32 Results for "

non-insulin dependent diabetes

" in MedChemExpress (MCE) Product Catalog:
Products (32)

32 Results for "non-insulin dependent diabetes" in MCE Product Catalog:

4
4 Cited Publications
Cat. No.: HY-112537
CAS No.: 56-73-5
Purity:  99.90%
D-Glucose 6-phosphate is a key central node metabolite in glucose metabolism. It serves as the initiating metabolite for glycolysis and the pentose phosphate pathway, as well as a substrate for glycogen synthesis. D-Glucose 6-phosphate acts as a metabolic stress signal, which activates the mTOR pathway to promote protein synthesis, especially when phosphoglucose isomerase (PGI) is inhibited, thereby participating in cardiac remodeling processes. D-Glucose 6-phosphate can be used in research related to non-insulin-dependent diabetes mellitus and heart failure .
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3
3 Cited Publications
Cat. No.: HY-112537B
CAS No.: 54010-71-8
Purity:  ≥98.0%
D-Glucose 6-phosphate sodium is a key central node metabolite in glucose metabolism. It serves as the initiating metabolite for glycolysis and the pentose phosphate pathway, as well as a substrate for glycogen synthesis. D-Glucose 6-phosphate sodium acts as a metabolic stress signal, which activates the mTOR pathway to promote protein synthesis, especially when phosphoglucose isomerase (PGI) is inhibited, thereby participating in cardiac remodeling processes. D-Glucose 6-phosphate sodium can be used in research related to non-insulin-dependent diabetes mellitus and heart failure .
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1
1 Cited Publications
Cat. No.: HY-P2802
CAS No.: 9001-42-7
Synonyms: α-D-Glucosidase, Yeast
Target:  

Glycosidase

Research Areas:  

Metabolic Disease

α-Glucosidase, Yeast (α-D-Glucosidase, Yeast), a carbohydrate hydrolyzing enzyme, catalyzes the liberation of α-glucose from the non-reducing end of the substrate. α-Glucosidase can facilitate the absorption of glucose by the small intestine. Inhibition of α-Glucosidase is an effective management of non-insulin-dependent diabetes mellitus (NIDDM) .
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Cat. No.: HY-W012241
CAS No.: 693-23-2
Dodecanedioic acid is an orally active straight-chain dicarboxylic acid. As an alternative energy substrate between lipids and carbohydrates, Dodecanedioic acid can be rapidly oxidized during exercise, reducing muscle fatigue without stimulating insulin secretion. Dodecanedioic acid also exhibits blood glucose-lowering activity in non-insulin-dependent diabetes mellitus .
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Cat. No.: HY-B0422
CAS No.: 105816-04-4
Synonyms: A4166; Senaglinide
Research Areas:  

Metabolic Disease

Nateglinide, a D-phenylalanine derivative, is an orally active and short-acting insulinotropic agent and a DPP IV inhibitor. Nateglinide inhibits ATP-sensitive K + channels in pancreatic β-cells. Nateglinide is used for the treatment of type 2 (non-insulin-dependent) diabetes mellitus .
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Cat. No.: HY-112537S1
Purity:  ≥98.0%
D-Glucose 6-Phosphate- 13C6 disodium xhydrate is a 13C-labeled D-Glucose 6-phosphate disodium xhydrate. D-Glucose 6-phosphate disodium xhydrate is a key central node metabolite in sugar metabolism, serving as the initial metabolite of glycolysis and pentose phosphate pathway, and also a substrate for glycogen synthesis. D-Glucose 6-phosphate disodium xhydrate can act as a metabolic stress signal, especially when phosphoglucomutase (PGI) is inhibited, activating the mTOR pathway, promoting protein synthesis, and thereby participating in the remodeling process of the heart. D-Glucose 6-phosphate disodium xhydrate can be used in research related to non-insulin-dependent diabetes and heart failure.
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Cat. No.: HY-100428
CAS No.: 161600-01-7
Purity:  99.88%
Synonyms: MCC-555; Isaglitazone
Target:  

PPAR

Research Areas:  

Metabolic Disease

Netoglitazone (MCC-555) is an orally active PPARγ ligand with an EC50 of 8 μM. Netoglitazone mediates cell type-specific functional regulation, and modulates the transcriptional activity of PPARγ as a full agonist, partial agonist or antagonist. Netoglitazone induces adipogenesis, inhibits osteoblastogenesis, alters the weight of extramedullary fat depots and enhances insulin sensitivity. Netoglitazone reduces blood glucose levels. Netoglitazone can be used in research related to type 2 diabetes and non-insulin-dependent diabetes mellitus .
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Cat. No.: HY-Y0749
CAS No.: 23150-65-4
Synonyms: Dimethyl glutamate hydrochloride
Target:  

iGluR Phosphatase

Dimethyl L-glutamate hydrochloride (Dimethyl glutamate hydrochloride) is a NMDA receptor ligand and a cell membrane-permeable glutamate precursor. Dimethyl L-glutamate hydrochloride binds to NMDA receptors to regulate osteoblast maturation, and promotes osteoblast proliferation, adhesion, extracellular calcium deposition, and alkaline phosphatase activity. Dimethyl L-glutamate hydrochloride replenishes the glutamate pool in insulin-secreting β cells. Dimethyl L-glutamate hydrochloride can be used in research related to bone defects and non-insulin-dependent diabetes mellitus .
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Cat. No.: HY-B1429R
CAS No.: 94-20-2
Research Areas:  

Endocrinology

Chlorpropamide (Standard) is the analytical standard of Chlorpropamide. This product is intended for research and analytical applications. Chlorpropamide is an oral hypoglycemic agent studied in non-insulin-dependent diabetes mellitus (NIDDM).
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Cat. No.: HY-112537S2
D-Glucose 6-phosphate- 13C is 13C labeled D-Glucose 6-phosphate (HY-112537). D-Glucose 6-phosphate is a key central node metabolite in glucose metabolism. It serves as the initiating metabolite for glycolysis and the pentose phosphate pathway, as well as a substrate for glycogen synthesis. D-Glucose 6-phosphate acts as a metabolic stress signal, which activates the mTOR pathway to promote protein synthesis, especially when phosphoglucose isomerase (PGI) is inhibited, thereby participating in cardiac remodeling processes. D-Glucose 6-phosphate can be used in research related to non-insulin-dependent diabetes mellitus and heart failure.
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Cat. No.: HY-118141
CAS No.: 170686-12-1
Target:  

Adrenergic Receptor

Research Areas:  

Metabolic Disease

BMS-194449 is a beta 3 receptor agonist with the Ki value of 160 nM. BMS-194449 can be used for study of obesity and non-insulin dependent diabetes .
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Cat. No.: HY-B0422S
CAS No.: 1227666-13-8
Synonyms: A4166 d5; Senaglinide d5
Nateglinide-d5 is a deuterium labeled Nateglinide. Nateglinide, a D-phenylalanine derivative, is an orally active and short-acting insulinotropic agent and a DPP IV inhibitor. Nateglinide inhibits ATP-sensitive K+ channels in pancreatic β-cells. Nateglinide is used for the treatment of type 2 (non-insulin-dependent) diabetes mellitus[1][2].
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Cat. No.: HY-W012241S1
CAS No.: 97543-02-7
Dodecanedioic acid-d4 is the deuterium labeled Dodecanedioic acid (HY-W012241). Dodecanedioic acid is an orally active straight-chain dicarboxylic acid. As an alternative energy substrate between lipids and carbohydrates, Dodecanedioic acid can be rapidly oxidized during exercise, reducing muscle fatigue without stimulating insulin secretion. Dodecanedioic acid also exhibits blood glucose-lowering activity in non-insulin-dependent diabetes mellitus .
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Cat. No.: HY-W012241R
CAS No.: 693-23-2
Dodecanedioic acid (Standard) is the analytical standard of Dodecanedioic acid (HY-W012241). This product is intended for research and analytical applications. Dodecanedioic acid is an orally active straight-chain dicarboxylic acid. As an alternative energy substrate between lipids and carbohydrates, Dodecanedioic acid can be rapidly oxidized during exercise, reducing muscle fatigue without stimulating insulin secretion. Dodecanedioic acid also exhibits blood glucose-lowering activity in non-insulin-dependent diabetes mellitus .
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Cat. No.: HY-W037817
CAS No.: 6525-53-7
Synonyms: Dimethyl glutamate
Dimethyl L-glutamate (Dimethyl glutamate) is a NMDA receptor ligand and a cell membrane-permeable glutamate precursor. Dimethyl L-glutamate binds to NMDA receptors to regulate osteoblast maturation, and promotes osteoblast proliferation, adhesion, extracellular calcium deposition, and alkaline phosphatase activity. Dimethyl L-glutamate replenishes the glutamate pool in insulin-secreting β cells. Dimethyl L-glutamate can be used in research related to bone defects and non-insulin-dependent diabetes mellitus .
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Cat. No.: HY-112537A
CAS No.: 5996-17-8
D-Glucose 6-phosphate dipotassium is a key central node metabolite in glucose metabolism. It serves as the initiating metabolite for glycolysis and the pentose phosphate pathway, as well as a substrate for glycogen synthesis. D-Glucose 6-phosphate dipotassium acts as a metabolic stress signal, which activates the mTOR pathway to promote protein synthesis, especially when phosphoglucose isomerase (PGI) is inhibited, thereby participating in cardiac remodeling processes. D-Glucose 6-phosphate dipotassium can be used in research related to non-insulin-dependent diabetes mellitus and heart failure .
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Cat. No.: HY-P11413
CAS No.: 139446-70-1
PAI-1 is a serine protease inhibitor (SERPIN). PAI-1 binds to and irreversibly inhibits uPA, tPA and furin; it also interacts with vitronectin, α1-acid glycoprotein, CRT, TLR4, proteasome α-3 subunit, uPAR, LRP1, Integrin αvβ3 and thrombin. PAI-1 regulates fibrinolysis, extracellular matrix turnover, cell migration, angiogenesis, inflammatory response and tissue remodeling; it mediates epithelial-mesenchymal transition (EMT)/endothelial-mesenchymal transition (EndMT), apoptosis and thrombus stabilization. PAI-1 can be used in research related to sepsis, acute lung injury, cardiovascular diseases, tissue fibrosis, diabetic nephropathy, obstructive nephropathy and non-insulin-dependent diabetes mellitus .
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Cat. No.: HY-N1743
CAS No.: 376362-03-7
1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl), isolated from Broussonetia kazinoki, shows in vitro inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 13.00 μM. PTP1B is a negative regulator of insulin action and an important mediator in the pathogenesis of insulinresistance and non-insulin dependent diabetes mellitus. PTP1B is regarded as a significant target for type 2 diabetes .
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Cat. No.: HY-186104
CAS No.: 3097592-82-7
Research Areas:  

Metabolic Disease

AMYR/CTR agonist 1 is an amylin receptor (AMYR) and calcitonin receptor (CTR) agonist with an amylin receptor cAMP stimulation EC50 of 0.0995 nM and a calcitonin receptor cAMP stimulation EC50 of 0.00616 nM. AMYR/CTR agonist 1 can be used for the research of non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, insulin dependent diabetes, non-insulin dependent diabetes, impaired glucose tolerance, obesity, syndrome x .
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Cat. No.: HY-19294
CAS No.: 197643-49-5
Target:  

Adrenergic Receptor

Research Areas:  

Metabolic Disease

BMS-201620 is a selective β3 full agonist, with a Ki of 93 nM. BMS-201620 can be used in the research of obesity and non-insulin-dependent diabetes .
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