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Results for "

hyperproliferative

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1157
    Trioxsalen
    3 Publications Verification

    Trisoralen; Trioxysalen; TMP

    		 DNA Alkylator/Crosslinker Inflammation/Immunology
    Trioxsalen (Trisoralen), a psoralen derivative, is a photochemical DNA crosslinker. Trioxsalen only works after photoactivation with near ultraviolet light. Trioxsalen is a photosensitizer that can be used for the research of vitiligo and hand eczema. Trioxsalen is used for visualization of genomic interstrand cross-links localized by laser photoactivation .
    Trioxsalen
  • HY-139561
    KDM2B-IN-2

    		Histone Demethylase Inflammation/Immunology Cancer
    KDM2B-IN-2, a potent histone demethylase (kdm2b) inhibitor with an IC50 of 0.021 μM in a KDM2B TR-FRET assay. KDM2B-IN-2 can be used for hyperproliferative diseases research .
    KDM2B-IN-2
  • HY-139601
    KDM2B-IN-4

    		Histone Demethylase Cancer
    KDM2B-IN-4 (Compound 182b) is a histone demethylase KDM2B inhibitor with an IC50 of 1.12 nM. KDM2B-IN-4 can be used for the research of hyperproliferative diseases such as cancers .
    KDM2B-IN-4
  • HY-139560
    KDM2B-IN-1

    		Histone Demethylase Inflammation/Immunology Cancer
    KDM2B-IN-1 (example 32) is a histone demethylase (kdm2b) inhibitor with an IC50 of 0.016 nM. KDM2B-IN-1 can be used for hyperproliferative diseases research .
    KDM2B-IN-1
  • HY-148088
    M1069
    1 Publications Verification

    		 Adenosine Receptor Cancer
    M1069 is a selective and orall active, dual A2A/A2B adenosine receptor antagonist with a selectivity of >100 fold against the A1 and A3 receptors. M1069 counteracts immune-suppressive mechanisms of adenosine, and exhibits anti-tumor activity .
    M1069
  • HY-16461
    Solenopsin

    (-)-Solenopsin A

    		 Akt Ribosomal S6 Kinase (RSK) PI3K PDK-1 FOXO Mitophagy Reactive Oxygen Species (ROS) Mitochondrial Metabolism Cardiovascular Disease
    Solenopsin ((-)-Solenopsin A) is an ATP-competitive and selective Akt-1 inhibitor with an IC50 of 5-10 μM, and also acts as an RSK1 inhibitor. Solenopsin inhibits the activities of PDK1 in lipid rafts, downregulates PI3K, blocks PI3K-dependent generation of 3-phosphoinositides, and suppresses the phosphorylation of FOXO1a. Solenopsin induces Mitophagy and ROS production, reduces mitochondrial oxygen consumption, and exhibits antiproliferative and antiangiogenic activities. Solenopsin can be used in research related to hyperproliferative skin diseases and malignant diseases .
    Solenopsin
  • HY-W000773
    7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine

    		Drug Derivative Cardiovascular Disease
    7-Bromopyrrolotriazin-4-amine (Compound 3-7) is a pyrrolotriazine derivative. 7-Bromopyrrolotriazin-4-amine is applicable to the study of hyperproliferative diseases and angiogenesis-related diseases .
    7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine
  • HY-142677
    PI3K-IN-27

    		PI3K Inflammation/Immunology Cancer
    PI3K-IN-27 is a potent inhibitor of PI3K. PI3K belongs to a large family of lipid signaling kinase that plays key role in cellular process including cell growth, differentiation, migration and apoptosis. PI3K-IN-27 has the potential for the research of hyper-proliferative diseases like cancer and inflammation, or immune and autoimmune diseases (extracted from patent WO2021233227A1, compound 1) .
    PI3K-IN-27
  • HY-121638B
    (E/Z)-CU-3

    		Bcl-2 Family Infection Cardiovascular Disease Inflammation/Immunology Cancer
    (E/Z)-CU-3 is a MCL-1 modulator. (E/Z)-CU-3 can be used to study hyperproliferative diseases, angiogenic diseases, cell cycle regulation diseases, autophagy regulation diseases, inflammatory diseases and/or infectious diseases .
    (E/Z)-CU-3
  • HY-175734
    PI3Kδ-IN-26

    		PI3K Inflammation/Immunology
    PI3Kδ-IN-26 (Compound 58) is a selective and orally active PI3Kδ inhibitor with an IC50 of 14  nM. PI3Kδ-IN-26 significantly attenuates the inflammatory responses in house dust mite (HDM) induced chronic asthma mouse models. PI3Kδ-IN-26 can be used for inflammatory, autoimmune and hyperproliferative diseases research .
    PI3Kδ-IN-26
  • HY-U00366
    S1PR1-MO-1

    		LPL Receptor Inflammation/Immunology
    S1PR-MO-1 is the modulator of sphingosine-1-phosphate receptor, used for research of hyperproliferative, inflammatory diseases.
    S1PR1-MO-1
  • HY-112294
    TIE-2/VEGFR-2 kinase-IN-1

    		Tie VEGFR Cardiovascular Disease Inflammation/Immunology Cancer
    TIE-2/VEGFR-2 kinase-IN-1 is used for the synthesis of TIE-2 and/or VEGFR-2 inhibitors, extracted from patent WO2003022852, example 14. TIE-2/VEGFR-2 kinase-IN-1 is used for the study of diseases associated with inappropriate angiogenesis .
    TIE-2/VEGFR-2 kinase-IN-1
  • HY-B1157R
    Trioxsalen (Standard)

    Trisoralen (Standard); Trioxysalen (Standard); TMP (Standard)

    		 Reference Standards DNA Alkylator/Crosslinker Inflammation/Immunology
    Trioxsalen (Standard) is the analytical standard of Trioxsalen. This product is intended for research and analytical applications. Trioxsalen (Trisoralen), a psoralen derivative, is a photochemical DNA crosslinker. Trioxsalen only works after photoactivation with near ultraviolet light. Trioxsalen is a photosensitizer that can be used for the research of vitiligo and hand eczema. Trioxsalen is used for visualization of genomic interstrand cross-links localized by laser photoactivation .
    Trioxsalen (Standard)
  • HY-155243
    12R-LOX-IN-1

    		DNA/RNA Synthesis Inflammation/Immunology
    12R-LOX-IN-1 (Compound 4a) is a 12R-LOX inhibitor (IC50: 28.25 μM). 12R-LOX-IN-1 inhibits the hyper-proliferative state and colony forming potential of Imiquimod (HY-B0180)-induced psoriatic keratinocytes. 12R-LOX-IN-1 inhibits reactive oxygen species, Ki67, IL-17A, TNF-α and IL-6 production. 12R-LOX-IN-1 can be used for antipsoriatic research .
    12R-LOX-IN-1
  • HY-155865
    CCT368772

    		Kinesin Cancer
    CCT368772 (compound 35) is a selective kinesin HSET inhibitor (HSET ADP-Glo IC50 = 0.019 μM). CCT368772 exhibits selectivity over Eg5 (Eg5 ADP-Glo IC50 >200 μM) . CCT368772 (compound 152) can be used for the study of hyperproliferative diseases and disorders such as cancer .
    CCT368772
  • HY-164534
    SIK2/3-IN-2

    		Salt-inducible Kinase (SIK) PAK Cardiovascular Disease Cancer
    SIK2/3-IN-2 (compound 12, compound I-200) is a potent SIK2/3 inhibitor (SIK2 IC50 = 65 nM, SIK3 IC50 = 14 nM). SIK2/3-IN-2 is also a p21-activated protein kinase (PAK) 1 inhibitor with a Ki of 20.7 nM. SIK2/3-IN-2 can be used for hyperproliferative diseases and cancer research, such as Paclitaxel (HY-B0015)-resistant ovarian cancer .
    SIK2/3-IN-2
  • HY-177274
    Antimitotic agent-2

    		Mitosis Inflammation/Immunology
    Antimitotic agent-2 (Compound 1) is an antimitotic agent. Antimitotic agent-2 inhibits the proliferation of human epidermal cells. Antimitotic agent-2 can be used in hyperproliferative skin disorders .
    Antimitotic agent-2

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