Tigogenin
Based on 1 Customer Validation
Tigogenin is a steroidal sapogenins. Tigogenin can inhibit adipocytic differentiation and induce osteoblastic differentiation in mouse bone marrow stromal cells. Tigogenin can inhibit cells proliferation and induce apoptosis. Tigogenin can be used for the researches of cancer, inflammation, immunology, metabolic and cardiovascular disease, such as mammary gland carcinoma, rheumatoid arthritis, osteoporosis and atherosclerosis.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 77-60-1
- Formula: C27H44O3
- Molecular Weight:416.64
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Tigogenin (10-90 μM, 3 days) promotes bone marrow stromal cells (BMSCs) proliferation in a dose-dependent manner[1].
Tigogenin (10-90 μM, 18 days) decreases lipid accumulation and visfatin secretions in BMSCs[1].
Tigogenin (10-90 μM, 5-18 days) reduces PPAR mRNA and ap2 levels in BMSCs[1].
Tigogenin (10-90 μM, 5 days) increases levels of mRNA for Cbfa1, COL I, OCN and ALP activity in BMSCs[1].
Tigogenin (30 μM, 5-40 mins) activates the phosphorylation of p38 kinase in BMSCs[1].
Tigogenin (40 μM, 24-96 h) inhibits proliferation in rheumatoid arthritis (RA) synoviocytes[2].
Tigogenin (40 μM, 6-24 h) induces apoptosis in RA synoviocytes[2].
Tigogenin (40 μM, 1-24 h) increases P38, COX-2 and PEG2 levels in RA synoviocytes[2].
Tigogenin (20 μM, 24 h) reduces FXR, SHP, and BSEP levels companied with CDCA (HY-76847) in HepG2 cells[3].
Tigogenin (L–serine derivative of Tigogenin) (48 h) inhibits MCF-7 and MDA-MB-231 cells proliferation with IC50 values of 1.5 and 10.5 μM[4].
Tigogenin (L–serine derivative of Tigogenin) (2.8-7 μM, 18 h) induces apoptosis and increases caspase 3/7 activity in MCF-7 cells[4].
Tigogenin (L–serine derivative of Tigogenin) (5 μM, 6 h) reduces TNF-α, IL-1, IL-12, IL-10 and IL-4 levels in THP–1 cells[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BMSCs
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Concentration:10, 30 and 90 μM
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Incubation Time:3 days
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Result:Promoted proliferation in a dose-dependent manner.
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Cell Line:BMSCs
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Concentration:10, 30 and 90 μM
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Incubation Time:5 or 18 days
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Result:Reduced PPAR mRNA and ap2 levels.
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Cell Line:RA synoviocytes
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Concentration:40 μM
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Incubation Time:6 and 24 h
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Result:Induced cell shrinkage, cytoplasm condensation and formation of cytoplasmic filaments.
Increased caspase-3, caspase-8 and caspase-9 activities.
Showed DNA fragmentation.
Chemical Information
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CAS No. 77-60-1
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Appearance Solid
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Molecular Weight 416.64
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Formula C27H44O3
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Color White to off-white
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SMILES
[H][C@]1(O[C@@]2(OC[C@H](C)CC2)[C@H]3C)C[C@@]4([H])[C@]5([H])CC[C@@]6([H])C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@]13[H]
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
Ethanol : 14.29 mg/mL (34.30 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Zhou H, et al. Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells. Mol Cell Endocrinol. 2007 May 30;270(1-2):17-22. [Content Brief]
[2]. Liagre B, et al. Inhibition of human rheumatoid arthritis synovial cell survival by hecogenin and tigogenin is associated with increased apoptosis, p38 mitogen-activated protein kinase activity and upregulation of cyclooxygenase-2. Int J Mol Med. 2007 Oct;20(4):451-60. [Content Brief]
[3]. Bao R, et al. Dioscin Ameliorates Hyperuricemia-Induced Atherosclerosis by Modulating of Cholesterol Metabolism through FXR-Signaling Pathway. Nutrients. 2022 May 9;14(9):1983. [Content Brief]
[4]. Michalak O, et al. Synthesis and anti-tumour, immunomodulating activity of diosgenin and tigogenin conjugates. J Steroid Biochem Mol Biol. 2020 Apr;198:105573. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 2.4002 mL | 12.0008 mL | 24.0015 mL | 60.0038 mL |
| 5 mM | 0.4800 mL | 2.4002 mL | 4.8003 mL | 12.0008 mL | |
| 10 mM | 0.2400 mL | 1.2001 mL | 2.4002 mL | 6.0004 mL | |
| 15 mM | 0.1600 mL | 0.8001 mL | 1.6001 mL | 4.0003 mL | |
| 20 mM | 0.1200 mL | 0.6000 mL | 1.2001 mL | 3.0002 mL | |
| 25 mM | 0.0960 mL | 0.4800 mL | 0.9601 mL | 2.4002 mL | |
| 30 mM | 0.0800 mL | 0.4000 mL | 0.8001 mL | 2.0001 mL |
Tigogenin Related Classifications
HY-N1403 Related Classifications
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