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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
gut-microbial
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "gut-microbial" in MCE Product Catalog:
48
5
5 Cited Publications
1
1 Cited Publications
Cat. No.: HY-W015061
CAS No.: 500-98-1
Cat. No.: HY-W674241
CAS No.: 85734-98-1
Research Areas:
4-Ethylphenyl sulfate is an orally active and brain-penetrant gut microbial metabolite. 4-Ethylphenyl sulfate downregulates Bcl2 expression, upregulates Bax expression, and induces cancer cell apoptosis via the endogenous apoptotic pathway. 4-Ethylphenyl sulfate induces G2/M cell cycle arrest and reactive oxygen species (ROS) production. 4-Ethylphenyl sulfate impairs oligodendrocyte maturation, reduces oligodendrocyte-neuron interactions, decreases axonal myelination levels, and shifts the oligodendrocyte population toward immature precursor cells. 4-Ethylphenyl sulfate alters brain region-specific neural activity and functional connectivity in mice, and correlates with anxiety-like behaviors in mice .
Synonyms: 7,12-Dioxolithocholic acid; 3-Hydroxy-7,12-diketocholanoic acid; 7,12-Diketo-LCA
Target:
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7,12-Diketolithocholic acid (7,12-Diketo-LCA) is a bile acid, which can be produced in the host-gut microbial co-metabolism of the bile acid pool .
Cat. No.: HY-N7761
CAS No.: 126979-84-8
Synonyms: Tetrahydro tanshinone I
Trijuganone B (Tetrahydro tanshinone I) is a naturally occurring covalent pan-inhibitor of gut microbial bile salt hydrolases that can be isolated from Salvia trijuga. Trijuganone B inhibits total gut microbial bile salt hydrolase activity in live microorganisms and murine gut luminal content. Trijuganone B can be used for the research of bile-acid-related metabolic disorders .
Cat. No.: HY-W015061R
CAS No.: 500-98-1
Target:
Research Areas:
M4284 is a selective and orally active biphenyl mannoside FimH antagonist. M4284 has activities against different UPEC (Urinary tract infections (UTI) caused by uropathogenic E. coli) strains in different host genetic backgrounds and gut microbial community contexts .
Cat. No.: HY-W674241A
Cat. No.: HY-W654264
Target:
Cat. No.: HY-W015061S
CAS No.: 1189920-31-7
Synonyms: 2-(2-Phenylacetamido)acetic acid-d5
Cat. No.: HY-100599S2
Category:
Target:
Cat. No.: HY-L078
473 compounds
Accumulating evidence has revealed that intestinal microbiota play an important role in human health and disease, including cardiovascular diseases, inflammatory bowel disease, diabetes, obesity, cancer, and depression, etc. Changes in the composition of gut microbiota associated with disease, referred to as dysbiosis, have been linked to pathologies. Indeed, the gut microbiome functions like an endocrine organ, generating bioactive metabolites which play important roles in human metabolism, health, and disease. Gut microbiome has become a novel therapeutic target for many diseases. Analysis and identification of gut microbial metabolite will contribute to the development of therapeutic methods.
In order to meet the need of gut microbiome research, MCE carefully selected a unique collection of 473 gut microbial metabolites. MCE gut microbial metabolite library is a powerful tool for gut microbiome research and gut microbiome -related drug discovery.
Cat. No.: HY-135897R
CAS No.: 165393-06-6
Category:
Cat. No.: HY-155385
CAS No.: 1036406-73-1
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Research Areas:
10-Oxo-12(Z),15(Z)-octadecadienoic acid is a gut microbial fatty acid metabolite .
Cat. No.: HY-N0894A
CAS No.: 408324-14-1
Synonyms: (3R,5R)-Hexahydrobisdemethoxycurcumin
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Target:
Cat. No.: HY-184139
CAS No.: 3027146-73-9
Target:
Research Areas:
KGDI-109 is an orally active and selective Porphyromonas gingivalis dipeptidyl peptidase 7 (PgDPP7) inhibitor with an IC50 of 53.8 µM and a Ki of 25.1 µM. KGDI-109 is also a selective antibacterial agent that suppresses Porphyromonas gingivalis growth, reduces oral Porphyromonas gingivalis levels, and suppresses alveolar bone resorption. KGDI-109 preserves gut microbial diversity. KGDI-109 can be used for the research of periodontitis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
