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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
human pancreatic beta cells
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "human pancreatic beta cells" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-P10102
CAS No.: 629628-53-1
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1 Cited Publications
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AS1269574 is a potent, orally available GPR119 agonist, with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates TRPA1 cation channels to stimulate glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induces glucose-dependent insulin secretion from pancreatic β-cells only under high-glucose conditions. AS1269574 has the potential for the research of type 2 diabetes .
Cat. No.: HY-120565
CAS No.: 1594041-84-5
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WB403 is an orally active TGR5 activator with an EC50 of 5.5 μM against human TGR5. WB403 activates TGR5 to stimulate downstream signaling pathways, promote GLP-1 secretion, improve glucose tolerance in mice with type 2 diabetes, and reduce levels of fasting blood glucose, postprandial blood glucose and HbA1c. WB403 increases pancreatic β-cell mass and restores the distribution of α-cells and β-cells in islets. WB403 is applicable to the research of type 2 diabetes .
Cat. No.: HY-P1654
CAS No.: 932699-03-1
Cat. No.: HY-P3622
CAS No.: 215777-46-1
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IDE 2 is a cell-permeable inducer of definitive endoderm differentiation that induces the differentiation of mouse and human embryonic stem cells into definitive endoderm. IDE2 activates the TGF‑β/Nodal signaling pathway, induces Smad2 phosphorylation, and increases Sox17 and FoxA2 expression. Endoderm induced by IDE 2 integrates into the developing gut tube, expresses gut tube markers, and differentiates into pancreatic progenitor cells. IDE 2 can be used for research related to directed endoderm differentiation of embryonic stem cells .
Cat. No.: HY-N2452
CAS No.: 956103-79-0
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Metabolic Disease Phenols Polyphenols Plants Other Families Extract Disease Research Fields
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Cat. No.: HY-P2501
CAS No.: 135702-23-7
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Cat. No.: HY-P990990
CAS No.: 2803875-75-2
Synonyms: YN011; YN012; YN015
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Cat. No.: HY-175420
CAS No.: 2696409-13-7
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K-757 is an orally active, gut-targeted GPR40 agonist with EC50 values of 2.1 nM, 5.6 nM, 4.2 nM and 166 nM in humans, mice, rats and dogs, respectively. K-757 activates nutrient receptors co-expressed on pancreatic β cells and intestinal enteroendocrine cells. K-757 mediates and induces the secretion of satiety hormones GLP-1 and PYY in multiple in vitro and in vivo models. When used in combination with GPR119 agonist K-833, K-757 acts as a potentiator to elevate circulating levels of satiety hormones. K-757 can be used in the research of type 2 diabetes, weight loss and other related metabolic disorders .
Cat. No.: HY-111141
CAS No.: 916219-50-6
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AM-3189 is an orally active and selective GPR40 agonist with EC50 values in buffer solution and in 100% human serum of 33 nM and 10 μM respectively. AM-3189 shows no significant activity on GPR41 and GPR43, and no agonistic activity on PPAR-α, -δ, and -γ. AM-3189 enhances glucose-stimulated insulin secretion by activating GPR40 on pancreatic β cells. AM-3189 has extremely low penetration into the central nervous system and significantly reduces blood glucose levels in two humanized GPR40 mouse models. AM-3189 can be used for the study of type 2 diabetes .
Cat. No.: HY-174559
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Human PAX4 mRNA encodes the human paired box 4 (PAX4) protein, a member of the paired box (PAX) family. PAX4 is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells.
Cat. No.: HY-169006
CAS No.: 2820245-53-0
Evo312 is a dose-dependent inhibitor of protein kinase CβⅠ (PKCβⅠ) (IC50 is 117.34 nM). Evo312 induces PANC-GR (acquired gemcitabine-resistant PC cells) cell cycle arrest and apoptosis by inhibiting PKCβ1 protein expression. Evo312 has antiproliferative effects in pancreatic cancer cells PANC-1 and PANC-GR cells with IC50 of 0.08 μM and 0.07 μM, and in human normal pancreatic ductal epithelial cells HPDE6-c7 with IC50 of 2.95 μM. Evo312 exhibits antitumor activity in a PANC-GR cell transplantation mouse model .
PAWI-2 is a p53-Activator and Wnt Inhibitor. PAWI-2 inhibits β3-KRAS signaling independent of KRAS. PAWI-2 selectively inhibits phosphorylation of TBK1. PAWI-2 activates apoptosis (activation of caspase-3/7), and induces PARP cleavage. PAWI-2 promotes optineurin translocation into the nucleus and causes G2/M arrest. PAWI-2 reverses cancer stemness and overcomes drug resistance in an integrin β3 KRAS-dependent human pancreatic cancer stem cells (hPCSCs). PAWI-2 inhibits growth of tumors from hPCSCs in orthopic xenograft mice model .
Cat. No.: HY-174585
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Human MAFA mRNA encodes the human MAF bZIP transcription factor A (MAFA) protein, a transcription factor that regulates pancreatic beta cell-specific expression of the insulin gene.
Cat. No.: HY-P12374
CAS No.: 121341-41-1
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hIAPP22-27 is a hexapeptide corresponding to residues 22-27 of human islet amyloid polypeptide (hIAPP) and is the key amyloid core sequence of hIAPP. hIAPP22-27 can self-assemble under neutral pH conditions to form β-sheet-containing amyloid fibrils and is cytotoxic to pancreatic β cells. hIAPP22-27 can be used in research related to type 2 diabetes .
Cat. No.: HY-N20713
CAS No.: 118524-14-4
Cat. No.: HY-D3174
CAS No.: 2688758-23-6
Cat. No.: HY-P992076
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
