mixed inhibition type

By Targets:	Amylases (1) Bacterial (3) Beta-secretase (1) Cholinesterase (ChE) (3) Dihydroceramide Desaturase 1 (DES1) (1) DNA/RNA Synthesis (1) Phosphatase (1) Proteasome (3) Xanthine Oxidase (1)
By Research Areas:	Cancer (5) Endocrinology (1) Infection (3) Inflammation/Immunology (4) Metabolic Disease (3) Neurological Disease (5)
Oligonucleotides:	Nucleotide Analogs (1)

Targets Recommended: Mixed Lineage Kinase C-type Lectin-like Receptors (CTLRs) PCSK9 Scavenger Receptor Class B type I (SR-BI）

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-16694

BAMB-4 1 Publications Verification ITPKA-IN-C14	Phosphatase	Cancer
BAMB-4 (ITPKA-IN-C14) is a specific and membrane-permeable ITPKA inhibitor. BAMB-4 has high stability and membrane permeability and against the inositol-1,4,5-trisphosphate (InsP3) kinase activity of inositol-1,4,5-trisphosphate-3-kinase A (ITPKA) with an IC₅₀ value of 20 μM. BAMB-4 can be used for the research of metastasis of lung cancer .

HY-130199

Psoromic acid Parellic acid	Others	Metabolic Disease
Psoromic acid is a potent and selective RabGGTase (Rab geranylgeranyl transferase) inhibitor with an IC₅₀ value of 1.3 µM. Psoromic acid is an antioxidative agent. Psoromic acid exhibits a competitive type of HMGR inhibition and mixed type of ACE (angiotensin converting enzyme) inhibition .

HY-135818

XM462	Dihydroceramide Desaturase 1 (DES1)	Cancer
XM462 is a dihydroceramide desaturase inhibitor. XM462 produced a mixed-type inhibition (K_i=2 μM) in vitro. XM462 has dihydroceramide desaturase inhibition both in vitro and in cultured cells with IC₅₀ values of 8.2 and 0.78 μM, respectively. XM462 can be used for the research of tumor .

HY-P2483B

Octaarginine acetate	Bacterial Proteasome	Infection Inflammation/Immunology Cancer
Octaarginine acetate is a cell-penetrating peptide and proteasome inhibitor. Octaarginine acetate exhibits mixed-type inhibition against 20S proteasome chymotrypsin-like, caspase-like, and trypsin-like activities, and inhibits 26S proteasome activity with decreased efficiency. Octaarginine acetate induces ubiquitin-conjugated protein accumulation, mediates HSPG-dependent cellular internalization via macropinocytosis, enhances liposomal cargo uptake and gene delivery. Octaarginine acetate can be used for the research of cervix carcinoma, collagen antibody-induced arthritis, and bacterial infections .

HY-P2483

Octaarginine	Proteasome Bacterial	Infection Inflammation/Immunology Cancer
Octaarginine is a cell-penetrating peptide and proteasome inhibitor. Octaarginine exhibits mixed-type inhibition against 20S proteasome chymotrypsin-like, caspase-like, and trypsin-like activities, and inhibits 26S proteasome activity with decreased efficiency. Octaarginine induces ubiquitin-conjugated protein accumulation, mediates HSPG-dependent cellular internalization via macropinocytosis, enhances liposomal cargo uptake and gene delivery. Octaarginine can be used for the research of cervix carcinoma, collagen antibody-induced arthritis, and bacterial infections .

HY-W324391

Coumarin 106 Coumarin 478	Cholinesterase (ChE)	Neurological Disease
Coumarin 106 (Coumarin 478) is a dipolar laser dye. Coumarin 106 is an inhibitor of AChE and BChE. Coumarin 106 displays mixed-type AChE inhibition with a pIC₅₀=4.97 and K_i=2.36 μM. Coumarin 106 inhibits BChE with slightly lower potency (pIC₅₀=4.56) .

HY-178363

α-Amylase-IN-13	Amylases	Metabolic Disease Endocrinology
α-Amylase-IN-13 is an orally active, selective, brain-penetrant α-amylase inhibitor (IC₅₀ = 0.71 μM). α-Amylase-IN-13 inhibits α-amylase through a mixed type of inhibition mechanism. α-Amylase-IN-13 leads to a significant reduction in blood glucose level in diabetic rats. α-Amylase-IN-13 causes significant histopathological improvements in the kidney, liver, and pancreas. α-Amylase-IN-13 can be used for the study of diabetic complications .

HY-N7887

Cassiaside	Beta-secretase	Neurological Disease Inflammation/Immunology
Cassiaside is a naphthopyrone glucoside, shows mixed-type inhibition against BACE1 (IC₅₀=4.45 μM; K_i=9.85 μM). Cassiaside possesses potential anti- Alzheimer's disease (AD) activity .

HY-136649

2'-Deoxy-2'-fluoroadenosine 5'-triphosphate tetralithium AfTP tetralithium, 2′-Fluoro-2′-deoxy-ATP (tetralithium）	DNA/RNA Synthesis	Others
2'-Deoxy-2'-fluoroadenosine 5'-triphosphate tetralithium is an ATP analog, it exerted a strong but mixed-type inhibition on poly(AU) synthesis.

HY-P2483A

Octaarginine TFA	Proteasome Bacterial	Infection Neurological Disease Cancer
Octaarginine TFA is a cell-penetrating peptide and proteasome inhibitor. Octaarginine TFA exhibits mixed-type inhibition against 20S proteasome chymotrypsin-like, caspase-like, and trypsin-like activities, and inhibits 26S proteasome activity with decreased efficiency. Octaarginine TFA induces ubiquitin-conjugated protein accumulation, mediates HSPG-dependent cellular internalization via macropinocytosis, enhances liposomal cargo uptake and gene delivery. Octaarginine TFA can be used for the research of cervix carcinoma, collagen antibody-induced arthritis, and bacterial infections .

HY-181744

AChE-IN-108	Cholinesterase (ChE)	Neurological Disease
AChE-IN-108 is a potent mixed-type acetylcholinesterase (AChE) inhibitor with an in vitro IC₅₀ of 0.17 nM. AChE-IN-108 acts on both free AChE and the enzyme-substrate complex to exert mixed-type inhibition. AChE-IN-108 can be used for the study of acetylcholinesterase inhibition in Alzheimer’s disease (AD) .

HY-181095

Xanthine oxidase-IN-22	Xanthine Oxidase	Metabolic Disease Inflammation/Immunology
Xanthine oxidase-IN-22 is an orally active inhibitor of xanthine oxidase (XO) (IC₅₀: 0.0034 μM). Xanthine oxidase-IN-22 exhibits a mixed-type inhibition mode against XO. Xanthine oxidase-IN-22 reduces serum uric acid levels in mice. Xanthine oxidase-IN-22 can be used in research related to hyperuricemia and gout .

HY-181161

AChE-IN-107	Cholinesterase (ChE)	Neurological Disease
AChE-IN-107 is a selective acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 0.22 μM and a K_i of 0.207 μM. AChE-IN-107 shows no inhibitory effect on equine serum BChE at 10 μM. AChE-IN-107 exhibits mixed-type inhibition of electric eel acetylcholinesterase, binding to both free enzyme and enzyme-substrate complex. AChE-IN-107 acts as a cytotoxin, reduces cell viability in hepatocellular carcinoma HepG2 cells.AChE-IN-107 can be used for the research of alzheimer's disease .

Cat. No.	Nombre del producto	Type

HY-W324391

Coumarin 106 Coumarin 478	Fluorescent Dyes
Coumarin 106 (Coumarin 478) is a dipolar laser dye. Coumarin 106 is an inhibitor of AChE and BChE. Coumarin 106 displays mixed-type AChE inhibition with a pIC₅₀=4.97 and K_i=2.36 μM. Coumarin 106 inhibits BChE with slightly lower potency (pIC₅₀=4.56) .

Cat. No.	Nombre del producto	Target	Research Area

HY-P2483B

Octaarginine acetate	Bacterial Proteasome	Infection Inflammation/Immunology Cancer
Octaarginine acetate is a cell-penetrating peptide and proteasome inhibitor. Octaarginine acetate exhibits mixed-type inhibition against 20S proteasome chymotrypsin-like, caspase-like, and trypsin-like activities, and inhibits 26S proteasome activity with decreased efficiency. Octaarginine acetate induces ubiquitin-conjugated protein accumulation, mediates HSPG-dependent cellular internalization via macropinocytosis, enhances liposomal cargo uptake and gene delivery. Octaarginine acetate can be used for the research of cervix carcinoma, collagen antibody-induced arthritis, and bacterial infections .

HY-P2483

Octaarginine	Proteasome Bacterial	Infection Inflammation/Immunology Cancer
Octaarginine is a cell-penetrating peptide and proteasome inhibitor. Octaarginine exhibits mixed-type inhibition against 20S proteasome chymotrypsin-like, caspase-like, and trypsin-like activities, and inhibits 26S proteasome activity with decreased efficiency. Octaarginine induces ubiquitin-conjugated protein accumulation, mediates HSPG-dependent cellular internalization via macropinocytosis, enhances liposomal cargo uptake and gene delivery. Octaarginine can be used for the research of cervix carcinoma, collagen antibody-induced arthritis, and bacterial infections .

HY-P2483A

Octaarginine TFA	Proteasome Bacterial	Infection Neurological Disease Cancer
Octaarginine TFA is a cell-penetrating peptide and proteasome inhibitor. Octaarginine TFA exhibits mixed-type inhibition against 20S proteasome chymotrypsin-like, caspase-like, and trypsin-like activities, and inhibits 26S proteasome activity with decreased efficiency. Octaarginine TFA induces ubiquitin-conjugated protein accumulation, mediates HSPG-dependent cellular internalization via macropinocytosis, enhances liposomal cargo uptake and gene delivery. Octaarginine TFA can be used for the research of cervix carcinoma, collagen antibody-induced arthritis, and bacterial infections .

Cat. No.	Nombre del producto	Category	Target	Chemical Structure

HY-130199

Psoromic acid Parellic acid	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Disease Research Fields Source Classification	Others
Psoromic acid is a potent and selective RabGGTase (Rab geranylgeranyl transferase) inhibitor with an IC₅₀ value of 1.3 µM. Psoromic acid is an antioxidative agent. Psoromic acid exhibits a competitive type of HMGR inhibition and mixed type of ACE (angiotensin converting enzyme) inhibition .

HY-N7887

Cassiaside	Seeds of Cassia tora Linn. other families Leguminosae Phenols Polyphenols Plants Source Classification	Beta-secretase
Cassiaside is a naphthopyrone glucoside, shows mixed-type inhibition against BACE1 (IC₅₀=4.45 μM; K_i=9.85 μM). Cassiaside possesses potential anti- Alzheimer's disease (AD) activity .

Cat. No.	Nombre del producto		Classification

HY-136649

2'-Deoxy-2'-fluoroadenosine 5'-triphosphate tetralithium AfTP tetralithium, 2′-Fluoro-2′-deoxy-ATP (tetralithium）		Nucleotide Analogs
2'-Deoxy-2'-fluoroadenosine 5'-triphosphate tetralithium is an ATP analog, it exerted a strong but mixed-type inhibition on poly(AU) synthesis.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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mixed inhibition type

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