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Art. -Nr.: HY-183521

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D 15414

D 15414 is an estrogen receptor ligand and the hydroxylated metabolite of Zindoxifene (HY-106056). D 15414 binds to estrogen receptors and mediates estrogen-like cellular responses. D 15414 stimulates prolactin production, progesterone receptor synthesis and cancer cell proliferation. D 15414 inhibits the growth of hormone-dependent human breast cancer cells. D 15414 can be used in research related to breast cancer and hormone-dependent human breast cancer.

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CAS. Nr.: 86111-11-7
Formel: C₁₇H₁₇NO₂
Molecular Weight:267.32

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

D 15414 Chemical Structure

CAS. Nr.: 86111-11-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Estrogen Receptor/ERR Isoform-spezifische Produkte anzeigen :

In Vitro

Anti-cancerCell Cycle RegulationOthers

Anti-cancer

Cell Cycle Regulation

D 15414 (0.01-10 μM; 7 days) inhibits the growth of MCF-7 human breast cancer cells in a concentration-dependent manner following 7 days of incubation^[2].

Others

D 15414 (0.1-10 nM; 48 h) fully induces progesterone receptor synthesis in MCF-7 human breast cancer cells, with an ED₅₀ of 0.8 nM^[1].
D 15414 (0.1-100 nM; 5 days) fully stimulates the proliferation of MCF-7 human breast cancer cells, with an ED₅₀ of 0.6 M^[1].
D 15414 (1-100 nM; 6 days) fully stimulates prolactin synthesis in primary Sprague-Dawley rat pituitary cells, with an ED₅₀ of 2.8 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

MCF-7 human breast cancer cells
Concentration:

0.1, 1, 10 and 100 M; 1 μM (for slight reduction observation)
Incubation Time:

5 days
Result:

Stimulated MCF-7 cell growth to the same maximum level as 17β-estradiol, with an ED₅₀ of 0.6 nM.
Maximal stimulation occurred at 10 nM and 100 nM, with a slight reduction at 1 μM.

Cell Proliferation Assay^[2]

Cell Line:

hormone-dependent human breast cancer MCF-7 cell line
Concentration:

0.01, 0.1, 1, 10 μM
Incubation Time:

7 days
Result:

Inhibited MCF-7 cell growth in a concentration-dependent manner, as measured by reduced cell number and reduced [³H]-thymidine incorporation after 7 days of incubation.

Related Protocols :

Chemical Information

CAS. Nr. 86111-11-7
Molecular Weight 267.32
Formel C₁₇H₁₇NO₂
SMILES

OC1=CC=C(C2=C(C)C3=CC(O)=CC=C3N2CC)C=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Robinson SP, et al. In vitro estrogenic actions in rat and human cells of hydroxylated derivatives of D16726 (zindoxifene), an agent with known antimammary cancer activity in vivo. Cancer research. 1988 Feb 15;48(4):784-7. [Content Brief]

[2]. von Angerer, E. (1984). Development of new drugs for endocrine tumour chemotherapy. Cancer treatment reviews, 11, 147-153.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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