2. Neuronal Signaling GPCR/G Protein
  3. Serotonin Transporter 5-HT Receptor
  4. SERT/5-HT-IN-1

SERT/5-HT-IN-1 (compound D17) is an orally active and potent dual target inhibitor of SERT/5-HT3A (SERT IC50 = 1.5 nM, NET IC50 = 49 nM, DAT IC50 = 91 nM, 5-HT3A Ki = 12 nM). SERT/5-HT-IN-1 has an IC50 of 39 nM to 5-HT3A. SERT/5-HT-IN-1 has a lower risk of liver, kidney, and cardiac toxicity. SERT/5-HT-IN-1 can be used for research on depressive disorders.

For research use only. We do not sell to patients.

SERT/5-HT-IN-1

SERT/5-HT-IN-1 Chemical Structure

CAS No. : 3120534-54-2

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SERT/5-HT-IN-1 Related Antibodies

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Description

SERT/5-HT-IN-1 (compound D17) is an orally active and potent dual target inhibitor of SERT/5-HT3A (SERT IC50 = 1.5 nM, NET IC50 = 49 nM, DAT IC50 = 91 nM, 5-HT3A Ki = 12 nM). SERT/5-HT-IN-1 has an IC50 of 39 nM to 5-HT3A. SERT/5-HT-IN-1 has a lower risk of liver, kidney, and cardiac toxicity. SERT/5-HT-IN-1 can be used for research on depressive disorders[1].

IC50 & Target[1]

SERT

1.5 nM (IC50)

NET

49 nM (IC50)

DAT

91 nM (IC50)

5-HT3A Receptor

12 nM (Ki)

5-HT3A Receptor

39 nM (IC50)

Molecular Weight

258.38

Formula

C15H18N2S
CAS No.
SMILES

N1(C2=C(SC=C3)C3=CC=C2)CCC4(CNC4)CC1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SERT/5-HT-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SERT/5-HT-IN-13120534-54-2Serotonin Transporter5-HT Receptor5-HTTSERTSLC6A4Serotonin Receptor5-hydroxytryptamine Receptor5-HT3ANETDATdepressiveInhibitorinhibitorinhibit

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