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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
89 Results for "
viral entry
" in MedChemExpress (MCE) Product Catalog:
Products (89)
89 Results for "viral entry" in MCE Product Catalog:
21
21 Publications Verification
Cat. No.: HY-U00434
CAS No.: 890405-51-3
Research Areas:
3BDO is a IFITM3 modulator and mTOR activator with antiviral and autophagy-inhibiting effects. 3BDO exhibits inhibitory activity against porcine coronaviruses. 3BDO increases the protein abundance of IFITM3, inhibits virus-cell membrane fusion, and blocks viral entry. 3BDO inhibits the entry of transmissible gastroenteritis virus, porcine epidemic diarrhea virus, and porcine respiratory coronavirus into host cells. 3BDO can be used for research on porcine coronavirus infection .
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Research Areas:
Taurolithocholic acid is an orally active bile acid and antiviral agent. Taurolithocholic acid upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis (Ferroptosis), viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic acid also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis .
6
6 Cited Publications
4
4 Cited Publications
Cat. No.: HY-P1034
CAS No.: 106362-34-9
Synonyms: D-Ala-peptide T-amide; Adaptavir
Research Areas:
2
2 Cited Publications
SSAA09E3 is a SARS-CoV entry inhibitor that inhibits SARS/HIV pseudotyped virus entry with an EC50 of 9.7 μM in 293T cells and inhibits SARS-CoV infection of Vero cells with an EC50 of 0.15 μM .
1
Target:
Research Areas:
Carbinoxamine maleate salt is a blood-brain barrier-permeable histamine H1 receptor antagonist. Carbinoxamine maleate salt blocks the action of histamine on H1 receptors, reducing symptoms such as sneezing, rhinitis, rhinorrhea, erythema, pruritus and urticaria. Carbinoxamine maleate salt inhibits influenza virus entry into cells via endocytosis, targets the early stage of the viral life cycle, and simultaneously reduces viral replication levels in the lungs, alleviating pathological damage and inflammatory responses in lung tissues. Carbinoxamine maleate salt can be used in research on allergic rhinitis, influenza, etc.
1
1 Cited Publications
Cat. No.: HY-N4183
CAS No.: 72357-31-4
Category:
Flavonoids Leguminosae Flavones Phenols Polyphenols Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer
Target:
Cat. No.: HY-P3161
CAS No.: 936541-36-5
Cat. No.: HY-N0168A
CAS No.: 69097-99-0
Category:
other families Flavonoids Flavonones Phenols Polyphenols Plants
Target:
Category:
Infection Triterpenes other families Terpenoids Plants Disease Research Fields Inflammation/Immunology
Target:
Cat. No.: HY-P990015
CAS No.: 2645440-65-7
Synonyms: VIR-3434
Cat. No.: HY-P991069
CAS No.: 1412901-55-3
Cat. No.: HY-P990825
Target:
Research Areas:
Cat. No.: HY-P11460
Target:
Research Areas:
Neuraminidase, arthrobacter ureafaciens is a neuraminidase derived from Arthrobacter ureafaciens. Neuraminidase, arthrobacter ureafaciens catalyzes the removal of sialic acid residues from cell surfaces and viral glycoconjugates. Neuraminidase, arthrobacter ureafaciens enhances HIV-1-mediated syncytium formation and promotes the viral binding and entry steps in the HIV-1 replication cycle .
Cat. No.: HY-155386
CAS No.: 14042-01-4
Research Areas:
Peroxynitrite sodium is a product of the diffusion-controlled reaction between nitric oxide and superoxide radicals, as well as an oxidant and an antiviral agent. Peroxynitrite sodium inhibits Mitochondrial respiration. Peroxynitrite sodium suppresses the replication of Coxsackievirus, partly by inhibiting viral RNA entry into host cells. Peroxynitrite sodium induces a significant nociceptive response .
Target:
BC-11 hydrobromide is a selective TMPRSS2 inhibitor (TMPRSS2 is a key host cellular factor for viral entry and SARS-CoV-2 pathogenesis), and a selective urokinase (uPA) inhibitor (IC50=8.2 μM). BC-11 hydrobromide is cytotoxic to triple-negative MDA-MB231 breast cancer cells. BC-11 hydrobromide is used in research on viral infections and cancer .
Cat. No.: HY-115488A
CAS No.: 1859189-55-1
BNM-III-170, CD4-mimeticcompound, is an anti-HIV-1 agent. BNM-III-170 binds to the Phe43 cavity of HIV 1 gp120. BNM-III-170 can inhibits HIV-1 viral entry into target cells. BNM-III-170 can be used for the research of HIV-1 infection .
Cat. No.: HY-P99346
CAS No.: 2444308-95-4
Synonyms: CT-P59
Research Areas:
Cat. No.: HY-158405
CAS No.: 2923674-83-1
Synonyms: MAV-104
Target:
Research Areas:
PAV-104 (MAV-104) is a host-targeted, pan-respiratory viral assembly inhibitor. PAV-104 targets a small subset of the host protein 14-3-3 within a transient multi-protein complex. PAV-104 inhibits SARS-CoV-2 replication by blocking post-entry viral assembly/budding through interaction with viral nucleocapsid (N) protein and interference with its oligomerization. PAV-104 is orally active in cats and shows favorable pharmacokinetic properties in rats. PAV-104 can be used for the study of COVID-19 and other respiratory viral infections, including Feline Infectious Peritonitis (FIP) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
