1. GPCR/G Protein
    Neuronal Signaling
    Anti-infection
  2. Dopamine Receptor
    Influenza Virus
  3. Trimethobenzamide hydrochloride

Trimethobenzamide hydrochloride (Synonyms: Ro 2-9578)

Cat. No.: HY-12751A Purity: 99.80%
Handling Instructions

Trimethobenzamide hydrochloride is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting.

For research use only. We do not sell to patients.

Trimethobenzamide hydrochloride Chemical Structure

Trimethobenzamide hydrochloride Chemical Structure

CAS No. : 554-92-7

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Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 106 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 106 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 96 In-stock
Estimated Time of Arrival: December 31
200 mg USD 132 In-stock
Estimated Time of Arrival: December 31
500 mg USD 204 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Trimethobenzamide hydrochloride:

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Description

Trimethobenzamide hydrochloride is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting.

IC50 & Target

D2 receptor[1]

In Vitro

Trimethobenzamide is a (non-phenothiazine) benzamide antiemetic that acts centrally to block D2 receptors, thereby inhibiting the medullary chemoreceptor trigger zone by blocking emetic impulses to the vomiting center[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The oral bioavailability of Trimethobenzamide is 60% to 100%. The time to peak is about 45 minutes after oral administration and; Intramuscular (I.M.) administration about 30 minutes after intramuscular administration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

424.92

Formula

C₂₁H₂₉ClN₂O₅

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (235.34 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3534 mL 11.7669 mL 23.5338 mL
5 mM 0.4707 mL 2.3534 mL 4.7068 mL
10 mM 0.2353 mL 1.1767 mL 2.3534 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Trimethobenzamide hydrochloride
Cat. No.:
HY-12751A
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