147 Results for "

triterpenoid saponin

" in MedChemExpress (MCE) Product Catalog:
Products (147)

147 Results for "triterpenoid saponin" in MCE Product Catalog:

8
Hederagenin
Hederagenin
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8 Publications Verification
Cat. No.: HY-N0256
CAS No.: 465-99-6
Category:  

Triterpenes Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd. Terpenoids Plants Disease Research Fields Araliaceae Cancer

Target:  

COX NF-κB E1/E2/E3 Enzyme

Hederagenin is a triterpenoid saponin with orally active and antitumor activity. Hederagenin can inhibit the expression of iNOS, COX-2, and NF-κB in cells induced by LPS stimulation. Hederagenin also increases ROS production in cancer cells, disrupts mitochondrial membrane potential, and induces apoptosis. Hederagenin also sensitizes cancer cells to Cisplatin (HY-17394) and Paclitaxel (HY-B0015), enhancing induced apoptosis. Hederagenin can also bind to SKP2, with KD = 67.9 μM. Hederagenin also has preventive potential against alcoholic liver injury .
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Momordin Ic
Momordin Ic
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5 Cited Publications
Cat. No.: HY-N0330
CAS No.: 96990-18-0
Category:  

Kochia scoparia L. Schrad. Triterpenes Terpenoids Plants Disease Research Fields Cancer Chenopodiaceae

Target:  

Apoptosis Autophagy PI3K c-Myc

Momordin Ic is an orally active triterpenoid saponin that can be isolated from Kochia scoparia. It is also a SUMO specific protease 1 (SENP1) inhibitor, SENP1/c-MYC signaling pathway inhibitor, and apoptosis inducer. Momordin Ic induces autophagy and apoptosis in liver cancer cells through the PI3K/Akt and MAPK signaling pathways mediated by reactive oxygen species. Momordin Ic has the ability to control glucose induced blood glucose elevation, inhibit gastric emptying, resist rheumatoid arthritis, reduce CCl4 (HY-Y0298) induced hepatotoxicity and anti-tumor activity .
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4
alpha-Hederin
alpha-Hederin
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4 Cited Publications
Cat. No.: HY-N0255
CAS No.: 27013-91-8
Synonyms: α-Hederin
Category:  

Triterpenes Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd. Terpenoids Other Diseases Plants Disease Research Fields Araliaceae

Target:  

Apoptosis

alpha-Hederin (α-Hederin), a monodesmosidic triterpenoid saponin, exhibits promising antitumor potential against a variety of human cancer cell lines. alpha-Hederin could inhibit the proliferation and induce apoptosis of gastric cancer accompanied by glutathione decrement and reactive oxygen species generation via activating mitochondrial dependent pathway .
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3
Escin
Escin
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3 Cited Publications
Cat. No.: HY-B2114
CAS No.: 6805-41-0
Category:  

Triterpenes Hippocastanaceae Terpenoids Aesculus hippocastanum Plants Saccharides

Target:  

Apoptosis

Escin, a natural compound of triterpenoid saponins that can be isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent .
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3
Deapioplatycodin D
Deapioplatycodin D
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3 Cited Publications
Cat. No.: HY-N0588
CAS No.: 78763-58-3
Category:  

Infection Triterpenes Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Disease Research Fields

Target:  

HCV

Deapioplatycodin D is a triterpenoid saponin isolated from Platycodon grandiflorum, with anti-HCV activity .
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3
Platycodin D2
Platycodin D2
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3 Cited Publications
Cat. No.: HY-N4087
CAS No.: 66663-90-9
Category:  

Triterpenes Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Disease Research Fields Cancer

Target:  

Mitophagy Autophagy Ferroptosis Interleukin Related IFNAR Reactive Oxygen Species (ROS)

Platycodin D2 is an orally active triterpenoid saponin found in Platycodon grandiflorum. Platycodin D2 induces mitophagy in cancer cells through NIX, thereby activating the P21/CyclinA2 pathway and promoting cell senescence. Platycodin D2 induces mitochondrial dysfunction, enhances autophagy, inhibits hepatocellular carcinoma cell proliferation, and exhibits anti-tumor activity against multiple cancer cell types. Platycodin D2 promotes mRNA expression of T-bet, GATA-3, Th1 cytokines IL-2 and IFN-γ, and Th2 cytokines IL-4 and IL-10, enhances splenocyte proliferation, and acts as a vaccine adjuvant with low rabbit red blood cell hemolytic activity. Platycodin D2 induces mitochondrial ROS production, incomplete autophagy, and ferroptosis to inhibit breast cancer cell proliferation. Platycodin D2 can be used for the research of cancer, inflammation and immunology .
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Tubeimoside III
Tubeimoside III
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2 Cited Publications
Cat. No.: HY-N2542
CAS No.: 115810-13-4
Category:  

Triterpenes Terpenoids Cucurbitaceae Plants Bolbostemma paniculaum (Maxim)Franguet Disease Research Fields Inflammation/Immunology

Target:  

Interleukin Related NO Synthase

Tubeimoside III is a triterpenoid saponin. Tubeimoside III has anti-inflammatory and antitumor effects. Tubeimoside III has an LD50 of 15 mg/kg by intraperitoneal injection in ICR mice. Tubeimoside III can be used for the research of tumors and inflammatory diseases .
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2
Astragaloside III
Astragaloside III
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2 Cited Publications
Cat. No.: HY-N0434
CAS No.: 84687-42-3
Category:  

Triterpenes other families Leguminosae Terpenoids Other Diseases Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Disease Research Fields

Target:  

C-type Lectin-like Receptors (CTLRs) Apoptosis Dengue Virus

Astragaloside III is a triterpenoid saponin. Astragaloside III can be extracted from Astragalus root. Astragaloside III increases NKG2D and induces TACE phosphorylation. Astragaloside III induces Apoptosis. Astragaloside III has antiviral activity against dengue serotypes 1 and 3. Astragaloside III has anticancer activity against breast and colon cancer .
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2
Araloside A
Araloside A
0 Images
2 Cited Publications
Cat. No.: HY-N2115
CAS No.: 7518-22-1
Synonyms: Chikusetsusaponin IV
Category:  

Cardiovascular Disease Triterpenes other families Terpenoids Plants Disease Research Fields Araliaceae

Target:  

Renin Apoptosis Bcl-2 Family Interleukin Related

Araloside A (Chikusetsusaponin IV), triterpenoid saponins, is an orally active component of Aralia elata. Araloside A shows low-renin-inhibitory activity with an IC50 of 77.4 μM. Araloside A can inhibit cell proliferation and induce apoptosis. Araloside A suppresses inflammatory cytokines IL-1β and IL-6 production. Araloside A can be used for the researches of cancer, inflammation and cardiovascular disease, such as renal cell carcinoma and rheumatoid arthritis .
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Ziyuglycoside II
Ziyuglycoside II
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1 Cited Publications
Cat. No.: HY-N0332
CAS No.: 35286-59-0
Category:  

Triterpenes Sanguisorba officinalis Linn. Terpenoids Rosaceae Plants Disease Research Fields Inflammation/Immunology

Target:  

Reactive Oxygen Species (ROS) Apoptosis

Ziyuglycoside II is a triterpenoid saponin compound extracted from Sanguisorba officinalis L.. Ziyuglycoside II induces reactive oxygen species (ROS) production and apoptosis. Anti-inflammation and anti-cancer effect .
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Deapi-platycodin D3
Deapi-platycodin D3
0 Images
1 Cited Publications
Cat. No.: HY-N3520
CAS No.: 67884-05-3
Category:  

Triterpenes Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Metabolic Disease Plants Disease Research Fields

Target:  

Others

Deapi-platycodin D3 is a triterpenoid saponin from the roots of Platycodon grandiflorum .
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1
Hederasaponin B
Hederasaponin B
0 Images
1 Cited Publications
Cat. No.: HY-N0306
CAS No.: 36284-77-2
Category:  

Infection Triterpenes Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd. Terpenoids Plants Disease Research Fields Araliaceae

Target:  

Enterovirus

Hederasaponin B is an orally active oleanane-type triterpenoid saponin and antiviral agent. Hederasaponin B is isolated from the leaves of Acanthopanax senticosus, Hedera nepalensis var. sinensis, and the rhizomes of Souliea vaginata. Hederasaponin B inhibits the expression of the viral capsid protein VP2 and attenuates virus-induced cytopathic effects. Hederasaponin B exhibits activity against Enterovirus 71 subtypes C3 and C4a. Hederasaponin B shows no hepatoprotective effect against CCl4-induced hepatocyte injury. Hederasaponin B is used in research on hand, foot, and mouth disease .
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Celosin H
Celosin H
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1 Cited Publications
Cat. No.: HY-N7919
CAS No.: 1623405-28-6
Category:  

Celosia argentea Linn. Terpenoids Amaranthaceae Plants Pentacyclic Triterpenoids

Target:  

Others

Celosin H is a hepatoprotective triterpenoid saponin that can be isolated from Celosiae Semen .
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Gypenoside XLVI
Gypenoside XLVI
0 Images
1 Cited Publications
Cat. No.: HY-N6252
CAS No.: 94705-70-1
Category:  

Triterpenes Terpenoids Cucurbitaceae Plants Disease Research Fields Gynostemma pentaphyllum (Thunb.) Makino Cancer

Target:  

Others

Gypenoside XLVI is one of the major dammarane-type triterpenoid saponins from Gynostamma pentaphallum . Gypenoside XLVI has a tetracyclic triterpene structure and possess potent non-small cell lung carcinoma A549 cell inhibitory activity .
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Bacoside A3
Bacoside A3
0 Images
1 Cited Publications
Cat. No.: HY-N5064
CAS No.: 157408-08-7
Category:  

Triterpenes Terpenoids Scrophulariaceae Plants Bacopa monnieri (Linn.) Wettst.

Target:  

Apoptosis NO Synthase COX

Bacoside A3 is a triterpenoid saponin isolated from Bacopa monnieri. Bacoside A3 has neuroprotective activity, downregulating β-amyloid-induced inflammatory responses and inhibiting neuronal apoptosis. Bacoside A3 can be used in the study of Alzheimer's disease .
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Celosin I
Celosin I
0 Images
1 Cited Publications
Cat. No.: HY-N7026
CAS No.: 1807732-38-2
Category:  

Celosia argentea Linn. Triterpenes Terpenoids Metabolic Disease Amaranthaceae Plants Disease Research Fields

Target:  

Others

Celosin I, an oleanane-type triterpenoid saponin isolated from the seeds of Celosia argentea L, could be used as chemical markers for the quality control of C. argentea seeds. Celosin I exhibits significant hepatoprotective effect on carbon tetrachloride-induced and N,N-dimethylformamide-induced hepatotoxicity in mice .
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Gynostemma Extract
Gynostemma Extract
0 Images
1 Cited Publications
Cat. No.: HY-N0167
CAS No.: 80321-63-7
Synonyms: Ginsenoside C-Mx1; Gypenoside IX
Category:  

Triterpenes Terpenoids Cucurbitaceae Plants Endogenous metabolite Disease Research Fields Gynostemma pentaphyllum (Thunb.) Makino Cancer

Target:  

p38 MAPK Akt NF-κB COX Interleukin Related NO Synthase

Gynostemma Extract (Gypenoside IX) is a triterpenoid saponin. Gynostemma Extract can be isolated from Panax notoginseng. Gynostemma Extract reduces NFκB nuclear translocation and transcriptional activity by inhibiting the p38 MAPK/Akt/NFκB signaling pathway. Gynostemma Extract reduces the expression of cytokines (COX-2, IL-6) and the production of NO. Gynostemma Extract has anti-inflammatory activity. Gynostemma Extract can be used in the study of liver injury and neuroinflammation .
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Kudinoside D
Kudinoside D
0 Images
1 Cited Publications
Cat. No.: HY-N4253
CAS No.: 173792-61-5
Category:  

Other Terpenoids other families Terpenoids Metabolic Disease Plants Disease Research Fields Pentacyclic Triterpenoids

Target:  

AMPK Acetyl-CoA Carboxylase PPAR Chloride Channel

Kudinoside D is a triterpenoid saponin. Kudinoside D is isolated from the leaves of Ilex kudingcha. Kudinoside D enhances the phosphorylation levels of AMPK and its downstream molecule ACC, and inhibits the expression of PPARγ, C/EBPα, SREBP-1c as well as the target genes of adipogenic transcription factors. Kudinoside D inhibits the activity of ANO1. Kudinoside D possesses hypolipidemic activity. Kudinoside D can be used in obesity-related research .
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Platycodin D3
Platycodin D3
0 Images
1 Cited Publications
Cat. No.: HY-N3519
CAS No.: 67884-03-1
Category:  

Infection Triterpenes Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Disease Research Fields

Target:  

HCV Branched Chain Amino Acid Transaminase (BCAT) Interleukin Related NF-κB ERK p38 MAPK JNK

Platycodin D3 is a triterpenoid saponin that can be found in Platycodon grandiflorum. Platycodin D3 exhibits multiple activities including anti-inflammation, regulation of airway mucus secretion, improvement of asthmatic airway inflammation and remodeling, and inhibition of hepatitis C virus (HCV) replication. The IC50 value of Platycodin D3 against HCV NS5B RNA-dependent RNA polymerase is 8 μg/mL. Platycodin D3 can be used in studies related to asthma, hepatitis C virus infection and inflammatory diseases .
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Calenduloside E
Calenduloside E
0 Images
1 Cited Publications
Cat. No.: HY-N6850
CAS No.: 26020-14-4
Category:  

Triterpenes other families Terpenoids Other Diseases Aralia elata (Miq.) Seem. Plants Endogenous metabolite Disease Research Fields Araliaceae

Target:  

Apoptosis Pyroptosis AMPK Bcl-2 Family JAK STAT Calcium Channel Interleukin Related TNF Receptor SOD Reactive Oxygen Species (ROS) PPAR

Calenduloside E is a pentacyclic triterpenoid saponin that can be extracted from the bark and roots of Aralia ovata, and has anti-inflammatory and anti-apoptotic activities. Calenduloside E alleviates atherosclerosis by regulating macrophage polarization, improves mitochondrial function by regulating the AMPK-SIRT3 pathway, and alleviates acute liver injury. In addition, Calenduloside E promotes the interaction between L-type calcium channels and Bcl-2 related apoptosis genes, inhibits calcium overload, and alleviates myocardial ischemia/reperfusion injury. Calenduloside E also improves non-alcoholic fatty liver disease by regulating heat shock-dependent pathways, and inhibits ROS mediated JAK1-STAT3 pathways to reduce cellular inflammatory responses .
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