2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation Metabolic Enzyme/Protease
  3. Histamine Receptor Lipoxygenase
  4. UCB-35440

UCB-35440 is an orally active histamine H1 receptor antagonist and 5-lipoxygenase inhibitor. UCB-35440 inhibits LTB4 formation in human whole blood and reduces polymorphonuclear cell infiltration in mouse models. UCB-35440 inhibits histamine-stimulated bronchoconstriction and reduces skin inflammation in guinea pigs. UCB-35440 can be used for research on asthma and skin inflammation.

For research use only. We do not sell to patients.

UCB-35440

UCB-35440 Chemical Structure

CAS No. : 299460-62-1

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Based on 1 publication(s) in Google Scholar

UCB-35440 Related Antibodies

Top Publications Citing Use of Products

View All Histamine Receptor Isoform Specific Products:

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H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

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Description

UCB-35440 is an orally active histamine H1 receptor antagonist and 5-lipoxygenase inhibitor. UCB-35440 inhibits LTB4 formation in human whole blood and reduces polymorphonuclear cell infiltration in mouse models. UCB-35440 inhibits histamine-stimulated bronchoconstriction and reduces skin inflammation in guinea pigs. UCB-35440 can be used for research on asthma and skin inflammation[1][2].

Molecular Weight

576.09

Formula

C31H34ClN5O4
CAS No.
Appearance

Solid

Color

Off-white to pink

SMILES

O=C(N)C1=CC(C#CCCN(C(N)=O)O)=CC=C1OCCN2CCN([C@@H](C3=CC=C(Cl)C=C3)C4=CC=CC=C4)CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (34.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7358 mL 8.6792 mL 17.3584 mL
5 mM 0.3472 mL 1.7358 mL 3.4717 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7358 mL 8.6792 mL 17.3584 mL 43.3960 mL
5 mM 0.3472 mL 1.7358 mL 3.4717 mL 8.6792 mL
10 mM 0.1736 mL 0.8679 mL 1.7358 mL 4.3396 mL
15 mM 0.1157 mL 0.5786 mL 1.1572 mL 2.8931 mL
20 mM 0.0868 mL 0.4340 mL 0.8679 mL 2.1698 mL
25 mM 0.0694 mL 0.3472 mL 0.6943 mL 1.7358 mL
30 mM 0.0579 mL 0.2893 mL 0.5786 mL 1.4465 mL
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UCB-35440 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UCB-35440299460-62-1UCB35440UCB 35440Histamine ReceptorLipoxygenaseLOXCHO-K1LTB4inflammationasthmapolymorphonuclear cellInhibitorinhibitorinhibit

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