ZBTB14 - zinc finger and BTB domain containing 14 Gene

Also Known as ZF5; ZFP-5; ZFP161; ZNF478; ZFP-161

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7541

About ZBTB14

Cytogenetic location: 18p11.31 Genomic coordinates (GRCh38): 18:5,289,022-5,297,053 (from NCBI)

This gene has 9 transcripts (splice variants), 192 orthologues and 28 paralogues. Ubiquitous expression in lymph node (RPKM 9.0), appendix (RPKM 6.6) and 25 other tissues.

Summary

Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in negative regulation of transcription, DNA-templated. Located in aggresome; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

ZBTB14 Products (4)

mRNA Protein Name
NM_001143823.3 NP_001137295.1 zinc finger and BTB domain-containing protein 14
NM_001243702.2 NP_001230631.1 zinc finger and BTB domain-containing protein 14
NM_001243704.2 NP_001230633.1 zinc finger and BTB domain-containing protein 14
NM_003409.5 NP_003400.2 zinc finger and BTB domain-containing protein 14

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
17714511 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15629158 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17714511 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
17714511 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
17714511 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
15629158 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZBTB14 Protein Structure

BTB

BTB: BTB/POZ domain (26 - 128)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (292 - 316)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (319 - 342)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (347 - 372)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (375 - 399)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 449 a.a.
Protein Preferred Names Protein Names

zinc finger and BTB domain-containing protein 14

  • ZFP161 zinc finger protein

ZBTB14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZBTB14 O43829 rnps1 Homo sapiens D3DU92
Y2H Prey Pooling
25416956
Intra
ZBTB14 O43829 rnps1 Homo sapiens D3DU92
Validated Y2H
25416956
Intra
ZBTB14 O43829 SYT16 Homo sapiens Q17RD7
Validated Y2H
25416956
Intra
ZBTB14 O43829 SYT16 Homo sapiens Q17RD7
Y2H Prey Pooling
25416956
Intra
ZBTB14 O43829 BAZ2B Homo sapiens Q9UIF8-2
Y2H Array
25416956
Intra
ZBTB14 O43829 PNKP Homo sapiens Q96T60
Validated Y2H
32296183
Intra
ZBTB14 O43829 PNKP Homo sapiens Q96T60
Y2H Prey Pooling
25416956
Intra
ZBTB14 O43829 SNRPB2 Homo sapiens P08579
Y2H Prey Pooling
25416956
Intra
ZBTB14 O43829 SNRPB2 Homo sapiens P08579
Validated Y2H
32296183
Intra
ZBTB14 O43829 SNRPB2 Homo sapiens P08579
Validated Y2H
25416956
Intra
ZBTB14 O43829 C2orf68 Homo sapiens Q2NKX9
Validated Y2H
32296183
Intra
ZBTB14 O43829 TCEANC Homo sapiens Q8N8B7-2
Validated Y2H
32296183
Intra
ZBTB14 O43829 RNASEH2B Homo sapiens Q8N451
Validated Y2H
32296183
Intra
ZBTB14 O43829 CDK16 Homo sapiens Q00536-3
Validated Y2H
32296183
Intra
ZBTB14 O43829 NAA11 Homo sapiens Q9BSU3
Validated Y2H
32296183
Intra
ZBTB14 O43829 q96bh6_human Homo sapiens Q96BH6
Validated Y2H
32814053
Intra
ZBTB14 O43829 q96bh6_human Homo sapiens Q96BH6
Y2H Array
32814053
Intra
ZBTB14 O43829 q96bh6_human Homo sapiens Q96BH6
Y2H Pooling
32814053
Intra
ZBTB14 O43829 INTS3 Homo sapiens Q68E01
Y2H Prey Pooling
25416956
Intra
ZBTB14 O43829 ZMAT2 Homo sapiens Q96NC0
Y2H Prey Pooling
25416956
Intra
ZBTB14 O43829 ZMAT2 Homo sapiens Q96NC0
Y2H Array
25416956
Intra
ZBTB14 O43829 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
ZBTB14 O43829 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
ZBTB14 O43829 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
ZBTB14 O43829 HRAS Homo sapiens P01112
Y2H Array
32814053
Intra
ZBTB14 O43829 HRAS Homo sapiens P01112
Y2H Pooling
32814053
Intra
ZBTB14 O43829 HRAS Homo sapiens P01112
Validated Y2H
32814053
Intra
ZBTB14 O43829 DDX6 Homo sapiens P26196
Validated Y2H
32296183
Intra
ZBTB14 O43829 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
ZBTB14 O43829 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
ZBTB14 O43829 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
ZBTB14 O43829 RPS25 Homo sapiens P62851
Validated Y2H
32296183
Intra
ZBTB14 O43829 RPS7 Homo sapiens P62081
Y2H Array
31515488
Intra
ZBTB14 O43829 RPS7 Homo sapiens P62081
Validated Y2H
25416956
Intra
ZBTB14 O43829 RPS7 Homo sapiens P62081
Y2H Array
25416956
Intra
ZBTB14 O43829 RPS7 Homo sapiens P62081
Y2H Prey Pooling
25416956
Intra
ZBTB14 O43829 ATP5PO Homo sapiens P48047
Y2H Array
25416956
Intra
ZBTB14 O43829 ATP5PO Homo sapiens P48047
Y2H Prey Pooling
25416956
Intra
ZBTB14 O43829 ATP5PO Homo sapiens P48047
Validated Y2H
25416956
Intra
ZBTB14 O43829 BYSL Homo sapiens Q13895
Y2H Prey Pooling
25416956
Intra
ZBTB14 O43829 BYSL Homo sapiens Q13895
Validated Y2H
25416956
Intra
ZBTB14 O43829 BYSL Homo sapiens Q13895
Validated Y2H
32296183
Intra
ZBTB14 O43829 BYSL Homo sapiens Q13895
Y2H Array
25416956
Intra
ZBTB14 O43829 RPL9 Homo sapiens P32969
Y2H Prey Pooling
25416956
Intra
ZBTB14 O43829 POLR2L Homo sapiens P62875
Y2H Prey Pooling
25416956
Intra
ZBTB14 O43829 POLR2L Homo sapiens P62875
Validated Y2H
25416956
Intra
ZBTB14 O43829 CDKL3 Homo sapiens Q8IVW4
Validated Y2H
25416956
Intra
ZBTB14 O43829 KAT5 Homo sapiens Q92993
Y2H Prey Pooling
25416956
Intra
ZBTB14 O43829 MORF4L2 Homo sapiens Q15014
Y2H Array
25416956
Intra
ZBTB14 O43829 MORF4L2 Homo sapiens Q15014
Y2H Prey Pooling
25416956
Intra
ZBTB14 O43829 MORF4L2 Homo sapiens Q15014
Validated Y2H
25416956
Intra
ZBTB14 O43829 CYCS Homo sapiens P99999
Y2H Pooling
32814053
Intra
ZBTB14 O43829 CYCS Homo sapiens P99999
Validated Y2H
32814053
Intra
ZBTB14 O43829 CYCS Homo sapiens P99999
Y2H Array
32814053
Intra
ZBTB14 O43829 HIP1 Homo sapiens O00291
Validated Y2H
32814053
Intra
ZBTB14 O43829 HIP1 Homo sapiens O00291
Y2H Pooling
32814053
Intra
ZBTB14 O43829 HIP1 Homo sapiens O00291
Y2H Array
32814053
Intra
ZBTB14 O43829 AP1M1 Homo sapiens Q9BXS5
Y2H Prey Pooling
25416956
Intra
ZBTB14 O43829 AP1M1 Homo sapiens Q9BXS5
Validated Y2H
32296183
Intra
ZBTB14 O43829 AP1M1 Homo sapiens Q9BXS5
Validated Y2H
25416956
Intra
ZBTB14 O43829 MRPL11 Homo sapiens Q9Y3B7
Validated Y2H
32296183
Intra
ZBTB14 O43829 ZCCHC10 Homo sapiens Q8TBK6
Validated Y2H
25416956
Intra
ZBTB14 O43829 ZCCHC10 Homo sapiens Q8TBK6
Y2H Array
25416956
Intra
ZBTB14 O43829 ZCCHC10 Homo sapiens Q8TBK6
Y2H Prey Pooling
25416956
Intra
ZBTB14 O43829 EPM2AIP1 Homo sapiens Q7L775
Y2H Prey Pooling
25416956
Intra
ZBTB14 O43829 EPM2AIP1 Homo sapiens Q7L775
Validated Y2H
32296183
Intra
ZBTB14 O43829 FAM90A1 Homo sapiens Q86YD7
Y2H Prey Pooling
25416956
Intra
ZBTB14 O43829 FAM90A1 Homo sapiens Q86YD7
Y2H Array
25416956
Intra
ZBTB14 O43829 MAD2L1BP Homo sapiens Q15013
Validated Y2H
32296183
Intra
ZBTB14 O43829 MAD2L1BP Homo sapiens Q15013
Y2H Array
25416956
Intra
ZBTB14 O43829 MAD2L1BP Homo sapiens Q15013
Y2H Prey Pooling
25416956
Intra
ZBTB14 O43829 CBX8 Homo sapiens Q9HC52
Validated Y2H
32296183
Intra
ZBTB14 O43829 CBX8 Homo sapiens Q9HC52
Y2H Prey Pooling
25416956
Intra
ZBTB14 O43829 CBX8 Homo sapiens Q9HC52
Y2H Array
25416956
Intra
ZBTB14 O43829 PIN1 Homo sapiens Q13526
Validated Y2H
25416956
Intra
ZBTB14 O43829 PIN1 Homo sapiens Q13526
Y2H Prey Pooling
25416956
Intra
ZBTB14 O43829 CAPN6 Homo sapiens Q9Y6Q1
Validated Y2H
32296183
Intra
ZBTB14 O43829 FAM161A Homo sapiens Q3B820
Y2H Prey Pooling
25416956
Intra
ZBTB14 O43829 FAM161A Homo sapiens Q3B820
Y2H Array
25416956
Intra
ZBTB14 O43829 CDK16 Homo sapiens Q00536
Y2H Array
25416956
Intra
ZBTB14 O43829 CDK16 Homo sapiens Q00536
Y2H Prey Pooling
25416956
Intra
ZBTB14 O43829 SDCBP Homo sapiens O00560
Validated Y2H
25416956
Intra
ZBTB14 O43829 SDCBP Homo sapiens O00560
Y2H Array
25416956
Intra
ZBTB14 O43829 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
25416956
Intra
ZBTB14 O43829 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
25416956
Intra
ZBTB14 O43829 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
25416956
Intra
ZBTB14 O43829 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
29892012
Intra
ZBTB14 O43829 CEP19 Homo sapiens Q96LK0
Validated Y2H
32296183
Intra
ZBTB14 O43829 CEP19 Homo sapiens Q96LK0
Y2H Array
25416956
Intra
ZBTB14 O43829 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
25416956
Intra
ZBTB14 O43829 NAA10 Homo sapiens P41227
Y2H Prey Pooling
25416956
Intra
ZBTB14 O43829 NAA10 Homo sapiens P41227
Validated Y2H
32296183
Intra
ZBTB14 O43829 SCNM1 Homo sapiens Q9BWG6
Validated Y2H
25416956
Intra
ZBTB14 O43829 SCNM1 Homo sapiens Q9BWG6
Y2H Prey Pooling
25416956
Intra
ZBTB14 O43829 OPTN Homo sapiens Q96CV9
Y2H Array
32814053
Intra
ZBTB14 O43829 OPTN Homo sapiens Q96CV9
Validated Y2H
32814053
Intra
ZBTB14 O43829 OPTN Homo sapiens Q96CV9
Y2H Pooling
32814053
Intra
ZBTB14 O43829 EIF1AD Homo sapiens Q8N9N8
Y2H Prey Pooling
25416956
Intra
ZBTB14 O43829 EAF1 Homo sapiens Q96JC9
Validated Y2H
25416956
Intra
ZBTB14 O43829 EAF1 Homo sapiens Q96JC9
Y2H Array
25416956
Intra
ZBTB14 O43829 TSTD2 Homo sapiens Q5T7W7
Validated Y2H
32296183
Intra
ZBTB14 O43829 TCEANC Homo sapiens Q8N8B7
Y2H Prey Pooling
25416956
Intra
ZBTB14 O43829 TCEANC Homo sapiens Q8N8B7
Validated Y2H
25416956
Intra
ZBTB14 O43829 TCEANC Homo sapiens Q8N8B7
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Holoprosencephaly 4

  • HPE4

  • Holoprosencephaly-4

  • Holoprosencephaly, Type 4
Myopia

  • Near-Sightedness

  • Short-Sightedness

  • Nearsightedness

  • Nearsighted

  • Near Vision

  • Close Sighted

  • Myopic

  • Short-Sighted

  • Near Sighted
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15963 ZBTB14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ZBTB14 VGNC VGNC:67162
Rattus norvegicus ZBTB14 RGD RGD:628712
Bos taurus ZBTB14 VGNC VGNC:37061
Canis familiaris ZBTB14 VGNC VGNC:48523
Macaca mulatta ZBTB14 VGNC VGNC:78823
Mus musculus ZBTB14 MGD MGI:1195345
Others ZBTB14 NCBI