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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
59 Results for "
nuclear receptor ligand
" in MedChemExpress (MCE) Product Catalog:
Products (59)
59 Results for "nuclear receptor ligand" in MCE Product Catalog:
18
18 Publications Verification
Art. -Nr.: HY-P7425
Reinheit: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFSF11; Tumor Necrosis Factor (ligand) Superfamily, Member 11; TNF Superfamily Member 11; receptor Activator Of nuclear Factor Kappa-B ligand; TRANCE; TNLG6B; RANKL; receptor Activator Of nuclear Factor Kappa B ligand; OPGL; Tumor Necrosis Factor ligand Superfamily Member; ODF; Tumor Necrosis Factor Superfamily Member 11; Tumor Necrosis Factor ligand Superfamily Member 11; Tumor Necrosis Factor ligand 6B; TNF-Related Activation-Induced Cytokine; CD254 Antigen; Osteoclast Differentiation Factor; HRANKL2; Osteoprotegerin ligand; OPTB2; CD254; SOdf
Species:
Mouse
Source:
E. coli
11
11 Cited Publications
Art. -Nr.: HY-P7424
Reinheit: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFSF11; Tumor Necrosis Factor (ligand) Superfamily, Member 11; TNF Superfamily Member 11; receptor Activator Of nuclear Factor Kappa-B ligand; TRANCE; TNLG6B; RANKL; receptor Activator Of nuclear Factor Kappa B ligand; OPGL; Tumor Necrosis Factor ligand
Species:
Human
Source:
E. coli
6
6 Cited Publications
Art. -Nr.: HY-P73388
Reinheit: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFSF11; Tumor Necrosis Factor (ligand) Superfamily, Member 11; TNF Superfamily Member 11; receptor Activator Of nuclear Factor Kappa-B ligand; TRANCE; TNLG6B; RANKL; receptor Activator Of nuclear Factor Kappa B ligand; OPGL; Tumor Necrosis Factor ligand
Species:
Mouse
Source:
HEK293
5
5 Cited Publications
Art. -Nr.: HY-N1427A
CAS. Nr.: 1079043-81-4
Target:
4
4 Cited Publications
Art. -Nr.: HY-P73386
Reinheit: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFSF11; Tumor Necrosis Factor (ligand) Superfamily, Member 11; TNF Superfamily Member 11; receptor Activator Of nuclear Factor Kappa-B ligand; TRANCE; TNLG6B; RANKL; receptor Activator Of nuclear Factor Kappa B ligand; OPGL; Tumor Necrosis Factor ligand
Species:
Human
Source:
HEK293
3
Target:
Forschungsgebiete:
3
3 Cited Publications
Art. -Nr.: HY-P9958A
CAS. Nr.: 615258-40-7
Target:
Forschungsgebiete:
2
Category:
Alkaloids Other Alkaloids Ranunculaceae Aconitum carmichaeli Debx. Plants Disease Research Fields Cancer
Target:
1
1 Cited Publications
Art. -Nr.: HY-169703
CAS. Nr.: 1251839-15-2
Target:
Forschungsgebiete:
SPA0355 is a thiourea derivative that has antioxidant and anti-inflammatory properties. SPA0355 inhibits the RANKL (receptor activator of nuclear factor κB ligand) induced osteoclast formation in primary bone marrow-derived macrophages. SPA0355 also suppresses the activation of the MAPKs, Akt, and NF-κB pathways. Additionally, SPA0355 promotes osteoblast differentiation, increases alkaline phosphatase activity, and enhances mineral nodule formation. SPA0355 can protect ovariectomized mice from bone loss by stimulating osteoblast differentiation and inhibiting osteoclast resorption, making it useful for studying postmenopausal osteoporosis .
1
1 Cited Publications
Art. -Nr.: HY-P700226AF
Reinheit: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFSF11; Tumor Necrosis Factor (ligand) Superfamily, Member 11; TNF Superfamily Member 11; receptor Activator Of nuclear Factor Kappa-B ligand; TRANCE; TNLG6B; RANKL; receptor Activator Of nuclear Factor Kappa B ligand; OPGL; Tumor Necrosis Factor ligand
Species:
Mouse
Source:
E. coli
1
1 Cited Publications
Art. -Nr.: HY-P7425B
Reinheit: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFSF11; Tumor Necrosis Factor (ligand) Superfamily, Member 11; TNF Superfamily Member 11; receptor Activator Of nuclear Factor Kappa-B ligand; TRANCE; TNLG6B; RANKL; receptor Activator Of nuclear Factor Kappa B ligand; OPGL; Tumor Necrosis Factor ligand
Species:
Mouse
Source:
HEK293
1
1 Cited Publications
Art. -Nr.: HY-P81124
Synonyms: OPGL; CD254; hRANKL2; ODF; OPGL; Osteoclast differentiation factor; Osteoprotegerin ligand; RANKL; receptor activator of nuclear factor kappa B ligand; sOdf; SOFA; TNF related activation induced cytokine; TNFSF 11; TNFSF11; TRANCE; Tumor necrosis factor ligand superfamily member 11; Osteoprotegerin ligand; TNF11_HUMAN.
Art. -Nr.: HY-U00425
CAS. Nr.: 1264754-13-3
Forschungsgebiete:
PROTAC ERRα ligand 1 is a PROTAC target protein ligand. PROTAC ERRα ligand 1 is an orally active ERRα inverse agonist with IC50 values of 0.6 μM for ERRα. PROTAC ERRα ligand 1 shows no significant activity against a panel of other nuclear receptors, including ERα c, ERRγ, ERβ, PPARα, PPARγ, PPARδ, and RXRα. PROTAC ERRα ligand 1 can provide enhanced insulin sensitivity in vivo. PROTAC ERRα ligand 1 can be used for metabolic diseases research, such as type 2 diabetes and obesity .
Art. -Nr.: HY-161574
CAS. Nr.: 3061315-33-8
Target:
Forschungsgebiete:
LLC0424 is a potent and selective cereblon-based PROTAC nuclear receptor-binding SET domain-containing 2 (NSD2) degrader. LLC0424 effectively degraded NSD2 with a DC50 of 20 nM in RPMI-8402 cells. LLC0424 selectively induces NSD2 degradation in a cereblon- and proteasome-dependent fashion. (Blue: CRBN ligand (HY-14658), Black: linker (HY-40002); Pink: NSD2 inhibitor (HY-161575)) .
Target:
Forschungsgebiete:
NR2F2-IN-1 (free base) is a COUP-TFII (orphan nuclear receptor NR2F2) inhibitor with antitumor activity against prostate cancer. NR2F2-IN-1 (free base) directly binds to the COUP-TFII ligand-binding domain and disrupts COUP-TFII interaction with transcription regulators including FOXA1. NR2F2-IN-1 (free base) can be used for the research of prostate cancer .
Target:
Forschungsgebiete:
LTβR-IN-1 (Compound 919278) is a potent, selective lymphotoxin β receptor (LTβR) inhibitor. LTβR-IN-1 also selectively inhibits the nuclear translocation of p52 depended on TNF12A, instead of the nuclear translocation of p65 mediated by TNF-α receptor. LTβR-IN-1 regulates the NF-kB signaling pathway IN a ligand-independent manner .
Synonyms: Dafachronic acid A; Δ7-Dafachronic acid
Target:
Forschungsgebiete:
(25S)-Δ7-Dafachronic acid is a ligand and activator of DAF-12 receptor. DAF-12 is a nuclear hormone receptor that regulates larval diapause, developmental age, and adult longevity in Caenorhabditis elegans .
Target:
Forschungsgebiete:
Δ4‑Dafachronic acid is an endogenous steroid hormone, an agonist of the DAF‑12 nuclear receptor, and a key ligand for the vitamin D receptor (VDR). Δ4‑Dafachronic acid promotes the active escape developmental trajectory in Austrofundulus limnaeus embryos even under diapause‑inducing conditions. Δ4‑Dafachronic acid is suitable for research on the developmental biology .
Forschungsgebiete:
PROTAC RAR degrader-1 (Compound 9) is a potent and selective RAR PROTAC Degrader consisting of apoptotic protein inhibitors (IAPs) ligands. IAPs-based degraders are also known as SNIPERs. PROTAC RAR Degrader-1 reduces RARα levels in HT1080 cells in a concentration-dependent manner but is blocked by the proteasome inhibitor MG132 (HY-13259). PROTAC RAR Degrader-1 can be used in the study of nuclear receptor-related diseases. (Pink: RAR ligand 1 (HY-111843); Black: Linker (HY-140189); Blue: IAPs Ligand (HY-B0134)) .
Art. -Nr.: HY-N11798
CAS. Nr.: 850894-19-8
Target:
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
