UBB - ubiquitin B Gene

Also Known as HEL-S-50

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7314

About UBB

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:16,380,779-16,382,745 (from NCBI)

This gene has 9 transcripts (splice variants), 101 orthologues, 10 paralogues and is associated with 4 phenotypes. Ubiquitous expression in liver (RPKM 498.1), testis (RPKM 495.1) and 25 other tissues.

Summary

This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. An aberrant form of this protein has been detected in patients with Alzheimer's disease and Down syndrome. Pseudogenes of this gene are located on chromosomes 1, 2, 13, and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

UBB Products (6)

mRNA	Protein	Name
NM_001281716.2	NP_001268645.1	polyubiquitin-B precursor
NM_001281717.1	NP_001268646.1	polyubiquitin-B precursor
NM_001281718.1	NP_001268647.1	polyubiquitin-B precursor
NM_001281719.1	NP_001268648.1	polyubiquitin-B precursor
NM_001281720.2	NP_001268649.1	polyubiquitin-B precursor
NM_018955.4	NP_061828.1	polyubiquitin-B precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14755250	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within mitochondrion transport along microtubule	IDA IDA: Inferred from direct assay	17571083	GOA
acts upstream of or within neuron projection morphogenesis	IMP IMP: Inferred from mutant phenotype	17571083	GOA
acts upstream of or within positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator	IDA IDA: Inferred from direct assay	17571083	GOA
involved in positive regulation of protein monoubiquitination	IMP IMP: Inferred from mutant phenotype	24660806	GOA
involved in positive regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	24660806	GOA
acts upstream of or within regulation of mitochondrial membrane potential	IDA IDA: Inferred from direct assay	17571083	GOA
acts upstream of or within regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	17571083	GOA
acts upstream of or within regulation of proteasomal protein catabolic process	IDA IDA: Inferred from direct assay	17571083	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	17571083	GOA
located in neuron projection	IDA IDA: Inferred from direct assay	17571083	GOA
located in neuronal cell body	IDA IDA: Inferred from direct assay	17571083	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBB Protein Structure

ubiquitin

0
100
200
229 a.a.

Protein Preferred Names	Protein Names
polyubiquitin-B	epididymis secretory protein Li 50

UBB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UBB	P0CG47	OTUB1	Homo sapiens	Q96FW1	Y2H Pooling	32814053
Intra	UBB	P0CG47	OTUB1	Homo sapiens	Q96FW1	Validated Y2H	32814053
Intra	UBB	P0CG47	OTUB1	Homo sapiens	Q96FW1	Y2H Array	32814053
Intra	UBB	P0CG47	MTURN	Homo sapiens	Q8N3F0	Validated Y2H	32296183
Intra	UBB	P0CG47	USP5	Homo sapiens	P45974-2	Validated Y2H	32814053
Intra	UBB	P0CG47	USP5	Homo sapiens	P45974-2	Y2H Array	32814053
Intra	UBB	P0CG47	USP5	Homo sapiens	P45974-2	Y2H Pooling	32814053
Cross	UBB	P0CG47	Pax3	Mus musculus	P24610	Anti Bait CoIP	17662948
Cross	UBB	P0CG47	Pax3	Mus musculus	P24610	GMS	17662948
Intra	UBB	P0CG47	RNF43	Homo sapiens	Q68DV7	Anti Tag CoIP	18313049
Intra	UBB	P0CG47	OTUD7B	Homo sapiens	Q6GQQ9-2	Y2H Array	32814053
Intra	UBB	P0CG47	OTUD7B	Homo sapiens	Q6GQQ9-2	Y2H Pooling	32814053
Intra	UBB	P0CG47	OTUD7B	Homo sapiens	Q6GQQ9-2	Validated Y2H	32814053
Intra	UBB	P0CG47	WDR31	Homo sapiens	Q8NA23-2	Validated Y2H	32814053
Intra	UBB	P0CG47	WDR31	Homo sapiens	Q8NA23-2	Y2H Array	32814053
Intra	UBB	P0CG47	WDR31	Homo sapiens	Q8NA23-2	Y2H Pooling	32814053
Intra	UBB	P0CG47	DESI1	Homo sapiens	Q6ICB0	Y2H Array	32296183
Intra	UBB	P0CG47	DESI1	Homo sapiens	Q6ICB0	Y2H Prey Pooling	32296183
Intra	UBB	P0CG47	DESI1	Homo sapiens	Q6ICB0	Validated Y2H	32296183
Intra	UBB	P0CG47	CDIP1	Homo sapiens	Q9H305	Validated Y2H	32296183
Intra	UBB	P0CG47	PLEKHB2	Homo sapiens	Q96CS7	Validated Y2H	32296183
Intra	UBB	P0CG47	PLEKHB2	Homo sapiens	Q96CS7	Y2H Array	32296183
Intra	UBB	P0CG47	PLEKHB2	Homo sapiens	Q96CS7	Y2H Prey Pooling	32296183
Intra	UBB	P0CG47	RNF11	Homo sapiens	Q9Y3C5	Anti Tag CoIP	14755250
Intra	UBB	P0CG47	STAMBP	Homo sapiens	O95630	Anti Tag CoIP	14755250
Intra	UBB	P0CG47	SMURF2	Homo sapiens	Q9HAU4	Anti Tag CoIP	14755250
Intra	UBB	P0CG47	SMURF2	Homo sapiens	Q9HAU4	Enzymatic Study	17719543
Intra	UBB	P0CG47	GGA1	Homo sapiens	Q9UJY5	Y2H	15143060
Intra	UBB	P0CG47	GGA1	Homo sapiens	Q9UJY5	Pull Down	15143060
Intra	UBB	P0CG47	GGA1	Homo sapiens	Q9UJY5	Affinity Chrom	15143060
Intra	UBB	P0CG47	GGA3	Homo sapiens	Q9NZ52	Y2H	15039775
Intra	UBB	P0CG47	GGA3	Homo sapiens	Q9NZ52	Affinity Chrom	15039775
Cross	UBB	P0CG47	Mast2	Mus musculus	Q60592	CoIP	14764729
Intra	UBB	P0CG47	TAX1BP1	Homo sapiens	Q86VP1	Y2H Prey Pooling	32296183
Intra	UBB	P0CG47	TAX1BP1	Homo sapiens	Q86VP1	Y2H Array	32296183
Intra	UBB	P0CG47	TAX1BP1	Homo sapiens	Q86VP1	Validated Y2H	32296183
Intra	UBB	P0CG47	CCDC50	Homo sapiens	Q8IVM0	Y2H	18029035
Intra	UBB	P0CG47	CCDC50	Homo sapiens	Q8IVM0	Pull Down	18029035
Intra	UBB	P0CG47	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	UBB	P0CG47	DAZAP2	Homo sapiens	Q15038	Y2H Pooling	16189514
Intra	UBB	P0CG47	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	UBB	P0CG47	DAZAP2	Homo sapiens	Q15038	Validated Y2H	32296183
Intra	UBB	P0CG47	NEDD4	Homo sapiens	P46934	Enzymatic Study	17719543
Intra	UBB	P0CG47	SDCBP	Homo sapiens	O00560	Y2H Array	32296183
Intra	UBB	P0CG47	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	32296183
Intra	UBB	P0CG47	UBAC1	Homo sapiens	Q9BSL1	Validated Y2H	32296183
Intra	UBB	P0CG47	RYBP	Homo sapiens	Q8N488	Y2H Array	32814053
Intra	UBB	P0CG47	RYBP	Homo sapiens	Q8N488	Validated Y2H	32814053
Intra	UBB	P0CG47	RYBP	Homo sapiens	Q8N488	Y2H Pooling	32814053
Intra	UBB	P0CG47	PLSCR4	Homo sapiens	Q9NRQ2	Validated Y2H	32296183
Intra	UBB	P0CG47	RABGEF1	Homo sapiens	Q9UJ41	Pull Down	16499958
Intra	UBB	P0CG47	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	UBB	P0CG47	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	UBB	P0CG47	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	UBB	P0CG47	RAD23B	Homo sapiens	P54727	Validated Y2H	32296183
Intra	UBB	P0CG47	DUSP1	Homo sapiens	P28562	Anti Bait CoIP	16286470

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71101	UBB Protein, Human	P0CG47 (M153-G228)	≥ 95%, as determined by reducing SDS-PAGE.

UBB Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80363	Ubiquitin Antibody (YA022)	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
HY-P80925	Ubiquitin Antibody	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
HY-P84039	Ubiquitin Antibody (YA3736)	WB, FC, ELISA	Human
HY-P84039A	Ubiquitin Antibody (YA3736)(PBS only)	WB, FC, ELISA	Human
HY-P85694	Ubiquitin Antibody (YA5386)	IHC-P, WB	Species independent
HY-P85761	Ubiquitin Antibody (YA5453)	WB, ICC/IF, IHC-P	Human, Rat, Mouse, Pig

Related Diseases

Diseases	Alias
Cleft Hard Palate	Cleft Of Hard Palate Hard Palate Perforation
Submucosal Cleft Palate
Cleft Soft Palate	Cleft Velum Cleft Velum Palatinum Soft Cleft Palate Soft Palate Perforation
Uvula, Bifid	Bifid Uvula Uvular Cleft Uvula, Cleft Bifidity Of The Uvula
Down Syndrome	Trisomy 21 Complete Trisomy 21 Syndrome Down'S Syndrome Trisomy 21 Syndrome Down'S Syndrome - Trisomy 21 Downs Syndrome G Trisomy 47,Xx,+21 47,Xy,+21 Trisomy G Down Syndrome, Susceptibility To Chromosome 21 Trisomy Trisomy 21 Nos Abnormal Autosomes 21
Middle East Respiratory Syndrome	Mers Mers - [Middle East Respiratory Syndrome]
Myoclonic Epilepsy Of Lafora	Lafora Disease Epilepsy, Progressive Myoclonic 2b EPM2 Melf Epilepsy, Progressive Myoclonic 2a Epm2a Lafora'S Disease Lafora Body Disease Lbd Epilepsy, Progressive Myoclonic, 2a Lafora Progressive Myoclonic Epilepsy Epilepsy Progressive Myoclonic 2 Lafora Body Disorder Pme Type 2 Progressive Myoclonic Epilepsy Type 2 Progressive Myoclonus Epilepsy Type 2 Epilepsy, Progressive Myoclonic 2 Epm2b Ld Progressive Myoclonic Epilepsy 2 Progressive Myoclonic Epilepsy 2a Progressive Myoclonic Epilepsy 2b Progressive Myoclonic Epilepsy Lafora Type Epilepsy, Myoclonic, Of Lafora
Smith-Magenis Syndrome	SMS Chromosome 17p11.2 Deletion Syndrome 17p11.2 Microdeletion Syndrome 17p11.2 Monosomy Chromosome 17p Deletion Syndrome Del(17) P11.2 17p- Syndrome Deletion 17p Syndrome Partial Monosomy 17p
Encephalopathy, Familial, With Neuroserpin Inclusion Bodies	Familial Encephalopathy With Neuroserpin Inclusion Bodies FENIB Encephalopathy, Familial, With Collins Bodies Familial Dementia With Neuroserpin Inclusion Bodies Familial Encephalopathy With Collins Bodies
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Pick Disease Of Brain	Pick Disease Pick'S Disease Pick Disease Of The Brain Lobar Atrophy Of Brain Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions Behavioral Variant Of Frontotemporal Dementia Dementia In Pick'S Disease Lobar Atrophy Of The Brain Bvftd Bv-Ftd PIDB Picks Disease
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS18903	Ubb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20593	Rps27a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15333	UBB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17875	Ubc Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20505	Uba52 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25394	Ubb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27013	Uba52 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	UBB	RGD	RGD:621562
Macaca mulatta	UBB	VGNC	VGNC:99329
Canis familiaris	UBB	VGNC	VGNC:49664
Mus musculus	UBB	MGD	MGI:98888
Bos taurus	UBB	VGNC	VGNC:107281
Others	UBB	NCBI