43 Results for "

urate

" in MedChemExpress (MCE) Product Catalog:
Products (43)

43 Results for "urate" in MCE Product Catalog:

  • Targets Recommended:
22
22 Publications Verification
Cat. No.: HY-B2130A
CAS No.: 1198-77-2
Synonyms: Monosodium urate
Uric acid sodium (Monosodium urate), scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid sodium can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation .
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2
2 Cited Publications
Cat. No.: HY-W016814
CAS No.: 585-84-2
Synonyms: cis-Aconitic acid
(Z)-Aconitic acid is an orally active glutamate decarboxylase inhibitor. (Z)-Aconitic acid reduces IκB-α phosphorylation. (Z)-Aconitic acid inhibits Antigen-induced arthritis and Monosodium urate (HY-B2130A)-induced gout .
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2
2 Cited Publications
Cat. No.: HY-N8599
CAS No.: 531-58-8
Cichoriin is an orally active coumarin glycoside with broad biological activities. Cichoriin exhibits inhibitory activities against α-amylase, α-glucosidase, pancreatic lipase and DPP-IV, with IC50 values of 5.76, 2.94, 16.83 and 9.16 μg/mL, respectively. Cichoriin significantly improves metabolic dysfunction-associated steatohepatitis (MASH) in mice by activating the AMPK signaling pathway. Cichoriin upregulates PPAR-γ in adipose tissue and alleviates obesity and associated cardiorenal injury in rats. Cichoriin blocks monosodium urate crystal-induced activation of the NLRP3 inflammasome and cell pyroptosis by inhibiting P2Y14R (IC50 = 8.47 nM). In silico virtual screening reveals that Cichoriin has a strong binding affinity for SARS-CoV-2 .
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1
1 Cited Publications
Cat. No.: HY-N3005
CAS No.: 33627-28-0
Britannin is an NLRP3 inhibitor with an IC50 of 3.630 μM, exhibiting anti-inflammatory activity. Britannin inhibits the activation and assembly of the NLRP3 inflammasome by blocking the interaction between NLRP3 and NEK7. Additionally, Britannin demonstrates antitumor activity by inhibiting the proliferation of tumor cells through blocking the interaction between HIF-1α and Myc, thereby suppressing PD-L1 expression and enhancing cytotoxic T lymphocyte activity. Britannin can also induce apoptosis and autophagy in liver cancer cells by activating ROS-regulated AMPK. Britannin holds promise for research in the fields of anti-inflammatory and antitumor therapeutics .
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1 Cited Publications
Cat. No.: HY-108844
CAS No.: 134774-45-1
Purity:  95.00%
Rasburicase is a recombinant form of urate oxidase that works by catalyzing the oxidation of uric acid to allantoin, which has a higher solubility. Rasburicase specifically degrades uric acid, rapidly lowers blood uric acid levels, and improves inflammation and kidney damage caused by uric acid crystal deposition. Rasburicase can effectively lower uric acid and prevent uric acid nephropathy, and is used in the study of severe hyperuricemia associated with tumor lysis syndrome (TLS) and refractory gout .
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Cat. No.: HY-19657
CAS No.: 2465-59-0
Synonyms: Oxipurinol
Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout .
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Cat. No.: HY-W011711
CAS No.: 1477-19-6
Benzarone is an oral inhibitor of human urate transporter 1 (hURAT1) with an IC50 value of 2.8 μM, and it also acts as an uncoupler of oxidative phosphorylation. Benzarone can cause liver damage and promote cell apoptosis and necrosis. Benzarone can be used to lower serum uric acid levels and for research in vascular diseases .
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Cat. No.: HY-P2921
CAS No.: 9002-12-4
Synonyms: Uox, Microorganism
Uricase, Microorganism (Uox, Microorganism) is a uricase (urate oxidase) derived from Microorganism. Uricase, Microorganism converts uric acid into allantoin. The absence of Uricase in mammals causes kidney diseases resulting from uric acid accumulation. Uricase, Microorganism can be used for research on chronic refractory gout and hyperuricemia .
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Cat. No.: HY-P2921C
CAS No.: 9002-12-4
Synonyms: Uox (Recombinant)
Uricase (Recombinant) (Uox (Recombinant)) is a uricase (urate oxidase). Uricase (Recombinant) converts uric acid into allantoin. The deficiency of Uricase in mammals causes kidney diseases resulting from uric acid accumulation. Uricase (Recombinant) can be used for research on chronic refractory gout and hyperuricemia .
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Cat. No.: HY-P2921D
CAS No.: 9002-12-4
Synonyms: Uox, candida utilis
Uricase, candida utilis (Uox, candida utilis) is a uricase (urate oxidase) derived from Candida utilis. Uricase, candida utilis converts uric acid into allantoin. The absence of Uricase in mammals causes kidney diseases resulting from uric acid accumulation. Uricase, candida utilis can be used for research on chronic refractory gout and hyperuricemia .
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Cat. No.: HY-111345
CAS No.: 1198153-15-9
Purity:  99.75%
Synonyms: UR-1102; URC-102
Target:  

OAT URAT1

Epaminurad (UR-1102) is an orally active, potent and selective URAT1 (urate transporter 1) inhibitor, with a Ki of 0.057 μM. Epaminurad quite modestly inhibits OAT1 and OAT3 (organic anion transporter). Epaminurad is a uricosuric agent. Epaminurad can be used for gout and hyperuricemia research .
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Cat. No.: HY-W016814R
CAS No.: 585-84-2
Synonyms: cis-Aconitic acid (Standard)
(Z)-Aconitic acid (Standard) is the analytical standard of (Z)-Aconitic acid. This product is intended for research and analytical applications. (Z)-Aconitic acid is a glutamate decarboxylase inhibitor. (Z)-Aconitic acid reduces IκB-α phosphorylation. (Z)-Aconitic acid inhibits Antigen-induced arthritis and Monosodium urate (HY-B2130A)-induced gout .
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Cat. No.: HY-P2921B
CAS No.: 9002-12-4
Synonyms: Uox, Arthrobacter globiformis
Uricase, Arthrobacter globiformis (Uox, Arthrobacter globiformis) is a uricase (urate oxidase) derived from Arthrobacter globiformis. Uricase, Arthrobacter globiformis converts uric acid into allantoin. The absence of Uricase in mammals causes kidney diseases resulting from uric acid accumulation. Uricase, Arthrobacter globiformis can be used for research on chronic refractory gout and hyperuricemia .
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Cat. No.: HY-156624
CAS No.: 2088176-96-7
Target:  

URAT1

Research Areas:  

Metabolic Disease

Lingdolinurad is urate transporter inhibitor, targeting to hURAT1.Lingdolinurad can be used for research in hyperuricemia in vitro and in vivo .
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Cat. No.: HY-P2921A
CAS No.: 9002-12-4
Synonyms: Uox, Bacillus fastidious
Uricase, Bacillus fastidious (Uox, Bacillus fastidious) is a uricase (urate oxidase) derived from Bacillus fastidious. Uricase, Bacillus fastidious converts uric acid into allantoin. The absence of Uricase in mammals causes kidney diseases resulting from uric acid accumulation. Uricase, Bacillus fastidious can be used for research on chronic refractory gout and hyperuricemia .
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Cat. No.: HY-147300
CAS No.: 2013582-27-7
Purity:  99.96%
Synonyms: YL-90148
Target:  

URAT1

Puliginurad (YL-90148) is a potent urate transporter (URAT) inhibitor. Puliginurad can be used for hyperuricemia and gout research .
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Cat. No.: HY-111345A
CAS No.: 1198153-46-6
Synonyms: UR-1102 hydrochloride; URC-102 hydrochloride
Target:  

OAT URAT1

Epaminurad (UR-1102) hydrochloride is an orally active, potent and selective URAT1 (urate transporter 1) inhibitor, with a Ki of 0.057 μM. Epaminurad hydrochloride quite modestly inhibits OAT1 and OAT3 (organic anion transporter). Epaminurad hydrochloride is a uricosuric agent. Epaminurad hydrochloride can be used for gout and hyperuricemia research .
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Cat. No.: HY-W750387
CAS No.: 209799-75-7
Research Areas:  

Metabolic Disease

Immucillin-G is a purine nucleoside phosphorylase (PNP) inhibitor. Immucillin-G can reduce urate levels and can be used for the research of metabolic disease, such as hyperuricemia .
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Cat. No.: HY-19657R
CAS No.: 2465-59-0
Synonyms: Oxipurinol (Standard)
Oxypurinol (Standard) is the analytical standard of Oxypurinol. This product is intended for research and analytical applications. Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout .
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Cat. No.: HY-19657S
Synonyms: Oxypurinol-13C,15N2
Oxypurinol- 13C, 15N2 is 15N and 13C labeled Oxypurinol (HY-19657). Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout .
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