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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
hormone-dependent breast cancer
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "hormone-dependent breast cancer" in MCE Product Catalog:
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7 Cited Publications
Synonyms: FCE 24304; EXE
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Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research .
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1 Cited Publications
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TH5427 is a promising, targeted inhibitor that can be used to further study NUDT5 activity and ADP-ribose metabolism. TH5427, blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells. NUDT5 is recently identified as a rheostat of hormone-dependent gene regulation and proliferation in breast cancer cells .
Synonyms: FCE 24304(Standard); EXE (Standard)
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Exemestane (Standard) is the analytical standard of Exemestane. This product is intended for research and analytical applications. Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research .
Cat. No.: HY-179450
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Aromatase-IN-7 (compound 75) is a potent and selective aromatase inhibitor (IC50 = 5.78 nM), exhibiting potency comparable to Letrozole (HY-14248). Aromatase-IN-7 exhibits potent aromatase inhibition both in vitro and in vivo. Aromatase-IN-7 can be used for hormone-dependent breast cancer (HDBC) research .
Cat. No.: HY-125916
CAS No.: 58523-30-1
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Cat. No.: HY-178419
CAS No.: 666852-12-6
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GnRH-R antagonist-3 (Compound 37) is a Gonadotropin releasing hormone receptor (GnRH-R) antagonist with IC50s of 94 and 275 nM for rat and human GnRH-R, respectively. GnRH-R antagonist-3 can be used for hormone dependent diseases such as endometriosis, breast and prostate cancer research .
Cat. No.: HY-150542
CAS No.: 2413880-39-2
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Steroid sulfatase -IN-2 is an active steroid sulfatase (STS) inhibitor with an IC50 value of 109.5 nM. Steroid sulfatase-IN-2 can be used for the research of hormone-dependent cancers, such as estrogen-dependent breast and endometrial cancer .
Cat. No.: HY-13632S
Synonyms: FCE 24304-d2; EXE-d2
Cat. No.: HY-13632S2
Synonyms: FCE 24304-d3; EXE-d3
Cat. No.: HY-13632S1
CAS No.: 1092371-24-8
Synonyms: FCE 24304-13C3; EXE-13C3
Cat. No.: HY-13632S6
Synonyms: FCE 24304-d4; EXE-d4
Cat. No.: HY-13632S5
Synonyms: FCE 24304-13C,d2; EXE-13C,d2
Cat. No.: HY-W267205
CAS No.: 10441-27-7
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3-Acetyl-7-Hydroxycoumarin (Compound 2) is a high selective 17-beta-hydroxysteroid dehydrogenase type 1 (17β-HSD1) inhibitor. 3-Acetyl-7-Hydroxycoumarin shows a significant improvement of the inhibitory potency, with 57% inhibition of 17β-HSD1 at 6 μM. 3-Acetyl-7-Hydroxycoumarin is promising for research of hormone-dependent diseases, such as breast cancer and endometriosis .
Cat. No.: HY-178418
CAS No.: 1000819-21-5
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GnRH-R antagonist-2 (Compound 44c) is a Gonadotropin releasing hormone receptor (GnRH-R) antagonist with IC50s of 43 and 88 nM for rat and human GnRH-R, respectively. GnRH-R antagonist-2 can be used for hormone dependent diseases such as endometriosis, breast and prostate cancer research .
Cat. No.: HY-183521
CAS No.: 86111-11-7
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D 15414 is an estrogen receptor ligand and the hydroxylated metabolite of Zindoxifene (HY-106056). D 15414 binds to estrogen receptors and mediates estrogen-like cellular responses. D 15414 stimulates prolactin production, progesterone receptor synthesis and cancer cell proliferation. D 15414 inhibits the growth of hormone-dependent human breast cancer cells. D 15414 can be used in research related to breast cancer and hormone-dependent human breast cancer .
Cat. No.: HY-187733
CAS No.: 77016-85-4
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Plomestane is an orally active second-generation steroidal aromatase inhibitor that, as an enzyme-activated pseudosubstrate, is converted via NADPH-dependent catalysis into a reactive intermediate, which covalently binds to aromatase to produce irreversible inhibition, thereby persistently suppressing peripheral aromatase activity. Plomestane can be used for the study of hormone-dependent breast cancer .
Cat. No.: HY-43322
CAS No.: 108530-10-5
7-Coumaryl triflate is a type 17β-HSD1 inhibitor of 17β-hydroxysteroid dehydrogenase. Its IC50 is 360 nM and Ki is 173 nM. 7-Coumaryl triflate shows selectivity for 17β-HSD2 and has no detectable affinity for ERα or ERβ. 7-Coumaryl triflate can be used in related research on hormone-dependent breast cancer .
Cat. No.: HY-175554
CAS No.: 2785358-47-4
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CYP1B1-IN-10 (Compound 15C) is a highly selective human cytochrome P450 1B1 (hCYP1B1) inhibitor (IC50=0.11 μM). CYP1B1-IN-10 is promising for research of hormone-dependent tumors (e.g., breast and ovarian cancers) .
Cat. No.: HY-119080
CAS No.: 532435-68-0
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CP8754 is an orally active, selective human progesterone receptor (hPR) antagonist that blocks progesterone-mediated signaling pathways. CP8754 competitively inhibits the binding of [ 3H]-progesterone to hPR. And in vitro, CP8754 inhibits progesterone-dependent exogenous luciferase and endogenous alkaline phosphatase expression; while in vivo, CP8754 inhibits rabbit endometrial transformation. CP8754 does not significantly bind to human glucocorticoid receptors (hGR), estrogen receptors (hER), or rat androgen receptors (rAR). CP8754 can be used in the study of progesterone-related diseases such as breast cancer, endometriosis, uterine fibroids, and meningioma, as well as hormone-dependent tumors .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
