UCB-35440
Based on 1 Customer Validation
UCB-35440 is an orally active histamine H1 receptor antagonist and 5-lipoxygenase inhibitor. UCB-35440 can be used for the research of dermatologic inflammatory conditions.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 99.38%
- CAS No.: 299460-62-1
- Formule: C31H34ClN5O4
- Masse moléculaire:576.09
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Stockage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Voir tous les produits spécifiques à Isoform Histamine Receptor
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Activité biologique
Description
In Vivo
UCB-35440 (0.3-10% w/v; topical; twice daily; 8 doses) inhibits chronic PMA-induced mouse ear inflammation[1].
UCB-35440 (10 mg/kg; oral; twice daily) significantly inhibits Histamine (HY-B1204)-induced dermal extravasation in guinea pigs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD-1 mice (Crl:CD-1 (ICR) BR) (female, 8-10 weeks old, acute PMA-induced dermatitis model)[1]
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Dosage:0.3% w/v; 1% w/v; 3% w/v
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Administration:topical; 4 h
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Result:Inhibited PMA-induced ear weight gain by 57% at the 3% w/v dose.
Produced moderate reduction of polymorphonuclear cell infiltration and edema at the 3% w/v dose.
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Animal Model:CD-1 mice (Crl:CD-1 (ICR) BR) (female, 8-10 weeks old, chronic PMA-induced dermatitis model)[1]
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Dosage:0.3% w/v; 1% w/v; 3% w/v; 10% w/v
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Administration:topical; twice daily; 8 doses
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Result:Inhibited PMA-induced ear weight gain by 43% at the 3% w/v dose.
Produced substantial reduction of inflammatory/immune cell infiltrate and edema at the 3% w/v dose.
Showed no apparent effect on epidermal hyperplasia at the 3% w/v dose.
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Animal Model:Hartley Guinea pigs (male, 350-400 g, ~4-5 weeks old, histamine-induced dermal extravasation model)[1]
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Dosage:10 mg/kg
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Administration:oral; twice daily
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Result:Produced minimal inhibition of Histamine-induced dermal extravasation with single-dose regimens.
Produced highly significant inhibition (P<0.001) of extravasation induced by 0.1 μg and 1.0 μg Histamine with the 2-dose (24 h + 2 h pre-challenge) regimen.
Produced substantial inhibition (P<0.001) of extravasation induced by 0.1 μg, 1.0 μg, and 10.0 μg Histamine with the 5.5-day twice-daily regimen.
Chemical Information
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CAS No. 299460-62-1
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Appearance Solid
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Masse moléculaire 576.09
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Formule C31H34ClN5O4
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Color Off-white to pink
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SMILES
O=C(N)C1=CC(C#CCCN(C(N)=O)O)=CC=C1OCCN2CCN([C@@H](C3=CC=C(Cl)C=C3)C4=CC=CC=C4)CC2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvant et solubilité
In Vitro:
DMSO : 20 mg/mL (34.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.7358 mL | 8.6792 mL | 17.3584 mL | 43.3960 mL |
| 5 mM | 0.3472 mL | 1.7358 mL | 3.4717 mL | 8.6792 mL | |
| 10 mM | 0.1736 mL | 0.8679 mL | 1.7358 mL | 4.3396 mL | |
| 15 mM | 0.1157 mL | 0.5786 mL | 1.1572 mL | 2.8931 mL | |
| 20 mM | 0.0868 mL | 0.4340 mL | 0.8679 mL | 2.1698 mL | |
| 25 mM | 0.0694 mL | 0.3472 mL | 0.6943 mL | 1.7358 mL | |
| 30 mM | 0.0579 mL | 0.2893 mL | 0.5786 mL | 1.4465 mL |
UCB-35440 Related Classifications
HY-19443 Related Classifications
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Keywords
- UCB-35440
- 299460-62-1
- UCB35440
- UCB 35440
- Histamine Receptor
- Lipoxygenase
- mouse ears
- guinea pig skin
- mouse ear inflammation
- inflammatory cell infiltration
- inflammatory cell infiltrate
- dermatologic inflammatory conditions
- 5-lipoxygenase
- histamine H1 receptor
- dermal extravasation
- polymorphonuclear cell
- Inhibitor
- inhibitor
- inhibit