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Results for "

pigs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (39) Acyltransferase (1) Adenosine Kinase (1) Adenosine Receptor (5) Adenylate Cyclase (3) Adrenergic Receptor (43) Akt (1) Aminotransferases (Transaminases) (1) Amyloid-β (1) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (2) Angiotensin Receptor (2) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (28) AP-1 (2) Apoptosis (18) Arenavirus (1) ATP Synthase (1) Autophagy (1) Bacterial (42) Bcl-2 Family (2) Biochemical Assay Reagents (20) Bradykinin Receptor (6) Cadherin (1) Calcium Channel (23) Cannabinoid Receptor (3) Carnitine Palmitoyltransferase (CPT) (4) Caspase (5) Cathepsin (1) CDK (1) CGRP Receptor (1) Cholecystokinin Receptor (13) CMV (3) Collagen (1) COX (10) CRAC Channel (1) Cyclic GMP-AMP Synthase (1) Cyclin G-associated Kinase (GAK) (1) Cytochrome P450 (7) DGK (1) DNA/RNA Synthesis (5) Dopamine Receptor (4) Drug Derivative (8) Drug Intermediate (4) Drug Isomer (4) Drug Metabolite (4) Elastase (1) Endogenous Metabolite (38) Endothelin Receptor (6) Environmental Pollutants (7) ERK (2) Estrogen Receptor/ERR (7) FAP (1) Fluorescent Dye (2) Fungal (3) FXR (2) G protein-coupled Bile Acid Receptor 1 (2) GABA Receptor (2) GHSR (1) Glucocorticoid Receptor (2) Glycosidase (1) Heme Oxygenase (HO) (1) Herbicide (1) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (37) HIV (5) HSV (2) iGluR (2) Influenza Virus (3) Insulin Receptor (1) Interleukin Related (6) Isotope-Labeled Compounds (28) JNK (2) L-Selectin (1) Lactate Dehydrogenase (1) Leukotriene Receptor (34) Lipoxygenase (9) LPL Receptor (3) mAChR (16) METTL3 (1) mGluR (2) Na+/Ca2+ Exchanger (3) Na+/H+ Exchanger (NHE) (1) Na+/K+ ATPase (4) nAChR (5) NADPH Oxidase (1) Neurokinin Receptor (23) Neuropeptide Y Receptor (2) Neurotensin Receptor (3) NF-κB (7) NO Synthase (10) NOD-like Receptor (NLR) (1) Nucleoside Antimetabolite/Analog (2) Opioid Receptor (16) Orthopoxvirus (3) Oxytocin Receptor (1) P-glycoprotein (2) P2X Receptor (3) P2Y Receptor (2) p38 MAPK (1) PACAP Receptor (4) Parasite (9) PARP (1) PGE synthase (5) Phosphatase (4) Phosphodiesterase (PDE) (13) Phospholipase (6) Phytohormone (1) PKA (2) PKC (2) Platelet-activating Factor Receptor (PAFR) (5) Potassium Channel (23) PPAR (3) Prostaglandin Receptor (23) Reactive Oxygen Species (ROS) (6) Reference Standards (63) Renin (2) Reverse Transcriptase (2) SARS-CoV (5) Ser/Thr Protease (1) Sigma Receptor (15) Sirtuin (1) Small Interfering RNA (siRNA) (8) Sodium Channel (2) Squalene Monooxygenase (1) STING (1) Tau Protein (1) Thrombin (1) Thrombopoietin Receptor (1) TNF Receptor (4) Toll-like Receptor (TLR) (2) Trace Amine-associated Receptor (TAAR) (6) TRP Channel (4) Tyrosinase (1) VEGFR (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (47) Cardiovascular Disease (111) Endocrinology (31) Infection (68) Inflammation/Immunology (196) Metabolic Disease (90) Neurological Disease (152)
Oligonucleotides:	Nucleotide Analogs (1) Pre-designed siRNA Sets (3) Adjuvant (1) mRNA (1) Human Pre-designed siRNA Sets (1) Cholesterol (1) Adenine Nucleotide (1) siRNAs (6)

589

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101044

PPADS tetrasodium 5+ Cited Publications	P2X Receptor Na+/Ca2+ Exchanger	Neurological Disease
PPADS tetrasodiuma is a non-selective P2X receptor antagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 with IC₅₀s ranging from 1 to 2.6 μM. PPADS tetrasodiuma blocks native P2Y2-like (IC₅₀~0.9 mM) and recombinant P2Y4 (IC₅₀~15 mM) receptors. PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca ²⁺ exchanger in guinea pig airway smooth muscle .

HY-P3479

Insulin (swine)	Insulin Receptor	Metabolic Disease
Insulin (swine) is an orally active insulin derived from pigs. Insulin (swine) when administered orally acts as an antigen to reduce the severity of pancreatic lymphocyte infiltration, but has no metabolic effect on blood glucose levels. Insulin (swine) increases glucose oxidation, stimulates lipogenesis, and lowers blood glucose levels. Insulin (swine) can be used in diabetes research .

HY-N0165

Methyl-Hesperidin	HIV Reverse Transcriptase	Cardiovascular Disease Infection Inflammation/Immunology
Methyl-Hesperidin is a glycoside compound. Methyl-Hesperidin has hypotensive, coronary dilating, smooth muscle relaxing, capillary stabilizing, choleretic, and anti-ulcer activities. Methyl-Hesperidin act as a competitive substrate to inhibit HIV-1 reverse transcriptase activity. Methyl-Hesperidin potentiates coronary dilating actions of adenine nucleotides and 3'-AMP, enhances depressant action on isolated atria, and prolongs adenosine- and ATP-induced heart block in guinea pigs .

HY-B2162C

*Chondroitin sulfate (from pig)* Chondroitin polysulfate (from pig)	Endogenous Metabolite	Inflammation/Immunology
Chondroitin sulfate (from pig) (Chondroitin polysulfate (from pig)) is a sulfated linear polysaccharide extracted from pigs, which belongs to glycosaminoglycans. Chondroitin sulfate (from pig) exerts inconsistent inhibitory effects on the resorptive activity of human osteoclasts. Chondroitin sulfate (from pig) can be used in studies related to osteoarthritis .

HY-137243

Adenosine 3',5'-diphosphate disodium	Endogenous Metabolite Nucleoside Antimetabolite/Analog	Others
Adenosine 3',5'-diphosphate disodium is an endogenous purine nucleotide. Adenosine 3',5'-diphosphate disodium acts as an inhibitor of bovine adrenal estrogen sulfotransferase (EST) with a K_i value of 7.0 μM. It also serves as an indispensable specific cofactor for the pregnenolone-binding protein (PBP) steroid-binding complex, with an EC₅₀ value of 1.5 μM in guinea pigs .

HY-B0487

Ethisterone Pregneninolone; 17α-Ethynyltestosterone	Estrogen Receptor/ERR	Metabolic Disease
Ethisterone (Pregneninolone; 17α-Ethynyltestosterone) is a synthetic steroidal estrogen, is an orally active steroidal contraceptive agent. Ethisterone has almost no effect on the phagocytic activity of the reticuloendothelial system in male guinea pigs, while in utero exposure can induce abnormalities in the urogenital system of offspring .

HY-90002

4-Phenylpiperidine	Sigma Receptor	Neurological Disease
4-Phenylpiperidine is a σ receptor ligand with a K_i value of 1980 nM for guinea pig σ receptors. 4-Phenylpiperidine binds to σ receptors. 4-Phenylpiperidine is used in psychiatric disease research .

HY-B1421

Ractopamine hydrochloride LY031537	Adrenergic Receptor Trace Amine-associated Receptor (TAAR)	Metabolic Disease
Ractopamine hydrochloride (LY031537) is a potent and orally active β-adrenergic receptor (βAR) agonist with K_d value of ~25 nM for pig β1AR and β2AR. Ractopamine hydrochloride also is a mTAAR1 agonist with an EC₅₀ of 16 μM. Ractopamine hydrochloride promotes muscle mass development, limits fat deposition, reduces feed consumption, increases total cellular protein synthesis, and improves growth rate and feed efficiency in finishing swine. Ractopamine hydrochloride can be used for researching to increase lean tissue growth and improve production efficiency in pigs .

HY-B1042

Oxolamine citrate SKF-9976 citrate; AF-438 citrate	Cytochrome P450	Inflammation/Immunology
Oxolamine citrate (SKF-9976 citrate) is an orally active antitussive. Oxolamine citrate can inhibit CYP2B1/2. Oxolamine citrate has anti-inflammatory effects on the respiratory organs of guinea pigs. Oxolamine citrate increases the AUC of Warfarin (HY-B0687) and prolongs its terminal half-life. Oxolamine citrate can be used in respiratory disease research .

HY-123068

Captopril disulfide SQ 14551	Drug Derivative	Cardiovascular Disease
Captopril disulfide (SQ 14551) is an orally active disulfide dimer prodrug. Captopril disulfide is metabolized to Captopril and acts as a Bradykinin potentiator. Captopril disulfide enhances the vasodilatory effect of Bradykinin in anesthetized rats and the contractile response of isolated guinea pig ileum to Bradykinin. Captopril disulfide exhibits antihypertensive activity in spontaneously hypertensive rats. Captopril disulfide can be used in hypertension-related research .

HY-116326

BayCysLT2	Leukotriene Receptor	Inflammation/Immunology
BayCysLT2, an isophthalic acid derivative, is a selective and potent cysteinyl leukotriene 2 (CysLT2) receptor antagonist with an IC₅₀ value of 53 nM. BayCysLT2 inhibits calcium mobilization induced by leukotriene D4 in HEK293 cells expressing human CysLT2 receptors. BayCysLT2 reverses LTC4-induced increases in coronary artery perfusion pressure and decreases in contractility in isolated perfused guinea pig hearts .

HY-101810

Tazanolast TO 188; Tazalest; Tazanol	Calcium Channel PKC	Inflammation/Immunology
Tazanolast is a selective mast-cell-stabilizing agent, on ozone-induced airway hyperresponsiveness in guinea pigs.

HY-W145481A

D-Galacto-D-mannan Carob galactomannan	Sirtuin	Inflammation/Immunology
D-Galacto-D-mannan (Carob galactomannan) is an orally active Dectin-2 agonist. D-Galacto-D-mannan exerts antioxidant activity against hydroxyl radical generation. D-Galacto-D-mannan activates Dectin-2 to trigger downstream signaling pathways, promote the expression of immunoregulatory molecules, coordinate innate and adaptive immune responses, and inhibit excessive inflammatory responses by upregulating the expression of Sirtuin 1. When used as a vaccine adjuvant, D-Galacto-D-mannan induces cellular and humoral immune responses, promotes IFNγ secretion, increases antibody levels and virus neutralization titers, and elevates the levels of immunoglobulin G and A. D-Galacto-D-mannan can serve as an adjuvant for foot-and-mouth disease vaccines, enhance the vaccine-mediated ability of hosts to defend against viral infection in mice, and reduce local side effects at the inoculation site in pigs. D-Galacto-D-mannan can be used in the research of inflammatory and immune diseases, such as foot-and-mouth disease .

HY-P1015

*VIP(Guinea pig)* Vasoactive Intestinal Peptide, guinea pig	PACAP Receptor	Neurological Disease Metabolic Disease
VIP Guinea pig (Vasoactive intestinal peptide), a trophic and mitogenic factor, stimulates growth in whole cultured embryos. VIP Guinea pig functions as a simple gastrointestinal hormone and suggest a possible neurotransmitter function .

HY-RS29455

*UBE2E2 Pig* Pre-designed siRNA Set A**	Small Interfering RNA (siRNA)	Cancer
UBE2E2 Pig Pre-designed siRNA Set A contains three designed siRNAs for UBE2E2 gene (Pig), as well as a negative control, a positive control, and a FAM-labeled negative control.

UBE2E2 Pig Pre-designed siRNA Set A UBE2E2 Pig Pre-designed siRNA Set A

HY-167902

YM-31636 free base	5-HT Receptor	Metabolic Disease
YM-31636 free base is an orally active, potent and selective 5-HT₃ receptor agonist with a K_i value of 0.2 nM. YM-31636 free base induces contraction of isolated guinea pig distal colon. YM-31636 free base induces tachycardia with the relative intrinsic activity of approximately 0.23 in isolated guinea pig right atrium. YM-31636 free base is promising for research of constipation .

HY-151198

CHF-6366	mAChR Adrenergic Receptor Calcium Channel	Inflammation/Immunology Endocrinology
CHF-6366 is a potent M3 muscarinic antagonist and β2-adrenergic receptors agonist with pK_i values of 10.4 and 11.4, respectively. CHF-6366 is also a weak calcium channel inhibitor (IC₅₀~50 μM). CHF-6366 inhibits bronchoconstriction in guinea pigs. CHF-6366 can be used to research chronic obstructive pulmonary disease (COPD) .

HY-115877

GDC-0334	TRP Channel	Others
GDC-0334 is a selective TRPA1 antagonist. GDC-0334 inhibits TRPA1 function on airway smooth muscle and sensory neurons by decreasing cough and allergic airway inflammation in rats and guinea pigs. GDC-0334 can be used for TRPA1-mediated diseases research, such as pain or asthma .

HY-P2807J

*L-Lactate Dehydrogenase (L-LDH), pig* muscle**	Lactate Dehydrogenase	Metabolic Disease
L-Lactate Dehydrogenase (L-LDH), pig muscle is an L-lactate dehydrogenase found in pig muscle, mainly present in anaerobic tissues (skeletal muscle, red blood cells). L-Lactate Dehydrogenase (L-LDH), pig muscle can interact with acidic liposomes at low pH, causing protein to adsorb onto the liposomes and inhibit enzyme activity. The IC₅₀ values for L-Lactate Dehydrogenase (L-LDH), pig muscle are 0.05 μM for cardiolipin and 1.3 μM for phosphatidylserine liposomes .

HY-RS29454

*UBE2E1 Pig* Pre-designed siRNA Set A**	Small Interfering RNA (siRNA)	Cancer
UBE2E1 Pig Pre-designed siRNA Set A contains three designed siRNAs for UBE2E1 gene (Pig), as well as a negative control, a positive control, and a FAM-labeled negative control.

UBE2E1 Pig Pre-designed siRNA Set A UBE2E1 Pig Pre-designed siRNA Set A

HY-B2058

Triticonazole	Fungal Androgen Receptor	Infection
Triticonazole is an orally active triazole fungicide and androgen receptor antagonist. Triticonazole inhibits testosterone-induced androgen receptor activation and reduces basal testosterone secretion. Prenatal exposure to Triticonazole causes shortened anogenital distance in male rat fetuses and induces organ-specific histopathological changes in pigs. Triticonazole can be used for detoxification of seeds contaminated with fungal pathogens, but there is a risk of animal poisoning if the treated seeds are used as animal feed .

HY-RS10501

PIGS Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PIGS Human Pre-designed siRNA Set A contains three designed siRNAs for PIGS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PIGS Human Pre-designed siRNA Set A PIGS Human Pre-designed siRNA Set A

HY-147014

Cyclic HPMPC	CMV Orthopoxvirus	Infection
Cyclic HPMPC is a potent antiviral agent. Cyclic HPMPC can increase arterial oxygen saturation levels in lethal vaccinia virus (IHD strain)-infected mice. Cyclic HPMPC improves the outcome of congenital guinea pig cytomegalovirus (GPCMV) infection and decreases viral replication in guinea pig model .

HY-116033

BMS-363131	Ser/Thr Protease	Inflammation/Immunology
BMS-363131 is a selective inhibitor for tryptase, with an IC₅₀ <1.7 nM. BMS-363131 is hydrolytic stable at pH=7 and pH=9. BMS-363131 attenuates the astham in a guinea pig model .

HY-P10768

Ro 25-1553	PACAP Receptor	Inflammation/Immunology
Ro 25-1553 is a 31 amino acid vasoactive intestinal peptide (VIP) analog, that acts as an agonist for VIP2 receptor (VPAC2 receptor). Ro 25-1553 exhibits a bronchodilator effect in nerve-induced or Carbachol (HY-B1208)-induced tracheal smooth muscle contraction in guinea pig model .

HY-P10599

Scyliorhinin I	Neurokinin Receptor	Neurological Disease
Scyliorhinin I is a tachykinin-1 (NK-1) and tachykinin-2 (NK-2) receptor agonist with a K_i value of 0.9 nM for rat submandibular gland NK-1 receptor and 2 nM for hamster bladder NK-2 receptor. Scyliorhinin I has the ability to contract the longitudinal muscles of the guinea pig ileum .

HY-101390D

(R)-Niguldipine	Calcium Channel	Cardiovascular Disease
(R)-Niguldipine, a R-epimer of Niguldipine (HY-101390B), is a calcium channel antagonist. (R)-Niguldipine exerts a vasodilatory effect by blocking calcium channels and reducing the transmembrane influx of calcium ions. (R)-Niguldipine can inhibit U-46619 (HY-108566)-induced coronary artery contraction in guinea pig Langendorff hearts (pID₅₀ of 9.93), has high affinity for calcium channel binding sites on guinea pig skeletal muscle membranes (K_i of 8.10), and lowers blood pressure in spontaneously hypertensive rats (pED₃₀ of 5.55). (R)-Niguldipine can improve cardiovascular diseases such as hypertension, angina pectoris, and arrhythmias .

HY-P2703

*Peptide YY (pig)*	Neuropeptide Y Receptor	Metabolic Disease Endocrinology
Peptide YY (pig) is a 36 amino acid gastrointestinal peptide, can be isolated from porcine duodenum. Peptide YY (pig) decreases appetite and food-intake by activation of the Y2 receptor. Peptide YY (pig) is present mainly in pancreatic endocrine cells with effect on both intestinal motility and the cardiovascular system .

HY-E70197

*Calpain-1 (pig)* μ-Calpain	Cathepsin	Others
Calpain-1 (pig) (μ-Calpain) is an intracellular Ca ²⁺-regulated cysteine protease. Calpain-1 (pig) exhibits neuroprotective effect .

HY-P2841

Elastin from pig	Biochemical Assay Reagents	Others
Elastin from pig (Elastin) is a key matrix protein that imparts elasticity to organs and tissues. Elastin from pig is a stable, insoluble protein, and utilized in biomaterial for human tissue repairment .

HY-103296

Bombinakinin M	Bradykinin Receptor	Endocrinology
Bombinakinin M is a bradykinin receptor agonist with contractile activity in the guinea pig ileum .

HY-113442A

6-trans-Leukotriene B4	Endogenous Metabolite	Inflammation/Immunology
6-trans-leukotriene B4 is a neutrophil chemotaxin in the guinea pig dermis .

HY-136831

SR2640 QMPB	Leukotriene Receptor	Inflammation/Immunology
SR2640 is a highly efficient and selective LTD4/LTE4 antagonist that can specifically inhibit the smooth muscle contractions induced by LTD4 in the guinea pig ileum and trachea in a concentration-dependent manner, without affecting the contractions caused by histamine. SR2640 can concentration-dependently prevent the binding of 0.4 nM [3H] LTD4 to membrane receptors in guinea pig lung tissue, with an IC₅₀ of 23 nM. SR2640 can shift the dose-response curve for bronchoconstriction induced by intravenous LTD4 in guinea pigs to the right, and the extent of this shift is positively correlated with the dose of SR2640 administered. SR2640 can be used in asthma research .

HY-120688

L-772405	5-HT Receptor	Neurological Disease
L-772405 is a selective 5-HT_1D receptor agonist with the K_i values of 318, 29 and ＞ 1000 nM aganist guinea pig 5-HT1_B receptor, guinea pig 5-HT_1D receptor and rat 5-HT rransporter, respectively. L-772405 decreases the potassium-induced outflow of 5-HT with an IC₅₀ value of 240 nM .

HY-15718B

Istaroxime oxalate PST2744 oxalate	Na+/K+ ATPase	Cardiovascular Disease
Istaroxime oxalate (PST2744 oxalate) is the oxalate form of Istaroxime (HY-15718). Istaroxime oxalate is is an inotropic agent, that inhibits Na ⁺/K ⁺-ATPase with an IC₅₀ of 0.11 μM. Istaroxime oxalate increases force of contraction in guinea pig atria and twitch amplitude in isolated guinea pig myocytes without causing lethal arrhythmias .

HY-118674

AK-2-38	Calcium Channel	Cardiovascular Disease
AK-2-38, a Nifedipine (HY-B0284) analogue, is a calcium channel antagonist. AK-2-38 also has partial agonist effects on isolated guinea pig left atrium .

HY-W754020

Elbanizine	Histamine Receptor	Others
Elbanizine inhibits histamine, bradykinin, histamin-release from rat mast cells (IC₅₀ of 0.26 μM) and the IgE-mediated passive cutaneous anaphylaxis (PCA) reaction. Elbanizine exhibits antiallergic and antiasthmatic in guinea pig model .

HY-NP015

SLT/SLT-IIe (O139) protein	Bacterial	Infection
SLT/SLT-IIe (O139) protein is a cytotoxin that can be isolated from enterotoxigenic E. coli (ETEC). SLT/SLT-IIe (O139) protein causes edema in pigs .

HY-N3167

Nyasicoside	Nucleoside Antimetabolite/Analog	Cardiovascular Disease
Nyasicoside is a norlignan glucosides that can be isolated from Curculigo capitulate. Nyasicoside has potent activity against ouabain-induced arrhythmia in the heart preparations of guinea pig .

HY-164010

SUN-1334H free base	Histamine Receptor Dopamine Receptor Adrenergic Receptor Sigma Receptor	Cardiovascular Disease Inflammation/Immunology
SUN-1334H free base is an orally active inhibitor for histamine H1 receptor, with an IC₅₀ of 20.3 nM and K_i of 9.7 nM. SUN-1334H free base inhibits histamine-induced contractions of isolated guinea-pig ileum with an IC₅₀ of 0.198 μM. SUN-1334H free base inhibits histamine-induced bronchoconstriction in guinea pigs, histamine-induced skin wheals in beagle dogs, and ovalbumin-induced rhinitis in guinea pigs .

HY-101590A

Symetine dihydrochloride L 16726 dihydrochloride	Parasite	Infection
Symetine dihydrochloride (L 16726 dihydrochloride) is the dihydrochloride form of Symetine (HY-101590). Symetine dihydrochloride exhibits antiprotozoal activity aginst Entamoeba histolytica, and ameliorates the amebic liver abscess in guinea pig model .

HY-164650

Pirodomast Sch 37224	Leukotriene Receptor	Inflammation/Immunology
Pirodomast (Sch 37224) is a leukotriene formation inhibitor. Pirodomast inhibits LTD4 andthromboxane B2 release by anaphylactic guinea pig lung with the IC₅₀ values of 3.9 and 1.9 μM, respectively. Pirodomast can be used for study of asthma .

HY-114724

HSR-609	Histamine Receptor	Inflammation/Immunology
HSR-609 is an orally active amphoteric antiallergic agent. HSR-609 has a high affinity for histamine H1-receptor in the guinea pig cerebral cortex. HSR-609 inhibits allergic airway hyperresponsiveness to Acetylcholine. HSR-609 shows poor ability to penetrate into the CNS in mice and guinea pigs .

HY-117706

LY 292728	Leukotriene Receptor	Inflammation/Immunology
LY 292728 is a potent leukotriene B4 (LTB4) receptor antagonist. LY 292728 binds to human neutrophils with a K_i of 0.47 nM and binds to guinea pig lung membranes with a K_i of 0.04 nM .

HY-113465A

11-trans Leukotriene E4	Endogenous Metabolite	Inflammation/Immunology
11-trans Leukotriene E4 is an isomer of Leukotriene E4 (LTE4). Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans Leukotriene E4 is equipotent to LTE4 in contracting guinea pig ileum .

HY-120476

JNJ-39729209	TRP Channel	Neurological Disease Inflammation/Immunology
JNJ-39729209 is an antagonist for transient receptor potential vanilloid 1 (TRPV1) with pIC₅₀ of 7.9, 8.5, 7.9 and 7.7 for TRPV1 from human, rat, canine and guinea pig. JNJ-39729209 inhibits Capsaicin (HY-10448)-induced hypotension and inhibit thereby hypothermia. JNJ-39729209 exhibits anti-inflammatory and analgesic activities in Carrageenan (HY-125474)- and CFA (HY-153808)-induced thermal hyperalgesia rat models. JNJ-39729209 exhibits anti-cough effects in guinea pigs .

HY-160932

RS-15385-198	Adrenergic Receptor	Endocrinology
RS-15385-198 is the enantiomer of Delequamine (RS-15385-197) (HY-106874). RS-15385-198 exhibits a pK_i of 6.32 for α₂-adrenoceptors in the rat cortex. RS-15385-198 is an antagonist for UK-14304 (HY-B0659) in the rat vas deferens and in the guinea-pig ileum .

HY-117255

ZM260384	Potassium Channel	Others
ZM260384 is a K_ATP channel opener that accelerates metabolism and inhibits the decline of guinea pig isolated diaphragm function, thereby affecting muscle contraction. ZM260384 can be used to study muscle function under hypoxic conditions .

HY-N12108

Forphenicine	Phosphatase	Infection Inflammation/Immunology Cancer
Forphenicine is a bacterial metabolite that is found in S. fulvoviridis and an inhibitor of alkaline phosphatase. Forphenicine inhibits the growth of HL-60 leukemia cells at 10 µM. Forphenicine also increases survival in a guinea pig model of experimental autoimmune encephalomyelitis (EAE) .

HY-112739

SC-41930	Leukotriene Receptor	Inflammation/Immunology
SC-41930 is a orally active eukotriene-B4 receptor antagonist. SC-41930 alleviates inflammation in guinea pig acetic acid-induced colonic inflammation model .

Cat. No.	Product Name	Type

HY-D0808

Meldola blue	Fluorescent Dye
Meldola blue is a biosensor for measuring lactate in serum based on screen-printed carbon electrodes modified with Meldola's Blue-Reinecke salt (MBRS-SPCE) coated with lactate dehydrogenase NAD+-dependent enzyme (from pig heart) and NAD+.

HY-D2337

Quinophthalone	Fluorescent Dye
Quinophthalone is a dye with distinctive greenish yellow color. Quinophthalone is used as coloring agents for various materials. Quinophthalone is a strong sensitizer in guinea pigs, and its threshold concentration for induction and challenge is 10 ppm .

Cat. No.	Product Name	Type

HY-Y1168

DMTMM

2 Publications Verification

4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

Biochemical Assay Reagents

DMTMM (4-(4,6-dimethoxy-1,3,5-triazine-2-yl)-4-methylmorpholinium chloride) is a coupling agent. DMTMM can activate carboxyl groups and promote the formation of amide bonds. DMTMM plays an important role in promoting the chemical modification of biomacromolecules such as polysaccharides and proteins. DMTMM can be used for research of tissue engineering, breast cancer, corneal regeneration, and biomaterials .

HY-B1770

Sodium Iodide,99%	Biochemical Assay Reagents
Sodium Iodide is a compound composed of sodium ions and iodine ions. Sodium Iodide scavenges hydrogen peroxide. Sodium Iodide maintains the level of thyroid hormone T3 through its iodine component. Sodium Iodide protects tissues from oxidative damage and regulates thyroid homeostasis. Sodium Iodide relieves acute myocardial infarction .

HY-141582

Ceramide 3

N-Stearoyl phytosphingosine

Biochemical Assay Reagents

Ceramide 3 (N-Stearoyl phytosphingosine) is an orally active major component of intercellular lipids in the stratum corneum of the skin, and belongs to the ceramide family. Ceramide 3 inhibits c-jun and NF-κB activation induced by Histamine (HY-B1204), and suppresses the expression of IL-4 and TNF-α. Ceramide 3 inhibits scratching behavior and vascular permeability in mice, and exhibits antihistamine effects in guinea pig ileum. Ceramide 3 improves skin barrier function, reduces transepidermal water loss, erythema and the number of circulating epidermal cells, and accelerates barrier repair of irritated or dysfunctional skin .

HY-Y1217

1-Cyclohexanol Hydroxycyclohexane; NSC 54711; Naxol; Cyclohexanol	Biochemical Assay Reagents
1-Cyclohexanol (Hydroxycyclohexane; NSC 5471) is an orally active Cramer Class I flavor ingredient that can be used in fragrances. 1-Cyclohexanol has a wide margin of safety and is environmentally friendly .

HY-B2162C

*Chondroitin sulfate (from pig)* Chondroitin polysulfate (from pig)	Biochemical Assay Reagents
Chondroitin sulfate (from pig) (Chondroitin polysulfate (from pig)) is a sulfated linear polysaccharide extracted from pigs, which belongs to glycosaminoglycans. Chondroitin sulfate (from pig) exerts inconsistent inhibitory effects on the resorptive activity of human osteoclasts. Chondroitin sulfate (from pig) can be used in studies related to osteoarthritis .

HY-W133891

Peptone from soya Peptones, soybean	Biochemical Assay Reagents
Peptone from soy (peptones, soybean) is a peptone. Peptone from soy provides nitrogen and carbon sources, as well as other nutrients. Peptone from soy can stimulate/regulate the biosynthesis of cyclic eicosanoids. Peptone from soy induces dose-dependent contraction of guinea pig lung parenchyma. Peptone from soy can be used in microbial and cell culture .

HY-Y0850U3

PVA (Mw 125000, 98-99% hydrolyzed, ~2800 polymerization)

Polyvinyl alcohol (Mw 125000, 98-99% hydrolyzed, ~2800 polymerization); Poly(Ethenol) (Mw 125000, 98-99% hydrolyzed, ~2800 polymerization)

Biochemical Assay Reagents

PVA (Polyvinyl alcohol) (Mw 125000, 98-99% hydrolyzed, ~2800 polymerization) is a water-soluble, biodegradable, biocompatible and non-immunogenic polymer. PVA (Mw 125000, 98-99% hydrolyzed, ~2800 polymerization) causes no irritation to rabbit eyes, no skin sensitization in guinea pigs, promotes the proliferation of human skin keratinocytes, and reduces the loss of corneal endothelial cells. The LD₅₀ of PVA (Mw 125000, 98-99% hydrolyzed, ~2800 polymerization) in rats and dogs is greater than 10 g/kg. PVA (Mw 125000, 98-99% hydrolyzed, ~2800 polymerization) is hardly absorbed by the digestive system, causes no adverse effects upon long-term oral administration, and shows no mutagenicity or carcinogenicity. However, repeated intravenous or portal vein injection of PVA (Mw 125000, 98-99% hydrolyzed, ~2800 polymerization) may induce pathological changes such as glomerular lesions, anemia, hypertension or liver fibrosis in rats or dogs. Crosslinked nanofibers prepared by modifying PVA (Mw 125000, 98-99% hydrolyzed, ~2800 polymerization) can be used in studies related to wound dressings and other applications .

HY-90002

4-Phenylpiperidine	Biochemical Assay Reagents
4-Phenylpiperidine is a σ receptor ligand with a K_i value of 1980 nM for guinea pig σ receptors. 4-Phenylpiperidine binds to σ receptors. 4-Phenylpiperidine is used in psychiatric disease research .

HY-W145481A

D-Galacto-D-mannan

Carob galactomannan

Biochemical Assay Reagents

D-Galacto-D-mannan (Carob galactomannan) is an orally active Dectin-2 agonist. D-Galacto-D-mannan exerts antioxidant activity against hydroxyl radical generation. D-Galacto-D-mannan activates Dectin-2 to trigger downstream signaling pathways, promote the expression of immunoregulatory molecules, coordinate innate and adaptive immune responses, and inhibit excessive inflammatory responses by upregulating the expression of Sirtuin 1. When used as a vaccine adjuvant, D-Galacto-D-mannan induces cellular and humoral immune responses, promotes IFNγ secretion, increases antibody levels and virus neutralization titers, and elevates the levels of immunoglobulin G and A. D-Galacto-D-mannan can serve as an adjuvant for foot-and-mouth disease vaccines, enhance the vaccine-mediated ability of hosts to defend against viral infection in mice, and reduce local side effects at the inoculation site in pigs. D-Galacto-D-mannan can be used in the research of inflammatory and immune diseases, such as foot-and-mouth disease .

HY-P2995A

Hemoglobin porcine	Biochemical Assay Reagents
Hemoglobin porcine is an oxygen-transporting protein present in the blood of domestic pigs, and also an oxygen carrier with higher oxygen affinity than human hemoglobin. Hemoglobin porcine exhibits cooperative oxygen-binding properties, with weaker heme-heme interactions than those of human hemoglobin .

HY-106150

Eniporide

EMD-96785

Biochemical Assay Reagents

Eniporide (EMD 96785) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide specifically inhibits the NHE-1 isoform. Eniporide improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide regulates cardiac performance and high-energy phosphate content in clinically relevant pig models of CPB and cardiac arrest .

HY-P2841

Elastin from pig	Biochemical Assay Reagents
Elastin from pig (Elastin) is a key matrix protein that imparts elasticity to organs and tissues. Elastin from pig is a stable, insoluble protein, and utilized in biomaterial for human tissue repairment .

HY-NP015

SLT/SLT-IIe (O139) protein	Biochemical Assay Reagents
SLT/SLT-IIe (O139) protein is a cytotoxin that can be isolated from enterotoxigenic E. coli (ETEC). SLT/SLT-IIe (O139) protein causes edema in pigs .

HY-NP036

Pig Insulin-PE	Biochemical Assay Reagents
Pig Insulin-PE is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-P2995E

Guinea Pig Hemoglobin

Biochemical Assay Reagents

Guinea Pig Hemoglobin is a hemoglobin derived from guinea pigs. Hemoglobin is a iron-containing protein in red blood cells with oxygen binding properties. Hemoglobin is an inducer of HO-1. Hemoglobin consits of heme, which binds to oxygen. Hemoglobin also transports other gases, such as carbon dioxide, nitric oxide, hydrogen sulfide and sulfide. Hemoglobin absorbs unneeded oxygen in tissues, as an antioxidant .

HY-W127485

cis-9,10-Methyleneoctadecanoic Acid

Biochemical Assay Reagents

cis-9,10-Methyleneoctadecanoic acid is a cyclopropane fatty acid that has been found in bacteria and in the digestive glands of P. globosa. It is a component of the cell membrane of Staphylococcus aureus, and levels were reduced after treatment with carvacrol. cis-9,10-Methyleneoctadecanoic acid is secreted by H. pylori and enhances histamine- and dibutyryl cAMP-stimulated acid secretion in isolated guinea pig parietal cells. It also activates protein kinase C (PKC) in a calcium-dependent manner.

HY-NP0216

*Guinea pig* Immunoglobulin G**	Biochemical Assay Reagents
Guinea pig Immunoglobulin G is a guinea pig serum immunoglobulin that can be used in immunolabeling and coating protein in a variety of immunoassays including ELISA .

HY-NP002M

*Guinea Pig* serum albumin**	Biochemical Assay Reagents
Guinea Pig Serum Albumin is a plasma protein derived from guinea pig. Serum albumin is a multifunctional protein with extraordinary ligand binding capacity, making it a transporter molecule for a diverse range of metabolites, drugs, nutrients, metals and other molecules .

Cat. No.	Product Name	Target	Research Area

HY-P3479

Insulin (swine)	Insulin Receptor	Metabolic Disease
Insulin (swine) is an orally active insulin derived from pigs. Insulin (swine) when administered orally acts as an antigen to reduce the severity of pancreatic lymphocyte infiltration, but has no metabolic effect on blood glucose levels. Insulin (swine) increases glucose oxidation, stimulates lipogenesis, and lowers blood glucose levels. Insulin (swine) can be used in diabetes research .

HY-P1096

A71623	Cholecystokinin Receptor	Metabolic Disease
A71623, a CCK-4-based peptide, is a potent and highly selective CCK-A full agonist. The IC₅₀s for A-71623 are 3.7 nM in guinea pig pancreas (CCK-A) and 4500 nM in cerebral cortex (CCK-B) in radioligand binding assays, respectively .

HY-P10927A

BRP TFA BRINP2-related peptide TFA	PKA AP-1	Metabolic Disease
BRP (BRINP2-related peptide) TFA is a 12-peptide derived from BRINP2 that can cross the blood-brain barrier. BRP TFA induces the central activation of FOS in neuronal cells via the cAMP-PKA-CREB signaling pathway. BRP TFA exerts anorectic and anti-obesity effects without triggering nausea or aversive responses. The action of BRP TFA is independent of the leptin, GLP-1 receptor and melanocortin 4 receptor pathways. BRP TFA is applicable to obesity-related research .

HY-P0004

Lysipressin 2 Publications Verification Lysine vasopressin; [Lys8]-Vasopressin	Adenylate Cyclase Oxytocin Receptor	Cardiovascular Disease Neurological Disease
Lysipressin (Lysine vasopressin) is antidiuretic hormone that have been found in pigs. Lysipressin activates Oxytocin receptors and adenylate-cyclase. Lysipressin adjusts blood pressure and heart rate. Lysipressin shows antinociceptive activity .

HY-P1192

GR-73632	Neurokinin Receptor	Neurological Disease
GR-73632 is a tachykinin NK1 receptor agonist. GR-73632 activates spinal NK1 receptors to induce scratching, biting and licking behaviors. GR-73632 activates peripheral NK1 receptors to trigger lacrimation in guinea pigs, and activates central NK1 receptors to induce repetitive hind paw tapping behavior in gerbils. GR-73632 is applicable to research related to pruritus .

HY-P10927

BRP BRINP2-related peptide	AP-1 PKA	Metabolic Disease
BRP is a 12-peptide derived from BRINP2 that can cross the blood-brain barrier. BRP induces the central activation of FOS in neuronal cells via the cAMP-PKA-CREB signaling pathway. BRP exerts anorectic and anti-obesity effects without triggering nausea or aversive responses. The action of BRP is independent of the leptin, GLP-1 receptor and melanocortin 4 receptor pathways. BRP is applicable to obesity-related research .

HY-135108

QWF Peptide	Neurokinin Receptor	Neurological Disease
QWF Peptide (Compound 4a) is a substance P antagonist with an IC₅₀ of 0.09 μM. QWF Peptide antagonizes the SP-induced contraction of isolated guinea pig trachea strips with an IC₅₀ of 4.7 μM .

HY-P4405

(D-Ala2)-GRF (1-29) amide (human)	GHSR	Endocrinology
(D-Ala2)-GRF (1-29) amide (human) is a superagonist of GRF, exhibiting extremely high GH-releasing activity about 50 times that of GRF (1-29) in both pigs and rats .

HY-P1494

Substance P (1-9)	Neurokinin Receptor	Neurological Disease
Substance P (1-9) is nonapeptide, which decreases the inactivation of substance P by the guinea-pig ileum and urinary bladder.

HY-P2317

Cecropin P1, porcine	Bacterial Endogenous Metabolite	Infection
Cecropin P1, porcine is an antibacterial peptide that can be isolated from the upper part of the small intestine of the pig. Cecropin P1, porcine shows antibacterial activity against Gram-negative bacteria. Cecropin P1, porcine shows antiviral activity and inhibits PRRSV infection .

HY-P1112

Sarafotoxin S6a	Endothelin Receptor	Cardiovascular Disease Neurological Disease
Sarafotoxin S6a, a sarafotoxin analogue, is a endothelin receptor agonist and has an ET_A/ET_B selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a elicits the pig coronary artery with an EC₅₀ value of 7.5 nM .

HY-P1256C

JMV 449 acetate	Neurotensin Receptor	Neurological Disease
JMV 449 acetate is a potent neurotensin receptor agonist. JMV 449 acetate shows an IC₅₀ of 0.15 nM for inhibition of ¹²⁵I-neurotensin binding to neonatal mouse brain and an EC₅₀ of 1.9 nM in contracting the guinea-pig ileum. JMV 449 acetate has highly potent and long-lasting hypothermic and analgesic effects in the mouse .

HY-P1015

*VIP(Guinea pig)* Vasoactive Intestinal Peptide, guinea pig	PACAP Receptor	Neurological Disease Metabolic Disease
VIP Guinea pig (Vasoactive intestinal peptide), a trophic and mitogenic factor, stimulates growth in whole cultured embryos. VIP Guinea pig functions as a simple gastrointestinal hormone and suggest a possible neurotransmitter function .

HY-P1048

Myelin Basic Protein (MBP) (68-82), guinea pig	Peptides	Inflammation/Immunology
Myelin Basic Protein (MBP) (68-82), guinea pig is a fragment of myelin basic protein (MBP).

HY-P0004A

Lysipressin acetate 2 Publications Verification Lysine vasopressin acetate; [Lys8]-Vasopressin acetate	Adenylate Cyclase	Others
Lysipressin (Lysine vasopressin) acetate is antidiuretic hormone that have been found in pigs and some marsupial families. Lysipressin acetate induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase .

HY-12523

Peptide M	Peptides	Others
Peptide M is a synthetic amino acid (18 amino acids in length which correspond to the amino acid positions 303-322 of bovine S-antigen: DTNLASSTIIKEGIDKTV), is capable of inducing experimental autoimmune uveitis in monkeys and Hartley guinea pigs as well as Lewis rats .

HY-P3895A

Substance P (3-11) acetate	Neurokinin Receptor	Neurological Disease
Substance P (3-11) acetate is a substance P (SP) fragment peptide that can cross the BBB. Substance P (3-11) acetate has contracting activities on guinea pig ileum. Substance P (3-11) acetate also promotes human monocyte chemotaxis .

HY-P1016B

BQ-3020 ammonium	Endothelin Receptor	Cardiovascular Disease
BQ-3020 ammonium is a selective endothelin receptor (ET_B receptor) agonist. BQ-3020 ammonium inhibits [ ¹²⁵I] ET-1 binding to ET_B receptors, with an IC₅₀ value of 0.2 nM. BQ-3020 ammonium elicits vasoconstriction in the rabbit pulmonary artery. BQ-3020 ammonium makes relaxation of the pig urinary bladder neck and can be used for cardiovascular disease research . .

HY-P3563

[Lys4] Sarafotoxin S6c	Endothelin Receptor	Cardiovascular Disease
[Lys4] Sarafotoxin S6c, a sarafotoxin analogue, is a potent and partial agonist of endothelin receptor. [Lys4] Sarafotoxin S6c elicits contraction of pig coronary artery, with an EC₅₀ of 1.5 nM .

HY-P3896

Substance P (2-11)	Neurokinin Receptor	Neurological Disease
Substance P (2-11) is a substance P (SP) fragment peptide. Substance P (2-11) has contracting activities on guinea pig ileum. Substance P (2-11) inhibits the permeation of ³H SP in BBMEC monolayers .

HY-P3895

Substance P (3-11)	Neurokinin Receptor	Neurological Disease
Substance P (3-11) is a substance P (SP) fragment peptide that can cross the BBB. Substance P (3-11) has contracting activities on guinea pig ileum. Substance P (3-11) also promotes human monocyte chemotaxis .

HY-P5769

Endothelin (16-21)	Endothelin Receptor	Cardiovascular Disease
Endothelin (16-21) is a selective ETB receptor agonist (EC₅₀=228 nM in guinea-pig bronchus). Endothelin (16-21) can induce smooth muscle contraction. Endothelin (16-21) is promising for research of respiratory (e.g., asthma) and cardiovascular (e.g., hypertension) diseases .

HY-P1256

JMV 449	Neurotensin Receptor	Neurological Disease
JMV 449 is a potent neurotensin receptor agonist. JMV 449 shows an IC₅₀ of 0.15 nM for inhibition of [ ¹²⁵I]-neurotensin binding to neonatal mouse brain and an EC₅₀ of 1.9 nM in contracting the guinea-pig ileum. JMV 449 has highly potent and long-lasting hypothermic and analgesic effects in the mouse .

HY-P10768A

Ro 25-1553 TFA	PACAP Receptor	Inflammation/Immunology
Ro 25-1553 TFA is a 31 amino acid vasoactive intestinal peptide (VIP) analog, that acts as an agonist for VIP2 receptor (VPAC2 receptor). Ro 25-1553 TFA exhibits a bronchodilator effect in nerve-induced or Carbachol (HY-B1208)-induced tracheal smooth muscle contraction in guinea pig model .

HY-P1016

BQ-3020	Endothelin Receptor	Cardiovascular Disease
BQ-3020 is a selective endothelin receptor (ET_B receptor) agonist that displaces [ ¹²⁵I] ET-1 binding to ET_B receptors, with an IC₅₀ value of 0.2 nM. BQ-3020 elicits vasoconstriction in the rabbit pulmonary artery. BQ-3020 makes relaxation of the pig urinary bladder neck and can be used for cardiovascular disease research ¹ ².

HY-P11418

Pyr-Gly-Arg-pNA	Peptides	Others
Pyr-Gly-Arg-pNA is a substrate for both guinea pig and human lung tryptase .

HY-P3754

Experimental allergic encephalitogenic peptide (human)	Peptides	Inflammation/Immunology
Experimental allergic encephalitogenic peptide (human) is a EAE peptide. Experimental allergic encephalitogenic peptide (human) induces encephalomyelitis in guinea pigs .

HY-P10768

Ro 25-1553	PACAP Receptor	Inflammation/Immunology
Ro 25-1553 is a 31 amino acid vasoactive intestinal peptide (VIP) analog, that acts as an agonist for VIP2 receptor (VPAC2 receptor). Ro 25-1553 exhibits a bronchodilator effect in nerve-induced or Carbachol (HY-B1208)-induced tracheal smooth muscle contraction in guinea pig model .

HY-P10599

Scyliorhinin I	Neurokinin Receptor	Neurological Disease
Scyliorhinin I is a tachykinin-1 (NK-1) and tachykinin-2 (NK-2) receptor agonist with a K_i value of 0.9 nM for rat submandibular gland NK-1 receptor and 2 nM for hamster bladder NK-2 receptor. Scyliorhinin I has the ability to contract the longitudinal muscles of the guinea pig ileum .

HY-P2703

*Peptide YY (pig)*	Neuropeptide Y Receptor	Metabolic Disease Endocrinology
Peptide YY (pig) is a 36 amino acid gastrointestinal peptide, can be isolated from porcine duodenum. Peptide YY (pig) decreases appetite and food-intake by activation of the Y2 receptor. Peptide YY (pig) is present mainly in pancreatic endocrine cells with effect on both intestinal motility and the cardiovascular system .

HY-151413A

MEN 10207 acetate	Neurokinin Receptor	Neurological Disease
MEN 10207 (acetate) is a selective antagonist of the NK-2 tachykinin receptor. MEN 10207 (acetate) induces tachykinin-induced contractions in rat bladder and guinea pig airways in vivo. MEN 10207 (acetate) inhibits [β-Ala 8 ]-NKA (4-10)-induced enhancement of bladder motility in anesthetized rats and [β-Ala 8 ]-NKA (4-10)-induced enhancement of bronchoconstriction in anesthetized guinea pigs .

HY-P3817

Des-[Gly77,His78] Myelin Basic Protein (68-84), bovine	Peptides	Neurological Disease
Des-[Gly77,His78] Myelin Basic Protein (68-84) is a 68-84 sequence fragment of guinea pig myelin basic protein (GPMBP). Des-[Gly77,His78] Myelin Basic Protein (68-84) regulates functionally diverse encephalitogenic and proliferative activities of experimental autoimmune encephalomyelitis (EAE)-associated T cells .

HY-P2289

*β-defesin 1 (pig)* pBD-1	Bacterial	Infection
β-defesin 1 (pig) (pBD-1) is an endogenous and constitutively expressed antimicrobial peptide (AMP) from porcine tissues, particularly expresses in pig mucosal epithelial sites. β-defesin 1 (pig) has antimicrobial activities and contributes to mucosal and systemic host defenses in pigs .

HY-P2289A

*β-defesin 1 (pig) TFA* pBD-1 TFA	Bacterial	Infection
β-defesin 1 (pig) (pBD-1) TFA is an endogenous and constitutively expressed antimicrobial peptide (AMP) from porcine tissues, particularly expresses in pig mucosal epithelial sites. β-defesin 1 (pig) TFA has antimicrobial activities and contributes to mucosal and systemic host defenses in pigs .

HY-P3629

*Dynorphin B 29 (pig)* Leumorphin (pig)	Opioid Receptor	Neurological Disease Inflammation/Immunology
Dynorphin B 29 (Leumorphin) (pig) is a petide. Dynorphin B 29 (pig) can interact with multiple receptors in the brain, as well as in isolated tissue systems. Dynorphin B 29 (pig) can be used for the research of immunoreaction .

HY-P1015A

*VIP(Guinea pig) TFA* Vasoactive Intestinal Peptide, guinea pig TFA	PACAP Receptor	Neurological Disease Metabolic Disease
VIP Guinea pig TFA (Vasoactive intestinal peptide), a trophic and mitogenic factor, stimulates growth in whole cultured embryos. VIP Guinea pig functions as a simple gastrointestinal hormone and suggest a possible neurotransmitter function .

HY-P2015

Diacetylsplenopentine BCH 069	HIV	Infection Inflammation/Immunology
Diacetylsplenopentine (BCH 069) is an antiviral agent, and protects guinea pigs from foot-and-mouth disease (FMD) infection. Berlopentin has immunostimulatory properties .

HY-P10006

Leumorphin, human	Opioid Receptor	Neurological Disease
Leumorphin, human is a potent kappa opioid receptor (κ opioid receptor) agonist. Leumorphin, human inhibits the contraction of the myenteric plexus-longitudinal muscle preparation of the guinea pig ileum .

HY-P3611

Valosin (porcine)	Peptides	Metabolic Disease
Valosin (porcine) is a biologically active peptide with 25-amino-acid. Valosin (porcine) can be isolated recently from pig intestine. Valosin (porcine) can be used for the research of digestive system .

HY-P2291

Beta-defensin 103 isoform X1, pig	Bacterial	Inflammation/Immunology
Beta-defensin 103 isoform X1, pig is an antimicrobial peptide found in different living organisms, involved in the first line of defense in their innate immune response against pathogens .

HY-P2291A

*Beta-defensin 103 isoform X1, pig* TFA**	Bacterial	Inflammation/Immunology
Beta-defensin 103 isoform X1, pig TFA is an antimicrobial peptide found in different living organisms, involved in the first line of defense in their innate immune response against pathogens .

HY-P10291

[Pro34]Neuropeptide Y, porcine	Neuropeptide Y Receptor	Neurological Disease
[Pro34]Neuropeptide Y, porcine is a selective NPY receptor (Y1 receptor) agonist. [Pro34]Neuropeptide Y, porcine evokes vasoconstrictions in the guinea pig caval vein .

HY-P3562

PL-3994	Peptides	Others
PL-3994 is a natriuretic peptide receptor-A (NPR-A) agonist that is resistant to neutral endopeptidase and acts as a bronchodilator. PL-3994 produces concentration-dependent relaxation of pre-contracted guinea-pig trachea with an IC₅₀ value of 42.7 nM .

HY-P0004R

Lysipressin (Standard) Lysine vasopressin (Standard); [Lys8]-Vasopressin (Standard)	Reference Standards Adenylate Cyclase	Others
Lysipressin (Standard) is the analytical standard of Lysipressin. This product is intended for research and analytical applications. Lysipressin (Lysine vasopressin) is antidiuretic hormone that have been found in pigs and some marsupial families. Lysipressin induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase .

HY-P1112A

Sarafotoxin S6a TFA	Endothelin Receptor	Cardiovascular Disease Neurological Disease
Sarafotoxin S6a TFA , a sarafotoxin analogue, is a endothelin receptor agonist and has an ET_A/ET_B selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a TFA elicits the pig coronary artery with an EC₅₀ value of 7.5 nM .

HY-P2317A

Cecropin P1, porcine acetate	Bacterial Endogenous Metabolite	Infection
Cecropin P1, porcine acetate is an antibacterial peptide that can be isolated from the upper part of the small intestine of the pig. Cecropin P1, porcine acetate shows antibacterial activity against Gram-negative bacteria. Cecropin P1, porcine acetate shows antiviral activity and inhibits PRRSV infection .

HY-P3057

[D-Trp11]-Neurotensin	Neurotensin Receptor	Cardiovascular Disease Neurological Disease
[D-Trp11]-Neurotensin, an analogue of Neurotensin (NT), is a selective antagonist of NT in perfused rat hearts but behaves as a full agonist in guinea pig atria and rat stomach strips. [D-Trp11]-Neurotensin can inhibit NT-induced hypotension .

HY-N11615R

Cyclo(Pro-Val) (Standard)	Peptides Reference Standards	Others
Tylosin (tartrate) (Standard) is the analytical standard of Tylosin (tartrate). This product is intended for research and analytical applications. Tylosin tartrate is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin tartrate exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin tartrate is widely used as a feed additive for promoting animal growth. Tylosin tartrate is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle .

HY-P3809

[D-Pro2,D-Phe7,D-Trp9] Substance P	Neurokinin Receptor	Neurological Disease
[D-Pro2,D-Phe7,D-Trp9] Substance P is a Substance P (HY-P0201) analogue. [D-Pro2,D-Phe7,D-Trp9] Substance P is an inhibitor of Substance P. [D-Pro2,D-Phe7,D-Trp9] Substance P contracts guinea-pig ileum (GPI) indirectly .

HY-P2601A

Tyr-α-CGRP (human) TFA	CGRP Receptor	Others
Tyr-α-CGRP (human) TFA is an N-terminally extended human α-CGRP analog. Tyr-α-CGRP (human) TFA can bind to membrane preparations from rat brain and spleen with IC₅₀ values of 0.2 nM and 0.5 nM, respectively, and induce positive chronotropic and inotropic effects in isolated guinea pig right and left atria with EC₅₀ values of 282 nM and 74 nM, respectively. Tyr-α-CGRP (human) TFA also inhibits contractile responses in rat vas deferens with an EC₅₀ value of 1.9 nM .

Cat. No.	Product Name

HY-K6013

Organoid Dissociation Solution
MCE Organoid Dissociation Solution is versatile and suitable for routine dissociation and passaging of organoids derived from various mammals (including humans, mice, pigs, cows, and more).

HY-K6014

Organoid Cryopreservation Medium (Serum Free)
MCE Organoid Cryopreservation Medium (Serum Free) is a ready-to-use cryopreservation medium, widely applicable to organoids and cell lines derived from various mammals (such as human, mouse, pig, cow, etc.). The 100 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Cat. No.	Product Name	Target	Research Area	Image

HY-P990197

Anti-Mouse MAdCAM-1 Antibody (MECA-367)	L-Selectin	Metabolic Disease Inflammation/Immunology
Anti-Mouse MAdCAM-1 Antibody (MECA-367) is an anti-mouse MAdCAM-1 IgG2a monoclonal antibody. Anti-Mouse MAdCAM-1 Antibody (MECA-367) significantly inhibits the migration of pig peripheral blood lymphocytes (PBL) by blocking the function of MAdCAM-1. Anti-Mouse MAdCAM-1 Antibody (MECA-367) selectively inhibits B cell migration to exacerbate inflammation. Anti-Mouse MAdCAM-1 Antibody (MECA-367) can be used for researches on inflammation, metabolic conditions and xenotransplantation such as colitis and diabetes .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-108213

Inosinic acid 4 Publications Verification 5'-IMP; IMP; Inosine 5'-dihydrogen phosphate	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Inosinic acid is an endogenous metabolite. Inosinic acid is used as umami tastant, or as the dietary supplement to improve the yield and meat quality of pigs .

HY-103447

Zearalenone Maximum Cited Publications 10 Publications Verification Mycotoxin F2; Toxin F2	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Phenols Polyphenols Disease Research Fields Source Classification	Estrogen Receptor/ERR
Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .

HY-B0519A

Tylosin 1 Publications Verification	Infection Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Animal Husbandry Mammalian Cell Culture Antibacterial Disease Research Disease Research Fields Source Classification	Bacterial Antibiotic
Tylosin (Tylosin A) is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin is widely used as a feed additive for promoting animal growth. Tylosin is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle .

HY-113449

Ubiquinone-1	Quinones Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Classification of Application Fields Disease markers Other Diseases Benzene Quinones Nervous System Disorder Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite NADPH Oxidase
Ubiquinone-1 is an intermediate in the synthesis of Coenzyme Q. Ubiquinone-1 can be reduced by NADPH oxidase, hepatoma cells, Ascorbic acid (HY-B0166) .

HY-128965

N-Glycolylneuraminic acid NeuGc; GcNeu	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Influenza Virus Endogenous Metabolite
N-Glycolylneuraminic acid is a nonhuman sialic acid molecule synthesized in pigs but not in humans. N-Glycolylneuraminic acid works as a decoy receptor of N-Glycolylneuraminic acid-binding influenza A viruses (IAVs) .

HY-Y0488A

Formic acid ammonium 2 Publications Verification Ammonium formate	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Calcium Channel NO Synthase Bacterial ATP Synthase
Formic acid ammonium is the ammonium salt form of formic acid, which is an endogenous metabolite. Formic acid ammonium activates the nitric oxide/cyclic guanosine monophosphate (NO/cGMP) signaling pathway in endothelial cells and inhibits calcium ion influx in vascular smooth muscle cells, resulting in vasomotor relaxation. Formic acid ammonium inhibits cytochrome C oxidase (CcO) and disrupts the electron transport chain, leading to ATP depletion. Formic acid ammonium can be used as a feed additive, which can lower the feed pH value, inhibit the growth of microorganisms (such as Escherichia coli, Salmonella), and extend the shelf life of the feed .

HY-N0340

Scopolamine butylbromide 1 Publications Verification Hyoscine butylbromide; (-)-Scopolamine butylbromide; Butylscopolamine bromide	Alkaloids Structural Classification Other Alkaloids Datura metel L. Solanaceae Plants Source Classification	mAChR
Scopolamine butylbromide (Hyoscine butylbromide) is an orally active anticholinergic agent and spasmolytic. Scopolamine butylbromide binds with high affinity to rat cardiac M2 (K_i 83 nmol/L), hM2 (K_i 233 nmol/L), rat intestinal M3 (K_i 290 nmol/L) and hM3 (K_i 643 nmol/L) muscarinic receptors. Scopolamine butylbromide exerts a dose-dependent antagonistic effect on Carbachol-induced gastrointestinal smooth muscle spasm. Scopolamine butylbromide can be used for the research of abdominal colic and pain associated with gastrointestinal spasm, functional abdominal pain, chronic gastropathy and gastric ulcer .

HY-B0519

Tylosin tartrate 1 Publications Verification	Infection Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Animal Husbandry Mammalian Cell Culture Antibacterial Disease Research Disease Research Fields Source Classification	Bacterial Antibiotic
Tylosin tartrate is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin tartrate exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin tartrate is widely used as a feed additive for promoting animal growth. Tylosin tartrate is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle .

HY-N2424

Flavone 2-Phenyl-4-chromone	Flavonoids Classification of Application Fields Flavones Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	CDK Apoptosis Caspase
Flavone is an anti-tumor compound that targets cell cycle regulatory proteins (such as cyclin B1) and apoptosis-related factors (such as p21_waf1, *PIG3*). Flavone selectively induces mitochondrial-mediated apoptosis pathways in tumor cells, inhibits cyclin B1 protein expression, upregulates p21_waf1, and activates p63/p73 proteins. Flavone has immunomodulatory functions that enhance natural killer cell (NK cell) activity and lymphocyte proliferation. Flavone is used in cancer research, especially for its inhibitory potential in solid tumor models such as esophageal cancer and liver cancer .

HY-N0165

Methyl-Hesperidin	Structural Classification Flavonoids other families Classification of Application Fields Flavonones Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	HIV Reverse Transcriptase
Methyl-Hesperidin is a glycoside compound. Methyl-Hesperidin has hypotensive, coronary dilating, smooth muscle relaxing, capillary stabilizing, choleretic, and anti-ulcer activities. Methyl-Hesperidin act as a competitive substrate to inhibit HIV-1 reverse transcriptase activity. Methyl-Hesperidin potentiates coronary dilating actions of adenine nucleotides and 3'-AMP, enhances depressant action on isolated atria, and prolongs adenosine- and ATP-induced heart block in guinea pigs .

HY-B1340

Carbadox 1 Publications Verification	Infection Alkaloids Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification	Bacterial Antibiotic Endogenous Metabolite
Carbadox is a quinoxaline-di-N-oxide antibiotic compound which is widely fed to nursery-age pigs to control enteric diseases and improve feed efficiency.

HY-N10424

Brazilein 2 Publications Verification	Structural Classification Classification of Application Fields Leguminosae Caesalpinia sappan L. Phenols Polyphenols Pigments Plants Inflammation/Immunology Disease Research Fields Source Classification Food Research	Na+/K+ ATPase Apoptosis Interleukin Related NO Synthase Bacterial Parasite
Brazilein is a compound with anti-inflammatory and neuroprotective activities, with an IC₅₀ of 500 μM against guinea pig Na ⁺,K ⁺-ATPase. Brazilein reduces iNOS mRNA expression, thereby inhibiting nitric oxide production in immune cells. Brazilein suppresses inflammatory responses by reducing the mRNA expression of TNF-α and IL-6, but has no effect on IL-1β expression. Brazilein reduces the cerebral infarction volume and improves the neurological function scores of rats with cerebral ischemia-reperfusion injury. Brazilein induces apoptosis of splenic lymphocytes in mice. Brazilein inhibits humoral immune responses in mice, and causes thymus and spleen atrophy as well as body weight loss in mice. Brazilein also possesses antimalarial and antibacterial activities. Brazilein is also a red dye. Brazilein can be used in studies related to the infection, nervous system, cardiovascular system and inflammatory diseases .

HY-B0519B

Tylosin phosphate 1 Publications Verification	Infection Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Animal Husbandry Antibacterial Disease Research Disease Research Fields Source Classification	Bacterial Antibiotic
Tylosin phosphate is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin tartrate exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin phosphate is widely used as a feed additive for promoting animal growth. Tylosin phosphate is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle .

HY-133091

7-Ethoxycoumarin 7-O-Ethylumbelliferone	Citrus × aurantium Linnaeus Classification of Application Fields Rutaceae Other Diseases Coumarins Phenylpropanoids Plants Disease Research Fields Source Classification	Cytochrome P450
7-Ethoxycoumarin is a substrate of cytochrome P450 (CYP450). 7-Ethoxycoumarin has been used for the functional characterization of various CYPs and for the generation of 7-hydroxycoumarin (HY-N0573) .

HY-N1750

3-(2,4-Dihydroxyphenyl)propanoic acid	Structural Classification Natural Products Classification of Application Fields Plants Moraceae Endogenous metabolite Human Gut Microbiota Metabolites Ficus carica L. Other Diseases Phenols Polyphenols Disease Research Fields Source Classification	Tyrosinase
3-(2,4-Dihydroxyphenyl) propanoic acid (DPPacid) is a competitive Tyrosinase inhibitor. It exhibits an IC₅₀ value of 3.02 μM against mushroom tyrosinase with L-tyrosine as the substrate, an IC₅₀ value of 62 μM with DL-DOPA as the substrate, and a K_i value of 11.5 μM. 3-(2,4-Dihydroxyphenyl) propanoic acid shows no DPPH radical scavenging activity. It can be used in studies related to ultraviolet B (UVB)-induced hyperpigmentation .

HY-N0352

Tuberostemonine 1 Publications Verification	Infection Alkaloids other families Pyrrole Alkaloids Classification of Application Fields Plants Disease Research Fields Source Classification	Parasite
Tuberostemonine is a stenine alkaloid that can be isolated from Stemona tuberosa and Stemona sessifolia. Tuberostemonine is an antimalarial agent that has inhibitory activity against Ferredoxin-NADP ⁺ reductases (FNRs) from Plasmodium falciparum (PfFNR). Tuberostemonine can reduce the number of citric acid-induced coughs in guinea pigs. Tuberostemonine decreases bronchoalveolar lavage fluid (BALF), neutrophil and macrophage infiltration and reduces peribronchial and perivascular inflammatory cell infiltration in mouse model of acute lung inflammation. Tuberostemonine has a level of activity as a feeding deterrent .

HY-N2255

Crebanine 4 Publications Verification	Cardiovascular Disease Structural Classification Alkaloids Stephania venosa Classification of Application Fields Other Alkaloids Plants Menispermaceae Inflammation/Immunology Disease Research Fields	Akt Apoptosis NF-κB Reactive Oxygen Species (ROS) p38 MAPK ERK Interleukin Related TNF Receptor NO Synthase nAChR Bacterial
Crebanine is an isoquinoline-like alkaloid that can be derived from Stephania. Crebanine is an antagonist of the α7-nAChR with an IC₅₀ of 19.1 μM. Crebanine suppresses the proliferation, migration, and invasion of cancer cells, triggers reactive oxygen species (ROS) burst, and promotes apoptosis. Crebanine inhibits the AKT/FoxO3a, NF-κB and MAPK signaling pathways. Crebanine attenuates NOX2 hyperactivation, exhibits antioxidant properties by reducing reactive oxygen species and peroxidation in microglia cells. Crebanine inhibits voltage-dependent Na ⁺ current in guinea-pig ventricular myocytes. Crebanine has high inhibitory activity against gram-positive animal pathogenic bacteria. Crebanine ameliorates ischemia-reperfusion brain damage in middle cerebral artery occlusion and reperfusion (MCAO/R) rats. Crebanine significantly improves Scopolamine (HY-N0296)-induced cognitive deficits in ICR mice. Crebanine can be used for the study of hepatocellular carcinoma (HCC), cerebral ischemia and Alzheimer's disease .

HY-59132

2-Amino-1-phenylethanol	Structural Classification Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Drug Intermediate
2-Amino-1-phenylethanol is a pharmaceutical intermediate that can be used for the synthesis of antimalarial agents and β₂-adrenergic receptor agonists .

HY-101408

Docosatrienoic Acid 1 Publications Verification cis-13,16,19-docosatrienoic acid; (13Z,16Z,19Z)-13,16,19-Docosatrienoic acid	Cardiovascular Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Docosatrienoic acid is a rare ω-3 fatty acid; inhibits LTB4 binding to pig neutrophil membranes with an K_i of 5 μM.

HY-P0004

Lysipressin 2 Publications Verification Lysine vasopressin; [Lys8]-Vasopressin	Monophenols Animals Classification of Application Fields Other Diseases Phenols Disease Research Fields Source Classification	Adenylate Cyclase Oxytocin Receptor
Lysipressin (Lysine vasopressin) is antidiuretic hormone that have been found in pigs. Lysipressin activates Oxytocin receptors and adenylate-cyclase. Lysipressin adjusts blood pressure and heart rate. Lysipressin shows antinociceptive activity .

HY-N2106

Dehydroevodiamine 2 Publications Verification	Alkaloids Classification of Application Fields Evodia rutaecarpa (Juss.) Benth. Rutaceae Plants Inflammation/Immunology Disease Research Fields Indole Alkaloids Source Classification	NF-κB COX PGE synthase NO Synthase
Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes . Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells .

HY-N6678

Zearalanone 2 Publications Verification	Structural Classification Classification of Application Fields Antibacterial Disease Research Microorganisms Macrolide Antibiotics Antibiotics Phenols Polyphenols Anticancer Disease Research Fields Endocrinology Source Classification	Drug Metabolite
Zearalanone is a reductive metabolite of Zearalenone (HY-103447). Zearalanone binds to serum albumin across multiple species. Zearalanone enhances the binding affinity of Warfarin (HY-B0687) to serum albumin .

HY-50723

3-Methylxanthine	Structural Classification Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate (GMP) inhibitor, with an IC₅₀ of 920 μM on guinea-pig isolated trachealis muscle.

HY-108213R

Inosinic acid (Standard) 5'-IMP (Standard); IMP (Standard); Inosine 5'-dihydrogen phosphate (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite	Reference Standards Endogenous Metabolite
Inosinic acid (Standard) is the analytical standard of Inosinic acid. This product is intended for research and analytical applications. Inosinic acid is an endogenous metabolite. Inosinic acid is an endogenous metabolite. Inosinic acid is used as umami tastant, or as the dietary supplement to improve the yield and meat quality of pigs .

HY-N4031

Humantenine	Alkaloids Structural Classification Classification of Application Fields Other Diseases Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Disease Research Fields Indole Alkaloids Source Classification	Anaplastic lymphoma kinase (ALK) METTL3
Humantenine is a highly toxic indole alkaloid from Gelsemium elegans (Gardn. & Champ.) Benth. that binds to RNA m6A modification regulatory proteins (ALKBH5, METTL). Humantenine stably binds via hydrogen bonding and hydrophobic interactions and disrupts the m6A methylation level of target genes, thereby impairing the expression of intestinal epithelial cell tight junction and cytoskeleton-related genes, causing intestinal barrier dysfunction and significant intestinal cytotoxicity. The intraperitoneal injection LD₅₀ values of Humantenine are <1 mg/kg in mice, 1.2 mg/kg in male rats and 1.5 mg/kg in female rats, respectively. Species differences exist in the metabolism of Humantenine in human, porcine, goat and rat liver microsomes, and demethylation, dehydrogenation and oxidation occur in liver microsomes .

HY-N10620

Melitidin	Flavonoids Citrus maxima (Burm.) Merr. Flavones Rutaceae Plants	Others
Melitidin is a flavanone glycoside, that can be isolated from Citrus grandis 'Tomentosa'. Melitidin shows a good antitussive effect on cough induced by citric acid in Guinea pig .

HY-50723R

3-Methylxanthine (Standard)	Structural Classification Natural Products Microorganisms Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Reference Standards
3-Methylxanthine (Standard) is the analytical standard of 3-Methylxanthine. This product is intended for research and analytical applications. 3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate (GMP) inhibitor, with an IC₅₀ of 920 μM on guinea-pig isolated trachealis muscle.

HY-N12520

Helveticoside Strophanthidin-digitoxoside	Structural Classification Senegalia pennata (L.) Maslin Cardiacglycosides Labiatae Plants Steroids Source Classification	Others
Helveticoside (Strophanthidin-digitoxoside) is a helveticosid, possesses an ED₅₀ of 0.17 μM for isolated guinea-pig ileum. Helveticoside has anticancer effect .

HY-108213A

Inosinic acid disodiumhydrate(1:2:X) 4 Publications Verification 5'-IMP disodiumhydrate(1:2:X); IMP disodiumhydrate(1:2:X); Inosine 5'-dihydrogen phosphate disodiumhydrate(1:2:X)	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Inosinic acid (disodium)(hydrate)(1:2:X) (5'-IMP (disodium)(hydrate)(1:2:X)) is an endogenous metabolite. Inosinic acid (disodium)(hydrate)(1:2:X) is used as umami tastant, or as the dietary supplement to improve the yield and meat quality of pigs .

HY-N3931

Gardneramine	Alkaloids Nepenthes mirabilis (Lour.) Druce Plants Nepenthaceae Source Classification	Others
Gardneramine is an orally active alkaloid that acts like papaverine. Gardneramine has peripheral vascular diastolic effect, direct inhibition on myocardium and central inhibition. Gardneramine showed antihypertensive, vasodilatation and atrial inhibition effects in rabbit, dog and guinea pig models, respectively. Gardneramine also inhibits the movement of smooth muscle organs such as the stomach and intestines .

HY-B0519BR

Tylosin phosphate (Standard)	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Animal Husbandry Antibacterial Disease Research Source Classification	Reference Standards Bacterial Antibiotic
Tylosin (phosphate) (Standard) is the analytical standard of Tylosin (phosphate). This product is intended for research and analytical applications. Tylosin phosphate is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin tartrate exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin phosphate is widely used as a feed additive for promoting animal growth. Tylosin phosphate is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle .

HY-118834

Teleocidin A1 Lyngbyatoxin A	Alkaloids Structural Classification Microorganisms Classification of Application Fields Disease Research Fields Indole Alkaloids Source Classification Cancer	PKC
Teleocidin A1 (Lyngbyatoxin A) is a PKC activator with a K_i value of 0.11 nM for binding to the PKCδ-C1B peptide. Teleocidin A1 exhibits anticancer activity against cervical cancer and leukemia. Teleocidin A1 can induce seaweed dermatitis, food poisoning and local skin toxicity. Teleocidin A1 can be used in studies related to cervical cancer, seaweed dermatitis and food poisoning .

HY-103447R

Zearalenone (Standard) Mycotoxin F2(Standard); Toxin F2 (Standard)	Microorganisms Classification of Application Fields Other Diseases Disease Research Fields Source Classification	Reference Standards Estrogen Receptor/ERR
Zearalenone (Standard) is the analytical standard of Zearalenone. This product is intended for research and analytical applications. Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .

HY-103447R1

Zearalenone in Acetonitrile (Standard) Mycotoxin F2 in Acetonitrile (Standard); Toxin F2 in Acetonitrile (Standard)	Microorganisms Ketones, Aldehydes, Acids Phenols Polyphenols Source Classification	Reference Standards Estrogen Receptor/ERR
Zearalenone in Acetonitrile (Standard) is the solution of Zearalenone (Standard) . This product is intended for research and analytical applications. Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .

HY-113829

Valnemulin 2 Publications Verification	Natural Products Animals Source Classification	Antibiotic Bacterial
Valnemulin is an orally active broad-spectrum antibiotic against Gram-negative and Gram-positive bacteria, anaerobic bacteria, Mycoplasma, and Spirochetes. Valnemulin ameliorates enteric diseases, acute polyarthritis and enzootic pneumonia in pigs . Valnemulin exhibits anti-inflammatory efficacy against lipopolysaccharide (HY-D1056)-induced lung injury .

HY-133091R

7-Ethoxycoumarin (Standard) 7-O-Ethylumbelliferone (Standard)	Structural Classification Citrus × aurantium Linnaeus Rutaceae Coumarins Phenylpropanoids Plants Source Classification	Cytochrome P450 Reference Standards
7-Ethoxycoumarin (Standard) is the analytical standard of 7-Ethoxycoumarin. This product is intended for research and analytical applications. 7-Ethoxycoumarin is a substrate of cytochrome P450 (CYP450). 7-Ethoxycoumarin has been used for the functional characterization of various CYPs and for the generation of 7-hydroxycoumarin (HY-N0573) .

HY-B0519AR

Tylosin (Standard)	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Animal Husbandry Mammalian Cell Culture Antibacterial Disease Research Source Classification	Reference Standards Bacterial Antibiotic
Tylosin (Standard) is the analytical standard of Tylosin. This product is intended for research and analytical applications. Tylosin (Tylosin A) is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin is widely used as a feed additive for promoting animal growth. Tylosin is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle .

HY-B0519R

Tylosin tartrate (Standard)	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Animal Husbandry Mammalian Cell Culture Antibacterial Disease Research Source Classification	Reference Standards Bacterial Antibiotic
Tylosin (tartrate) (Standard) is the analytical standard of Tylosin (tartrate). This product is intended for research and analytical applications. Tylosin tartrate is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin tartrate exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin tartrate is widely used as a feed additive for promoting animal growth. Tylosin tartrate is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle .

HY-N3167

Nyasicoside	Curculigo orchioides Gaertn. Phenols Polyphenols Plants Amaryllidaceae Source Classification	Nucleoside Antimetabolite/Analog
Nyasicoside is a norlignan glucosides that can be isolated from Curculigo capitulate. Nyasicoside has potent activity against ouabain-induced arrhythmia in the heart preparations of guinea pig .

HY-113465A

11-trans Leukotriene E4	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
11-trans Leukotriene E4 is an isomer of Leukotriene E4 (LTE4). Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans Leukotriene E4 is equipotent to LTE4 in contracting guinea pig ileum .

HY-N12108

Forphenicine	Microorganisms Ketones, Aldehydes, Acids Phenols Source Classification	Phosphatase
Forphenicine is a bacterial metabolite that is found in S. fulvoviridis and an inhibitor of alkaline phosphatase. Forphenicine inhibits the growth of HL-60 leukemia cells at 10 µM. Forphenicine also increases survival in a guinea pig model of experimental autoimmune encephalomyelitis (EAE) .

HY-118463

Benzomalvin A (-)-Benzomalvin A	Alkaloids Human Gut Microbiota Metabolites Microorganisms Quinoline Alkaloids Endogenous metabolite Source Classification	Neurokinin Receptor
Benzomalvin A is a potent antagonist of neurokinin receptor isolated from Penicillium sp. Benzomalvin A shows inhibitory activity against substance P with K_i values of 12, 42 and 43 μM at the guinea pig, rat and human neurokinin NK1 receptors, respectively .

HY-N3136

Onitin	Monophenols Onychium siliculosum (Desv.) C. Chr. Sinopteridaceae Phenols Plants Source Classification	Histamine Receptor
Onitin is a natural product, that can be isolated from Onychium siliculosum. Onitin is also a non-competitive antagonist of histamine. Onitin shows activity in blocking the peristaltic reflex of the guinea-pig ileum, in inhibition of the responses of guinea-pig ileum to histamine and of inhibition of the responses of guinea-pig tracheal muscle to histamine .

HY-N8671R

Withanoside V (Standard)	Withania somnifera Solanaceae Plants Steroids Source Classification	Reference Standards Others
Withanoside V (Standard) is the analytical standard of Withanoside V. This product is intended for research and analytical applications. Withanoside V, a withanolide glycoside, exhibits inhibitory activity for tachyphylaxis to Clonidine in isolated guinea-pig ileum .

HY-B1340R

Carbadox (Standard)	Structural Classification Alkaloids Other Alkaloids Endogenous metabolite Source Classification	Reference Standards Bacterial Antibiotic Endogenous Metabolite
Carbadox (Standard) is the analytical standard of Carbadox. This product is intended for research and analytical applications. Carbadox is a quinoxaline-di-N-oxide antibiotic compound which is widely fed to nursery-age pigs to control enteric diseases and improve feed efficiency.

HY-128965R

N-Glycolylneuraminic acid (Standard) NeuGc (Standard); GcNeu (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Influenza Virus Endogenous Metabolite
N-Glycolylneuraminic acid (Standard) is the analytical standard of N-Glycolylneuraminic acid. This product is intended for research and analytical applications. N-Glycolylneuraminic acid is a nonhuman sialic acid molecule synthesized in pigs but not in humans. N-Glycolylneuraminic acid works as a decoy receptor of N-Glycolylneuraminic acid-binding influenza A viruses (IAVs) .

HY-P0004R

Lysipressin (Standard) Lysine vasopressin (Standard); [Lys8]-Vasopressin (Standard)	Structural Classification Monophenols Animals Phenols Source Classification	Reference Standards Adenylate Cyclase
Lysipressin (Standard) is the analytical standard of Lysipressin. This product is intended for research and analytical applications. Lysipressin (Lysine vasopressin) is antidiuretic hormone that have been found in pigs and some marsupial families. Lysipressin induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase .

HY-N2106R

Dehydroevodiamine (Standard)	Alkaloids Structural Classification Evodia rutaecarpa (Juss.) Benth. Rutaceae Plants Indole Alkaloids Source Classification	Reference Standards NF-κB COX PGE synthase NO Synthase
Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes . Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells .

HY-N11615R

Cyclo(Pro-Val) (Standard)	Alkaloids Microorganisms Other Alkaloids Source Classification	Others Reference Standards
Tylosin (tartrate) (Standard) is the analytical standard of Tylosin (tartrate). This product is intended for research and analytical applications. Tylosin tartrate is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin tartrate exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin tartrate is widely used as a feed additive for promoting animal growth. Tylosin tartrate is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle .

HY-108213AR

Inosinic acid disodiumhydrate(1:2:X) (Standard) 5'-IMP disodiumhydrate(1:2:X) (Standard); IMP disodiumhydrate(1:2:X) (Standard); Inosine 5'-dihydrogen phosphate disodiumhydrate(1:2:X) (Standard)	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Inosinic acid (disodium)(hydrate)(1:2:X) (Standard) is the analytical standard of Inosinic acid (disodium)(hydrate)(1:2:X). This product is intended for research and analytical applications. Inosinic acid (disodium)(hydrate)(1:2:X) (5'-IMP (disodium)(hydrate)(1:2:X)) is an endogenous metabolite. Inosinic acid (disodium)(hydrate)(1:2:X) is used as umami tastant, or as the dietary supplement to improve the yield and meat quality of pigs .

Cat. No.	Product Name	Chemical Structure

HY-17498S

Atenolol-d7
Atenolol-d₇ is the deuterium labeled Atenolol. Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a K_i of 697 nM atβ1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris .

HY-B0519AS

Tylosin-d3

Tylosin-d₃ is the deuterium labeled Tylosin. Tylosin (Tylosin A) is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin is widely used as a feed additive for promoting animal growth. Tylosin is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle .

HY-103447S1

Zearalenone-13C18
Zearalenone- ¹³C₁₈ (Mycotoxin F2- ¹³C₁₈; Toxin F2- ¹³C₁₈) is the ¹³C labeled Zearalenone (HY-103447) . Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .

HY-103447S

(Rac)-Zearalenone-d6
(Rac)-Zearalenone-d₆ is the deuterium labled Zearalenone (HY-103447). Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .

HY-141582S

Ceramide 3-d3

Ceramide 3-d₃ (N-Stearoyl phytosphingosine-d₃) is deuterium labeled Ceramide 3. Ceramide 3 is an orally active major component of intercellular lipids in the stratum corneum of the skin, and belongs to the ceramide family. Ceramide 3 inhibits c-jun and NF-κB activation induced by Histamine (HY-B1204), and suppresses the expression of IL-4 and TNF-α. Ceramide 3 inhibits scratching behavior and vascular permeability in mice, and exhibits antihistamine effects in guinea pig ileum. Ceramide 3 improves skin barrier function, reduces transepidermal water loss, erythema and the number of circulating epidermal cells, and accelerates barrier repair of irritated or dysfunctional skin.

HY-B1421S

Ractopamine-d6 hydrochloride

Ractopamine-d₆ (LY031537-d₆) hydrochloride is the deuterium labeled Ractopamine hydrochloride (HY-B1421). Ractopamine (LY031537) hydrochloride is a potent β-adrenergic receptor (βAR) agonist with K_d values of ~25 nM for pig β₁AR and β₂AR. Ractopamine hydrochloride is linked to protein metabolism. Ractopamine hydrochloride can be used for researching to increase lean tissue growth and improve production efficiency in pigs .

HY-50723S1

3-Methylxanthine-d3
3-Methylxanthine-d₃ is deuterated labeled 3-Methylxanthine (HY-50723). 3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate (GMP) inhibitor, with an IC₅₀ of 920 μM on guinea-pig isolated trachealis muscle.

HY-B0905S

Tilmicosin-d3

Tilmicosin-d3 is the deuterium labeled Tilmicosin. Tilmicosin (LY-177370) is an orally active calcium channel antagonist and macrolide antibiotic with antimicrobial activity. Tilmicosin mainly acts on the 50S subunit of bacterial ribosomes, inhibiting protein synthesis. Tilmicosin is effective in the treatment of respiratory diseases in livestock such as cattle, sheep and pigs. In addition, Tilmicosin has immunomodulatory and anti-inflammatory effects .

HY-176524S

PDE3/4-IN-3
PDE3/4-IN-3 (Compound 7) is an orally active dual PDE3/4 inhibitor with IC₅₀s of 0.17 and ≤50 nM for PDE3A and PDE4B2, respectively. PDE3/4-IN-3 significantly inhibits methacholine-induced bronchoconstriction in guinea pigs. PDE3/4-IN-3 can be used for chronic obstructive pulmonary disease (COPD) and asthma research .

HY-13402S

Varespladib-d7

Varespladib-d₇ (LY315920-d₇) is a deuterated labeled Varespladib (HY-13402). Varespladib is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC₅₀ of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC₅₀s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .

HY-B1340S

Carbadox-d3
Carbadox-d₃ is the deuterium labeled Carbadox. Carbadox is a quinoxaline-di-N-oxide antibiotic compound which is widely fed to nursery-age pigs to control enteric diseases and improve feed efficiency.

HY-W766785

Tiamulin Fumarate-13C4
Tiamulin Fumarate- ¹³C₄ is the ¹³C-labeled Tiamulin. Tiamulin (Thiamutilin) fumarate is a diterpenic antibiotic that is widely used in pigs and poultry for the control of infectious diseases. Tiamulin fumarate is effectively used in the study of airsacculitis, which is primarily caused by Mycoplasma spp .

HY-B2060S1

Tiamulin-d10-1 hydrochloride
Tiamulin-d₁₀-1 (hydrochloride) is deuterium labeled Tiamulin. Tiamulin (Thiamutilin) is a diterpenic antibiotic that is widely used in pigs and poultry for the control of infectious diseases. Tiamulin is effectively used in the study of airsacculitis, which is primarily caused by Mycoplasma spp .

HY-W769319

Inosinic acid-13C5
Inosinic acid- ¹³C₅ (5'-IMP- ¹³C₅) is the ¹³C-labeled Inosinic acid (HY-108213). Inosinic acid is an endogenous metabolite. Inosinic acid is used as umami tastant, or as the dietary supplement to improve the yield and meat quality of pigs .

HY-13511AS

Rupatadine-d4 fumarate
Rupatadine-d₄ fumarate is a deuterium labeled Rupatadine fumarate. Rupatadine Fumarate (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with K_i values of 0.55/0.1 μM (rabbit platelet membranes/guinea pig cerebellum membranes) .

HY-W751275

Ractopamine-13C2

Ractopamine- ¹³C₂ is the ¹³C-labeled Ractopamine (HY-113781). Ractopamine (LY031537 free base) is a potent and orally active β-adrenergic receptor (βAR) agonist with K_d value of ~25 nM for pig β1AR and β2AR. Ractopamine also is a mTAAR1 agonist with an EC₅₀ of 16 μM. Ractopamine promotes muscle mass development, limits fat deposition, reduces feed consumption, increases total cellular protein synthesis, and improves growth rate and feed efficiency in finishing swine. Ractopamine can be used for researching to increase lean tissue growth and improve production efficiency in pigs .

HY-W751276

Ractopamine-13C6

Ractopamine- ¹³C₆ is the ¹³C-labeled Ractopamine (HY-113781). Ractopamine (LY031537 free base) is a potent and orally active β-adrenergic receptor (βAR) agonist with K_d value of ~25 nM for pig β1AR and β2AR. Ractopamine also is a mTAAR1 agonist with an EC₅₀ of 16 μM. Ractopamine promotes muscle mass development, limits fat deposition, reduces feed consumption, increases total cellular protein synthesis, and improves growth rate and feed efficiency in finishing swine. Ractopamine can be used for researching to increase lean tissue growth and improve production efficiency in pigs .

HY-103447S2

Zearalenone-13C7
Zearalenone- ¹³C₇ (Mycotoxin F2- ¹³C₇) is ¹³C labeled Zearalenone. Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .

HY-17498S1

Atenolol-d6
Atenolol-d₆ ((RS)-Atenolol-d₆) is deuterium labeled Atenolol. Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a K_i of 697 nM at β1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris .

HY-17498S3

Atenolol-13C6
Atenolol- ¹³C₆ ((RS)-Atenolol- ¹³C₆) is ¹³C labeled Atenolol. Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a K_i of 697 nM at β1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris .

HY-108213S1

Inosinic acid-15N4 dilithium
Inosinic acid- ¹⁵N₄ dilithium (5'-IMP-15N4 (dilithium); IMP-15N4 (dilithium); Inosine 5'-(dihydrogen phosphate)-15N4 (dilithium)) is ¹⁵N-labeled Inosinic acid (HY-108213). Inosinic acid is an endogenous metabolite. Inosinic acid is used as umami tastant, or as the dietary supplement to improve the yield and meat quality of pigs .

HY-124410S

Mitoquinol-d15

Mitoquinol-d₁₅ is deuterium labeled Mitoquinol (HY-124410). Mitoquinol is an orally active mitochondria-targeted antioxidant. Mitoquinol can regulate mitochondrial respiration and oxidation. Mitoquinol inhibits ROS production, and improves phagocytosis and glycolysis in ethanol-exposed macrophages via the HIF-1α-PFKP axis. Additionally, Mitoquinol can partially alleviate heat stress-induced decreases in growth performance, inflammatory responses, and metabolic disorders in pigs .

HY-B0281AS

Ranitidine-d6 hydrochloride

Ranitidine-d₆ hydrochloride is the deuterium labeled Ranitidine hydrochloride (HY-B0281A) . Ranitidine hydrochloride is a potent, selective and orally active histamine H2-receptor antagonist that inhibits gastric secretion. Ranitidine hydrochloride antagonizes Histamine (HY-B1204)-induced increases of the guinea-pig isolated rat atrium and Histamine-induced relaxations of the rat isolated uterine horn, with pA₂ values of 7.2 and 6.95, respectively. Ranitidine hydrochloride inhibits breast tumor development and spread in mice .

HY-B0693S

Ranitidine-d6

Ranitidine-d₆ is the deuterium labeled Ranitidine (HY-B0693). Ranitidine is a potent, selective and orally active histamine H2-receptor antagonist that inhibits gastric secretion. Ranitidine antagonizes Histamine (HY-B1204)-induced increases of the guinea-pig isolated rat atrium and Histamine-induced relaxations of the rat isolated uterine horn, with pA2 values of 7.2 and 6.95, respectively. Ranitidine inhibits breast tumor development and spread in mice .

HY-A0168S

Regadenoson-d3

Regadenoson-d₃ is the deuterium labeled Regadenoson. Regadenoson (CVT-3146) is a potent and selective A2A adenosine receptor agonist, with K_is of 290 and 1120 nM for rat and pig adenosine A2A receptor, respectively. Regadenoson is selective for the adenosine A2A receptor over adenosine A1 and A2B receptors, and shows 13-fold selectivity over the human adenosine A1 receptor. Regadenoson is a vasodilator stress agent has shifted the landscape of vasodilator myocardial perfusion imaging. Regadenoson increases blood-brain barrier (BBB) permeability in rodents .

HY-113781S

Ractopamine-d6

Ractopamine-d₆ is the deuterium labeled Ractopamine (HY-113781). Ractopamine (LY031537) hydrochloride is a potent β-adrenergic receptor (βAR) agonist with K_d values of ~25 nM for pig β₁AR and β₂AR. Ractopamine hydrochloride is linked to protein metabolism. Ractopamine hydrochloride can be used for researching to increase lean tissue growth and improve production efficiency in pigs .

HY-B1421S1

Ractopamine-d9 hydrochloride

Ractopamine-d₉ (LY031537-d₉) hydrochloride is the deuterium labeled Ractopamine hydrochloride (HY-B1421). Ractopamine (LY031537) hydrochloride is a potent β-adrenergic receptor (βAR) agonist with K_d values of ~25 nM for pig β₁AR and β₂AR. Ractopamine hydrochloride is linked to protein metabolism. Ractopamine hydrochloride can be used for researching to increase lean tissue growth and improve production efficiency in pigs .

HY-B1421S3

Ractopamine-d5 hydrochloride

Ractopamine-d₅ (LY031537-d₅) hydrochloride is the deuterium labeled Ractopamine hydrochloride (HY-B1421). Ractopamine (LY031537) hydrochloride is a potent β-adrenergic receptor (βAR) agonist with K_d values of ~25 nM for pig β₁AR and β₂AR. Ractopamine hydrochloride is linked to protein metabolism. Ractopamine hydrochloride can be used for researching to increase lean tissue growth and improve production efficiency in pigs .

HY-W769319A

Inosinic acid-13C5 TEA
Inosinic acid- ¹³C₅ (5'-IMP- ¹³C₅) TEA is the ¹³C-labeled Inosinic acid (HY-108213). Inosinic acid is an endogenous metabolite. Inosinic acid is used as umami tastant, or as the dietary supplement to improve the yield and meat quality of pigs .

HY-B1421S2

Ractopamine-d3 hydrochloride

Ractopamine-d₃ (LY031537-d₃) hydrochloride is the deuterium labeled Ractopamine hydrochloride (HY-B1421). Ractopamine hydrochloride (LY031537) is a potent and orally active β-adrenergic receptor (βAR) agonist with K_d value of ~25 nM for pig β1AR and β2AR. Ractopamine hydrochloride also is a mTAAR1 agonist with an EC₅₀ of 16 μM. Ractopamine hydrochloride promotes muscle mass development, limits fat deposition, reduces feed consumption, increases total cellular protein synthesis, and improves growth rate and feed efficiency in finishing swine. Ractopamine hydrochloride can be used for researching to increase lean tissue growth and improve production efficiency in pigs .

HY-W766130

Ethisterone-13C2

Ethisterone- ¹³C₂ (Pregneninolone- ¹³C₂) is the ¹³C-labeled Ethisterone (HY-B0487). Ethisterone (Pregneninolone; 17α-Ethynyltestosterone) is a synthetic steroidal estrogen, is an orally active steroidal contraceptive agent. Ethisterone has almost no effect on the phagocytic activity of the reticuloendothelial system in male guinea pigs, while in utero exposure can induce abnormalities in the urogenital system of offspring.

Cat. No.	Product Name		Classification

HY-137243

Adenosine 3',5'-diphosphate disodium		Nucleotide Analogs Adenine Nucleotide
Adenosine 3',5'-diphosphate disodium is an endogenous purine nucleotide. Adenosine 3',5'-diphosphate disodium acts as an inhibitor of bovine adrenal estrogen sulfotransferase (EST) with a K_i value of 7.0 μM. It also serves as an indispensable specific cofactor for the pregnenolone-binding protein (PBP) steroid-binding complex, with an EC₅₀ value of 1.5 μM in guinea pigs .

HY-121799A

Taurohyocholic acid sodium salt THCA sodium salt		Cholesterol
Taurohyocholic acid (THCA) sodium salt is a taurine-conjugated hyocholic acid. Taurohyocholic acid sodium salt is predictor of the efficacy of tyrosine kinase inhibitors combined withPD-1 inhibitors in hepatocellular carcinoma (HCC) .

HY-RS29455

*UBE2E2 Pig* Pre-designed siRNA Set A**		siRNAs
UBE2E2 Pig Pre-designed siRNA Set A contains three designed siRNAs for UBE2E2 gene (Pig), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS29454

*UBE2E1 Pig* Pre-designed siRNA Set A**		siRNAs
UBE2E1 Pig Pre-designed siRNA Set A contains three designed siRNAs for UBE2E1 gene (Pig), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS10501

PIGS Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PIGS Human Pre-designed siRNA Set A contains three designed siRNAs for PIGS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS29460

*SREBF1 Pig* Pre-designed siRNA Set A**		siRNAs Pre-designed siRNA Sets
SREBF1 Pig Pre-designed siRNA Set A contains three designed siRNAs for SREBF1 (Pig), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS29448

*ILF2 Pig* Pre-designed siRNA Set A**		siRNAs Pre-designed siRNA Sets
ILF2 Pig Pre-designed siRNA Set A contains three designed siRNAs for ILF2 gene (Pig), as well as a negative control, a positive control, and a FAM-labeled negative control. Components ILF2 siRNA-1: 5 nmol (HPLC) ILF2 siRNA-2: 5 nmol (HPLC) ILF2 siRNA-3: 5 nmol (HPLC) siRNA Negative Control: 5 nmol (HPLC) FAM-labeled siRNA Negative Control: 5 nmol (HPLC) GAPDH siRNA Positive Control: 5 nmol (HPLC)

HY-159750

M903		Adjuvant
M903 is a new type of mineral oil-based adjuvant, which belongs to water-in-oil-in-water (w/o/w) emulsion. It can enhance both cellular and humoral immunity against non-specific antigens, stimulate specific immunity against the antigens, delay the release of the antigens in the body, and improve the immunity of animals. It is applicable to various veterinary vaccines, including inactivated vaccines and genetically engineered subunit vaccines, such as pig vaccines for foot-and-mouth disease and blue ear disease.

HY-RS29485

*TLR2 Pig* Pre-designed siRNA Set A**		siRNAs Pre-designed siRNA Sets
TLR2 Pig Pre-designed siRNA Set A contains three designed siRNAs for TLR2 (Pig), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-185123

Pig TRIM56 mRNA		mRNA
Pig TRIM56 mRNA encodes the pig TRIM56 protein, an interferon-stimulated gene (ISG) that acts as an important innate immune factor. Overexpression of TRIM56 restricts viral replication by enhancing TLR3-TRAF3-mediated IFN-β production .

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