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Results for "

inducible nitric-oxide synthase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NO Synthase (91) PGE synthase (2) Akt (1) Angiotensin Receptor (1) Antibiotic (3) Apolipoprotein (1) Apoptosis (20) Autophagy (3) Bacterial (8) Biochemical Assay Reagents (1) COX (5) Drug Metabolite (2) Endogenous Metabolite (16) Environmental Pollutants (2) ERK (3) Estrogen Receptor/ERR (2) Fungal (1) Guanylate Cyclase (1) HMG-CoA Reductase (HMGCR) (2) HSV (1) iGluR (5) IKK (1) Interleukin Related (5) Isotope-Labeled Compounds (6) Keap1-Nrf2 (1) Lipoxygenase (1) LPL Receptor (1) MOFs (1) NF-κB (11) NOD-like Receptor (NLR) (1) p38 MAPK (2) Phosphatase (1) PI3K (1) PKC (1) Potassium Channel (2) Reactive Oxygen Species (ROS) (7) Reference Standards (13) Sigma Receptor (1) SOD (2) TNF Receptor (4)
By Research Areas:	Cancer (26) Cardiovascular Disease (24) Endocrinology (7) Infection (8) Inflammation/Immunology (73) Metabolic Disease (10) Neurological Disease (33)
Oligonucleotides:	Solubilizing Agents (1)

109

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: NO Synthase PGE synthase Salt-inducible Kinase (SIK) Acetolactate Synthase (ALS) Thymidylate Synthase Cellulose Synthase ATP Synthase Itk GSK-3 Fatty Acid Synthase (FASN) Glucosylceramide Synthase (GCS) AIM2 Cyclic GMP-AMP Synthase RIG-I-like receptor (RLR) HIF/HIF Prolyl-Hydroxylase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0455

L-Arginine 20+ Cited Publications	Environmental Pollutants Endogenous Metabolite NO Synthase	Cardiovascular Disease Inflammation/Immunology
L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-100807

Quinolinic acid 5+ Cited Publications	MOFs iGluR Endogenous Metabolite Reactive Oxygen Species (ROS) NO Synthase Apoptosis	Neurological Disease Inflammation/Immunology
Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates **nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis** .

HY-N1445

Isoquercitrin 5+ Cited Publications Isoquercetin; Quercetin 3-glucoside	NF-κB NO Synthase	Inflammation/Immunology Cancer
Isoquercetin (Quercetin 3-glucoside) is a naturally occurring polyphenol that has antioxidant, anti-proliferative, and anti-inflammatory properties. Isoquercetin alleviates ethanol-induced hepatotoxicity, oxidative stress, and inflammatory responses via the Nrf2/ARE antioxidant signaling pathway . Isoquercetin regulates the expression of nitric oxide synthase 2 (NO2) via modulating the nuclear factor-κB (NF-κB) transcription regulation system. Isoquercetin has high bioavailability and low toxicity, is a promising candidate agent to prevent birth defects in diabetic pregnancies .

HY-18731

1400W Dihydrochloride Maximum Cited Publications 28 Publications Verification	NO Synthase Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
1400W dihydrochloride is the dihydrochloride form of 1400W (HY-18730). 1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a K_d value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation .

HY-N0455A

L-Arginine hydrochloride Maximum Cited Publications 23 Publications Verification (S)-(+)-Arginine hydrochloride	NO Synthase Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-B1041

Aminoguanidine hydrochloride 5+ Cited Publications Pimagedine hydrochloride; GER-11; Aminoguanidinium chloride	NO Synthase Apoptosis ERK	Neurological Disease Metabolic Disease Inflammation/Immunology
Aminoguanidine (Pimagedine) hydrochloride is an inhibitor of diamine oxidase (DAO) and nitric oxide synthase (NOS). Aminoguanidine hydrochloride can reduce the formation of advanced glycation end products (AGEs). Aminoguanidine hydrochloride has a dose-dependent inhibitory effect on Doxorubicin (HY-15142)-induced cell apoptosis. Aminoguanidine hydrochloride has antioxidant properties. Aminoguanidine hydrochloride can be used in the research of diabetic nephropathy .

HY-17408

Mevastatin 5+ Cited Publications Compactin; ML236B	HMG-CoA Reductase (HMGCR) Bacterial Autophagy Apoptosis Antibiotic	Infection Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Mevastatin (Compactin) is a first HMG-CoA reductase inhibitor that belongs to the statins class. Mevastatin is a lipid-lowering agent, and induces apoptosis, arrests cancer cells in G₀/G₁ phase. Mevastatin also increases endothelial nitric oxide synthase (eNOS) mRNA and protein levels. Mevastatin has antitumor activity and has the potential for cardiovascular diseases treatment .

HY-100986

L-NIO dihydrochloride 1 Publications Verification	NO Synthase	Cardiovascular Disease
L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with K_is of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively . L-NIO dihydrochloride induces a consistentfocal ischemic infarctin rats .

HY-N6966

Ethyl Caffeate 2 Publications Verification	NF-κB NO Synthase COX PGE synthase	Inflammation/Immunology Cancer
Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E₂ (PGE₂) in vitro or in mouse skin .

HY-W251598C

Sodium bicarbonate, for cell culture Sodium hydrogen carbonate for cell culture; Soda bicarbonate for cell culture	Environmental Pollutants Bacterial	Inflammation/Immunology Cancer
Sodium bicarbonate, for cell culture (Sodium hydrogen carbonate for cell culture; Soda bicarbonate for cell culture) is an inorganic salt that is neutral to slightly alkaline and easily decomposes when exposed to moisture in the air. Sodium bicarbonate, for cell culture can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, medicine, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort .

HY-N0577

Apiin 1 Publications Verification Apigenin 7-O-apiosylglucoside; Apigenin 7-(2-O-apiosylglucoside)	NO Synthase	Inflammation/Immunology
Apiin is a flavonoid glycoside-based iNOS inhibitor. Apiin inhibits the expression of inducible nitric oxide synthase in activated macrophages. Apiin exhibits anti-inflammatory activity .

HY-112234

L-Sepiapterin 1 Publications Verification Sepiapterin	Endogenous Metabolite	Cancer
L-Sepiapterin (Sepiapterin), is a phenylalanine hydroxylase activator, is a precursor of the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4). L-Sepiapterin improves endothelial dysfunction in small mesenteric arteries from db/db mice, and induces angiogenesis. L-Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70 ^S6K-dependent VEGFR-2 expression. L-Sepiapterin can be used for the study of hyperphenylalaninemia .

HY-110275

RA839	Keap1-Nrf2 NO Synthase	Infection Inflammation/Immunology
RA839 is a selective Nrf2/ARE pathway agonist and non-covalent small molecule binder of Keap1 (K_d is approximately 6 μM). RA839 prevents inducible **nitric oxide synthase** expression and nitric oxide release. RA839 exerts anti-rotaviral and anti-inflammatory effects .

HY-100807S

Quinolinic acid-d3 2 Publications Verification	Isotope-Labeled Compounds iGluR Endogenous Metabolite Reactive Oxygen Species (ROS) NO Synthase Apoptosis	Neurological Disease Inflammation/Immunology
Quinolinic acid-d₃ is the deuterium labeled Quinolinic acid. Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates **nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis**.

HY-N2406

Dihydrocaffeic acid 2 Publications Verification 3,4-Dihydroxy-benzenepropanoic acid	p38 MAPK Endogenous Metabolite Reactive Oxygen Species (ROS) NO Synthase	Inflammation/Immunology
Dihydrocaffeic acid is a microbial metabolite of flavonoids. Dihydrocaffeic acid scavenges intracellular ROS and increases nitric oxide synthase activity. Dihydrocaffeic acid reduces phosphorylation of MAPK p38 and prevent UVB-induced skin damage. Dihydrocaffeic acid has antioxidant, anti-inflammatory and anti-cartilage degradation activities .

HY-W251598B

Sodium bicarbonate, for molecular biology Sodium hydrogen carbonate for molecular biology; Soda bicarbonate for molecular biology	Bacterial NO Synthase	Inflammation/Immunology Cancer
Sodium bicarbonate, for molecular biology (Sodium hydrogen carbonate for molecular biolog; Soda bicarbonate for molecular biolog) is an inorganic salt. Sodium bicarbonate can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort .

HY-18730

1400W Maximum Cited Publications 28 Publications Verification W1400	NO Synthase Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a K_d value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation .

HY-N1382

Asperuloside 2 Publications Verification	NO Synthase	Metabolic Disease Inflammation/Immunology
Asperuloside is an iridoid isolated from Hedyotis diffusa, with anti-inflammatory activity. Asperuloside inhibits inducible nitric oxide synthase (iNOS), suppresses NF-κB and MAPK signaling pathways .

HY-136341

7,8-Dihydroneopterin	Apoptosis NO Synthase Endogenous Metabolite	Neurological Disease Inflammation/Immunology
7,8-Dihydroneopterin, an inflammation marker, induces cellular apoptosis in astrocytes and neurons via enhancement of nitric oxide synthase (iNOS) expression. 7,8-Dihydroneopterin can be used in the research of neurodegenerative diseases .

HY-N0455R

L-Arginine (Standard)	Reference Standards NO Synthase Endogenous Metabolite	Cardiovascular Disease Cancer
L-Arginine (Standard) is the analytical standard of L-Arginine. This product is intended for research and analytical applications. L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-107260

Lucidenic acid D Lucidenic acid D2	NO Synthase COX	Infection Inflammation/Immunology Cancer
Lucidenic acid D is a highly oxidized triterpenoid with anti-inflammatory and antiviral activities. Lucidenic acid D attenuates lipopolysaccharide-induced release of proinflammatory cytokines and nitric oxide, reduces the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and inhibits skin inflammation. Lucidenic acid D suppresses 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of Epstein-Barr virus (EBV) early antigen and maintains the viability of Raji cells. Lucidenic acid D can be used in studies of cancer chemoprevention .

HY-W005255

3-(3-Hydroxyphenyl)propionic acid	Endogenous Metabolite	Cardiovascular Disease
3-(3-Hydroxyphenyl)propionic acid (3HPPA) is an endothelium-dependent nitric oxide (NO) release promoter and *endothelial nitric oxide* synthase (eNOS)** activator. 3-(3-Hydroxyphenyl)propionic acid activates eNOS to mediate vascular smooth muscle relaxation and enhances endothelial cell NO synthesis, inducing vasodilation and reducing peripheral vascular resistance. 3-(3-Hydroxyphenyl)propionic acid can dose-dependently reduce systolic and diastolic blood pressure in spontaneously hypertensive rats (SHR) without affecting cardiac contractility or heart rate. 3-(3-Hydroxyphenyl)propionic acid has antihypertensive and vascular protective effects and can be used in the prevention and treatment of cardiovascular diseases .

HY-12119

GW274150 2 Publications Verification	NO Synthase	Neurological Disease Inflammation/Immunology
GW274150 is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC₅₀=2.19 μM; K_d=40 nM) and rat iNOS (ED₅₀=1.15 μM). GW274150 also displays less potency for both humans or rats endothelial NOS (eNOS) and neuronal NOS (nNOS). GW274150 exerts a protective role in an acute model of lung injury inflammation .

HY-N0617

Sanggenon C 2 Publications Verification	Phosphatase ERK NF-κB Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
Sanggenon C, a flavonoid, exerts protective effects against cardiac hypertrophy and fibrosis via suppression of the calcineurin/NFAT2 pathway. Sanggenon C inhibits mitochondrial fission to induce apoptosis by blocking the ERK signaling pathway. Sanggenon C inhibits inducible nitric oxide synthase expression in RAW264.7 cells, and TNF-α-stimulated cell adhesion and VCAM-1 expression, by suppressing NF-κB activity. Sanggenon C possesses antioxidant, anti-inflammatory and antitumor activities .

HY-N0268

Irisflorentin 4 Publications Verification	NO Synthase	Inflammation/Immunology
Irisflorentin, a naturally occurring isoflavone, is an abundant active constituent in Belamcanda chinensis. Irisflorentin markedly reduces the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. Anti-inflammatory activity .

HY-100807R

Quinolinic acid (Standard) 5+ Cited Publications	Reference Standards iGluR Endogenous Metabolite Reactive Oxygen Species (ROS) NO Synthase Apoptosis	Neurological Disease Inflammation/Immunology
Quinolinic acid (Standard) is the analytical standard of Quinolinic acid. This product is intended for research and analytical applications. Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates **nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis**.

HY-B0503

2-Thiouracil 2 Publications Verification Thiouracil	NO Synthase	Endocrinology Cancer
2-Thiouracil (Thiouracil) is a selective neuronal nitric oxide synthase (nNOS) inhibitor with a K_i value of 20 μM. 2-Thiouracil antagonizes BH4-induced nNOS dimerization. 2-Thiouracil is also an antithyroid compound and a highly specific melanoma detector. 2-Thiouracil stimulates the growth of pea and corn root segments .

HY-118700

2-Iminobiotin Guanidinobiotin	NO Synthase	Neurological Disease
2-Iminobiotin (Guanidinobiotin) is a biotin (vitamin H or B7) analog. 2-Iminobiotin is a reversible **nitric oxide synthases inhibitor with K_is of 21.8 and 37.5μM for murine iNOS and rat n-cNOS*, respectively . 2-Iminobiotin superimposes on hypothermia protects human neuronal cells from hypoxia-induced* cell damage .

HY-B0780

Fimasartan 4 Publications Verification BR-A-657	Angiotensin Receptor Apoptosis NF-κB	Cardiovascular Disease Neurological Disease Inflammation/Immunology Endocrinology
Fimasartan (BRA-657) is an orally effective angiotensin receptor AT1 non-peptide antagonist. Fimasartan has antihypertensive effects. Fimasartan improves neuroinflammation and brain injury mediated by NLRP3 inflammatome after intracerebral hemorrhage, and has neuroprotective effect. Fimasartan inhibits the expression of inducible nitric oxide synthase through the inactivation of NF-κB and activator protein-1 .

HY-W251598S

Bicarbonate-13C sodium	Reference Standards Bacterial NO Synthase	Inflammation/Immunology Cancer
Bicarbonate- ¹³C sodium is the ¹³C-labeled Sodium bicarbonate (HY-Y0756). Sodium bicarbonate is an inorganic salt that is neutral to slightly alkaline and easily decomposes when exposed to moisture in the air. Sodium bicarbonate can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, medicine, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort .

HY-79457

S-Methylisothiourea sulfate 1 Publications Verification	NO Synthase HSV	Infection Inflammation/Immunology
S-Methylisothiourea sulfate is a potent, selective and competitive inhibitor of inducible nitric oxide synthase (iNOS). S-Methylisothiourea sulfate exerts beneficial effects in rodent models of septic shock .

HY-12119A

GW274150 phosphate 2 Publications Verification	NO Synthase	Neurological Disease Inflammation/Immunology
GW274150 phosphate is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC₅₀=2.19 μM; K_d=40 nM) and rat iNOS (ED₅₀=1.15 μM). GW274150 phosphate displays less potency for both humans or rats endothelial NOS (eNOS) and neuronal NOS (nNOS). GW274150 phosphate exerts a protective role in an acute model of lung injury inflammation .

HY-34748

3-Penten-2-one Ethylideneacetone; (3Z)-pent-3-en-2-one	Biochemical Assay Reagents Endogenous Metabolite	Inflammation/Immunology
3-Penten-2-one (Ethylideneacetone) inhibits nitric oxide production and inducible nitric oxide synthase expression via heme oxygenase-1 induction in RAW264.7 macrophages activated with Lipopolysaccharides (HY-D1056) (LPS) .

HY-145846

iNOs-IN-1 1 Publications Verification	NO Synthase Interleukin Related	Inflammation/Immunology
iNOs-IN-1 (YPW) is a potent inducible nitric oxide synthase (iNOS) inhibitor. iNOs-IN-1 can significantly inhibit the expression of IL-6 and iNOS, as well as reduce LPS-induced NO generation with dose-dependent manner in mouse macrophages. Anti-inflammatory effects .

HY-B1041A

Aminoguanidine Pimagedine; GER-11free base ; Aminoguanidinium	NO Synthase Apoptosis	Endocrinology
Aminoguanidine (Pimagedine hydrochloride) is an inhibitor of diamine oxidase and **nitric oxide synthase. Aminoguanidine has a dose-dependent inhibitory effect on apoptosis** induced by Doxorubicin (HY-15142). Aminoguanidine has antioxidant properties. Aminoguanidine can be used in diabetic nephropathy research .

HY-100807S2

Quinolinic acid-13C4,15N	Isotope-Labeled Compounds iGluR Endogenous Metabolite Reactive Oxygen Species (ROS) NO Synthase Apoptosis	Neurological Disease Inflammation/Immunology
Quinolinic acid-13C4, 15N is an isotopic labeled Quinolinic acid (HY-100807). Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates **nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis**.

HY-127029A

Umbelliprenin	NO Synthase Lipoxygenase	Neurological Disease Inflammation/Immunology Cancer
Umbelliprenin, a prenylated coumarin, is an antioxidant with anticancer, anti-inflammatory and immunomodulatory effects. Umbelliprenin inhibits lipoxygenase managing the inflammation pathways. In inflammatory macrophages, Umbelliprenin suppresses nitric oxide production as well as **inducible nitric oxide synthase (NO synthase)** .

HY-N6770

Curvularin (S)-Curvularin	NO Synthase	Infection Inflammation/Immunology
Curvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC₅₀ of 9.5 µM .

HY-12122A

AR-C102222 hydrochloride	NO Synthase	Neurological Disease Inflammation/Immunology
AR-C102222 hydrochloride is a potent, competitive, orally active and highly selective inducible nitric oxide synthase (iNOS) inhibitor, with an IC₅₀ of 37 nM . AR-C102222 hydrochloride has antinociception and anti-inflammatory activities .

HY-W022047

nNOS-IN-1 1 Publications Verification	NO Synthase	Cardiovascular Disease Neurological Disease
nNOS-IN-1(Compound 14) is an inhibitor for nitric oxide synthases (NOS), that exhibits inhibitory activities against neuroal, inducible and endothelial NOS, with IC₅₀s of 2.5, 5.7 and 13 μM, respectively .

HY-135224

1,4-PBIT dihydrobromide 1,4-PB-ITU dihydrobromide	NO Synthase	Cancer
1,4-PBIT (1,4-PB-ITU) dihydrobromide (compound 46) is a potent nitric oxide synthases (NOS) inhibitor, with K_i values of 7.6 nM, 360 nM, and 16 nM for the inducible (iNOS), endothelial (eNOS), and neuronal (nNOS) isozymes, respectively .

HY-W251598I

Sodium bicarbonate, meets analytical specification of Ph. Eur., BP, USP, FCC, E500 Sodium hydrogen carbonate, meets analytical specification of Ph. Eur., BP, USP, FCC, E500	Bacterial NO Synthase	Inflammation/Immunology Cancer
Sodium bicarbonate, meets analytical specification of Ph. Eur., BP, USP, FCC, E500 is an inorganic salt that is neutral to slightly alkaline and easily decomposes when exposed to moisture in the air. Sodium bicarbonate can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, medicine, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort .

HY-146765

AMS-17	NOD-like Receptor (NLR)	Neurological Disease Inflammation/Immunology
AMS-17 is a potent NLRP3 inhibitor, inhibiting microglia activation in vitro and in vivo. AMS-17 also inhibits cytokines such as caspase-1, TNF-α, IL-1β and inducible nitric oxide synthase (iNOS) in N9 cells. AMS-17 can be used for researching inflammation-associated neurological disorders, such as vascular dementia (VaD) .

HY-118700A

2-Iminobiotin hydrobromide Guanidinobiotin hydrobromide	NO Synthase	Neurological Disease
2-Iminobiotin hydrobromide (Guanidinobiotin hydrobromide) is a biotin (vitamin H or B7) analog. 2-Iminobiotin hydrobromide is a reversible **nitric oxide synthases inhibitor with K_is of 21.8 and 37.5 μM for murine iNOS and rat n-cNOS*, respectively . 2-Iminobiotin hydrobromide superimposes on hypothermia protects human neuronal cells from hypoxia-induced* cell damage .

HY-12124

BBS-4	NO Synthase	Cardiovascular Disease
BBS-4 is a potent and selective inducible nitric oxide synthase (NOS2) dimerization inhibitor, with an IC₅₀ of 0.49 nM. BBS-4 can protect mice from the cardiovascular dysfunction of sepsis .

HY-100986B

L-NIO	NO Synthase	Cardiovascular Disease
L-NIO is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with K_is of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively . L-NIO induces a consistentfocal ischemic infarctin rats .

HY-100807S1

Quinolinic acid-13C7	Isotope-Labeled Compounds iGluR Endogenous Metabolite Reactive Oxygen Species (ROS) NO Synthase Apoptosis	Neurological Disease
Quinolinic acid- ¹³C₇ is the ¹³C labeled Quinolinic acid (HY-100807). Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates **nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis**.

HY-122060

BYK 191023	NO Synthase	Metabolic Disease
BYK 191023 is a selective and L-arginine competitive **inducible nitric-oxide synthase inhibitor with an IC₅₀** value of 86 nM, 17 µM, 162 µM for inducible (iNOS), neuronal (nNOS), and endothelial (eNOS) NO synthases respectively .

HY-107584

BYK 191023 dihydrochloride	NO Synthase	Metabolic Disease
BYK 191023 is a highly selective inducible nitric-oxide synthase (iNOS) inhibitor. BYK 191023 interacts with the catalytic center of the enzyme. BYK 191023 can be used to study the in vivo and in vitro effects mediated by iNOS .

HY-150055

iNOs-IN-3	NO Synthase	Inflammation/Immunology
iNOs-IN-3 (Compound 2d) is an orally active nitric oxide synthase (iNOS) inhibitor (IC₅₀=3.342 µM). iNOs-IN-3 shows anti-inflammatory activity and can be used in LPS-induced acute lung injury (ALI) research .

Cat. No.	Product Name	Type

HY-W251598C

Sodium bicarbonate, for cell culture

Sodium hydrogen carbonate for cell culture; Soda bicarbonate for cell culture

Biochemical Assay Reagents

Sodium bicarbonate, for cell culture (Sodium hydrogen carbonate for cell culture; Soda bicarbonate for cell culture) is an inorganic salt that is neutral to slightly alkaline and easily decomposes when exposed to moisture in the air. Sodium bicarbonate, for cell culture can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, medicine, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort .

HY-W251598B

Sodium bicarbonate, for molecular biology

Sodium hydrogen carbonate for molecular biology; Soda bicarbonate for molecular biology

Biochemical Assay Reagents

Sodium bicarbonate, for molecular biology (Sodium hydrogen carbonate for molecular biolog; Soda bicarbonate for molecular biolog) is an inorganic salt. Sodium bicarbonate can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort .

HY-NP203

High density lipoprotein (human)

HDL (human)

Biochemical Assay Reagents

High density lipoprotein (human) (HDL (human)) is a human-derived high-density lipoprotein. High density lipoprotein can cross the blood-brain barrier, and partially acts on endothelial nitric oxide synthase (eNOS) by activating surface receptors such as SR-B1 and S1P3R, as well as intracellular signaling cascades involving Akt, PI3K and MAPK, thereby inducing the production of NO in endothelial cells. High density lipoprotein (human) can be used in research related to type 2 diabetes, Alzheimer's disease, cancer and atherosclerosis .

HY-34748

3-Penten-2-one Ethylideneacetone; (3Z)-pent-3-en-2-one	Biochemical Assay Reagents
3-Penten-2-one (Ethylideneacetone) inhibits nitric oxide production and inducible nitric oxide synthase expression via heme oxygenase-1 induction in RAW264.7 macrophages activated with Lipopolysaccharides (HY-D1056) (LPS) .

HY-W251598I

Sodium bicarbonate, meets analytical specification of Ph. Eur., BP, USP, FCC, E500

Sodium hydrogen carbonate, meets analytical specification of Ph. Eur., BP, USP, FCC, E500

Biochemical Assay Reagents

Sodium bicarbonate, meets analytical specification of Ph. Eur., BP, USP, FCC, E500 is an inorganic salt that is neutral to slightly alkaline and easily decomposes when exposed to moisture in the air. Sodium bicarbonate can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, medicine, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort .

HY-W251598J

Sodium bicarbonate, United States Pharmacopeia (USP) Reference Standard

Sodium hydrogen carbonate (Pharmaceutical primary standard, USP); Soda bicarbonate (Pharmaceutical primary standard, USP)

Biochemical Assay Reagents

Sodium bicarbonate, United States Pharmacopeia (USP) Reference Standard is an inorganic salt. Sodium bicarbonate, United States Pharmacopeia (USP) Reference Standard can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate, United States Pharmacopeia (USP) Reference Standard is widely used in the fields of food, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate, United States Pharmacopeia (USP) Reference Standard is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0455

L-Arginine 20+ Cited Publications	Cardiovascular Disease Structural Classification Classification of Application Fields Amino acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Environmental Pollutants Endogenous Metabolite NO Synthase
L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-100807

Quinolinic acid 5+ Cited Publications	Alkaloids Structural Classification Microorganisms Disease markers Pyridine Alkaloids Nervous System Disorder Endogenous metabolite	MOFs iGluR Endogenous Metabolite Reactive Oxygen Species (ROS) NO Synthase Apoptosis
Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates **nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis** .

HY-N1445

Isoquercitrin 5+ Cited Publications Isoquercetin; Quercetin 3-glucoside	Apocynaceae Flavonols Flavonoids Classification of Application Fields Phenols Polyphenols Plants Apocynum venetum Linn. Disease Research Fields Source Classification Cancer	NF-κB NO Synthase
Isoquercetin (Quercetin 3-glucoside) is a naturally occurring polyphenol that has antioxidant, anti-proliferative, and anti-inflammatory properties. Isoquercetin alleviates ethanol-induced hepatotoxicity, oxidative stress, and inflammatory responses via the Nrf2/ARE antioxidant signaling pathway . Isoquercetin regulates the expression of nitric oxide synthase 2 (NO2) via modulating the nuclear factor-κB (NF-κB) transcription regulation system. Isoquercetin has high bioavailability and low toxicity, is a promising candidate agent to prevent birth defects in diabetic pregnancies .

HY-N0455A

L-Arginine hydrochloride Maximum Cited Publications 23 Publications Verification (S)-(+)-Arginine hydrochloride	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	NO Synthase Endogenous Metabolite
L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-17408

Mevastatin 5+ Cited Publications Compactin; ML236B	Infection Cardiovascular Disease Natural Products Microorganisms Neurological Disease Classification of Application Fields Metabolic Disease Disease Research Fields Source Classification	HMG-CoA Reductase (HMGCR) Bacterial Autophagy Apoptosis Antibiotic
Mevastatin (Compactin) is a first HMG-CoA reductase inhibitor that belongs to the statins class. Mevastatin is a lipid-lowering agent, and induces apoptosis, arrests cancer cells in G₀/G₁ phase. Mevastatin also increases endothelial nitric oxide synthase (eNOS) mRNA and protein levels. Mevastatin has antitumor activity and has the potential for cardiovascular diseases treatment .

HY-N6966

Ethyl Caffeate 2 Publications Verification	Classification of Application Fields Phenols Polyphenols Amburana cearensis (Allemão) A.C.Sm. Plants Compositae Inflammation/Immunology Disease Research Fields Cancer	NF-κB NO Synthase COX PGE synthase
Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E₂ (PGE₂) in vitro or in mouse skin .

HY-N0577

Apiin 1 Publications Verification Apigenin 7-O-apiosylglucoside; Apigenin 7-(2-O-apiosylglucoside)	Structural Classification Flavonoids Classification of Application Fields Flavones Phenols Polyphenols Umbelliferae Plants Baccharis sarothroides A.Gray Inflammation/Immunology Disease Research Fields Source Classification	NO Synthase
Apiin is a flavonoid glycoside-based iNOS inhibitor. Apiin inhibits the expression of inducible nitric oxide synthase in activated macrophages. Apiin exhibits anti-inflammatory activity .

HY-112234

L-Sepiapterin 1 Publications Verification Sepiapterin	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite
L-Sepiapterin (Sepiapterin), is a phenylalanine hydroxylase activator, is a precursor of the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4). L-Sepiapterin improves endothelial dysfunction in small mesenteric arteries from db/db mice, and induces angiogenesis. L-Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70 ^S6K-dependent VEGFR-2 expression. L-Sepiapterin can be used for the study of hyperphenylalaninemia .

HY-N2406

Dihydrocaffeic acid 2 Publications Verification 3,4-Dihydroxy-benzenepropanoic acid	Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Phenols Polyphenols Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	p38 MAPK Endogenous Metabolite Reactive Oxygen Species (ROS) NO Synthase
Dihydrocaffeic acid is a microbial metabolite of flavonoids. Dihydrocaffeic acid scavenges intracellular ROS and increases nitric oxide synthase activity. Dihydrocaffeic acid reduces phosphorylation of MAPK p38 and prevent UVB-induced skin damage. Dihydrocaffeic acid has antioxidant, anti-inflammatory and anti-cartilage degradation activities .

HY-N1382

Asperuloside 2 Publications Verification	Iridoids Classification of Application Fields Terpenoids Rubiaceae Plants Inflammation/Immunology Disease Research Fields Hedyotis diffusa Willd. Source Classification	NO Synthase
Asperuloside is an iridoid isolated from Hedyotis diffusa, with anti-inflammatory activity. Asperuloside inhibits inducible nitric oxide synthase (iNOS), suppresses NF-κB and MAPK signaling pathways .

HY-136341

7,8-Dihydroneopterin	Natural Products Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Apoptosis NO Synthase Endogenous Metabolite
7,8-Dihydroneopterin, an inflammation marker, induces cellular apoptosis in astrocytes and neurons via enhancement of nitric oxide synthase (iNOS) expression. 7,8-Dihydroneopterin can be used in the research of neurodegenerative diseases .

HY-N0455R

L-Arginine (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Amino acids Endogenous metabolite Source Classification	Reference Standards NO Synthase Endogenous Metabolite
L-Arginine (Standard) is the analytical standard of L-Arginine. This product is intended for research and analytical applications. L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-107260

Lucidenic acid D Lucidenic acid D2	Cardiovascular Disease Triterpenes Structural Classification Classification of Application Fields Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Inflammation/Immunology Disease Research Fields Source Classification	NO Synthase COX
Lucidenic acid D is a highly oxidized triterpenoid with anti-inflammatory and antiviral activities. Lucidenic acid D attenuates lipopolysaccharide-induced release of proinflammatory cytokines and nitric oxide, reduces the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and inhibits skin inflammation. Lucidenic acid D suppresses 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of Epstein-Barr virus (EBV) early antigen and maintains the viability of Raji cells. Lucidenic acid D can be used in studies of cancer chemoprevention .

HY-W005255

3-(3-Hydroxyphenyl)propionic acid	Cardiovascular Disease Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Phenols Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
3-(3-Hydroxyphenyl)propionic acid (3HPPA) is an endothelium-dependent nitric oxide (NO) release promoter and *endothelial nitric oxide* synthase (eNOS)** activator. 3-(3-Hydroxyphenyl)propionic acid activates eNOS to mediate vascular smooth muscle relaxation and enhances endothelial cell NO synthesis, inducing vasodilation and reducing peripheral vascular resistance. 3-(3-Hydroxyphenyl)propionic acid can dose-dependently reduce systolic and diastolic blood pressure in spontaneously hypertensive rats (SHR) without affecting cardiac contractility or heart rate. 3-(3-Hydroxyphenyl)propionic acid has antihypertensive and vascular protective effects and can be used in the prevention and treatment of cardiovascular diseases .

HY-N0617

Sanggenon C 2 Publications Verification	Cardiovascular Disease Structural Classification Classification of Application Fields Plants Moraceae Flavanonols Flavonoids Phenols Polyphenols Inflammation/Immunology Disease Research Fields Morus alba Linn. Source Classification	Phosphatase ERK NF-κB Apoptosis
Sanggenon C, a flavonoid, exerts protective effects against cardiac hypertrophy and fibrosis via suppression of the calcineurin/NFAT2 pathway. Sanggenon C inhibits mitochondrial fission to induce apoptosis by blocking the ERK signaling pathway. Sanggenon C inhibits inducible nitric oxide synthase expression in RAW264.7 cells, and TNF-α-stimulated cell adhesion and VCAM-1 expression, by suppressing NF-κB activity. Sanggenon C possesses antioxidant, anti-inflammatory and antitumor activities .

HY-W008646

7,8-Dihydro-L-biopterin 1 Publications Verification	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	SOD Apoptosis NO Synthase
7,8-Dihydro-L-biopterin is a NOS uncoupling inducer with blood-brain barrier permeability, and it is a reduced non-conjugated pteridine. 7,8-Dihydro-L-biopterin is the main metabolite of 4-amino-tetrahydro-L-biopterin, and it undergoes photooxidation to form biopterin. 7,8-Dihydro-L-biopterin promotes the conversion of nitric oxide synthase to a superoxide-producing form, thereby increasing oxidative stress levels in the renal outer medulla and inducing apoptosis. 7,8-Dihydro-L-biopterin is sensitive to the inhibitory effect of SOD, and it can be applied to research related to salt-sensitive hypertension, moderate to severe traumatic brain injury, and neurodegenerative diseases .

HY-N0268

Irisflorentin 4 Publications Verification	Flavonoids Iridaceae Classification of Application Fields Plants Belamcanda chinensis (Linn.) Redouté Inflammation/Immunology Disease Research Fields Isoflavones Source Classification	NO Synthase
Irisflorentin, a naturally occurring isoflavone, is an abundant active constituent in Belamcanda chinensis. Irisflorentin markedly reduces the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. Anti-inflammatory activity .

HY-100807R

Quinolinic acid (Standard) 5+ Cited Publications	Structural Classification Alkaloids Microorganisms Ketones, Aldehydes, Acids Disease markers Pyridine Alkaloids Nervous System Disorder Endogenous metabolite Source Classification	Reference Standards iGluR Endogenous Metabolite Reactive Oxygen Species (ROS) NO Synthase Apoptosis
Quinolinic acid (Standard) is the analytical standard of Quinolinic acid. This product is intended for research and analytical applications. Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates **nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis**.

HY-125740

Malvidin-3-glucoside chloride Malvidin-3-O-glucoside chloride; Oenin chloride	Classification of Application Fields Vitis vinifera cv. Zalema Plants Vitaceae Anthocyans Flavonoids Sunscreen Phenols Polyphenols Cosmetic Research Inflammation/Immunology Disease Research Fields Source Classification	NF-κB TNF Receptor NO Synthase Interleukin Related
Malvidin-3-glucoside (Malvidin-3-O-glucoside; Oenin) chloride is an orally active inhibitor of the NF-κB pathway, which blocks inflammatory responses induced by TNF-α, reduces IκB-α degradation and p65 nuclear translocation, and upregulates endothelial nitric oxide synthase eNOS to increase NO production. Malvidin-3-glucoside chloride exerts anti-inflammatory and antioxidant effects by inhibiting pro-inflammatory molecules such as MCP-1, ICAM-1, and IL-6, and regulating intestinal microorganisms and metabolites, while protecting endothelial cells and improving intestinal microecological dysbiosis under inflammatory conditions. Malvidin-3-glucoside chloride can be used to study chronic inflammatory-related diseases such as atherosclerosis and inflammatory bowel disease, and has the potential to prevent vascular inflammation and improve intestinal health .

HY-N1445R

Isoquercitrin (Standard) 1 Publications Verification Isoquercetin (Standard); Quercetin 3-glucoside (Standard)	Apocynaceae Flavonols Structural Classification Flavonoids Phenols Polyphenols Plants Apocynum venetum Linn. Source Classification	Reference Standards NF-κB NO Synthase
Isoquercetin (Standard) is the analytical standard of Isoquercetin. This product is intended for research and analytical applications. Isoquercetin (Quercetin 3-glucoside) is a naturally occurring polyphenol that has antioxidant, anti-proliferative, and anti-inflammatory properties. Isoquercetin alleviates ethanol-induced hepatotoxicity, oxidative stress, and inflammatory responses via the Nrf2/ARE antioxidant signaling pathway . Isoquercetin regulates the expression of nitric oxide synthase 2 (NO2) via modulating the nuclear factor-κB (NF-κB) transcription regulation system. Isoquercetin has high bioavailability and low toxicity, is a promising candidate agent to prevent birth defects in diabetic pregnancies .

HY-127029A

Umbelliprenin	Natural Products Umbelliferae Carpesium faberi C. Winkl. Plants Source Classification	NO Synthase Lipoxygenase
Umbelliprenin, a prenylated coumarin, is an antioxidant with anticancer, anti-inflammatory and immunomodulatory effects. Umbelliprenin inhibits lipoxygenase managing the inflammation pathways. In inflammatory macrophages, Umbelliprenin suppresses nitric oxide production as well as **inducible nitric oxide synthase (NO synthase)** .

HY-N6770

Curvularin (S)-Curvularin	Infection Microorganisms Antifungal Macrolide Antibiotics Classification of Application Fields Antibiotics Phenols Polyphenols Disease Research Disease Research Fields Source Classification	NO Synthase
Curvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC₅₀ of 9.5 µM .

HY-W008646R

7,8-Dihydro-L-biopterin (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Reference Standards SOD Apoptosis NO Synthase
NADH (disodium salt) (Standard) is the analytical standard of NADH (disodium salt). This product is intended for research and analytical applications. 7,8-Dihydro-L-biopterin is a NOS uncoupling inducer with blood-brain barrier permeability, and it is a reduced non-conjugated pteridine. 7,8-Dihydro-L-biopterin is the main metabolite of 4-amino-tetrahydro-L-biopterin, and it undergoes photooxidation to form biopterin. 7,8-Dihydro-L-biopterin promotes the conversion of nitric oxide synthase to a superoxide-producing form, thereby increasing oxidative stress levels in the renal outer medulla and inducing apoptosis. 7,8-Dihydro-L-biopterin is sensitive to the inhibitory effect of SOD, and it can be applied to research related to salt-sensitive hypertension, moderate to severe traumatic brain injury, and neurodegenerative diseases .

HY-N6966A

Ethyl trans-caffeate	Erythrophleum fordii Oliv. Plants Compositae Source Classification	Others
Ethyl trans-caffeate is the trans form of Ethyl Caffeate (HY-N6966). Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E₂ (PGE₂) in vitro or in mouse skin .

HY-125740R

Malvidin-3-glucoside chloride (Standard) Malvidin-3-O-glucoside chloride (Standard); Oenin chloride (Standard)	Structural Classification Anthocyans Flavonoids Vitis vinifera cv. Zalema Phenols Polyphenols Plants Vitaceae Source Classification	Reference Standards Interleukin Related NO Synthase NF-κB TNF Receptor
Malvidin-3-glucoside (Malvidin-3-O-glucoside; Oenin) chloride (Standard) is the analytical standard of Malvidin-3-glucoside chloride (HY-125740). This product is intended for research and analytical applications. Malvidin-3-glucoside chloride is an orally active inhibitor of the NF-κB pathway, which blocks inflammatory responses induced by TNF-α, reduces IκB-α degradation and p65 nuclear translocation, and upregulates endothelial nitric oxide synthase eNOS to increase NO production. Malvidin-3-glucoside chloride exerts anti-inflammatory and antioxidant effects by inhibiting pro-inflammatory molecules such as MCP-1, ICAM-1, and IL-6, and regulating intestinal microorganisms and metabolites, while protecting endothelial cells and improving intestinal microecological dysbiosis under inflammatory conditions. Malvidin-3-glucoside chloride can be used to study chronic inflammatory-related diseases such as atherosclerosis and inflammatory bowel disease, and has the potential to prevent vascular inflammation and improve intestinal health .

HY-114798

Rabelomycin	Quinones Structural Classification Microorganisms Anthraquinones Phenols Polyphenols Source Classification	Antibiotic Bacterial NO Synthase
Rabelomycin is an angucycline antibiotic and **inducible nitric oxide synthase (iNOS) inhibitor with an IC₅₀** of 63.9 μM. Rabelomycin can be used in research on bacterial infections, Alzheimer's disease, and Huntington's disease .

HY-N3602A

rel-Cleroindicin F Rengyolone	Natural Products Oleaceae Forsythia koreana (Rehder) Nakai Plants Source Classification	TNF Receptor NF-κB NO Synthase
rel-Cleroindicin F (Rengyolone) is a cyclohexyl acetyl compound that can be isolated from the fruit of forsythia and has anti-inflammatory activity. It strongly inhibits the production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-α). rel-Cleroindicin F does this by downregulating the activity of NF-κB and NF-κB kinases in RAW 264.7 cells stimulated by LPS (HY-D1056), thus inhibiting the expression of inducible nitric oxide synthase (NO Synthase) and nitric oxide production .

HY-133098

Juncutol	Juncaceae Plants Juncus acutus L. Source Classification	NO Synthase
Juncutol is a potent inducible nitric oxide synthase (iNOS) inhibitor. Juncutol decreases the LPS (HY-D1056)-stimulated iNOS protein expression .

HY-N8444

Triptoquinone A	Quinones Celastraceae Plants Tripterygium wilfordii Hook. f. Naphthalene Quinones Source Classification	Interleukin Related
Triptoquinone A, an interleukin 1 inhibitor, inhibits endomycin (LPS) or interleukin (IL-1β)-promoted induction of nitric oxide synthase (NOS) in vascular smooth muscle, thereby inhibiting Arg-induced vascular relaxation .

HY-N11085

Isophysalin A	Natural Products Plants Solanaceae Source Classification Alkekengi officinarum Moench	NO Synthase IKK
Isophysalin A is a physalin with alpha and beta unsaturated ketone components. Isophysalin A binds to GSH and targets multiple cysteine residues on IKKβ. Isophysalin A also inhibits inducible NO synthase (iNOS) and nitric oxide (NO) production, showing anti-inflammatory activity .

HY-N1382R

Asperuloside (Standard)	Structural Classification Iridoids Terpenoids Rubiaceae Plants Hedyotis diffusa Willd. Source Classification	Reference Standards NO Synthase
Asperuloside (Standard) is the analytical standard of Asperuloside. This product is intended for research and analytical applications. Asperuloside is an iridoid isolated from Hedyotis diffusa, with anti-inflammatory activity. Asperuloside inhibits inducible nitric oxide synthase (iNOS), suppresses NF-κB and MAPK signaling pathways .

HY-N0455AR

L-Arginine hydrochloride (Standard) (S)-(+)-Arginine hydrochloride (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards NO Synthase Endogenous Metabolite
L-Arginine (hydrochloride) (Standard) is the analytical standard of L-Arginine (hydrochloride). This product is intended for research and analytical applications. L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-N0268R

Irisflorentin (Standard)	Structural Classification Flavonoids Iridaceae Plants Belamcanda chinensis (Linn.) Redouté Isoflavones Source Classification	Reference Standards NO Synthase
Irisflorentin (Standard) is the analytical standard of Irisflorentin. This product is intended for research and analytical applications. Irisflorentin, a naturally occurring isoflavone, is an abundant active constituent in Belamcanda chinensis. Irisflorentin markedly reduces the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. Anti-inflammatory activity .

HY-N6966R

Ethyl Caffeate (Standard)	Structural Classification Phenols Polyphenols Amburana cearensis (Allemão) A.C.Sm. Plants Compositae	Reference Standards NF-κB NO Synthase COX PGE synthase
Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2) in vitro or in mouse skin .

HY-156241

Meliadubin B	Melia dubia Cav. Triterpenes Terpenoids Plants Meliaceae Source Classification	NO Synthase Fungal
Meliadubin B is a natural triterpenoid with significant inflammatory inhibition effect toward superoxide anion generation in human neutrophils (EC₅₀ of 5.54 μM). Meliadubin B inhibits **inducible nitric oxide synthase*. Meliadubin B shows remarkable inhibition against the rice pathogenic fungus Magnaporthe oryzae* with IC₅₀ of 182.50 μM.

HY-N12224

1-Heptadecanoyl-rac-glycerol MG(17:0/0:0/0:0); 1-Heptadecanoin	Apocynaceae Natural Products Plants Trachelospermum jasminoides (Lindl.) Lem. Source Classification	NO Synthase
1-Heptadecanoyl-rac-glycerol (1-Heptadecanoin) is a glyceride compound with anti-inflammatory activity. 1-Heptadecanoyl-rac-glycerol inhibits the occurrence of inflammation by suppressing the expression of **inducible nitric oxide synthase (iNOS**) related to inflammation. 1-Heptadecanoyl-rac-glycerol can be used for research on diseases related to inflammation .

HY-N11996

Aloenin aglycone	Liliaceae Phenols Polyphenols Aloe vera (L.) Burm. f. Plants Source Classification	NO Synthase NF-κB
Aloenin aglycone (compound 13) is an NF-κB inhibitor that can be isolated from aloe exudate. Aloenin aglycone inhibits TNFα-induced NF-κB transcriptional activity (IC₅₀: 18.7 μM). Aloenin aglycone (10 μM) also reduced inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) gene expression after treatment of HepG2 cells with 10 ng/mL TNFα .

HY-N8936

Narchinol B	Terpenoids Sesquiterpenes Nardostachys jatamansi (D. Don) DC. Plants Valerianaceae Source Classification	Others
Narchinol B (Compound 4) is a sesquiter penoid compound. Narchinol B has anti-inflammatory effects. Narchinol B works by inhibiting proinflammatory mediators, including prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) proteins, as well as proinflammatory cytokines, such as interleukin-1b, IL-6, and tumor necrosis factor-α (TNF-α). Narchinol B significantly inhibits LPS-induced overproduction of NO in BV2 cells (IC₅₀=2.43 μM) .

HY-N16735

Isofouquierol	Structural Classification Ceriops tagal (Perr.) C. B. Rob. Terpenoids Rhizophoraceae Plants Pentacyclic Triterpenoids Source Classification	NO Synthase
Isofouquierol is a selective inhibitor targeting nitric oxide (NO) production with anti-inflammatory activity. Isofouquierol blocks NO overproduction by inhibiting the **inducible nitric oxide synthase (iNOS**)-related pathway. Isofouquierol can be used in the study of inflammation-related diseases (such as chronic inflammation, immune disorders) .

HY-N19854

Mariaterpenoside A	Structural Classification Glycine soya Plants Compositae Saccharides Monosaccharides Source Classification	NO Synthase
Mariaterpenoside A is an **inducible nitric oxide synthase (iNOS*) inhibitor. Mariaterpenoside A interacts with the active cavity of iNOS protein via hydrogen bonds with specific residues of the binding site. Mariaterpenoside A suppresses NO release in LPS (HY-D1056)-induced* murine microglial BV-2 cells. Mariaterpenoside A can be used for the research of neurodegenerative disease .

HY-N17131

24-O-Acetyllycoclavanol	Lycopodiaceae Triterpenes Structural Classification Ketones, Aldehydes, Acids Terpenoids Plants Source Classification	NF-κB ERK
24-O-Acetyllycoclavanol (compound 1) is a triterpenoid anti-inflammatory agent that selectively targets the NF-κB and ERK1/2 signaling pathways. It exerts its anti-inflammatory activity by inhibiting lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) and COX-2 expression, reducing the production of inflammatory mediators such as nitric oxide (NO), IL-1β, and IL-8. 24-O-Acetyllycoclavanol can be used in research related to inflammatory bowel disease (IBD). 24-O-Acetyllycoclavanol can be biologically isolated from the ethyl acetate extract of Lycopodium clavatum .

HY-N9541

Chaetoglobosin Vb	Alkaloids Microorganisms Pyrrole Alkaloids Source Classification	Others
Chaetoglobosin Vb is a novel cytotoxic alkaloid with anti-inflammatory and antioxidant activities. Chaetoglobosin Vb can inhibit oxidative stress induced by LPS stimulation, reduce the production of reactive oxygen species and increase the expression of the antioxidant enzyme superoxide dismutase (SOD). Chaetoglobosin Vb significantly reduced the gene and protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) induced by LPS, and alleviated the production of proinflammatory cytokines such as TNF-α, IL-6 and IL-1β. Chaetoglobosin Vb exerts its biological activity through the TLR4-mediated MyD88-dependent signaling pathway and the TRIF-dependent signaling pathway, which is specifically manifested by inhibiting the phosphorylation of p38, ERK, and JNK MAPK and the translocation of NF-κB p65 subunit to the nucleus. Chaetoglobosin Vb showed no cytotoxic effect in the concentration range of 25-100 μM and promoted SOD enzyme activity and phosphorylation of p38, ERK1/2 and JNK in a dose-dependent manner .

Cat. No.	Product Name	Chemical Structure

HY-100807S

Quinolinic acid-d3 2 Publications Verification
Quinolinic acid-d₃ is the deuterium labeled Quinolinic acid. Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates **nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis**.

HY-W251598S

Bicarbonate-13C sodium

Bicarbonate- ¹³C sodium is the ¹³C-labeled Sodium bicarbonate (HY-Y0756). Sodium bicarbonate is an inorganic salt that is neutral to slightly alkaline and easily decomposes when exposed to moisture in the air. Sodium bicarbonate can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, medicine, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort .

HY-100807S2

Quinolinic acid-13C4,15N

Quinolinic acid-13C4, 15N is an isotopic labeled Quinolinic acid (HY-100807). Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis.

HY-100807S1

Quinolinic acid-13C7
Quinolinic acid- ¹³C₇ is the ¹³C labeled Quinolinic acid (HY-100807). Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates **nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis**.

HY-138166S

Rosuvastatin lactone-d6

Rosuvastatin lactone-d₆ is the deuterium labeled Rosuvastatin lactone. Rosuvastatin lactone is a metabolite of Rosuvastatin (HY-17504A), a statin lipid-lowering agent and HMG-CoA inhibitor. Rosuvastatin lactone exhibits endothelium-independent and HMG-CoA reductase-independent vasorelaxant activity in rat aortic rings, and its vasorelaxant effect is jointly mediated by NO produced by inducible nitric oxide synthase (iNOS) located in vascular smooth muscle and activation of potassium channels. Rosuvastatin lactone itself has no lipid-lowering effect .

HY-163712S

17-Epiestriol-d5-1

17-Epiestriol-d₅-1 is the deuterium labeled 17-Epiestriol (HY-163712). 17-Epiestriol is an estrogen metabolite and a selective estrogen receptor (ER) β agonist. 17-epiestriol inhibits the mRNA and protein expression of the vascular cell adhesion molecule VCAM-1 induced by tumor necrosis factor α (TNFα). 17-epiestriol also inhibits TNFα-induced VCAM-1 expression and prevents NF-κB migration to the nucleus. 17-Epiestriol also induces the mRNA and protein expression of endothelial nitric oxide synthase .

Host:	Rabbit (2)
Reactivity:	Human (2) Rat (2) Mouse (2)
Application:	IHC-P (1) ICC/IF (2) IP (1) IHC-F (1) WB (2) ELISA (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Polyclonal (1) Monoclonal (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80725

	iNOS Antibody 3 Publications Verification NOS2; NOS2A; nitric oxide synthase; inducible; Hepatocyte NOS; HEP-NOS; inducible NO synthase; inducible NOS; iNOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2	WB, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
	iNOS Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to iNOS.

HY-P86080

	iNOS Antibody (YA5772) NOS2; NOS2A; nitric oxide synthase; inducible; Hepatocyte NOS; HEP-NOS; inducible NO synthase; inducible NOS; iNOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	iNOS Antibody (YA5772) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to iNOS.

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Cat. No.	Product Name		Classification

HY-N0455

L-Arginine 20+ Cited Publications		Solubilizing Agents
L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

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inducible nitric-oxide synthase

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