CA77.1
Based on 8 publication(s) in Google Scholar
CA77.1 is a potent, brain-penetrant and orally active chaperone-mediated autophagy (CMA) activator with favorable pharmacokinetics. CA77.1 is a derivative of AR7 (HY-101106) and can increase the expression of the lysosomal receptor LAMP2A in?lysosomes. CA77.1 improves behavior and neuropathology in PS19 mice model and can be used for alzheimer's?disease research.
For research use only. We do not sell to patients.
- Purity: 99.92%
- CAS No.: 2412270-22-3
- Formula: C16H12ClN3O
- Molecular Weight:297.74
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Storage:
4°C, protect from light
* In solvent : -80°C, 2 years; -20°C, 1 year (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Autophagy Compound Library
HY-L029
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Anti-Alzheimer's Disease Compound Library
HY-L069
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Neurodegenerative Disease-related Compound Library
HY-L086
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Targeted Diversity Library
HY-L099
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Cell Death Library
HY-L162
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) CA77.1
More- Autophagy. 2025 Nov 30:1-21. [Abstract]
- Sci Transl Med. 2026 Feb 18;18(837):eads9597. [Abstract]
- Sci Adv. 2023 Oct 6;9(40):eadi8343. [Abstract]
- Cell Rep. 2025 Apr 2;44(4):115489. [Abstract]
- Cell Rep. 2023 Aug 16;42(8):112998. [Abstract]
- Am J Physiol Cell Physiol. 2026 Mar 1;330(3):C590-C604. [Abstract]
- J Virol. 2025 Mar 31:e0016825. [Abstract]
- Res Sq. 2026 May 20.
Customer Validation & Images
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In Vivo Efficacy Study
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Histological Imaging/Staining
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Biological Activity
CA77.1 (0-30 μM; 16 hours) activates CMA in a dose-and time-dependent manner to NIH 3T3 cells stably expressing the KFERQ-PS-Dendra reporter. The CMA activity is quantified as the average of fluorescent puncta per cell[1].CA77.1 (20 μM; 6 hours) does not alter on LC3-II expression, and does not effects autophagic flux in NIH 3T3 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:9-month-old CTR or PS19 mice[1]
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Dosage:30 mg/kg
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Administration:Oral gavage; 30 mg/kg; 6 months
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Result:Improved behavior and neuropathology in a mouse model of frontotemporal-dementia-related proteotoxicity.
Chemical Information
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CAS No. 2412270-22-3
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Appearance Solid
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Molecular Weight 297.74
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Formula C16H12ClN3O
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Color Off-white to light yellow
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SMILES
CC(NC1=CC=C(C2=NC3=CC=C(Cl)C=C3N=C2)C=C1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 2 years; -20°C, 1 year (protect from light)
Publications (8)
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Journal Impact Factor
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Most Recent
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Autophagy
Activation of chaperone-mediated autophagy suppresses glioblastoma by promoting wild-type IDH1/isocitrate dehydrogenase 1 degradation. [Abstract]2025 Nov 30:1-21. PMID: 41231102 -
Sci Transl Med
Chaperone-mediated autophagy supports organ regeneration and fibroblast quiescence in mouse models of fibrosis. [Abstract]2026 Feb 18;18(837):eads9597. PMID: 41706873
CA77.1 purchased from MedChemExpress. Usage Cited in: Sci Transl Med. 2026 Feb 18;18(837):eads9597. [Abstract]
CA77.1 (20 μM; 24-48 h) decreased the expression of FN and α-SMA, and increased LAMP2A in TGF-β-treated NIH3T3 cells.
CA77.1 purchased from MedChemExpress. Usage Cited in: Sci Transl Med. 2026 Feb 18;18(837):eads9597. [Abstract]
CA77.1 (20 μM; 24-48 h) decreased the expression of FN and α-SMA, and increased LAMP2A in TGF-β-treated LX-2 cells.
CA77.1 purchased from MedChemExpress. Usage Cited in: Sci Transl Med. 2026 Feb 18;18(837):eads9597. [Abstract]
CA77.1 (10 mg/kg; i.p.; once daily for 2 weeks) improved respiratory function, as reflected by increased tidal volume and minute ventilation in pulmonary fibrosis mice.
CA77.1 purchased from MedChemExpress. Usage Cited in: Sci Transl Med. 2026 Feb 18;18(837):eads9597. [Abstract]
CA77.1 (10 mg/kg; i.p.; once daily for 2 weeks) reduced fibrotic pathology in pulmonary fibrosis mice.
CA77.1 purchased from MedChemExpress. Usage Cited in: Sci Transl Med. 2026 Feb 18;18(837):eads9597. [Abstract]
CA77.1 (10 mg/kg; i.p.; once daily for 2 weeks) reduced FN, LAMP2A, and α-SMA expression in lung tissue of pulmonary fibrosis mice.
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Sci Adv
Deficient chaperone-mediated autophagy facilitates LPS-induced microglial activation via regulation of the p300/NF-κB/NLRP3 pathway. [Abstract]2023 Oct 6;9(40):eadi8343. PMID: 37801503 -
Cell Rep
LAMP2A-mediated neuronal hyperexcitability by enhancing NKAβ1 degradation underlies depression-induced allodynia. [Abstract]2025 Apr 2;44(4):115489. PMID: 40178973 -
Cell Rep
Chaperone-mediated autophagy in neuronal dendrites utilizes activity-dependent lysosomal exocytosis for protein disposal. [Abstract]2023 Aug 16;42(8):112998. PMID: 37590146 -
Am J Physiol Cell Physiol
Central activation of chaperone-mediated autophagy reduces appetite by fine-tuning hypothalamic amino acid pools: new insights from fish. [Abstract]2026 Mar 1;330(3):C590-C604. PMID: 41525106 -
J Virol
Heat shock protein A1 inhibits the replication of foot-and-mouth disease virus by degrading viral RNA polymerase 3D through chaperone-mediated autophagy. [Abstract]2025 Mar 31:e0016825. PMID: 40162788 -
Solvent & Solubility
DMSO : 5 mg/mL (16.79 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : < 1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (protect from light). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (protect from light). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (protect from light). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3586 mL | 16.7932 mL | 33.5864 mL | 83.9659 mL |
| 5 mM | 0.6717 mL | 3.3586 mL | 6.7173 mL | 16.7932 mL | |
| 10 mM | 0.3359 mL | 1.6793 mL | 3.3586 mL | 8.3966 mL | |
| 15 mM | 0.2239 mL | 1.1195 mL | 2.2391 mL | 5.5977 mL |
CA77.1 Related Classifications
HY-134923 Related Classifications
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