1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. Trimethobenzamide

Trimethobenzamide (Synonyms: Ro 2-9578 free base)

Cat. No.: HY-12751
Handling Instructions

Trimethobenzamide (Ro 2-9578 free base) is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting.

For research use only. We do not sell to patients.

Trimethobenzamide Chemical Structure

Trimethobenzamide Chemical Structure

CAS No. : 138-56-7

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Description

Trimethobenzamide (Ro 2-9578 free base) is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting[1].

IC50 & Target

D2 receptor[1]

In Vitro

Trimethobenzamide is a (non-phenothiazine) benzamide antiemetic that acts centrally to block D2 receptors, thereby inhibiting the medullary chemoreceptor trigger zone by blocking emetic impulses to the vomiting center[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The oral bioavailability of Trimethobenzamide is 60% to 100%. The time to peak is about 45 minutes after oral administration and; Intramuscular (I.M.) administration about 30 minutes after intramuscular administration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

388.46

Formula

C₂₁H₂₈N₂O₅

CAS No.
SMILES

O=C(NCC1=CC=C(OCCN(C)C)C=C1)C2=CC(OC)=C(OC)C(OC)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

TrimethobenzamideRo 2-9578Dopamine ReceptorInhibitorinhibitorinhibit

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Trimethobenzamide
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