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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
hMT1
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "hMT1" in MCE Product Catalog:
9
Category:
Target:
9
9 Publications Verification
Cat. No.: HY-17038A
CAS No.: 1176316-99-6
Synonyms: S-20098 hydrochloride
Target:
Research Areas:
Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively [1]. Agomelatine hydrochloride is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively .
9
9 Publications Verification
Cat. No.: HY-17038B
CAS No.: 824393-18-2
Synonyms: S-20098 L(+)-Tartaric acid
7
7 Cited Publications
Cat. No.: HY-18962
CAS No.: 20324-87-2
Target:
Research Areas:
AMI-1 is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 exerts PRMTs inhibitory effects by blocking peptide-substrate binding [1].
7
Target:
Research Areas:
AMI-1 free acid is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 free acid exerts PRMTs inhibitory effects by blocking peptide-substrate binding [1].
1
1 Cited Publications
Target:
Research Areas:
S-22153 is a potent melatonin receptor antagonist with EC50 values of 19 nM, 4.6 nM for hMT1 and hMT2 melatonin receptor, respectively. S-22153 has Ki values of 8.6 nM (CHO cells) and 16.3 nM (HEK cells) for hMT1, and 6.0 nM (CHO cells) and 8.2 nM (HEK cells) for hMT2. S-22153 is a specific ligand of MT1 and MT2 melatonin receptors subtypes [1] .
Target:
Research Areas:
Metoprine (BW 197U) is a potent histamine N-methyltransferase (HMT) inhibitor. Metoprine, a diaminopyrimidine derivative, can cross the blood-brain barrier and increase brain histamine levels by inhibiting HMT . Metoprine is an antifolate and antitumor agent .
Cat. No.: HY-17038S2
CAS No.: 1079389-38-0
Synonyms: S-20098-d3
Cat. No.: HY-17038S1
CAS No.: 1079389-44-8
Synonyms: S-20098-d4
Cat. No.: HY-17038R
CAS No.: 138112-76-2
Synonyms: S-20098 (Standard)
Category:
Cat. No.: HY-17038AR
CAS No.: 1176316-99-6
Synonyms: S-20098 hydrochloride (Standard)
Category:
Cat. No.: HY-P702893
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PRMT2; Protein Arginine Methyltransferase 2 Isoform 3; Prev. HRMT1L1; hMT1 HnRNP Methyltransferase-Like 1; Histone-Arginine N-Methyltransferase PRMT2; PRMT2 Alpha; Protein Arginine N-Methyltransferase 2; PRMT2 Gamma; hMT1 (HnRNP Methyltransferase, S. Cere
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P702966
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PRMT2; Protein Arginine Methyltransferase 2 Isoform 3; Prev. HRMT1L1; hMT1 HnRNP Methyltransferase-Like 1; Histone-Arginine N-Methyltransferase PRMT2; PRMT2 Alpha; Protein Arginine N-Methyltransferase 2; PRMT2 Gamma; hMT1 (HnRNP Methyltransferase, S. Cere
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-169382
Target:
Research Areas:
Melatonin-Tamoxifen Conjugate (compound 16c) is an anticancer drug conjugate composed of Melatonin (HY-B0075) and Tamoxifen (HY-13757A), which is a potent antagonist of ERα (IC50=863 nM). Melatonin-Tamoxifen Conjugate binds to MLT receptor (Ki=3.1 nM) and promotes β-arrestin (EC50=914 nM) and ERK activation (EC50=98 nM) in cells expressing hMT1 receptor. Melatonin-Tamoxifen Conjugate against several common cell lines MCF-7, MDA-MB-231, and HT-1080 with IC50s of 6.8 μM, 6.4 μM, and 1.7 μM, respectively.
Cat. No.: HY-RS00586
Target:
Research Areas:
ALG1 Human Pre-designed siRNA Set A contains three designed siRNAs for ALG1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P75983
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRMT6; Heterogeneous Nuclear Ribonucleoprotein Methyltransferase-Like Protein 6; Prev. HRMT1L6; hMT1 HnRNP Methyltransferase-Like 6 (S. Cerevisiae); Histone-Arginine N-Methyltransferase PRMT6; hMT1 HnRNP Methyltransferase-Like 6; Protein Arginine N-Methyl
Species:
Human
Source:
HEK293
Cat. No.: HY-P76551
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRMT3; Protein Arginine N-Methyltransferase 3; Prev. HRMT1L3; hMT1 HnRNP Methyltransferase-Like 3; Heterogeneous Nuclear Ribonucleoprotein Methyltransferase-Like Protein 3; Protein Arginine Methyltransferase 3; hMT1 HnRNP Methyltransferase-Like 3 (S. Cere
Species:
Human
Source:
E. coli
Cat. No.: HY-156156
CAS No.: 2248752-25-0
Synonyms: Z1480758218; ZINC000157673384
Target:
Research Areas:
UCSF3384 (Z1480758218) is a selective, blood-brain barrier-permeable MT1 inverse agonist, with an EC50 of 21 nM for hMT1. UCSF3384 selectively elevates basal cAMP levels. UCSF3384 delays circadian rhythm resetting and advances the onset of wheel-running activity rhythm in Mus musculus. UCSF3384 is applicable to research related to circadian rhythm disorders [1] .
Cat. No.: HY-129441R
CAS No.: 7761-45-7
Synonyms: BW 197U (Standard)
Research Areas:
Metoprine (Standard) is the analytical standard of Metoprine. This product is intended for research and analytical applications. Metoprine (BW 197U) is a potent histamine N-methyltransferase (HMT) inhibitor. Metoprine, a diaminopyrimidine derivative, can cross the blood-brain barrier and increase brain histamine levels by inhibiting HMT . Metoprine is an antifolate and antitumor agent .
Cat. No.: HY-18962R
CAS No.: 20324-87-2
Target:
Research Areas:
AMI-1 (Standard) is the analytical standard of AMI-1. This product is intended for research and analytical applications. AMI-1 is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 exerts PRMTs inhibitory effects by blocking peptide-substrate binding [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
