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Results for "

scar

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (2) CCR (1) Claudin (1) CX3CR1 (1) Deubiquitinase (1) Drug Metabolite (1) E1/E2/E3 Enzyme (1) Endogenous Metabolite (1) Estrogen Receptor/ERR (2) GABA Receptor (3) Gap Junction Protein (1) Keap1-Nrf2 (1) MicroRNA (2) Monoamine Oxidase (4) NKCC (3) PGC-1α (1) Procollagen C Proteinase (1) Prostaglandin Receptor (1) PROTAC Linkers (2) Reference Standards (2) Small Interfering RNA (siRNA) (2) Src (1) TGF-beta/Smad (2) TNF Receptor (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (4) Endocrinology (1) Inflammation/Immunology (12) Metabolic Disease (5) Neurological Disease (2)
Oligonucleotides:	MicroRNAs (2) Aptamers (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Natural
Products

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W008574

TGN-020 Maximum Cited Publications 21 Publications Verification	PROTAC Linkers	Inflammation/Immunology Cancer
TGN-020 is a selective Aquaporin 4 (AQP4) inhibitor with an IC₅₀ of 3.1 μM . TGN-020 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .TGN-020 alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats .

HY-B0135

Furosemide 5+ Cited Publications	NKCC GABA Receptor	Cardiovascular Disease Metabolic Disease Cancer
Furosemide is a potent and orally active inhibitor of Na ⁺/K ⁺/2Cl ^- (NKCC) cotransporter, NKCC1 and NKCC2 . Furosemide is also a GABA_A receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema .

HY-13102

UK-383367	Procollagen C Proteinase	Others
UK-383367 is an orally available pro-collagen C-protease inhibitor (BMP-1) with an IC₅₀ value of 44 nM. UK-383367 can reduce renal fibrosis and inflammation in chronic kidney disease (CKD) and may be used to study postoperative skin scarring .

HY-W008574A

TGN-020 sodium Maximum Cited Publications 21 Publications Verification	PROTAC Linkers	Inflammation/Immunology Cancer
TGN-020 sodium is a selective Aquaporin 4 (AQP4) inhibitor with an IC₅₀ of 3.1 μM . TGN-020 sodium is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . TGN-020 sodium alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats .

HY-B0135A

Furosemide sodium 5+ Cited Publications	NKCC GABA Receptor	Cardiovascular Disease Metabolic Disease Cancer
Furosemide sodium is a potent and orally active inhibitor of Na ⁺/K ⁺/2Cl ^- (NKCC) cotransporter, NKCC1 and NKCC2 . Furosemide sodium is also a GABA_A receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide sodium acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema .

HY-P5225

Acetyl hexapeptide-38	PGC-1α	Others
Acetyl hexapeptide-38 is a tissue repair promoter that targets fibroblasts in the dermis of the skin. It works by promoting collagen synthesis in the dermis and thickening of subcutaneous fat. Acetyl hexapeptide-38 can activate the skin repair mechanism, increase the collagen content in the dermis, improve the skin tissue structure, and has the activity of promoting local tissue repair. Acetyl hexapeptide-38 can be used in the field of cosmetic medicine to repair congenital soft tissue defects, reduce tear grooves and nasolabial folds, eliminate postoperative scars, and conduct micro-plastic surgery of skin tissue .

HY-151499A

PXS-6302 hydrochloride	Monoamine Oxidase	Inflammation/Immunology
PXS-6302 hydrochloride is an irreversible lysyl oxidase inhibitor with IC₅₀s of 3.7 μM (Bovine LOX), 3.4 μM (rh LOXL1), 0.4 μM (rh LOXL2), 1.5 μM (rh LOXL3), 0.3 μM (rh LOXL4), respectively. PXS-6302 hydrochloride has readily skin penetrability, reduces collagen deposition and significantly improves scar appearance .

HY-175746

AZD0233	CX3CR1	Cardiovascular Disease
AZD0233 is an orally active CX3CR1 antagonist. AZD0233 modulates the CX3CR1/CX3CL1 signaling axis via immunomodulatory effects. AZD0233 has improved physicochemical properties, metabolic stability, low toxicity and CYP inhibition. AZD0233 improves cardiac function and reduces macrophages and fibrotic scar in mice model of dilated cardiomyopathy. AZD0233 can be used for cardiovascular diseases like dilated cardiomyopathy research .

HY-151499

PXS-6302	Monoamine Oxidase	Others
PXS-6302 is an irreversible lysyl oxidase inhibitor with IC₅₀s of 3.7 μM (Bovine LOX), 3.4 μM (rh LOXL1), 0.4 μM (rh LOXL2), 1.5 μM (rh LOXL3), 0.3 μM (rh LOXL4), respectively. PXS-6302 has readily skin penetrability, reduces collagen deposition and significantly improves scar appearance .

HY-103435

Vialinin A 2 Publications Verification Terrestrin A	Deubiquitinase TNF Receptor E1/E2/E3 Enzyme Keap1-Nrf2	Inflammation/Immunology Cancer
Vialinin A (Terrestrin A) is a p-terphenyl compound that can be derived from a Chinese edible mushroom. Vialinin A is an inhibitor of ubiquitin-specific peptidase 4 (USP4) and has anti-inflammatory and antioxidant properties. Vialinin A can alleviate cerebral ischaemia-reperfusion injury-induced neurological deficits and neuronal apoptosis. Vialinin A promotes activation of Keap1-Nrf2-ARE signaling pathway and increases the protein degradation of Keap1. Vialinin A possesses various pharmacological activities in cancer, Kawasaki disease, asthma, and pathological scarring. Vialinin A is a potent inhibitor of TNF-α, USP4, USP5, and sentrin/SUMO-specific protease 1 (SENP1). Vialinin A can be studied in reseach for autoimmune diseases, cancer and ischaemic stroke .

HY-P10886

Zifogaptide	Gap Junction Protein Claudin	Inflammation/Immunology
Zifogaptide is a gap junction protein channel regulator. Zifogaptide mimics the PDZ-binding motif at the C-terminal of Claudin C and competitively interferes with the interaction between Claudin–TJP1 (ZO-1) scaffold. Zifogaptide can promote epithelial cell migration, reduce scar formation, and accelerate wound healing. Zifogaptide can be used for radiation dermatitis, skin injuries, etc .

HY-151498A

PXS-4787 hydrochloride	Monoamine Oxidase	Others
PXS-4787 hydrochloride is a specific and effective pan-LOX (lysyl oxidase) inhibitor for abolishing lysyl oxidase activity. PXS-4787 hydrochloride inhibits LOX with IC₅₀s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), 0.2 μM (rh LOXL4), respectively. PXS-4787 hydrochloride reduces deposition and crosslinking of collagen I secreted by human fibroblasts .

HY-132602A

Remlarsen sodium MRG-201 sodium	MicroRNA	Inflammation/Immunology
Remlarsen (MRG-201), a miR-29b mimic, acts a miR-29b agonist. Remlarsen sodium has the potential for preventiong formation of a fibrotic scar or cutaneous fibrosis .

HY-132602

Remlarsen MRG-201	MicroRNA	Inflammation/Immunology
Remlarsen (MRG-201), a miR-29b mimic, acts a miR-29b agonist. Remlarsen has the potential for preventiong formation of a fibrotic scar or cutaneous fibrosis .

HY-P99695

Lerdelimumab CAT-152	TGF-beta/Smad	Neurological Disease
Lerdelimumab (CAT-152) is an IgG4 human anti-TGF-β2 recombinant monoclonal antibody. Lerdelimumab can be used as an anti-scarring agent for glaucoma research .

HY-B1234R

Octinoxate (Standard) Octyl methoxycinnamate (Standard)	Reference Standards Androgen Receptor Estrogen Receptor/ERR	Others
Octinoxate (Standard) is the analytical standard of Octinoxate. This product is intended for research and analytical applications. Octinoxate (Octyl methoxycinnamate) is an organic compound that is an ingredient in some sunscreens and lip balms, primarily used is in sunscreens and other cosmetics to absorb UV-B rays from the sun, protecting the skin from damage and can be used to reduce the appearance of scars. Octinoxate also has a complex androgenic and estrogenic effect .

HY-151498

PXS-4787	Monoamine Oxidase	Others
PXS-4787 is a specific and effective pan-LOX (lysyl oxidase) inhibitor for abolishing lysyl oxidase activity. PXS-4787 inhibits LOX with IC₅₀s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), 0.2 μM (rh LOXL4), respectively .

HY-B1234A

(E)-Octinoxate (E)-Octyl methoxycinnamate	Estrogen Receptor/ERR Androgen Receptor	Endocrinology
(E)-Octinoxate is the isomer of Octinoxate (HY-B1234). Octinoxate is an organic compound that is an ingredient in some sunscreens and lip balms, primarily used is in sunscreens and other cosmetics to absorb UV-B rays from the sun, protecting the skin from damage and can be used to reduce the appearance of scars. Octinoxate also has a complex androgenic and estrogenic effect .

HY-19864

Aganepag AGN 210937	Prostaglandin Receptor	Inflammation/Immunology
Aganepag is a potent Prostanoid EP2 receptor agonist, with an EC₅₀ of 0.19 nM, and shows no activity at EP4 receptor. Aganepag can be used in the research of wound healing, scar reduction, scar prevention and wrinkle treatment and prevention.

HY-110367A

LCB 03-0110	Src	Others
LCB 03-0110, a thienopyridine derivative, is a potent pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor. LCB 03-0110 suppresses scar formation by inhibiting fibroblast and macrophage activation .

HY-107386

PF-03671148	Anaplastic lymphoma kinase (ALK)	Others
PF-03671148 is an ALK5 inhibitor. PF-03671148 can reduce TGFβ induced fibrotic gene expression in fibroblasts. PF-03671148 has potential utility for the prevention of dermal scarring .

HY-167643

Hydroxy tipelukast	Drug Metabolite	Metabolic Disease Inflammation/Immunology
Hydroxy tipelukast (Compound MN-002), the metabolite of Compound MN-001, is an orally active phenoxyalkylcarboxylic acid. Hydroxy tipelukast inhibits liver steatosis, lobular inflammation, hepatic ballooning, and hepatic scarring, and reduces liver hydroxyproline levels. Hydroxy tipelukast is promising for research of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) .

HY-RS22917

Wasf1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Wasf1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Wasf1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Wasf1 Mouse Pre-designed siRNA Set A Wasf1 Mouse Pre-designed siRNA Set A

HY-RS12244

RPS4X Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RPS4X Human Pre-designed siRNA Set A contains three designed siRNAs for RPS4X gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RPS4X Human Pre-designed siRNA Set A RPS4X Human Pre-designed siRNA Set A

HY-B0135AR

Furosemide sodium (Standard)	NKCC GABA Receptor Reference Standards	Cardiovascular Disease Metabolic Disease Cancer
Furosemide (sodium) (Standard) is the analytical standard of Furosemide (sodium). This product is intended for research and analytical applications. Furosemide sodium is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2 . Furosemide sodium is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide sodium acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema .

HY-175076

Globotriaosylceramide (non-hydroxy) (porcine RBC)	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
Globotriaosylceramide (non-hydroxy) (porcine RBC) is a glycosphingolipid found in the cell membranes of mammals. Globotriaosylceramide (non-hydroxy) (porcine RBC) is the core pathogenic molecule of Fabry disease, and its level can be downregulated by supplementing α-galactosidase A. Globotriaosylceramide (non-hydroxy) (porcine RBC) amplifies B-cell receptor signals by regulating the localization of co-receptor CD19, and can be used as a vaccine adjuvant, capable of guiding the generation of broad-spectrum and cross-protective antibody responses. Globotriaosylceramide (non-hydroxy) (porcine RBC) promotes wound healing and reduces scar formation by regulating fibroblast heterogeneity .

HY-181431

PXS 64	TGF-beta/Smad	Inflammation/Immunology
PXS 64, a mannose-6-phosphate (M6P) analogue. a lipophilic prodrug of PXS 25 (HY-181430). PXS 64 is an effective anti-fibrotic agent by inhibiting the activation of latent TGF-β1. PXS64, inhibits fibrosis via TGF-β1 pathway in human lung fibroblasts. PXS 64 reduces TGFβ-mediated collagen IV, fibronectin, MCP-1, and phospho-smad2 expression in kidney cells. PXS 64 reduces collagen deposition in dermal scar fibroblasts. PXS 64 can be used for the research of chronic kidney disease, idiopathic pulmonary fibrosis, scarring .

HY-177933

mNOX-E36	CCR	Neurological Disease Inflammation/Immunology
mNOX-E36 is a murine-specific analogue of NOX-E36 (HY-148100), an anti-CCL-2 L-RNA aptamer that binds and neutralises the mouse chemokine CCL-2. mNOX-E36 reduces scarring in an experimental murine model of glaucoma filtration surgery (GFS). mNOX-E36 ameliorates lupus nephritis in mice. mNOX-E36 can be used for GFS and lupus nephritis research .

Cat. No.	Product Name

HY-L185

Anti-Fibrosis Compound Library	2,415 compounds
Fibrosis is a kind of repair response to long-term tissue damage, which is mainly manifested by excessive deposition of extracellular matrix (ECM) and scar formation. Myofibroblasts are the main generating cells of extracellular matrix, and their activation process is related to various pathological mechanisms including Oxidative stress, chronic inflammation and cytokine secretion. Fibrosis can occur in many organs, such as kidneys, liver, heart, lungs, etc. Continuous fibrosis can lead to the destruction of the normal structure of tissues and organs, and if not controlled in time, may cause organ failure or even life-threatening. MCE contains 2,415 compounds targeting ant-fibrosis targets such as TGF-β, PI3K, Wnt, MMP, etc. These compounds have clear or potential anti-fibrosis activity and can be used for mechanism research and drug screening of fibrosis diseases.

Anti-Fibrosis Compound Library

2,415 compounds

Fibrosis is a kind of repair response to long-term tissue damage, which is mainly manifested by excessive deposition of extracellular matrix (ECM) and scar formation. Myofibroblasts are the main generating cells of extracellular matrix, and their activation process is related to various pathological mechanisms including Oxidative stress, chronic inflammation and cytokine secretion. Fibrosis can occur in many organs, such as kidneys, liver, heart, lungs, etc. Continuous fibrosis can lead to the destruction of the normal structure of tissues and organs, and if not controlled in time, may cause organ failure or even life-threatening.

MCE contains 2,415 compounds targeting ant-fibrosis targets such as TGF-β, PI3K, Wnt, MMP, etc. These compounds have clear or potential anti-fibrosis activity and can be used for mechanism research and drug screening of fibrosis diseases.

Cat. No.	Product Name	Target	Research Area

HY-P5225

Acetyl hexapeptide-38	PGC-1α	Others
Acetyl hexapeptide-38 is a tissue repair promoter that targets fibroblasts in the dermis of the skin. It works by promoting collagen synthesis in the dermis and thickening of subcutaneous fat. Acetyl hexapeptide-38 can activate the skin repair mechanism, increase the collagen content in the dermis, improve the skin tissue structure, and has the activity of promoting local tissue repair. Acetyl hexapeptide-38 can be used in the field of cosmetic medicine to repair congenital soft tissue defects, reduce tear grooves and nasolabial folds, eliminate postoperative scars, and conduct micro-plastic surgery of skin tissue .

HY-P10886

Zifogaptide	Gap Junction Protein Claudin	Inflammation/Immunology
Zifogaptide is a gap junction protein channel regulator. Zifogaptide mimics the PDZ-binding motif at the C-terminal of Claudin C and competitively interferes with the interaction between Claudin–TJP1 (ZO-1) scaffold. Zifogaptide can promote epithelial cell migration, reduce scar formation, and accelerate wound healing. Zifogaptide can be used for radiation dermatitis, skin injuries, etc .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99695

Lerdelimumab CAT-152	TGF-beta/Smad	Neurological Disease
Lerdelimumab (CAT-152) is an IgG4 human anti-TGF-β2 recombinant monoclonal antibody. Lerdelimumab can be used as an anti-scarring agent for glaucoma research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1234R

Octinoxate (Standard) Octyl methoxycinnamate (Standard)	Structural Classification Natural Products other families Plants Source Classification	Reference Standards Androgen Receptor Estrogen Receptor/ERR
Octinoxate (Standard) is the analytical standard of Octinoxate. This product is intended for research and analytical applications. Octinoxate (Octyl methoxycinnamate) is an organic compound that is an ingredient in some sunscreens and lip balms, primarily used is in sunscreens and other cosmetics to absorb UV-B rays from the sun, protecting the skin from damage and can be used to reduce the appearance of scars. Octinoxate also has a complex androgenic and estrogenic effect .

Host:	Mouse (2) Rabbit (8)
Reactivity:	Human (10) Rat (4) Mouse (6) Monkey (2)
Application:	IHC-P (8) ICC/IF (2) IP (2) IHC-F (2) WB (10) FC (4) ELISA (2)
Isotype:	IgG (8) IgG1 (2)
Conjugation:	Non-conjugated (10)
Clonality:	Monoclonal (5) Recombinant (4)
Modification:	Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84149

	XRCC1 Antibody (YA3846) RCC; scar26	WB, IHC-P, FC, ELISA	Human, Monkey
	XRCC1 Antibody (YA3846) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to XRCC1.

HY-P84149A

	XRCC1 Antibody (YA3846)(PBS only) RCC; scar26	WB, IHC-P, FC, ELISA	Human, Monkey
	XRCC1 Antibody (YA3846) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to XRCC1.

HY-P82671

	WAVE 1 Antibody (YA2416) WAVE; scar1; WAVE1	WB	Human, Mouse, Rat
	WAVE 1 Antibody (YA2416) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to WAVE 1.

HY-P82499

	TPP1 Antibody (YA2244) CLN2; GIG1; LPIC; scar7; TPP-1	WB, IHC-P	Human
	TPP1 Antibody (YA2244) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TPP1.

HY-P82671A

	WAVE 1 Antibody (YA2416)(PBS only) WAVE; scar1; WAVE1	WB	Human, Mouse, Rat
	WAVE 1 Antibody (YA2416) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to WAVE 1.

HY-P82499A

	TPP1 Antibody (YA2244)(PBS only) CLN2; GIG1; LPIC; scar7; TPP-1	WB, IHC-P	Human
	TPP1 Antibody (YA2244) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TPP1.

HY-P83570

	WWOX Antibody (YA3315) FOR; WOX1; EIEE28; FRA16D; scar12; HHCMA56; PRO0128; SDR41C1; D16S432E	WB, IHC-P, FC, IP	Human, Mouse
	WWOX Antibody (YA3315) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to WWOX.

HY-P83570A

	WWOX Antibody (YA3315)(PBS only) FOR; WOX1; EIEE28; FRA16D; scar12; HHCMA56; PRO0128; SDR41C1; D16S432E	WB, IHC-P, FC, IP	Human, Mouse
	WWOX Antibody (YA3315) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to WWOX.

HY-P81624

	Nesprin1 Antibody (YA1369) ARCA1; C6orf98; CPG2; EDMD4; Enaptin; Myne-1; MYNE1; Nesp1; Nesprin-1; scar8; Syne-1; SYNE1	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Nesprin1 Antibody (YA1369) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nesprin1.

HY-P81624A

	Nesprin1 Antibody (YA1369)(PBS only) ARCA1; C6orf98; CPG2; EDMD4; Enaptin; Myne-1; MYNE1; Nesp1; Nesprin-1; scar8; Syne-1; SYNE1	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Nesprin1 Antibody (YA1369) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nesprin1.

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