D 15414
D 15414 is an estrogen receptor ligand and the hydroxylated metabolite of Zindoxifene (HY-106056). D 15414 binds to estrogen receptors and mediates estrogen-like cellular responses. D 15414 stimulates prolactin production, progesterone receptor synthesis and cancer cell proliferation. D 15414 inhibits the growth of hormone-dependent human breast cancer cells. D 15414 can be used in research related to breast cancer and hormone-dependent human breast cancer.
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- CAS No.: 86111-11-7
- Formule: C17H17NO2
- Masse moléculaire:267.32
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
D 15414 (1-100 nM; 6 days) fully stimulates prolactin synthesis in primary Sprague-Dawley rat pituitary cells, with an ED50 of 2.8 nM[1].
D 15414 (0.1-10 nM; 48 h) fully induces progesterone receptor synthesis in MCF-7 human breast cancer cells, with an ED50 of 0.8 nM[1].
D 15414 (0.1-100 nM; 5 days) fully stimulates the proliferation of MCF-7 human breast cancer cells, with an ED50 of 0.6 M[1].
D 15414 (0.01-10 μM; 7 days) inhibits the growth of MCF-7 human breast cancer cells in a concentration-dependent manner following 7 days of incubation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 human breast cancer cells
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Concentration:0.1, 1, 10 and 100 M; 1 μM (for slight reduction observation)
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Incubation Time:5 days
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Result:Stimulated MCF-7 cell growth to the same maximum level as 17β-estradiol, with an ED50 of 0.6 nM.
Maximal stimulation occurred at 10 nM and 100 nM, with a slight reduction at 1 μM.
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Cell Line:hormone-dependent human breast cancer MCF-7 cell line
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Concentration:0.01, 0.1, 1, 10 μM
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Incubation Time:7 days
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Result:Inhibited MCF-7 cell growth in a concentration-dependent manner, as measured by reduced cell number and reduced [3H]-thymidine incorporation after 7 days of incubation.
Chemical Information
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CAS No. 86111-11-7
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Masse moléculaire 267.32
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Formule C17H17NO2
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SMILES
OC1=CC=C(C2=C(C)C3=CC(O)=CC=C3N2CC)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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