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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
210 Results for "
immune cytokine
" in MedChemExpress (MCE) Product Catalog:
Products (210)
210 Results for "immune cytokine" in MCE Product Catalog:
616
Target:
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.
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178
178 Cited Publications
Cat. No.: HY-B2176A
CAS No.: 51963-61-2
Synonyms: Adenosine-5'-triphosphate disodium trihydrate
178
178 Cited Publications
Cat. No.: HY-B2176B
CAS No.: 74804-12-9
Synonyms: Adenosine 5'-triphosphate dimagnesium
175
175 Cited Publications
Synonyms: Adenosine 5'-triphosphate disodium salt; Disodium adenosine triphosphate
Category:
Natural Products other families Microorganisms Animals Plants Endogenous metabolite Disease Research Fields Inflammation/Immunology
Target:
171
171 Cited Publications
Cat. No.: HY-W010735
CAS No.: 34369-07-8
Synonyms: Adenosine 5'-triphosphate disodium salt hydrate
168
168 Cited Publications
Cat. No.: HY-B2176C
CAS No.: 42373-41-1
Synonyms: Adenosine 5'-triphosphate dipotassium
168
168 Cited Publications
Synonyms: Adenosine 5'-triphosphate magnesium
ATP (Adenosine 5'-triphosphate) magnesium is a central component of energy storage and metabolism in vivo. ATP magnesium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP magnesium is an important endogenous signaling molecule in immunity and inflammation. ATP magnesium can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP magnesium has anti-bacterial infection effects and can protect mice against bacterial infection in mice .
103
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
Tofacitinib (Tasocitinib) is an orally active, blood-brain barrier permeable selective inhibitor of JAK1/JAK3. Tofacitinib blocks the JAK-STAT/NF-κB signaling pathway, inhibits cytokine signal transduction, phosphorylation of STAT1/STAT5, and suppresses innate and adaptive immune responses. Tofacitinib can be used in research related to major depressive disorder, rheumatoid arthritis, pulmonary diseases, systemic lupus erythematosus, and immune-mediated liver injury .
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103 Cited Publications
Cat. No.: HY-40354A
CAS No.: 540737-29-9
Synonyms: Tasocitinib citrate; CP-690550 citrate
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
Tofacitinib citrate (Tasocitinib citrate) is an orally active, blood-brain barrier permeable selective inhibitor of JAK1/JAK3. Tofacitinib citrate blocks the JAK-STAT/NF-κB signaling pathway, inhibits cytokine signal transduction, phosphorylation of STAT1/STAT5, and suppresses innate and adaptive immune responses. Tofacitinib citrate can be used in research related to major depressive disorder, rheumatoid arthritis, pulmonary diseases, systemic lupus erythematosus, and immune-mediated liver injury .
87
87 Cited Publications
Synonyms: Amethopterin; CL14377; WR19039
Research Areas:
Methotrexate (Amethopterin; CL14377; WR19039) is an orally active antifolate (Antifolate). Methotrexate inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer .
87
87 Cited Publications
Synonyms: Amethopterin hydrate; CL14377 hydrate; WR19039 hydrate
87
87 Cited Publications
Synonyms: Amethopterin disodium; CL14377 disodium; WR19039 disodium
Methotrexate disodium (Amethopterin disodium; CL14377 disodium; WR19039 disodium) is an orally active antifolate (Antifolate). Methotrexate disodium inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate disodium promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate disodium induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate disodium is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer .
68
68 Cited Publications
Cat. No.: HY-18234A
CAS No.: 103476-89-7
16
Category:
Plants Endogenous metabolite Human Gut Microbiota Metabolites other families Flavonoids Flavonones Phenols Polyphenols Disease Research Fields Inflammation/Immunology
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12
12 Cited Publications
Target:
Research Areas:
GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells .
8
Category:
Triterpenes other families Terpenoids Plants Disease Research Fields Inflammation/Immunology
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6
Target:
Research Areas:
Poly(deoxyadenylic-thymidylic) acid (Poly(dA:dT)) sodium is a double-stranded DNA stimulant. Poly(deoxyadenylic-thymidylic) acid sodium is recognized by the intracellular DNA sensor DDX41 and activates the innate immune pathway via the adaptor protein STING, inducing the production of cytokines such as type I interferons. Poly(deoxyadenylic-thymidylic) acid sodium also serves as an in vitro transcription template for free RNA polymerase .
3
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Soquelitinib (CPI-818) is an orally active and highly selective covalent interleukin-2-inducible kinase (ITK) inhibitor. Soquelitinib is active in six different models of T cell-mediated inflammatory and immune disease, including acute and chronic asthma, pulmonary fibrosis, systemic sclerosis (scleroderma), psoriasis, and acute graft versus host disease with Th2 cytokine product inhibition. Soquelitinib increases tumor infiltration of normal CD8 + cells that possess enhanced T effector function .
3
3 Cited Publications
Synonyms: Methylprednisolone hydrogen succinate sodium
Target:
Research Areas:
Infection Neurological Disease Inflammation/Immunology Cancer
Methylprednisolone succinate (Methylprednisolone hydrogen succinate) sodium is a prodrug of Methylprednisolone (HY-B0260) and glucocorticoid with immunosuppressant and anti-inflammatory activity. Methylprednisolone succinate sodium binds cytosolic glucocorticoid receptors, translocates to nuclei, and modulates target gene transcription. Methylprednisolone succinate sodium alters Bax, Bcl-2, occludin, and ZO-1 expression; attenuates TLR4/NF-κB signaling; suppresses proinflammatory cytokine production and immune cell activation. Methylprednisolone succinate sodium can be used for the research of intracranial haemorrhage, rheumatoid arthritis, multiple sclerosis, preterminal cancer, inflammatory conditions, shock, immediate-type hypersensitivity, acute myocardial ischemia, hypoxic heart muscle damage, and traumatic spinal cord injury .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
