tBPC
Based on 1 Customer Validation
tBPC is a selective positive allosteric modulator for human Y4 receptor (Y4R), which enhances the activation of Y4R in G protein signaling and arrestin3 recruitment.
For research use only. We do not sell to patients.
- Purity: 98.41%
- CAS No.: 1942-71-8
- Formula: C16H24O2
- Molecular Weight:248.36
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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GPCR/G Protein Compound Library
HY-L006
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Neuronal Signaling Compound Library
HY-L013
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Neurotransmitter Receptor Compound Library
HY-L062
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Anti-Obesity Compound Library
HY-L087
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Membrane Protein-targeted Compound Library
HY-L149
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Membrane Receptor-targeted Compound Library
HY-L150
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Allosteric Modulators (AMs) Compound Library
HY-L170
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MCE Bioactive Compound Library
HY-L001V
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High-Throughput Bioactive Compound Library
HY-L205
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Lactylation Compound Library
HY-L249
All Neuropeptide Y Receptor Isoforms
More
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
4.5 nM
Compound: tBPC
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Positive allosteric modulation of human C-terminal eYFP-tagged NY4 receptor expressed in HEK293 cells assessed as potentiation of pancreatic polypeptide-induced arrestin 3 recruitment by measuring pancreatic polypeptide EC50 at 30 uM after 30 mins by BRET
Positive allosteric modulation of human C-terminal eYFP-tagged NY4 receptor expressed in HEK293 cells assessed as potentiation of pancreatic polypeptide-induced arrestin 3 recruitment by measuring pancreatic polypeptide EC50 at 30 uM after 30 mins by BRET
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[PMID: 28795803] |
| HEK293 | EC50 |
443 nM
Compound: tBPC
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Positive allosteric modulation of human C-terminal eYFP-tagged NY4 receptor expressed in HEK293 cells assessed as potentiation of neuropeptide Y-induced arrestin 3 recruitment by measuring neuropeptide Y EC50 at 30 uM after 30 mins by BRET assay (Rvb = 13
Positive allosteric modulation of human C-terminal eYFP-tagged NY4 receptor expressed in HEK293 cells assessed as potentiation of neuropeptide Y-induced arrestin 3 recruitment by measuring neuropeptide Y EC50 at 30 uM after 30 mins by BRET assay (Rvb = 13
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[PMID: 28795803] |
| HEK293 | EC50 |
845 nM
Compound: tBPC
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Positive allosteric modulation of human C-terminal eYFP-tagged NY4 receptor expressed in HEK293 cells assessed as potentiation of peptide YY-induced arrestin 3 recruitment by measuring peptide YY EC50 at 30 uM after 30 mins by BRET assay (Rvb = 1600 nM)
Positive allosteric modulation of human C-terminal eYFP-tagged NY4 receptor expressed in HEK293 cells assessed as potentiation of peptide YY-induced arrestin 3 recruitment by measuring peptide YY EC50 at 30 uM after 30 mins by BRET assay (Rvb = 1600 nM)
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[PMID: 28795803] |
Chemical Information
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CAS No. 1942-71-8
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Appearance Solid
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Molecular Weight 248.36
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Formula C16H24O2
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Color White to off-white
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SMILES
OC1C(OC2=CC=C(C(C)(C)C)C=C2)CCCC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (402.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.0264 mL | 20.1321 mL | 40.2641 mL | 100.6603 mL |
| 5 mM | 0.8053 mL | 4.0264 mL | 8.0528 mL | 20.1321 mL | |
| 10 mM | 0.4026 mL | 2.0132 mL | 4.0264 mL | 10.0660 mL | |
| 15 mM | 0.2684 mL | 1.3421 mL | 2.6843 mL | 6.7107 mL | |
| 20 mM | 0.2013 mL | 1.0066 mL | 2.0132 mL | 5.0330 mL | |
| 25 mM | 0.1611 mL | 0.8053 mL | 1.6106 mL | 4.0264 mL | |
| 30 mM | 0.1342 mL | 0.6711 mL | 1.3421 mL | 3.3553 mL | |
| 40 mM | 0.1007 mL | 0.5033 mL | 1.0066 mL | 2.5165 mL | |
| 50 mM | 0.0805 mL | 0.4026 mL | 0.8053 mL | 2.0132 mL | |
| 60 mM | 0.0671 mL | 0.3355 mL | 0.6711 mL | 1.6777 mL | |
| 80 mM | 0.0503 mL | 0.2517 mL | 0.5033 mL | 1.2583 mL | |
| 100 mM | 0.0403 mL | 0.2013 mL | 0.4026 mL | 1.0066 mL |
tBPC Related Classifications
HY-115575 Related Classifications
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