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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
73 Results for "
tetramer
" in MedChemExpress (MCE) Product Catalog:
Products (73)
73 Results for "tetramer" in MCE Product Catalog:
2
Category:
Xanthones Guttiferae Metabolic Disease Garcinia mangostana Linn. Phenols Polyphenols Plants Disease Research Fields
Target:
2
2 Cited Publications
Cat. No.: HY-D1806
Product Concentration: 0.8 mg/mL
1
1 Cited Publications
Category:
Cardiovascular Disease Neurological Disease Simple Phenylpropanols Labiatae Samanea saman (Jacq.) Merr. Phenylpropanoids Plants Disease Research Fields
Target:
1
1 Cited Publications
Cat. No.: HY-D1808
Product Concentration: 0.8 mg/mL
Cat. No.: HY-P1924
CAS No.: 1977546-93-2
Target:
Research Areas:
Cat. No.: HY-P991128
CAS No.: 2965214-50-8
Synonyms: NI-006; ALXN2220
Target:
Research Areas:
Cat. No.: HY-D1805
Product Concentration: 0.8 mg/mL
Cat. No.: HY-N6880
CAS No.: 263397-69-9
Synonyms: (+)-Rabdosiin
Category:
Labiatae Lignans Piliostigma thonningii (Schumach.) Milne-Redh. Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology
Target:
Cat. No.: HY-D1807
Product Concentration: 0.8 mg/mL
Target:
Research Areas:
TRAP1-IN-1 (compound 35) is a potent and selective inhibitor of TRAP1，a mitochondrial isoform of Hsp90. TRAP1-IN-1 has >250-fold TRAP1 selectivity over Grp94，and disrupts TRAP1 tetramer stability，induces TRAP1 client protein degradation. TRAP1-IN-1 also inhibits mitochondrial complex I of oxidative phosphorylation OXPHOS，disrupts the mitochondrial membrane potential，and enhances glycolysis metabolism .
Cat. No.: HY-106381A
Purity: ≥98.0%
Research Areas:
Aurothiomalate tetramer sodium is the tetrameric form of Aurothiomalate sodium (HY-106381). Aurothiomalate sodium acts as an inhibitor of PKCI and TrxR1. Aurothiomalate sodium disrupts the PKCI-Par6-Rac1 signaling pathway, and also inhibits TrxR1 activity, TNFα-induced NF-κB activation, and the expression of pro-inflammatory genes. Aurothiomalate sodium blocks Kras-mediated BASC expansion and lung tumor growth, inhibits anchorage-independent growth and tumorigenicity of lung cancer cells, and suppresses neutrophil chemotaxis, phagocytosis, and leukocyte extravasation. Aurothiomalate sodium can be used in research related to rheumatoid arthritis and non-small cell lung cancer .
Cat. No.: HY-158987
CAS No.: 1050202-63-5
Synonyms: APBADP
Target:
Research Areas:
Adenosine phosphonobutyric, 2'(3'), 5'-diposphate (APBADP) is an adenylosuccinate lyase substrate analog and competitive inhibitor. Adenosine phosphonobutyric, 2'(3'), 5'-diposphate binds to the tetramers of *Bacillus subtilis* adenylosuccinate lyase and wild-type human adenylosuccinate lyase. Adenosine phosphonobutyric, 2'(3'), 5'-diposphate can be used for research on adenylosuccinate lyase deficiency .
Cat. No.: HY-150311
Purity: ≥95.0%
Target:
Research Areas:
endo-BCN-PEG24-NHS ester is composed of a benzocyclonorbornene, a twenty-tetramer of polyethylene glycol (PEG) and an N-hydroxysuccinimide ester. endo-BCN-PEG24-NHS is utilized as linker for synthesis of PROTAC molecule .
Cat. No.: HY-D1804
Product Concentration: 0.8 mg/mL
Cat. No.: HY-D1809
Product Concentration: 0.8 mg/mL
Cat. No.: HY-157558
Synonyms: 8SGE
Target:
Research Areas:
KDRLKZ-1 (8SGE) is a small-molecule ligand of KLHDC2 E3 ligase (Kd = 0.36 μM), with an IC50 of 0.21 μM and 0.31 μM in alphaLISA and TR-FRET assays, respectively. KDRLKZ-1 binds to the substrate-binding pocket of the KLHDC2 kelch domain, mimics the interaction of natural substrates and displaces them. KDRLKZ-1 acts as an oligomer disruptor, regulates the oligomerization of the KLHDC2-EloB-EloC complex, and induces the dissociation of tetramers into smaller components. KDRLKZ-1 can be used in scaffold ligand research for PROTAC degraders targeting KLHDC2 .
Cat. No.: HY-P1924A
Target:
Research Areas:
Cat. No.: HY-P5229A
Cat. No.: HY-157559
Target:
Research Areas:
KDRLKZ-2 is a small-molecule ligand of KLHDC2 E3 ligase (Kd = 95 nM), with an IC50 of 68 nM and 0.1 μM in alphaLISA and TR-FRET assays, respectively. KDRLKZ-2 binds to the substrate-binding pocket of the kelch domain of KLHDC2, mimics the interaction of natural substrates and displaces them. KDRLKZ-2 acts as an oligomer disruptor, regulates the oligomerization of the KLHDC2-EloB-EloC complex, and induces the dissociation of tetramers into smaller components. KDRLKZ-2 can be used in scaffold ligand studies of PROTAC degraders targeting KLHDC2 .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
