Tocainide
Based on 1 Customer Validation
Tocainide hydrochloride is an orally activesodium channel blocker, it blocks the sodium channels in the pain-producing foci in the nerve membranes. Tocainide hydrochloride is a primary amine analog of lidocaine, can be used for the treatment of tinnitus.
For research use only. We do not sell to patients.
- Purity: 99.06%
- CAS No.: 41708-72-9
- Formula: C11H16N2O
- Molecular Weight:192.26
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Membrane Transporter/Ion Channel Compound Library
HY-L011
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FDA-Approved Drug Library
HY-L022
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Drug Repurposing Compound Library
HY-L035
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Anti-Cardiovascular Disease Compound Library
HY-L046
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Orally Active Compound Library
HY-L061
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FDA Approved & Pharmacopeial Drug Library
HY-L066
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Neuroprotective Compound Library
HY-L070
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Sodium Channel Blocker Library
HY-L118
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Human Metabolite Library
HY-L123
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Withdrawn Drug Compound Library
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Off-patent Drug Library
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Membrane Protein-targeted Compound Library
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Membrane Receptor-targeted Compound Library
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Ion Channel Compound Library
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Bioactive Compound Library Max
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MCE Bioactive Compound Library
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HY-L035P
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FDA-Approved Drug Library Mini
HY-L022M
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Mass Spectrometry Human Metabolite Library
HY-L215
Biological Activity
IC50: sodium channel[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 41708-72-9
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Appearance Solid
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Molecular Weight 192.26
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Formula C11H16N2O
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Color White to off-white
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SMILES
CC(N)C(NC1=C(C)C=CC=C1C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (650.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Alpert JS, et al. Chemistry, pharmacology, antiarrhythmic efficacy and adverse effects of tocainide hydrochloride, an orally active structural analog of lidocaine. Pharmacotherapy. 1983 Nov-Dec;3(6):316-23. [Content Brief]
[2]. De Luca A,et al.Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds.Mol Pharmacol. 2003 Oct;64(4):932-45. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.2013 mL | 26.0065 mL | 52.0129 mL | 130.0323 mL |
| 5 mM | 1.0403 mL | 5.2013 mL | 10.4026 mL | 26.0065 mL | |
| 10 mM | 0.5201 mL | 2.6006 mL | 5.2013 mL | 13.0032 mL | |
| 15 mM | 0.3468 mL | 1.7338 mL | 3.4675 mL | 8.6688 mL | |
| 20 mM | 0.2601 mL | 1.3003 mL | 2.6006 mL | 6.5016 mL | |
| 25 mM | 0.2081 mL | 1.0403 mL | 2.0805 mL | 5.2013 mL | |
| 30 mM | 0.1734 mL | 0.8669 mL | 1.7338 mL | 4.3344 mL | |
| 40 mM | 0.1300 mL | 0.6502 mL | 1.3003 mL | 3.2508 mL | |
| 50 mM | 0.1040 mL | 0.5201 mL | 1.0403 mL | 2.6006 mL | |
| 60 mM | 0.0867 mL | 0.4334 mL | 0.8669 mL | 2.1672 mL | |
| 80 mM | 0.0650 mL | 0.3251 mL | 0.6502 mL | 1.6254 mL | |
| 100 mM | 0.0520 mL | 0.2601 mL | 0.5201 mL | 1.3003 mL |
Tocainide Related Classifications
HY-B1798 Related Classifications
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