: 51627-14-6
Synonyms: BL-S-640; SK&F 60771
Target:
Cefatrizine (BL-S-640) is an orally active and broad-spectrum cephalosporin antibiotic. Cefatrizine is also a eEF2K inhibitor, with anti-proliferative activity in human breast cancer cells, which could induce ER stress, leading to cell death. Cefatrizine can be used in studies of cancer and bacterial infection [2].
Referencia número: HY-112393
No. CAS: 503473-32-3
TX-1918 is an inhibitor for eukaryotic elongation factor 2 kinase (eEF2-K) and Src kinase with IC50 of 0.44 and 4.4 μM, respectively. TX-1918 exhibits cytotoxicity in cell HepG2 and HCT116, with IC50 of 2.07 and 230 μM, respectively. TX-1918 inhibits the C-terminal domain of HIV-1 CA (CA CTD)(IC50 =3.81 μM), and inhibits the viral replication (IC50 =15.16 μM) [2].
Referencia número: HY-121828
No. CAS: 157397-06-3
TX-1123 is a potent protein tyrosine kinase (PTK) inhibitor for Src, eEF2-K, and PKA, and EGFR-K/PKC. TX-1123 is a cyclo-oxygenase (COX) inhibitor with IC50 values of 1.16 μM and 15.7 μM for COX2 and COX1, respectively. TX-1123 has low mitochondrial toxicity. TX-1123 can be used in research of cancer [2].
Referencia número: HY-181506
No. CAS: 3109321-90-3
Áreas de investigación:
TYMJ-01 is a fluorescent probe and eEF2K degrader. TYMJ-01 induces dose-dependent and specific degradation of eEF2K via the ubiquitin-proteasome pathway, with a DC50 of 82 nM. TYMJ-01 inhibits the proliferation, migration and invasion of triple-negative breast cancer cells. TYMJ-01 enables dynamic fluorescent imaging of eEF2K degradation in triple-negative breast cancer cells; it enhances the anti-tumor activity of Paclitaxel (HY-B0015). TYMJ-01 can be used for the research of triple-negative breast cancer .
Referencia número: HY-176149
Fluoxetine-Conjugated Platinum(IV) prodrug-1 (Compound 8) is an eEF2K inhibitor. Fluoxetine-Conjugated Platinum(IV) prodrug-1 inhibits cancer cell proliferation, induces DNA damage, cell cycle arrest at S phase and apoptosis. Fluoxetine-Conjugated Platinum(IV) prodrug-1 induces ROS accumulation and mitochondrial dysfunction. Fluoxetine-Conjugated Platinum(IV) prodrug-1 inhibits TNBC cell migration and invasion by inhibiting MMP-2 activity. Fluoxetine-Conjugated Platinum(IV) prodrug-1 induces autophagy in TNBC cells by activating AMPK. Fluoxetine-Conjugated Platinum(IV) prodrug-1 has antitumor activity and activates immunosuppression in the 4T1-Luc mouse model. Fluoxetine-Conjugated Platinum(IV) prodrug-1 can be used in triple-negative breast cancer (TNBC) research .
Referencia número: HY-P86858
Synonyms: C86191 antibody; Calcium/calmodulin dependent eukaryotic elongation factor 2 antibody; Calcium/calmodulin dependent eukaryotic elongation factor 2 kinase antibody; Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase antibody; Calmodulin dependent protein kinase III antibody; cb365 antibody; EC 2.7.11.20 antibody; eEF 2 kinase antibody; eEF 2K antibody; eEF-2 kinase antibody; C86191 antibody; Calcium/calmodulin dependent eukaryotic elongation factor 2 antibody; Calcium/calmodulin dependent eukaryotic elongation factor 2 kinase antibody; Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase antibody; Calmodulin dependent protein kinase III antibody; cb365 antibody; EC 2.7.11.20 antibody; eEF 2 kinase antibody; eEF 2K antibody; eEF-2 kinase antibody; eEF-2K antibody; eEF2K antibody; eEF2K protein antibody; EF2K_HUMAN antibody; Elongation factor 2 kinase antibody; Eukaryotic elongation factor 2 kinase antibody; fa04b08 antibody; HSU93850 antibody; kinase eEF2K antibody; MGC45041 antibody; SMEF2K antibody; wu:fa04b08 antibody; zgc:100973 antibody;
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
