1. Neuronal Signaling
  2. CaMK
  3. TIM-063

TIM-063 is a selective and cell-permeable CaMKK inhibitor, ATP competitive inhibitor, can directly target the catalytic domain of CaMKK, with the Ki values of 0.35 μM and 0.2 μM for CaMKKα and CaMKKβ, respectively, the IC50 values are 0.63 μM and 0.96 μM, respectively.

For research use only. We do not sell to patients.

TIM-063 Chemical Structure

TIM-063 Chemical Structure

CAS No. : 2493978-38-2

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Description

TIM-063 is a selective and cell-permeable CaMKK inhibitor, ATP competitive inhibitor, can directly target the catalytic domain of CaMKK, with the Ki values of 0.35 μM and 0.2 μM for CaMKKα and CaMKKβ, respectively, the IC50 values are 0.63 μM and 0.96 μM, respectively[1].

In Vitro

TIM-063 (0-29 μM, 6 h) dose-dependently inhibits endogenous CaMKK activity in HeLa cells and also inhibits CaMKK isoform-catalyzed phosphorylation of CaMKIV in transfected COS-7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

331.28

Formula

C18H9N3O4

CAS No.
SMILES

O=C1C2=CC=CC3=C([N+]([O-])=O)C(O)=CC(C4=NC5=C(N14)C=CC=C5)=C32

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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TIM-063 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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TIM-063
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HY-148757
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