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Pathways Recommended:	Protein Tyrosine Kinase/RTK

Results for "

protein tyrosine phosphatases (PTPs)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Aldose Reductase (1) Amyloid-β (1) Antibiotic (1) Apoptosis (8) Autophagy (1) Beta-secretase (1) Cytochrome P450 (1) Enterovirus (1) Glycosidase (4) Histone Methyltransferase (1) IFNAR (1) JAK (1) Lipoxygenase (1) MDM-2/p53 (1) MHC (1) Monoamine Oxidase (1) NF-κB (1) Parasite (3) Phosphatase (92) PPAR (1) Pregnane X Receptor (PXR) (1) PROTACs (1) PTEN (3) Reference Standards (4) SHP1 (6) SHP2 (8) STAT (1) Tie (3) TMV (1)
By Research Areas:	Cancer (21) Cardiovascular Disease (2) Endocrinology (5) Infection (6) Inflammation/Immunology (14) Metabolic Disease (52) Neurological Disease (8)
Oligonucleotides:	Antisense Oligonucleotides (2)

Inhibitors & Agonists

Screening Libraries

MCE Kits

Inhibitory Antibodies

Natural
Products

Oligonucleotides

Razuprotafib 4 Publications Verification AKB-9778	Phosphatase Tie	Inflammation/Immunology
Razuprotafib (AKB-9778) is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase) with an IC₅₀of 17 pM. Razuprotafib promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK. Razuprotafib inhibits the structurally related phosphatase PTP1B with an IC₅₀ of 780 nM. Razuprotafib shows excellent selectivity for VE-PTP versus a variety of phosphatases, with the exception of HPTPη (IC₅₀=36 pM) and HPTPγ (100 pM) .

MSI-1436 lactate Maximum Cited Publications 8 Publications Verification Trodusquemine lactate; Aminosterol-1436 lactate	Phosphatase	Endocrinology
MSI-1436 lactate is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B), with an IC₅₀ of 1 μM, 200-fold preference over TCPTP (IC₅₀ of 224 μM).

NSC-87877 3 Publications Verification	SHP2 SHP1 Phosphatase Apoptosis	Others
NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC₅₀ values of 0.318 μM, 0.355 μM shp2 and shp1, respectively . NSC-87877 also inhibits *dual-specificity phosphatase* 26 (DUSP26)** .

PTP inhibitor 1	Phosphatase	Cancer
PTP inhibitor 1 is a protein tyrosine phosphatase (PTP) inhibitor, with anti-angiogenic effect .

Prunin 4 Publications Verification Naringenin 7-0-glucoside	Enterovirus Phosphatase	Infection Metabolic Disease
Prunin is a potent inhibitor of human enterovirus A71 (HEVA71). Prunin shows strong inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), with an IC₅₀ of 5.5 μM .

NAZ2329 3 Publications Verification	Phosphatase	Cancer
NAZ2329, the first cell-permeable inhibitor of R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs), allosterically and preferentially inhibits PTPRZ (IC₅₀=7.5 µM for hPTPRZ1) and PTPRG (IC₅₀=4.8 µM for hPTPRG) over other PTPs. NAZ2329 binds to the active D1 domain and more potently inhibits PTPRZ-D1 fragment (IC₅₀ of 1.1 µM) than the whole intracellular (D1 + D2) fragment (IC₅₀ of 7.5 µM). NAZ2329 can effectively inhibit tumor growth of the glioblastoma cells and suppress stem cell-like properties .

BVT948 2 Publications Verification	Phosphatase Cytochrome P450 Histone Methyltransferase	Cancer
BVT948 is a **protein tyrosine phosphatase** (PTP) inhibitor which can also inhibit several cytochrome P450 (P450) isoforms and lysine methyltransferase SETD8 (KMT5A).

DPM-1001	Phosphatase	Metabolic Disease
DPM-1001 is a potent, specific, orally active and non-competitive inhibitor of **protein-tyrosine phosphatase (PTP1B) with an IC₅₀** of 100 nM. DPM-1001 is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 has anti-diabetic property .

Bis(maltolato)oxovanadium(IV) BMOV	SHP2 Phosphatase	Metabolic Disease
Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases) inhibitor. Bis(maltolato)oxovanadium(IV) inhibits HCPTPA, *PTP1B, HPTPβ* and SHP2 with IC₅₀s of 126 nM, 109 nM, 26 nM and 201 nM, respectively. Bis(maltolato)oxovanadium(IV) is a potent insulin sensitizer .

PTP1B-IN-2 4 Publications Verification	Phosphatase	Metabolic Disease
PTP1B-IN-2 is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC₅₀ of 50 nM.

SPI-112 1 Publications Verification	SHP2 Phosphatase	Cancer
SPI-112 is a potent, selective and competitive SHP2 (PTPN11) inhibitor with IC₅₀s of 1 μM, 18.3 μM and 14.5 μM for SHP2, protein tyrosine phosphatase (PTP) and PTP1B, respectively .

Licochalcone C 4 Publications Verification	Glycosidase	Metabolic Disease
Licochalcone C could inhibit α-glucosidase, with IC₅₀s of <100 nM and 92.43 μM for α-glucosidase and protein tyrosine phosphatase 1B (PTP1B), respectively.

MSI-1436 Trodusquemine; Aminosterol-1436	Phosphatase	Endocrinology
MSI-1436 is a selective, non-competitive inhibitor of the enzyme **protein-tyrosine phosphatase 1B (PTP1B), with an IC₅₀** of appr 1 μM, 200-fold preference over TCPTP (IC₅₀, 224 μM).

MY33-3	Phosphatase	Neurological Disease
MY33-3 is a potent and selective inhibitor of *receptor protein* tyrosine phosphatase (RPTP)β/ζ, with an IC₅₀ of ~0.1 μM. MY33-3 also inhibits PTP-1B (IC₅₀** ~0.7 μM). MY33-3 can reduce ethanol consumption and alleviate Sevoflurane-induced neuroinflammation and cognitive dysfunction .

bpV(phen) 3 Publications Verification	PTEN Phosphatase Parasite Apoptosis	Infection Metabolic Disease Inflammation/Immunology Cancer
bpV(phen), a insulin-mimetic agent, is a potent **protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC₅₀s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B*, respectively. bpV(phen) inhibits proliferation of the protozoan parasite Leishmania* in vitro. bpV(phen) strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ). bpV(phen) can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity .

TCS 401 2 Publications Verification	Phosphatase	Metabolic Disease
TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).

PTP1B-IN-4 1 Publications Verification	Phosphatase	Metabolic Disease
PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase *PTP1B, with an IC₅₀* of 8 μM. PTP1B-IN-4 is potentail for the research of obesity and diabetes .

DJ001	Phosphatase Apoptosis	Inflammation/Immunology
DJ001 is a highly specific, selective and non-competitive protein tyrosine phosphatase-σ (PTPσ) inhibitor with an IC₅₀ of 1.43 μM. DJ001 displays no inhibitory activity against other phosphatases, with only modest inhibitory activity against Protein Phosphatase 5. DJ001 promotes promote hematopoietic stem cell regeneration .

NSC-87877 disodium 3 Publications Verification	SHP2 SHP1 Phosphatase Apoptosis	Cancer
NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC₅₀ values of 0.318 μM, 0.355 μM shp2 and shp1, respectively . NSC-87877 also inhibits *dual-specificity phosphatase* 26 (DUSP26)** .

KY-226 2 Publications Verification	Phosphatase	Neurological Disease Metabolic Disease
KY-226 is a potent, selective, orally active and allosteric **protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC₅₀** of 0.25 μM, and without PPARγ agonist activity. KY-226 exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling, respectively. KY-226 also protects neurons from cerebral ischemic injury .

Licoflavone A 3 Publications Verification	Phosphatase	Neurological Disease
Licoflavone A is a flavonoid isolated from the roots of Glycyrrhiza uralensis, inhibits protein tyrosine phosphatase-1B (PTP1B), with an IC₅₀ of 54.5 μM .

MLS-0437605 1 Publications Verification	Phosphatase	Cardiovascular Disease
MLS-0437605 is a selective *dual-specificity phosphatase* 3 (DUSP3) inhibitor with an IC₅₀** of 3.7 μM. MLS-0437605 is more selective for DUSP3 than DUSP22 and other protein tyrosine phosphatases (PTPs) .

BpV(phen) trihydrate 3 Publications Verification Bisperoxovanadium(phen) trihydrate	PTEN Phosphatase Parasite Apoptosis	Infection Metabolic Disease Inflammation/Immunology Cancer
BpV(phen) trihydrate, a insulin-mimetic agent, is a potent **protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC₅₀s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B*, respectively. BpV(phen) trihydrate inhibits proliferation of the protozoan parasite Leishmania* in vitro. bpV(phen) trihydrate strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ). BpV(phen) trihydrate can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity .

PTP Inhibitor IV	Phosphatase SHP2	Cancer
PTP Inhibitor IV is a **protein tyrosine phosphatase (PTP)** inhibitor that competitively inhibits DUSP14 phosphatase activity with an ₅₀ of 5.21 μM . PTP Inhibitor IV inhibits SHP-2, PTP1B, PTP-ε, PTP Meg-2, PTP-σ, PTP-β, and PTP-μ with ₅₀s of 1.8 μM, 2.5 μM, 8.4 μM, 13 μM, 20 μM, 6.4 μM, and 6.7 μM, respectively .

DPM-1001 trihydrochloride	Phosphatase	Metabolic Disease
DPM-1001 trihydrochloride is a potent, specific, orally active and non-competitive inhibitor of **protein-tyrosine phosphatase (PTP1B) with an IC₅₀** of 100 nM. DPM-1001 trihydrochloride is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 trihydrochloride has anti-diabetic property .

MurA-IN-1 1 Publications Verification	Phosphatase	Others
MurA-IN-1 (compound 1a) is a PTPRR inhibitor, with IC₅₀ values of 0.23 μM, 0.8 μM, 0.75 μM and 0.09 μM for PTP1B, PTPN5, PTPN7 and PTPRR, respectively . (A family of human MAPK-specific protein tyrosine phosphatases)

Diorcinol	SHP1 Phosphatase	Metabolic Disease
Diorcinol is a potent SHP1 inhibitor with an IC₅₀ value of 0.96 μM. Diorcinol can be isolated from Aspergillus sydowii. Diorcinol has good blood-brain barrier penetration and can be used for diabetes research .

JTT 551	Phosphatase	Metabolic Disease
JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with K_is of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively; JTT 551 can be used in the research of type 2 diabetes mellitus.

3,5-Difluoro-L-tyrosine	Phosphatase	Others
3,5-Difluoro-L-tyrosine is a functional, tyrosinase-resistant mimetic of tyrosine. 3,5-Difluoro-L-tyrosine can be used to analyze the substrate specificity of protein tyrosine phosphatases (PTPs) .

(4-Phenylphenoxy)phosphonic acid	Phosphatase	Infection
(4-Phenylphenoxy) phosphonic acid is a protein tyrosine phosphatase (PTP) inhibitor (K_M: 86 μM). (4-Phenylphenoxy) phosphonic acid can be used in tuberculosis research .

Isotanshinone IIA	Phosphatase	Metabolic Disease
Isotanshinone IIA, an abietane-type diterpene metabolite, could non-competitively inhibit Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC₅₀ 0f 11.4 μM.

SPAA-52	Phosphatase	Metabolic Disease
SPAA-52 is an orally active, competitive and reversible low-molecular-weight protein tyrosine phosphatase (LMW-PTP) inhibitor (IC₅₀=4 nM, K_i=1.2 nM). SPAA-52 can be used in diabete research .

Lobaric acid	Phosphatase TMV Lipoxygenase	Cancer
Lobaric acid is a depsipeptide metabolite isolated from Stereocaulon lichen with antioxidant, antiproliferative, antiviral and enzyme inhibitory activities. Lobaric acid scavenges superoxide free radicals (IC₅₀=97.9 μM) and inhibits cancer cell proliferation (EC₅₀ of 15.2-63.9 μg/mL against leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic and lung cancer cell lines). Lobaric acid inhibits protein tyrosine phosphatase 1B (PTP1B; IC₅₀=0.87 μM for human recombinant enzyme) and 12(S)-HETE produced by 12(S)-lipoxygenase (IC₅₀=28.5 μM). Lobaric acid (250 μM) also reduced pathological changes in tobacco leaves infected with tobacco mosaic virus (TMV).

Momordicoside A	Phosphatase	Metabolic Disease
Momordicoside A is isolated from Momordica charantia L. Momordicoside A has the inhibitory effect on **protein tyrosine phosphatase (PTP1B)** .

Cyanidin 3-arabinoside	Phosphatase	Metabolic Disease
Cyanidin 3-arabinoside is a selective and reversible **protein tyrosine phosphatase 1B (PTP1B) inhibitor, with an IC₅₀** of 8.91 μM. Cyanidin 3-arabinoside is potential for the research of type 2 diabetes .

Sophoraisoflavone A Allolicoisoflavone B	Phosphatase	Inflammation/Immunology
Sophoraisoflavone A (Allolicoisoflavone B) is a nature product that could be isolated from Glycyrrhiza inflate. Sophoraisoflavone A is a potent **protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC₅₀** value of 0.80 μM. Sophoraisoflavone A can be used in research of inflammation .

Deoxyneocryptotanshinone	Beta-secretase Phosphatase	Neurological Disease
Deoxyneocryptotanshinone, a natural tanshinone, is a high affinity BACE1 (Beta-secretase) inhibitor with an IC₅₀ value of 11.53 μM. Deoxyneocryptotanshinone shows a promising dose-dependent inhibition of **protein tyrosine phosphatase 1B (PTP1B) with an IC₅₀** value of 133.5 μM. Deoxyneocryptotanshinone can be used for Alzheimer's disease research .

Cryptosporioptide A	Phosphatase SHP1	Metabolic Disease
Cryptosporioptide A (Compound 3) is a pigment protein tyrosine phosphatase inhibitor derived from the insect-parasitic fungus Cordyceps gracilioides. Cryptosporioptide A inhibits PTP1B, SHP2, CDC25B, LAR and SHP1 enzymes with IC₅₀ of 7.3, 5.7, 7.6, >50, 4.9 μg/mL, respectively .

GS-493	SHP2 SHP1 Phosphatase	Cancer
GS-493 is a selective protein tyrosine phosphatase SHP2 (PTPN11) inhibitor with an IC₅₀ of 71 nM. GS-493 is 29- and 45-fold more active toward SHP2 than related SHP1 and PTP1B. GS-493 blocks cellular motility and growth of cancer cells. Antitumor activity .

TP1L	PROTACs Phosphatase JAK IFNAR MHC	Cancer
TP1L is a potent and selective T-cell protein tyrosine phosphatase (TC-PTP) PROTAC degrader, with a DC₅₀ value of 35.8 nM. TP1L elevates the phosphorylation level of *TC-PTP* substrates including pSTAT1 and pJAK1. TP1L selectively enhances IFN-γ signaling and increases MHC-I expression. TP1L activates TCR signaling through increases phosphorylation of LCK. TP1L enhances CAR-T cell mediated tumor killing efficacy through activation of the CAR-T cells. TP1L can be used for the study of cancer. (Pink: TC-PTP ligand: (HY-138964), Blue: E3 ligase CRBN Ligand (HY-A0003), Black: Linker: (HY-140002)) .

PTP1B-IN-15	Phosphatase	Endocrinology
PTP1B-IN-15 is a potent and selective inhibitor of protein tyrosine phosphatase 1B (PTP1B). PTP1B-IN-15 has the potential for the research of type II diabetes and obesity .

PTP1B-IN-22	Phosphatase	Metabolic Disease
PTP1B-IN-22, a ZINC02765569 derivative, is a potent **protein tyrosine phosphatase 1B (PTP1B)** inhibitor. PTP1B-IN-22 has PTP1B inhibition and glucose uptake in skeletal muscle L6 myotubes .

SHP844	SHP2	Cancer
SHP844 is a SHP2 inhibitor with the IC₅₀ of 18.9 µM. SHP2 is a protein tyrosine phosphatase (PTP) that regulates tyrosine phosphorylation levels and is involved in cell proliferation, differentiation and survival .

IONIS PTP1BRx ISIS 404173	Phosphatase	Metabolic Disease
IONIS PTP1BRx (ISIS 404173) is an antisense inhibitor of **protein tyrosine phosphatase 1B (PTP-1B)*. IONIS PTP*1BRx shows antidiabetic activity, and can be used for the study of insulin resistance and type 2 diabetes mellitus associated with obesity .

cis-Emodin-physcion bianthrone	Phosphatase	Metabolic Disease
cis-Emodin-physcion bianthrone is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B), with an IC₅₀ value of 7.29 μM. cis-Emodin-physcion bianthrone can be used for research on type 2 diabetes .

Cassiaside B2	Phosphatase Monoamine Oxidase 5-HT Receptor	Inflammation/Immunology
Cassiaside B2 is a protein tyrosine phosphatase 1B *(PTP1B)* and human monoamine oxidase A (hMAO-A) inhibitor. Cassiaside B2 possesses antiallergic and is a 5-HT2C receptor agonist . ..

Cat. No.	Product Name

HY-L081

Phosphatase Inhibitor Library

175 compounds

Protein phosphorylation is a key post-translational modification underlying the regulation of many cellular processes. Phosphatases and kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. This reversible regulation of protein phosphorylation is critical for the proper control of a wide range of cellular activities, including cell cycle, proliferation and differentiation, metabolism, cell-cell interactions, etc.

Protein phosphatases have evolved in separate families that are structurally and mechanistically distinct. Based on substrate specificity and functional diversity, protein phosphatases are classified into two superfamilies: Protein serine/threonine phosphatases and Protein tyrosine phosphatases. Ser/Thr phosphatases are metalloenzymes belonging to two major gene families termed PPP (phosphoprotein phosphatase) and PPM (metal-dependent protein phosphatases), whereas protein tyrosine phosphatases (PTPs) belong to distinct classes of enzymes that utilize a phospho-cysteine enzyme intermediate as a part of their catalytic action.

MCE supplies a unique collection of 175 phosphatase inhibitors that mainly targeting protein tyrosine phosphatases (PTPs) and serine/threonine-specific protein phosphatases. MCE Phosphatase Inhibitor Library is a useful tool for phosphatase drug discovery and related research.

Cat. No.	Product Name

HY-K0022

Phosphatase Inhibitor Cocktail Ⅱ (100× in ddH₂O) 455+ Cited Publications
Phosphatase Inhibitor Cocktail Ⅱ (100× in ddH₂O) is a blend of 5 phosphatase inhibitors that can broadly inhibit acid phosphatases, alkaline phosphatases, and protein tyrosine phosphatases (PTPs).The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Cat. No.	Product Name	Target	Research Area	Image

HY-P991852

Anti-CD45RO Antibody (UCHL-1)	Phosphatase	Cancer
Anti-CD45RO Antibody (UCHL-1) reacts with the human CD45RO. CD45 is a glycoprotein member of the protein tyrosine phosphatase (PTP) family known for its involvement in regulating a variety of cellular processes. Recommend Isotype Controls: Mouse IgG2a kappa, Isotype Control (HY-P99978) .

Cat. No.	Product Name		Classification

HY-159694

IONIS PTP1BRx ISIS 404173		Antisense Oligonucleotides
IONIS PTP1BRx (ISIS 404173) is an antisense inhibitor of **protein tyrosine phosphatase 1B (PTP-1B)*. IONIS PTP*1BRx shows antidiabetic activity, and can be used for the study of insulin resistance and type 2 diabetes mellitus associated with obesity .

HY-159694A

IONIS PTP1BRx sodium ISIS 404173 sodium		Antisense Oligonucleotides
IONIS PTP1BRx (ISIS 404173) sodium is an antisense inhibitor of **protein tyrosine phosphatase 1B (PTP-1B)*. IONIS PTP*1BRx sodium shows antidiabetic activity, and can be used for the study of insulin resistance and type 2 diabetes mellitus associated with obesity .

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