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Cat. No.: HY-188282

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Trastuzumab botidotin

Trastuzumab botidotin is an antibody-drug conjugate (Antibody-Drug Conjugates) targeting HER2, formed by conjugating Trastuzumab (HY-P9907) with Duostatin-5 (HY-145149). Trastuzumab botidotin exerts antitumor effects through microtubule (Microtubule) inhibition and the ADCC mechanism. Trastuzumab botidotin can be used for HER2-positive breast cancer and HER2-positive solid tumors.

For research use only. We do not sell to patients.

Antibody:
Trastuzumab
Linker-Payload:
K‑Lock‑VC‑DUO‑5
Drug-to-Antibody Ratio:
2
Conjugate Type:
site-specific Lysines

CAS No.: 2699055-12-2

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Trastuzumab botidotin Chemical Structure

CAS No.: 2699055-12-2

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Use of MCE Products

One-Stop Platform：From Independent R&D to Pilot-Scale Production

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Product Details
- Antibody
- Linker-Payload
- Drug-to-Antibody Ratio
- Conjugate Type
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

HER2

All EGFR Isoforms :

In Vitro

Anti-cancer

Trastuzumab botidotin (DAR = 2) consists of Trastuzumab (HY-P9907), a protease-cleavable linker, and the Duostatin-5 (HY-145149) payload, and exerts antitumor effects through microtubule inhibition and ADCC mechanisms^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-cancer

Trastuzumab botidotin (3 mg/kg) produces stronger tumor growth inhibition than Trastuzumab emtansine (HY-P9921) in HER2-positive solid tumor xenograft models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Breast Cancer Modeling

Product Details

Antibody

Trastuzumab
Linker-Payload

K‑Lock‑VC‑DUO‑5
Drug-to-Antibody Ratio

2
Conjugate Type

site-specific Lysines

Chemical Information

CAS No. 2699055-12-2
SMILES

[Trastuzumab botidotin]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Liu X, et al. The clinical development of antibody-drug conjugates for non-small cell lung cancer therapy. Frontiers in Immunology. 2023;14.

[2]. Zhang J, et al. Trastuzumab Botidotin Versus Trastuzumab Emtansine in Human Epidermal Growth Factor Receptor 2-Positive Advanced Breast Cancer: A Phase III, Open-Label, Randomized Controlled Trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2026 Sep 11. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Trastuzumab botidotin

All EGFR Isoforms