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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
39 Results for "
thyroid carcinoma
" in MedChemExpress (MCE) Product Catalog:
Products (39)
39 Results for "thyroid carcinoma" in MCE Product Catalog:
65
65 Cited Publications
Synonyms: EGCG; Epigallocatechol Gallate
Category:
Anti-aging Plants Other Families Extract Endogenous metabolite Flavonoids Flavonones Phenols Polyphenols Disease Research Fields Inflammation/Immunology Cancer
Target:
1
1 Cited Publications
Synonyms: Telobufotoxin; Telocinobufogenin
Category:
Synonyms: EGCG(Standard); Epigallocatechol Gallate (Standard)
Cat. No.: HY-W009776
CAS No.: 38937-66-5
Synonyms: Suberohydroxamic acid; SBHA
Suberoyl bis-hydroxamic acid (Suberohydroxamic acid; SBHA) is a competitive and cell-permeable HDAC1 and HDAC3 inhibitor with ID50 values of 0.25 μM and 0.30 μM, respectively .Suberoyl bis-hydroxamic acid renders MM cells susceptible to apoptosis and facilitates the mitochondrial apoptotic pathways .Suberoyl bis-hydroxamic acid can be used for the study of medullary thyroid carcinoma (MTC) .
Target:
Research Areas:
NSC194598 is a p53 DNA-binding inhibitor with an IC50 value of 180 nM. NSC194598 inhibits p53 DNA binding and induction of target genesn when p53 is stabilized and activated by irradiation or chemotherapy. NSC194598 can interfere with transcriptional activation of mutated rearranged during transfection (RET) gene, induce apoptosis and G0/G1 phase arrest. NSC194598 can be used for the researches of acute radiation toxicity and medullary thyroid carcinoma .
RPI-1 is a specific, orally available 2-indolinone Ret tyrosine kinase inhibitor. RPI-1 inhibits proliferation, Ret tyrosine phosphorylation, Ret protein expression, and the activation of PLCgamma, ERKs and AKT in human medullary thyroid carcinoma TT cells. Antitumor activity .
Cat. No.: HY-150526
CAS No.: 2708237-76-5
Category:
Flavonoids Flavanols Endogenous metabolite Disease Research Fields Inflammation/Immunology Cancer
Target:
Cat. No.: HY-13653S1
Synonyms: EGCG-d4; Epigallocatechol Gallate-d4
Cat. No.: HY-P9972
CAS No.: 1935694-88-4
Synonyms: PDR001
Target:
Research Areas:
Cat. No.: HY-15855
CAS No.: 404886-32-4
Target:
Research Areas:
Fosbretabulin (tromethamine), also known as combretastatin A4 phosphate (CA4P), is a vascular disrupting agent evaluated for its efficacy against anaplastic thyroid carcinoma (ATC). It targets tumor neovasculature, causing acute and reversible reductions in tumor blood flow and central necrosis .
Cat. No.: HY-14815
CAS No.: 222030-63-9
Synonyms: Combretastatin A4 phosphate
Target:
Research Areas:
Fosbretabulin (Combretastatin A4 phosphate) is a vascular disruptor with antitumor activity against atypical thyroid carcinoma (ATC) cell lines and xenografts. Fosbretabulin inhibits tumor growth by inhibiting microtubule polymerization, inducing apoptosis, and suppressing angiogenesis in tumors .
Cat. No.: HY-170017S
Synonyms: EGCG-d3/d4; Epigallocatechol Gallate-d3/d4
Cat. No.: HY-170855A
Research Areas:
YW-N-7 TFA is a PROTAC degrader targeting RET kinase, with an IC50 of 8.4 nM. YW-N-7 TFA inhibits RET kinase activity and induces proteasome-mediated degradation of RET fusion proteins, while enhancing the anti-tumor activity of Selpercatinib (LOXO-292) (HY-114370). YW-N-7 TFA can be used in the research of cancers associated with RET gene abnormalities, including medullary thyroid carcinoma, papillary thyroid carcinoma and non-small cell lung cancer .
Cat. No.: HY-175302
CAS No.: 3044124-79-7
Target:
Research Areas:
TRK-IN-32 is a potent TRK inhibitor. TRK-IN-32 potently inhibits TRK WT, TRK G595R and TRK G667C with IC50 values of 0.08 nM, 2.14 nM and 0.68 nM, respectively. TRK-IN-32 also demonstrates antiproliferative activity against a panel of Ba/F3 cell lines transformed with wild type, xDFG, solvent-front as well as gatekeeper mutant TRK fusion proteins. TRK-IN-32 induces apoptosis of Ba/F3-TRKA WT and Ba/F3-TRKA G667C cells.TRK-IN-32 can be used for the study of various cancers (such as thyroid cancer, secretory breast carcinoma) .
Cat. No.: HY-183729
CAS No.: 2222758-09-8
Research Areas:
RET-IN-34 is a RET inhibitor with an IC50 of 0.89 nM. RET-IN-34 serves as a target protein ligand for PROTAC synthesis (Ligand for Target Protein for PROTAC). RET-IN-34 is applicable for the synthesis of PROTAC RET Degrader 2 (HY-183783). RET-IN-34 exhibits anticancer activity against medullary thyroid carcinoma. RET-IN-34 can be used in studies related to medullary thyroid carcinoma .
Cat. No.: HY-177011
CAS No.: 2170732-60-0
Target:
Research Areas:
ERRγ-IN-1 is a ERRγ inhibitor with an IC50 of 0.040 μM. ERRγ-IN-1 activates MAPK (p44/p42) and inhibits the activity of ERRγ. ERRγ-IN-1 significantly increases iodine uptake in anaplastic thyroid carcinoma xenografts and suppresses tumor growth in nude mice. ERRγ-IN-1 is applicable for the research of anaplastic thyroid carcinoma .
Cat. No.: HY-P73679
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RET; Cadherin Family Member 12; Prev. HSCR1; RET51; Prev. MEN2A; Ret Proto-Oncogene (Multiple Endocrine Neoplasia And Medullary thyroid carcinoma 1, Hirschsprung Disease); Prev. MEN2B; Multiple Endocrine Neoplasia And Medullary thyroid carcinoma 1; Prev.
Species:
Human
Source:
HEK293
Cat. No.: HY-P702542
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: RET; Cadherin Family Member 12; Prev. HSCR1; RET51; Prev. MEN2A; Ret Proto-Oncogene (Multiple Endocrine Neoplasia And Medullary thyroid carcinoma 1, Hirschsprung Disease); Prev. MEN2B; Multiple Endocrine Neoplasia And Medullary thyroid carcinoma 1; Prev.
Species:
Mouse
Source:
HEK293
Cat. No.: HY-N16764
CAS No.: 1977557-69-9
Target:
- 1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
