SERT/5-HT-IN-1
SERT/5-HT-IN-1 (compound D17) is an orally active and potent dual target inhibitor of SERT/5-HT3A (SERT IC50 = 1.5 nM, NET IC50 = 49 nM, DAT IC50 = 91 nM, 5-HT3A Ki = 12 nM). SERT/5-HT-IN-1 has an IC50 of 39 nM to 5-HT3A. SERT/5-HT-IN-1 has a lower risk of liver, kidney, and cardiac toxicity. SERT/5-HT-IN-1 can be used for research on depressive disorders.
For research use only. We do not sell to patients.
- Purity: 99.44%
- CAS No.: 3120534-54-2
- Formula: C15H18N2S
- Molecular Weight:258.38
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All 5-HT Receptor Isoforms
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Biological Activity
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SERT 1.5 nM (IC50) |
NET 49 nM (IC50) |
DAT 91 nM (IC50) |
5-HT3A Receptor 12 nM (Ki) |
5-HT3A Receptor 39 nM (IC50) |
Chemical Information
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CAS No. 3120534-54-2
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Appearance Solid
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Molecular Weight 258.38
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Formula C15H18N2S
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Color White to off-white
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SMILES
N1(C2=C(SC=C3)C3=CC=C2)CCC4(CNC4)CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 25 mg/mL (96.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8703 mL | 19.3513 mL | 38.7027 mL | 96.7567 mL |
| 5 mM | 0.7741 mL | 3.8703 mL | 7.7405 mL | 19.3513 mL | |
| 10 mM | 0.3870 mL | 1.9351 mL | 3.8703 mL | 9.6757 mL | |
| 15 mM | 0.2580 mL | 1.2901 mL | 2.5802 mL | 6.4504 mL | |
| 20 mM | 0.1935 mL | 0.9676 mL | 1.9351 mL | 4.8378 mL | |
| 25 mM | 0.1548 mL | 0.7741 mL | 1.5481 mL | 3.8703 mL | |
| 30 mM | 0.1290 mL | 0.6450 mL | 1.2901 mL | 3.2252 mL | |
| 40 mM | 0.0968 mL | 0.4838 mL | 0.9676 mL | 2.4189 mL | |
| 50 mM | 0.0774 mL | 0.3870 mL | 0.7741 mL | 1.9351 mL | |
| 60 mM | 0.0645 mL | 0.3225 mL | 0.6450 mL | 1.6126 mL | |
| 80 mM | 0.0484 mL | 0.2419 mL | 0.4838 mL | 1.2095 mL |
SERT/5-HT-IN-1 Related Classifications
HY-178907 Related Classifications
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