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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
mixed-type inhibition
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "mixed-type inhibition" in MCE Product Catalog:
Referencia número: HY-135818
No. CAS: 1045857-53-1
Áreas de investigación:
XM462 is a dihydroceramide desaturase inhibitor. XM462 produced a mixed-type inhibition (Ki=2 μM) in vitro. XM462 has dihydroceramide desaturase inhibition both in vitro and in cultured cells with IC50 values of 8.2 and 0.78 μM, respectively. XM462 can be used for the research of tumor .
Referencia número: HY-P2483B
Target:
Áreas de investigación:
Referencia número: HY-P2483
No. CAS: 148796-86-5
Target:
Áreas de investigación:
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Referencia número: HY-W324391
No. CAS: 41175-45-5
Synonyms: Coumarin 478
Referencia número: HY-178363
No. CAS: 3085413-64-2
Target:
Áreas de investigación:
α-Amylase-IN-13 is an orally active, selective, brain-penetrant α-amylase inhibitor (IC50 = 0.71 μM). α-Amylase-IN-13 inhibits α-amylase through a mixed type of inhibition mechanism. α-Amylase-IN-13 leads to a significant reduction in blood glucose level in diabetic rats. α-Amylase-IN-13 causes significant histopathological improvements in the kidney, liver, and pancreas. α-Amylase-IN-13 can be used for the study of diabetic complications .
Referencia número: HY-N7887
No. CAS: 13709-03-0
Category:
Seeds of Cassia tora Linn. Phenols Polyphenols Leguminosae Extract Plants Other Families Extract
Target:
Referencia número: HY-136649
Synonyms: AfTP tetralithium, 2′-Fluoro-2′-deoxy-ATP (tetralithium）
Target:
Áreas de investigación:
2'-Deoxy-2'-fluoroadenosine 5'-triphosphate tetralithium is an ATP analog, it exerted a strong but mixed-type inhibition on poly(AU) synthesis.
Referencia número: HY-P2483A
Target:
Áreas de investigación:
Referencia número: HY-181744
Target:
Áreas de investigación:
AChE-IN-108 is a potent mixed-type acetylcholinesterase (AChE) inhibitor with an in vitro IC50 of 0.17 nM. AChE-IN-108 acts on both free AChE and the enzyme-substrate complex to exert mixed-type inhibition. AChE-IN-108 can be used for the study of acetylcholinesterase inhibition in Alzheimer’s disease (AD) .
Referencia número: HY-181095
No. CAS: 3075445-37-0
Target:
Áreas de investigación:
Xanthine oxidase-IN-22 is an orally active inhibitor of xanthine oxidase (XO) (IC50: 0.0034 μM). Xanthine oxidase-IN-22 exhibits a mixed-type inhibition mode against XO. Xanthine oxidase-IN-22 reduces serum uric acid levels in mice. Xanthine oxidase-IN-22 can be used in research related to hyperuricemia and gout .
Referencia número: HY-184796
Target:
Áreas de investigación:
AChE-IN-119 is a selective acetylcholinesterase (AChE) inhibitor with an IC50 of 0.0641 μM and a Ki of 0.01648 μM. AChE-IN-119 exerts antioxidant effects by scavenging DPPH free radicals. AChE-IN-119 exhibits mixed-type inhibition and interacts with both the catalytic active site and the peripheral anionic site of acetylcholinesterase. AChE-IN-119 can be used for the research of Alzheimer's disease .
Referencia número: HY-181161
Target:
Áreas de investigación:
AChE-IN-107 is a selective acetylcholinesterase (AChE) inhibitor with an IC50 of 0.22 μM and a Ki of 0.207 μM. AChE-IN-107 shows no inhibitory effect on equine serum BChE at 10 μM. AChE-IN-107 exhibits mixed-type inhibition of electric eel acetylcholinesterase, binding to both free enzyme and enzyme-substrate complex. AChE-IN-107 acts as a cytotoxin, reduces cell viability in hepatocellular carcinoma HepG2 cells.AChE-IN-107 can be used for the research of alzheimer's disease .
Referencia número: HY-184980
No. CAS: 2180967-88-6
Urease-IN-23 is a cryptococcal urease inhibitor with antifungal activity. AF55 exhibits mixed-type inhibition against cryptococcal urease, binds to both the nickel ion site at the enzyme's catalytic center and the allosteric site, impairs urease catalytic efficiency, simultaneously disrupts fungal virulence structures and damages cell membrane integrity. The IC50 and Ki values of Urease-IN-23 against cryptococcal urease are 54.92 nM and 149.1 nM, respectively. Urease-IN-23 significantly reduces the capsule thickness of Cryptococcus neoformans and Cryptococcus gattii, increases fungal cell membrane permeability, and completely blocks melanin synthesis. Urease-IN-23 shows no toxicity in the Galleria mellonella larval model. Urease-IN-23 can be used in studies related to fungal infections .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
